• 제목/요약/키워드: outcome measurement

검색결과 424건 처리시간 0.026초

Toxicity Study of Streptococcus pneumoniae Vaccine Administrated Subcutaneously in Rats

  • Park, Sin-Jeong;Seo, Kook-Heon;Han, Sang-In
    • Toxicological Research
    • /
    • 제27권2호
    • /
    • pp.111-118
    • /
    • 2011
  • This study was performed to evaluate the toxicity of polysaccharide-based Streptococcus pneumoniae vaccine in Specific Pathogen Free (SPF), Sprague-Dawley (SD) rats. S. pneumoniae vaccine was administrated subcutaneously each dose level of high (560 ${\mu}g$/rat), medium (280 ${\mu}g$/rat) and low (140 ${\mu}g$/rat) on days 0, 14, 28. The rats were observed for 2 weeks or 4 weeks after the final injection. During this test, there were no significant dose-dependent changes in body weight, water and food consumption. In urinalysis and serum chemistry, dose-related changes were not detected. In hematology, the percent of neutrophils and lymphocytes in white blood cells were changed significantly. According to the measurement of organ weight, only spleen weight was significantly increased in all groups of administration compared to the control group. In the histopathological examination, an antigen-deposit, vacuolated macrophages, infiltrated inflammatory cells and a formation of granulation tissue were observed at the site of an administration. These results are considered as an outcome by immune responses through a vaccination. Consequently, the results of this study demonstrated that S. pneumoniae vaccine has no toxicity when it was administrated subcutaneously three times in 2-week interval at a high dose of 560 ${\mu}g$/rat.

마음챙김 기공이 소아청소년의 주의집중력에 미치는 영향 (Effects of mindfulness-based qigong for children's concentration ability)

  • 홍순상;조성훈
    • 동의신경정신과학회지
    • /
    • 제23권2호
    • /
    • pp.49-58
    • /
    • 2012
  • Objectives : The purpose of this study is to examine the effects of Mindfulness-based concentration qigong for children (MBCQ-C) in healthy children with subjective poor attention. Methods : This study examined the effects of MBCQ-C on healthy children with subjective poor attention, who vistied Korean medicine hospital neuropsychiatry outpatient clinic. The MBCQ-C was practiced with 11 participants, 2 of them quit in the middle of the program, and hence, they were excluded for data analysis. MBCQ-C consisted of 8 sessions, and each session took about 60 minutes. The outcome measurement was Frankfurter Aufmerksamkeits-Inventar (FAIR), which measured selective attention, self-control and sustained attention. Results : The results of this study showed that selective attention, and sustained attention were significantly improved. Self-control also improved, but without any statistical significance. These results indicate MBCQ-C was effective for the improvement of attention abilities, but self-control, including upper cognition area needs more consistent exercise. Conclusions : The MBCQ-C consisting of 8 sessions were shown to be an effective intervention in improving the attention abilities of healthy children with subjective poor attention.

Risk Index of Debris Flow Damage for Hydro- and Geographic Characteristics of Debris Flow with Bayesian Method

  • Lee, JunSeon;Yang, WooJun;You, KwangHo;Kim, MunMo;Lee, Seung Oh
    • 한국콘텐츠학회:학술대회논문집
    • /
    • 한국콘텐츠학회 2016년도 춘계 종합학술대회 논문집
    • /
    • pp.241-242
    • /
    • 2016
  • Recent abnormal climate change induces localized heavy rainfall and extreme disasters such as debris flow near urban area. Thus many researches have been conducted to estimate and prevent, especially in focus of physical behavior of debris flow. Even though it is hardly to consider overall related parameters to estimate the extent and degree of directly or indirectly damages due to debris flow. Those analytic restraint would be caused by the diversity and complexity of regional topographic and hydrodynamic characteristics of debris flow inside. We have utilized the Bayesian method to compensate the uncertainty due to the complex characteristics of it after analyzing the numerical results from FLO-2D and field measurement data. Revised values by field measurements will enhance the numerical results and the missing parameters during numerical simulation will be supplemented with this methodology. As a final outcome in this study, the risk index of debris flow damage will be suggested to provide quantitative estimation in terms of hazard protection including the impact on buildings, especially in inner and outer of urban area.

