Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Effects of Aerobic Training Intensity Difference on Cardiovascular Disease Pathophysiological Pathways Linking Oxidative Tissue Damage in Obese Children

유산소 훈련 강도 차이가 비만 어린이의 산화적 조직 손상에 의한 심혈관질환 병태생리적 경로에 미치는 영향

  • Woo, Jin-Hee (Department of Physical Education, Dong-A University) ;
  • Shin, Ki-Ok (Department of Physical Education, Dong-A University) ;
  • Kim, Keun-Soo (Korea Airforce Academy) ;
  • Kim, Young-Il (Department of Sports and Health Management, Youngsan University) ;
  • Kang, Sung-Hwun (Department of Physical Education, Dong-A University)
  • Received : 2010.07.22
  • Accepted : 2010.09.03
  • Published : 2010.09.30
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Abstract

The purpose of this study was to examine the effect of 12 wk of aerobic exercise on lipid profiles, antioxidant enzyme activities, oxidative products, and autonomic nervous activity (ANA) in children with obesity. We studied 16 children with obesity and 19 age-matched normal weight controls over a period of 12 wk, during which time moderate intense running exercise was performed. Measurements included peak oxygen uptake, body composition, blood lipid profiles, ox-LDL, 8-OHdG, SOD, GPx activities, total mRNA, and ANA. There were no differences in body weight between periods in the OW group, but body weight increased after 12 wk in OR and CO groups. There were no differences in WHR between periods in the OR and CO groups, but the WHR values decreased after 12 weeks in the OW group. In the obese group, the baseline TG was higher than in the controls (p<0.05), while the ANA level was lower. There were differences in antioxidant enzyme gene expressions between periods in all groups. In conclusion, oxidative damage and antioxidant enzyme activities in obese children were found to be similar to those of normal weight children. However, TG was higher and ANA was lower in obese children than in normal weight children. These results indicated that increased TG and decreased ANA levels begins in childhood in obese patients. Also, regular aerobic exercise may modify the antioxidant enzyme gene expression in early life.

본 연구는 12주 유산소 운동이 비만 어린이의 혈청지질성분, 항산화효소 활성 및 자율신경계 활동에 미치는 영향을 조사하였다. 피험자들은 16명의 비만어린이와 19명의 정상어린이를 대상으로 12주간 중강도 유산소 운동을 실시하였다. 측정 항목은 VO2peak, 신체조성, 혈청지질, ox-LDL, 8-OHdG, SOD, GPx 활성, total mRNA, 그리고 자율신경계 활성을 측정하였다. 그 결과 체중은 OW그룹에서 시기간 차이가 나타나지 않았으나, 12주 운동후 OR과 CO그룹에서 유의하게 증가하였다. WHR은 OR과 CO그룹에서 차이가 나타나지 않았으나, 12주 운동후 OW그룹에서 유의하게 감소하였다. 비만 그룹에서 baseline TG는 대조군 보다 더 높게 나타났으며(p<0.05), 자율신경계 활성은 낮게 나타났다. 항산화효소 유전자 발현은 모든 그룹에서 시기간 유의한 차이가 나타났다. 결론적으로 비만어린이에서 산화적 손상과 항산화효소 활성은 정상어린이와 유사하게 나타났다. 그러나 정상어린이에 비해 비만어린이의 TG는 더 높게 나타났고 자율신경계 활성은 더 낮게 나타났다. 따라서 비만어린이에서 TG의 증가와 자율신경계 활성의 감소는 비만환자의 출발점이 어린시기에 시작될 수 있음을 시사한다. 또한 규칙적인 유산소성 운동은 어린시기에서 항산화효소 발현을 수정하여 줄 수 있다고 사료된다.

Keywords

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