• Journal of Chest Surgery
• /
• v.8 no.2
• /
• pp.109-118
• /
• 1975

This is a report on four cases of the lobar emphysema due to proximal bronchial obstruction in the Department of Thoracic Surgery, Hanyang University Hospital, during the period of three and half years from 1972 to 1975. First case, a two years old male child was referred to our Department with the lobar emphysema of the lower lobe of the right lung with pneumonia. This emphysema was developed after aspiration of a piece of peanut. Bronchoscopy revealed that the bronchus of the right lower lobe was obstructed with the foreign body, however removal of the peanut through bronchoscope was not attempted because of corruption and softening of the peanut. The removal of the peanut by bronchotomy was performed after subsiding of acute phase of pulmonary infection. Postoperative course was uneventful and the emphysema was disappeared. Second case, a twenty months old female baby was referred to our Department with lobar emphysema of the lower lobe of the left lung. The emphysema was suddenly developed with coughing and dyspneic symptoms and the diagnosis was made roentgenologically. She gave a history of reccurrent infections of the respiratory tract after birth. Bronchoscopy showed an obstruction of the left main bronchus with the growing of fibrinous tissue on the bronchial mucosa. The protruded tissue in the left main bronchus taken out about O.8ml with biopsy forceps for histological examination. After this procedure, the emphysema of the left lung was disappeared. Histological finding was reported to be a chronic inflammatory granulation tissue. Third case, a two and half years old male child was referred to our Department with roentgenological lobar emphysema. Two weeks prior to admission he had an episode of sudden onset of coughing attack with dyspnea. Bronchoscopy revealed that the bronchus of the left lower lobe was obstructed with a mass which was strongly suspected of a neoplastic tissue. At operation, there was found a perforation of enlarged tuberculous lymph node in the bronchus of the left lower lobe and protrusion of granulation tissue into the bronchus. Ruptured orifice on themembranous wall of the left lower lobe bronchus was closed with interrupted suture after the" removal of a perforated tuberculous lymph node. Postoperative course was uneventful and antituberculous chemotherapy was given. Fourth case, a 47 years old man was admitted to our Department with the complaint of severe dyspnea of few months duration. Twenty years ago, he had a history of lung tuberculosis and was treated for many years. X-ray examination including tomography and bronchography revealed that the upper lobe of the right lung was destroyed with cavities, the lower lobe was completely shrunk, and the right middle lobe was strongly overdistended with narrowing bronchial trees. Differential bronchospirometry and lung scanning confirmed that the respiratory function of the affected lung was impaired almost totally. The value of the right lung was calculated on 6% of oxygen uptake, 1% of Minute volume, and 32% of vital capacity. The right pneumonectomy was performed under the careful consideration of anesthetic and surgical procedures. Postoperative course was uneventful and the respiratory function was improved nearly to the normal level.evel.

• The Journal of Korean Medicine
• /
• v.21 no.3
• /
• pp.119-128
• /
• 2000

This study was carried out to determine if Salviae Radix extract (SRE) exerts protective effect against alterations in membrane transport function in rabbits with rhabdomyo lysis-induced acute renal failure. Acute renal failure was induced by intramuscular administration of glycerol (50%, 10 ml/kg). GFR in the glycerol-injected animals was reduced to 11% of the basal value and the fractional $Na^{+}$ excretion was increased to 7.8-fold, indicating generation of acute renal failure. When animals received SRE pretreatment for 7 days prior to glycerol injection, such changes were significantly attenuated. The fractional excretion of glucose and phosphate was increased more than 43-fold and 27-fold, respectively, in rabbits treated with glycerol alone. However, they were increased to 17-and 4.3-fold, respectively, in SRE-pretreated rabbits, and these values were significantly lower than those in rabbits treated with glycerol alone. Uptakes of glucose and phosphate in purified isolated brush-border membrane, the $Na^{+}-K^{+}-ATPase$ activity in microsomal fraction, and cellular ATP levels all were reduced in rabbits treated with glycerol alone. Such changes were prevented by SRE pretreatment. Uptakes of organic ions, PAH and TEA, in renal cortical slices were inhibited by the administration of glycerol, which was prevented by SRE pretreatment. Pretreatment of an antioxidant DPPD significantly attenuated the increase in the fractional excretion of glucose and phosphate induced by rhabdomyolysis. These results indicate that rhabdomyolysis causesimpairment inreabsorption of solutes in the proximal tubule via the generation of reactive oxygen species, and SRE pretreatment may provide the protection against the rhabdomyolysis-induced impairment by its antioxidant action.

