• Radiation Oncology Journal
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• v.36 no.2
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• pp.103-113
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• 2018

Purpose: Anaplastic thyroid cancer (ATC) is a rare tumor with a lethal clinical course despite aggressive multimodal therapy. Intensity-modulated radiotherapy (IMRT) may achieve a good therapeutic outcome in ATC patients, and the role of IMRT should be assessed. We retrospectively reviewed outcomes for ATC treated with three-dimensional conformal radiotherapy (3D-CRT) or IMRT to determine the optimal treatment option and explore the role of radiotherapy (RT). Materials and Methods: Between December 2000 and December 2015, 41 patients with pathologically proven ATC received RT with a sufficient dose of ${\geq}40Gy$. Among them, 21 patients (51%) underwent surgery before RT. Twenty-eight patients received IMRT, and 13 received 3D-CRT. Overall survival (OS) and progression-free survival (PFS), patterns of failure, and toxicity were examined. Results: The median follow-up time for survivors was 38.0 months. The median and 1-year OS and PFS rates were 7.2 months and 29%, 4.5 months and 15%, respectively. Surgery significantly improved the prognosis (median OS: 10.7 vs. 3.9 months, p = 0.001; median PFS: 5.9 vs. 2.5 months, p = 0.007). IMRT showed significantly better PFS and OS than 3D-CRT, even in multivariate analysis (OS: hazard ratio [HR] = 0.30, p = 0.005; PFS: HR = 0.33, p = 0.005). Significantly higher radiation dose could be delivered with IMRT than 3D-CRT ($EQD2_{10}$ 66 vs. 60 Gy, p = 0.005). Only 2 patients had grade III dermatitis after IMRT. No other severe toxicity ${\geq}grade$ III occurred. Conclusion: Patients with ATC showed better prognosis through multimodal treatment. Furthermore, IMRT could achieve favorable survival rates by safely delivering higher dose than 3D-CRT.

• Korean Journal of Radiology
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• v.23 no.5
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• pp.548-554
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• 2022

Objective: To evaluate the safety and feasibility of prostatic artery embolization (PAE) via transradial access (TRA) compared with transfemoral access (TFA). Materials and Methods: This retrospective study included 53 consecutive men with lower urinary tract symptoms (LUTS) who underwent PAE between September 2018 and September 2021. Thirty-one patients (mean age ± standard deviation: 70.6 ± 8.4 years) were treated with TFA, including 14 patients treated before adopting TRA. Since December 2019, TRA has also been attempted with the procedure's selection criteria of patent carpal circulation and a height ≤ 172 cm, with 22 patients treated via TRA (69.1 ± 9.6 years). Parameters of technical success (defined as successful bilateral embolization), clinical success (defined as LUTS improvement), procedural time, radiation dose, and adverse events were compared between the two groups using the Fisher's exact test, independent sample t test, Wilcoxon signed-rank test, or Mann-Whitney test. Results: All patients received at least one-side PAE. Technical success of PAE was achieved in most patients (TRA, 21/22; TFA, 30/31; p > 0.999). No technical problem-related conversion from TRA to TFA occurred. The clinical success rate was 85% (11/13) in patients with TRA, and 89% (16/18) in patients with TFA for follow-up > 2 weeks post-PAE (median, 3 months) (p > 0.999). The median procedure time was similar in both groups (TRA, 81 minutes vs. TFA, 94 minutes; p = 0.570). No significant dose differences were found between the TRA and TFA groups in the dose-area product (median Gycm², 95 [range, 44-255] for TRA and 84 [34-255] for TFA; p = 0.678) or cumulative air kerma (median mGy, 609 [236-1584] for TRA and 634 [217-1594] for TFA; p = 0.551). No major adverse events occurred in either of the groups. Conclusion: PAE via TRA is a safe and feasible method comparable to conventional TFA. It can be safely implemented by selecting patients with patent carpal circulation and adequate height.

• Korean Journal of Pharmacognosy
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• v.16 no.4
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• pp.221-226
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• 1985

To screen biologically active components of the higher fungi of Korea, the dried carpophores of Auricularia polytricha were extracted with water. The extract was examined for acute toxicity in ICR mice. A low molecular weight toxin of this fungus was purified by acetone precipitation followed by cellulose, silica gel and LH-20 Sephadex column chromatography. Major symptoms of this toxin were eye extrusion, hair erection, trembling of head, paralysis, rapid running or moving before death and depression of respiration. The median lethal doses of the total extract were 1.25 g/kg and 4.18 g/kg by i.p. and p.o. administrations, respectively. The amounts of one mouse lethal unit (MLU) of the total extract and final fraction that killed a 20-g mouse within 30 minutes were 28.5 mg/mouse and 12 mg/mouse, respectively.

• Journal of the Korean Operations Research and Management Science Society
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• v.16 no.2
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• pp.137-137
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• 1991

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized p-median model. is proposed. Unlike existing p-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.

• Korean Management Science Review
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• v.16 no.2
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• pp.137-147
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• 1999

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized {{{{ { p}_{ } }}-median model. is proposed. Unlike existing {{{{ { p}_{ } }}-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.