  • PDF

만성(慢性) 신허요통(腎虛腰痛) 환자의 침치료가 양도락 점수에 미치는 영향 (Effect of Acupuncture Treatment on Ryodoraku Score of the Patients with Chronic Low Back Pain Due to the Kidney Deficiency)

  • 오명진;송호섭
    • Journal of Acupuncture Research
    • /
    • 제29권3호
    • /
    • pp.115-120
    • /
    • 2012
  • Objectives : This study was done for reporting the effect of acupuncture treatment on Ryodoraku score of the patients with chronic low back pain due to the kidney deficiency Methods : We investigated 37 cases of patients with chronic low back pain due to the kidney deficiency, and devided patients into two groups : We specially treated one group by acupuncture treatment, which was not applied to the other group we analyzed of each group the Ryodoraku score(F3) of each group before and after acupuncture treatment and compared it. Results : 1. In acupuncture treatment group compared with baseline, at final, Ryodoraku score(F3) was significantly increased. 2. At final, acupuncture treatment group showed significant increase on Ryodoraku score(F3) score compared with non acupuncture treatment group. Conclusions : It is suggested that Ryodoraku score(F3) should be available for diagnosing kidney deficiency-induced chronic low back pain as a promising diagnostic index and a outcome measurement.

보건소 중심의 노인운동 프로그램에 대한 체계적 문헌고찰 (A Systematic Review of Literature on Community Health Center Exercise Programs)

  • 한숙정;이영란;조정민;임미영
    • 지역사회간호학회지
    • /
    • 제26권1호
    • /
    • pp.18-30
    • /
    • 2015
  • Purpose: The purpose of this study was to investigate the research methods, types and effects of community health center exercise programs for the elderly. Methods: We established the PICOTS-SD (Participants, Interventions, Comparisons, Outcomes, Timing of outcome measurement, Setting, Study Design), reviewed 583 studies from electronic database of DBpia, KoreaMed, KISS, RISS, NDSL and Pubmed, and finally selected 20 studies based on the inclusion and exclusion criteria. Methodological quality was assessed with the Risk-of-Bias Assessment tool for non-randomized studies. Results: With regard to research methods, the majority of studies on community health center exercise programs for the elderly were performed after 2010 and using non-equivalent control group pretest-posttest research design. As for the types and effects of exercise programs, the exercise period ranged from 6 to 28 weeks, and the most common exercise frequency was three times a week for 60 minutes. In addition, mixed-type and group exercise programs were performed most commonly. Conclusion: The results of this study provide a basis for the development of exercise programs to improve elders' health.

간호학 실습교육에서 시뮬레이션기반학습의 방향 고찰 (Directions of Simulation-Based Learning in Nursing Practice Education: A Systematic Review)

  • 임경춘
    • 한국간호교육학회지
    • /
    • 제17권2호
    • /
    • pp.246-256
    • /
    • 2011
  • Purpose: With the decrease in available clinical sites, a decrease in adequately prepared clinical faculty, and demand to prepare health care students to begin work, we need alternative methods to teach clinical skills for health care professionals. The use of simulation as an educational process that can replicate clinical practices is becoming popular in nursing. Therefore, this study was conducted to review directions of simulation-based learning in nursing education. Methods: A systematic review of quantitative studies was undertaken using Medline, KERIS, and KISS. The primary search terms were simulation and nursing. Reference lists from relevant papers and the websites of relevant nursing organizations were also searched. Nine studies met inclusion criteria and were analyzed in detail. Results: All studies reported simulation as a valid teaching/learning strategy. Six of the studies (66.7%) showed that simulation technology was a practical and successful model to use in teaching a variety of clinical skills for nursing students and nurses. Conclusion: Simulation may have some advantages over other teaching methods, depending on the scenario, context, topic, and method. Further study is needed to determine the effect of team size on learning and to develop a universal method of outcome measurement.