• Asian-Australasian Journal of Animal Sciences
• /
• v.29 no.2
• /
• pp.288-298
• /
• 2016

Resveratrol acts as a free radical scavenger and a potent antioxidant in the inhibition of numerous reactive oxygen species (ROS). The function of resveratrol and resveratrol-loaded nanoparticles in protecting human lung cancer cells (A549) against hydrogen peroxide was investigated in this study. The 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay was performed to evaluate the antioxidant properties. Resveratrol had substantially high antioxidant capacity (trolox equivalent antioxidant capacity value) compared to trolox and vitamin E since the concentration of resveratrol was more than $50{\mu}M$. Nanoparticles prepared from ${\beta}$-lactoglobulin (${\beta}$-lg) were successfully developed. The ${\beta}$-lg nanoparticle showed 60 to 146 nm diameter in size with negatively charged surface. Non-cytotoxicity was observed in Caco-2 cells treated with ${\beta}$-lg nanoparticles. Fluorescein isothiocynate-conjugated ${\beta}$-lg nanoparticles were identified into the cell membrane of Caco-2 cells, indicating that nanoparticles can be used as a delivery system. Hydrogen peroxide caused accumulation of ROS in a dose- and time-dependent manner. Resveratrol-loaded nanoparticles restored $H_2O_2$-induced ROS levels by induction of cellular uptake of resveratrol in A549 cells. Furthermore, resveratrol activated nuclear factor erythroid 2-related factor 2-Kelch ECH associating protein 1 (Nrf2-Keap1) signaling in A549 cells, thereby accumulation of Nrf2 abundance, as demonstrated by western blotting approach. Overall, these results may have implications for improvement of oxidative stress in treatment with nanoparticles as a biodegradable and non-toxic delivery carrier of bioactive compounds.

• Journal of Korean Society of Environmental Engineers
• /
• v.28 no.1
• /
• pp.88-96
• /
• 2006

Among the various methods for minimization of waste activated sludge, maintaining a low F/M ratio in the bioreactor is known to be the most effective reliable one. In this research, various experiments were performed to check the capability of the nonwoven fabric filter bioreactor, which has been proved able to maintain a low F/M ratio by maintaining a high MLSS concentration, for excess sludge minimization. The reactor was intermittently fed with a synthetic wastewater having a COD concentration of approximately 300 mg/L and no SS. Results of the experiments showed that the F/M ratio in the reactor decreased to a minimum value of 0.02 g COD/g MLSS-day as the MLSS concentration increased to a maximum value of 31,010 mg/L. However, the measured endogenous decay coefficients and oxygen uptake rates of the MLSS confirmed that the activity of the MLSS decreased as the MLSS concentration increased. Based on the increase of MLSS in the reactor and the mass balance during the whole experimental period, the average microorganism yield coefficients were computed to be low values of 0.148 and 0.139 g MLSS/g COD, respectively. These results indicate that the nonwoven fabric filter bioreactor employed in this research is effective for minimization of excess sludge production.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.8
• /
• pp.190-199
• /
• 2017