• Journal of Technologic Dentistry
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• v.12 no.1
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• pp.95-102
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• 1990

The distances from the center line between maxillary right and left central incisors(the dental midline) to the various anatomical landmarks were measured. Fifty five students(thirth four males and twenty one females) who have at least natural teeth including maxillary and mandibular incisors and bicuspids were examined. 1. There was statistically significant difference between the dental midline and the center line of maxillary labial frenum(p<0.05). 2. There was no statistically significant difference between the dental midline and the point of incisive papilla, philtrum line, the center line between two mandibular central incisors, and the median palatine suture line(p>0.05). 3. There was no statistically significant sexual difference among data. 4. The philtrum line showed the highest value of correspondence to the center line between two maxillary central incisors followed by the center point of incisive papilla, the center line of two mandibular central incisors, median plaltine suture line and the center line of maxillary labial frenum at the decreasing rate.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.21 no.46
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• pp.59-72
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• 1998

This study is concerned in manufacturing cell formation with operation sequences. Operation sequences must be reflected for manufacturing cell formation anyway, because the primary aim of cellular manufacturing system is to minimize the inter-cell flows, and inter-cell flows are differed by operation sequences. In this study we propose flow-similarity(FS) of reflecting both inter-machine similarity and direct/indirect flow, and then apply the modified P-median model for grouping machines. We also use machine cell-part handling frequency(CPH) so as to be assigned parts to the machine cells having the most CPH. We confirm this approach through an application example. The performance of this approach(FS-model) is evaluated and compared with P-median model and F-model through computational experiments.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.4
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• pp.238-245
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• 2023

As technologies have been more quickly developed in this 4th Industry Revolution era, their application to defense industry has been also growing. With these much advanced technologies, we attempt to use Manned-Unmanned Teaming systems in various military operations. In this study, we consider the Location-Routing Problem for reconnaissance surveillance missions of the maritime manned-unmanned surface vehicles. As a solution technique, the two-phase method is presented. In the first location phase, the p-median problem is solved to determine which nodes are used as the seeds for the manned vehicles using Lagrangian relaxation with the subgradient method. In the second routing phase, using the results obtained from the location phase, the Vehicle Routing Problems are solved to determine the search routes of the unmanned vehicles by applying the Location Based Heuristic. For three network data sets, computational experiments are conducted to show the performance of the proposed two-phase method.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.117-122
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• 2014

Background: Breast cancer is the most common malignancy and the second leading cause of cancer-related death among women in the developed countries. Despite advances in screening, improved local therapies and adjuvant systemic treatments, median survival of metastatic breast cancer patients (MBC) is in the range of 2-3 years at most. We aimed to investigate whether the prognostic factors and therapeutic responses of our Turkish patients are similar to those in the literature. Materials and Methods: We reviewed the medical records of MBC patients who had been treated in our institution between 1999-2009 and analyzed their clinicopathological features and survival outcomes retrospectively Results: A hundred and sixty patients were included. Median age was 47 (23-82), median follow up was 24 (2-186) months. At the time of diagnosis 59% of patients were under the age of 50 and 46% were postmenopausal. The majority (37%) had multiple sites of metastases. Forty percent received endocrine therapy and 40% chemotherapy as first line metastatic treatment. Thirty (20%) patients were treated with molecular targeting agents like trastuzumab, lapatinib and sunitinib, frequently combined with a chemotherapy agent. Five-year overall survival (OS) was 32% and median OS was 38 months for the whole group. Five year progression free survival (PFS) was 10% and median PFS was 10 months. Menopausal status, hormone receptor expression and disease free status had a significant impact on overall survival in the multivariate analysis (p 0.018, p 0.018 and p:0.003, respectively). Conclusions: All our patients were treated with the modern oncologic therapies recommended by the international guidelines. From our data, MBC patients live up to 3-4 years, indicating that further improvement beyond that requires development of new treatment modalities. The survival outcomes of our patients were consistent with the data reported in the literature.

• Radiation Oncology Journal
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• v.32 no.3
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• pp.163-169
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• 2014

Purpose: To report the results of stereotactic body radiotherapy (SBRT) for unresectable primary or recurrent cholangiocarcinoma. Materials and Methods: From January 2005 through August 2013, 58 patients with unresectable primary (n = 28) or recurrent (n = 30) cholangiocarcinoma treated by SBRT were retrospectively analyzed. The median prescribed dose was 45 Gy in 3 fractions (range, 15 to 60 Gy in 1-5 fractions). Patients were treated by SBRT only (n = 53) or EBRT + SBRT boost (n = 5). The median tumor volume was 40 mL (range, 5 to 1,287 mL). Results: The median follow-up duration was 10 months (range, 1 to 97 months). The 1-year, 2-year overall survival rates, and median survival were 45%, 20%, and 10 months, respectively. The median survival for primary group and recurrent group were 5 and 13 months, respectively. Local control rate at 1-year and 2-year were 85% and 72%, respectively. Disease progression-free survival rates at 1-year and 2-year were 26% and 23%, respectively. In univariate analysis, ECOG performance score (0-1 vs. 2-3), treatment volume (<50 vs. ${\geq}50mL$), and pre-SBRT CEA level (<5 vs. ${\geq}5ng/mL$) were significant in overall survival rate. In multivariate analysis, ECOG score (p = 0.037) and tumor volume (p = 0.030) were statistically significant. In the recurrent tumor group, patients with >12 months interval from surgery to recurrence showed statistically significant higher overall survival rate than those with ${\leq}12$ months (p = 0.026). Six patients (10%) experienced ${\geq}$grade 3 complications. Conclusion: SBRT can be considered as an effective local modality for unresectable primary or recurrent cholangiocarcinoma.