보이스와 제스처를 통한 모방 측정방법 (Through Voice and Gesture Mimic Measurement Method)

  • 진정아;최연성;김상수
    • 한국정보통신학회:학술대회논문집
    • /
    • 한국정보통신학회 2013년도 추계학술대회
    • /
    • pp.442-444
    • /
    • 2013
  • 본 논문에서, 우리는 보이스와 제스처 기능을 통해 모방이 삶에 끼치는 영향을 알 수 있다. 이러한 모방을 측정하기 위해 데이터를 수집하고 짧은(1초) 단어로 말하는 대화도중 얼마만큼 무의식적으로 모방을 하고 있는지에 대해 측정한다. 심지어 미래의 결과를 예측하는 기준으로 사용할 수 있다. 우리 연구의 주요 한계는 이용 가능한 인터뷰 데이터의 양은 제한적이다. 우리는 우리 그룹과 다른 연구자들이 큰 데이터 집합 및 다른 인구 통계에서 이 분석을 지속적으로 추구할 것을 기대한다.

  • PDF

FCST 음양균형장치를 활용한 요골신경마비치료의 증례보고 (A Radial Nerve Palsy Cases Managed by Yinyang Balance Appliance of FCST, a TMJ Therapy for the Balance of Meridian and Neurological System)

  • 김영판;이상배
    • 턱관절균형의학회지
    • /
    • 제5권1호
    • /
    • pp.13-15
    • /
    • 2015
  • 본 증례에서는 자전거 교통사고후 어깨골절로서 금속판 나사제거수술후 주변 연부조직과 허혈성으로 요골신경마비증상에 음양균형장치(맞춤형 CBA, 표준형 TBA)를 포함한 PBT, 균형침치료 등 구조적 치료)를 통해서 아래와 같이 유의한 치료변화가 나타남을 관찰하였다. 1. 주증상인 요골신경마비증상은 85% 호전되었다. 2. 부증상인 불면증, 신경성위염, 간질성폐렴 증상은 시각적상사척도를 통해 VAS 10에서 VAS 0으로 개선됨을 확인하였다.

  • PDF

테이핑과 신장운동이 슬관절 굴곡근과 신전근의 근력 및 근지구력에 미치는 영향 (The Effect of Taping and Stretching Exercise on Muscle Strength and Endurance of Knee Flexors and Extensors)

  • 이호재;현상욱;서현규
    • 대한정형도수물리치료학회지
    • /
    • 제15권2호
    • /
    • pp.1-7
    • /
    • 2009
  • Purpose : to investigate change of isokinetic muscle strength and isokinetic muscle endurance of quadriceps femoris and hamstring after application of taping and static stretching. Methods : For this study, 14 male members of college soccer team participated in this research. Participants were divided into two groups: seven was assigned to a taping group(n=7) and the others were assigned to a static stretching exercise group(n=7). Main outcome was measured by using biodex. The isokinetic muscle strength test was processed at the speed of the $60^{\circ}$/sec five times, and isokinetic muscle endurance was processed at the speed of $180^{\circ}$/sec ten times. Results : From the outcomes of the measurement, the results show that there is a more significant difference in the taping group than in a static stretching exercise group. Conclusion : These results will be utilized for the preliminaries in the future.

  • PDF

하악 제1대구치 치근본체의 길이가 조직유도재생술의 임상결과에 미치는 영향 (Effects of root trunk length after GTR on clinical outcomes)

  • 피성희;신형식
    • Journal of Periodontal and Implant Science
    • /
    • 제36권2호
    • /
    • pp.427-434
    • /
    • 2006
  • The form of furcation influence both the pathogenesis of periodontal destruction and therapeutic results. The present study was performed to evaluate the effect of root trunk length on clinical outcomes of guided tissue regeneration. Total 30 mandibular first molars were evaluated in this study. Probing pocket depth, clinical attachment level, vertical defect depth and horizontal defect depth were measured at baseline and 6 month after GTR. Correlation coefficients between root trunk length and other clinical measurement were analyzed. The results of this study were as follows 1. The mean root trunk length in lower 1st molar was 2.15 mm. 2. Probing pocket depth, clinical attachment level, vertical defect depth and horizontal defect depth were significantly reduced at 6 month postoperatively compared to values of baseline 3. Correlation coefficient between root trunk length and vertical defect depth at baseline was 0.406 showing the positive correlation 4. Correlation coefficient between root trunk length and horizontal defect depth at baseline was -0.463 showing the negative correlation. 5. Correlation coefficient between root trunk length and decrease of horizontal defect depth after GTR was 0.654 showing the positive correlation. In conclusion, the root trunk length maybe effector for clinical outcome after guided tissue regeneration.