The purpose of this study is to propose the standard of health-related fitness evaluation according to the working styles of male manufacturing workers. The subjects were 15,329 male manufacturing workers aged from 40 to 59 years old who had taken a health-related fitness test by K Institution. Health-related fitness components are cardiorespiratory endurance, muscular strength, muscular endurance, flexibility and body composition. We measured Vo2max, grip strength, sit-up, trunk flexion forward, and body fat percentage to ascertain each component. Data were analyzed with Two-way ANOVA, T-test, One-way ANOVA(Scheffe) and Percentile using SPSS version 18.0 program. The analysis results are as follows. First, the health-related fitness of manufacturing workers varied significantly according to their working styles(maximum oxygen uptake : F=88.67(p<.001), grip strength : F=20.09(p<.001), sit-up : F=42.06(p<.001), trunk flexion forward : F=69.44(p<.001), body fat percentage : F=136.75(p<.001)).Therefore, the evaluation standard was set based on the percentile of health fitness items. Second, the average Vo2max, grip strength, and trunk flexion forward of blue-collar workers were higher than those of white-collar workers at all ages. On the other hand, the average sit-up and body fat percentage of white-collar workers were higher than those of blue-collar workers at all ages. Third, these evaluation criteria differed greatly when compared with the results of the National Physical Fitness Survey. Therefore, we have confirmed that the evaluation criteria should be applied differently according to the working style of a worker when evaluating his health-related fitness.

• Journal of Life Science
• /
• v.20 no.9
• /
• pp.1394-1401
• /
• 2010

The purpose of this study was to examine the effect of 12 wk of aerobic exercise on lipid profiles, antioxidant enzyme activities, oxidative products, and autonomic nervous activity (ANA) in children with obesity. We studied 16 children with obesity and 19 age-matched normal weight controls over a period of 12 wk, during which time moderate intense running exercise was performed. Measurements included peak oxygen uptake, body composition, blood lipid profiles, ox-LDL, 8-OHdG, SOD, GPx activities, total mRNA, and ANA. There were no differences in body weight between periods in the OW group, but body weight increased after 12 wk in OR and CO groups. There were no differences in WHR between periods in the OR and CO groups, but the WHR values decreased after 12 weeks in the OW group. In the obese group, the baseline TG was higher than in the controls (p<0.05), while the ANA level was lower. There were differences in antioxidant enzyme gene expressions between periods in all groups. In conclusion, oxidative damage and antioxidant enzyme activities in obese children were found to be similar to those of normal weight children. However, TG was higher and ANA was lower in obese children than in normal weight children. These results indicated that increased TG and decreased ANA levels begins in childhood in obese patients. Also, regular aerobic exercise may modify the antioxidant enzyme gene expression in early life.

• Journal of Korean Society of Water and Wastewater
• /
• v.21 no.6
• /
• pp.727-735
• /
• 2007

The use of water by cities is increasing owing to industrialization, the concentration of population, and the enhancement of the standard of living. Accordingly, the amount of waste water is also increasing, and the degree of pollution of the water system is rising. In order to solve this problem, it is necessary to remove organisms and suspended particles as well as the products of eutrophication such as nitrates and phosphates. This study developed a high-end treatment engineering solution with maximum efficiency and lower costs by researching and developing a advanced treatment engineering solution with the use of Biosorption. As a result, the study conducted a test with a $50m^3/day$ Pilot Scale Plant by developing treatment engineering so that only the secondary treatment satisfies the standard of water quality and which provided optimal treatment efficiency along with convenient maintenance and management. The removal of organisms, which has to be pursued first for realizing nitrification during the test period, was made in such a way that there would be no oxidation by microorganisms in the reactor while preparing oxygen as an inhibitor for the growth of microorganism in the course of moving toward the primary settling pond. The study introduced microorganisms in the endogeneous respiration stage to perform adhesion, absorption, and filtering by bringing them into contact with the inflowing water with the use of a sludge returning from the secondary settling pond. Also a test was conducted to determine how effective the microorganisms are as an inner source of carbon. The HRT(Hydraulic Retention Time) in the nitrification tank (aerobic tank) could be reduced to two hours or below, and the stable treatment efficiency of the process using the organisms absorbed in the NAR reactor as a source of carbon could be proven. Also, given that the anaerobic condition of the pre-treatment tank becomes basic in the area of phosphate discharge, it was found that there was excellent efficiency for the removal of phosphate when the pre-treatment tank induced the discharge of phosphate and the polishing reactor induced the uptake of phosphate. The removal efficiency was shown to be about 94.4% for $BOD_5$. 90.7% for $COD_{Cr}$ 84.3% for $COD_{Mn}$, 96.0% for SS, 77.3% for TN, and 96.0% for TP.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.33 no.4
• /
• pp.356-360
• /
• 2000

