• The Korean Journal of Physiology and Pharmacology
• /
• 제2권6호
• /
• pp.653-659
• /
• 1998

• 한국환경성돌연변이발암원학회:학술대회논문집
• /
• 한국환경성돌연변이발암원학회 2003년도 춘계학술대회
• /
• pp.38-38
• /
• 2003

• 한국화재소방학회:학술대회논문집
• /
• 한국화재소방학회 2003년도 추계학술논문발표회논문집
• /
• pp.142-145
• /
• 2003

• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 1998년도 정보화시공 및 터널분과위원회 논문집
• /
• pp.17-34
• /
• 1998

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2002년도 춘계공동학술발표회요약집
• /
• pp.94.1-94
• /
• 2002

• 한국시뮬레이션학회:학술대회논문집
• /
• 한국시뮬레이션학회 1997년도 춘계 학술대회 발표집
• /
• pp.72-72
• /
• 1997

• 간호행정학회지
• /
• 제6권1호
• /
• pp.109-122
• /
• 2000

The present study examined the causal relationships among nurses' perceived autonomy, job satisfaction, work environment (work overload, role conflict, situational support, head nurses' leadership), personal aspects(experiences, need for achievement, professional knowledge and skill) by constructing and testing a theoretical framework. Based on literature review nurses' perceived autonomy and job satisfaction were conceived of as outcomes of the interplay among work environment and personal characteristics. Work environment factors involved work overload, role conflict, situational support, and head nurses' leadership (task oriented leadership, relation oriented leadership). Personal charateristics included experiences, need for achievement, and professional knowledge and skill. Three large general hospital in Chonbuk were selected to participate. The total sample of 516 registered nurses represents a response rate of 92 percent. Data for this study was collected from July to September in 1998 by Questionnaire. Path analyses with LISREL 7.16 program were used to test the fit of the proposed conceptual model to the data and to examine the causal relationship among variables. The result showed that both the proposed model and the modified model fit the data excellently. It needs to be notified, however, that path analisis can not count measurement errors; measurement error can attenuate estimates of coefficient and explanatory power. Nevertheless the model revealed relatively high explanatory power. 42 percent of nurses' perceived autonomy was explained by predicted variables; 32 percent of nurses' job satisfaction was explained by by predicted variables. Tn predicting nurses' perceived autonomy the findings of this study clearly demonstrated the work overload might be the most important variable of all the antecedent variables. Head nurses' relation oriented leadership, situational supports, need for achievement, and role conflict were also found to be important determinants for nurses' perceived autonomy. As for the job satisfaction, role conflict, situational supports, need for the achievement, and head nurses' relation oriented leadership were in turn important predictors. Unexpectedly the result showed perceived autonomy have few influence on job satisfaction. The results were discussed, including directions for the future research and practical implication drawn from the research were suggested.

• 대한한방내과학회지
• /
• 제38권6호
• /
• pp.877-890
• /
• 2017

Objectives: Lonicerae flos (LF), a dried flower part of Lonicera japonica Thunb., has been widely used in Korean medicine as anti-inflammatory and antioxidative agent. The purpose of this study was to determine the cardioprotective effects of LF, through potential antioxidant effects, on the pressure overload (PO)-induced heart failure (HF) in C57BL/6 mice after transverse aortic constriction (TAC) surgery. Methods: Resveratrol (10 mg/kg body weight) or LF (125, 250 or 500 mg/kg body weight) was orally administered, once daily for 14 days, starting 14 days after TAC surgery. Changes in the mortality, body weights, heart weights, histopathology of the heart, and antioxidant defense systems of the heart were analyzed. Results: Marked and noticeable increases of heart weights, mortalities, and hypertrophic, focal, and lytic fibrotic histological changes in the LVs were observed, with destruction of heart antioxidant defense systems after surgery. However, HF signs, induced by TAC surgery through PO, and destruction of heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days of maintained oral treatment with LF 500, 250 or 125 mg/kg. Treatment with 250 mg/kg LF was comparable to treatment with 10 mg/kg resveratrol. Conclusions: The results in this study suggest that oral administration of LF favorably relieves PO-induced HF following TAC, through increase of heart antioxidant defense systems. The overall effects of 250 mg/kg LF were similar to those of 10 mg/kg resveratrol. More detailed mechanistic studies should be conducted in the future, with screening of the biologically active compounds in LF.

• Toxicological Research
• /
• 제31권4호
• /
• pp.347-354
• /
• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• 자원ㆍ환경경제연구
• /
• 제17권4호
• /
• pp.875-901
• /
• 2008

본 연구는 일반인들이 알기 쉬운 새로운 등급기준을 이용하여 팔당호 유출입 물의 수질변화가 지니는 경제적 가치를 추정하였다. 현재 '좋음' 등급인 팔당호 유출입 물이 '약간 좋음' 또는 '보통' 등급의 수질로 악화되면 평균적인 가계의 효용도 매월 5,221원 또는 9,649원 하락할 것이므로, 수도권 가계의 사회적 효용도 연간 4,718억 원 또는 8,720억 원 하락할 것으로 추정되었다. 만일 현재 수질이 '매우 좋음' 등급으로 개선된다면 평균적인 가계의 효용도 매월 3,157원 증가함으로써 수도권에 연간 2,853억 원의 가치상송이 발생할 것으로 추정되었다. 본 연구는 설문조사의 시간제약하에서 이해하기 어려운 환경재 속성들을 이해하고 그 선택문제까지 학습해야 하는 일반 응답자들에게 과도한 정보부하량(information overload)을 주는 경향이 있는 CE(choice experiment) 연구의 한계를 극복하고자 수질 속성에 대하여 보다 알기 쉬운 용어를 사용할 수 있었다는데 의의가 있다고 할 것이다.