In order to utilize the processing wastes of squid, chitosan was prepared by intermittent deacetylation treatment of ${\beta}-chitin$ richly contained in the pen of squid, and then their characteristics of chitosan and N-acetylchitosan film were studied. The acetylation time of N-acetylchitosan film-1 (N-ACE-1) manufactured from chitosan solution by treating with acetic anhydride was about 12 hrs. In SEM photomicrographs, the surface of chitosan film was regularly arranged netlike, and that of N-acetylchitosan film-2 (N-ACE-2) was rough like snowflake and larger than chitosan film. The chitosan film (thickness 0.02 mm, time 60 min) had the highest tensile strength ($1,240 kg/cm^2$) and elongation ($58.25{\%}$), N-ACP-1 (thickness 0.02 mm, time 60 min) had the highest water permeability ($539 g/m^2{\cdot}24 hrs$), oxygen permeability ($20,000 cm^3/m^2{\cdot}24 hrs{\cdot}atm$) and water uptake ($350{\%}$) among the tested films.

• Journal of Digital Convergence
• /
• v.10 no.11
• /
• pp.541-550
• /
• 2012

The purpose of this study was to investigate the effect of aerobic exercise training and half bath on blood component, cardiorespiratory function, and vascular compliance of middle-aged obese men. The subjects were 3 groups; aerobic exercise(n=10), half bath(n=10), and controlled group(n=10). They were tested on their blood component, cardiorespiratory function, and vascular compliance at the beginning and at the end of the 12-week study(pre-post test). For data analysis, mean and standard deviation scores were calculated, and repeated measure two-way ANOVA and Scheffe were used. The results of this study are as follows. First, aerobic exercise group was significantly improved on all blood component after the 12-weeks, and showed significant difference among groups. Half bath group was better than control groups on Triglyceride, LDL-C, and HDL-C levels. Second, aerobic exercise group was significantly improved on maximum oxygen uptake, maximum heart rate, and maximum ventilation after the 12-weeks. Third, in vascular compliance measured in both hands and both feet, the half bath group and aerobic exercise training group were significantly increases the control group. Therefore, these results imply that aerobic exercise and half bath can be helpful for better blood component, cardiorespiratory function, and vascular compliance in middle-aged obese men.

• Journal of Life Science
• /
• v.25 no.7
• /
• pp.819-825
• /
• 2015

The use of fructose-containing sports beverage drinks has increased in recent years, especially at sport events, because of their reported ergogenic effects. However, the ingestion of low to moderate doses of caffeinated energy drinks has been associated with adverse side effects such as insomnia or increased nervousness. The purpose of this study was to investigate the effects of fructose beverage supplementation on cardiopulmonary function, blood lactate levels, and inflammatory reactions. We recruited 8 young adult subjects from D university and measured their cardiopulmonary functions before and after supplementation with sports beverage drinks. We also measured blood lactate and inflammatory reactions after a 20 min recovery period. Exercise time, maximal oxygen uptake (V0₂max), and AT HRmax were significantly increased (p<0.05) in the period of before and after sports beverage supplementation. However, no significant differences were observed in RPE, AT RER, V0₂max RER, AT V0₂max, and maximum heart rate (HRmax). Lactate levels also significantly decreased after 20 min recovery with sports beverage supplementation. Sports beverage supplementation therefore may enhance maximal V0₂max and increase the exercise duration time. These drinks may also be helpful in promoting rapid recovery of fatigue variables and increasing exercise performance time.