• Journal of Communications and Networks
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• v.12 no.5
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• pp.449-458
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• 2010

In this paper, we present a distributed resource allocation algorithm for multi-cell uplink systems that increases the weighted sum of the average data rates over the entire network under the average transmit power constraint of each mobile station. For the distributed operation, we arrange each base station (BS) to allocate the resource such that its own utility gets maximized in a noncooperative way. We define the utility such that it incorporates both the weighted sum of the average rates in each cell and the induced interference to other cells, which helps to instigate implicit cooperation among the cells. Since the data rates of different cells are coupled through inter-cell interferences, the resource allocation taken by each BS evolves over iterations. We establish that the resource allocation converges to a unique fixed point under reasonable assumptions. We demonstrate through computer simulations that the proposed algorithm can improve the weighted sum of the average rates substantially without requiring any coordination among the base stations.

• Journal of Microbiology and Biotechnology
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• v.19 no.9
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• pp.904-910
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• 2009

The development of effective cellular imaging requires a specific labeling method for targeting, tracking, and monitoring cellular/molecular events in the living organism. For this purpose, we studied the cellular uptake of isocyanide-functionalized silver and gold nanoparticles by surface-enhanced Raman scattering (SERS). Inside a single mammalian cell, we could monitor the intracellular behavior of such nanoparticles by measuring the SERS spectra. The NC stretching band appeared clearly at ${\sim}2,100cm^{-1}$ in the well-isolated spectral region from many organic constituents between 300 and 1,700 or 2,800 and $3,600cm^{-1}$. The SERS marker band at ${\sim}2,100cm^{-1}$ could be used to judge the location of the isocyanide-functionalized nanoparticles inside the cell without much spectral interference from other cellular constituents. Our results demonstrate that isocyanide-modified silver or gold nanoparticle-based SERS may have high potential for monitoring and imaging the biological processes at the single cell level.

• Clinical and Experimental Reproductive Medicine
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• v.39 no.2
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• pp.58-67
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• 2012

Objective: Previously, we identified that transketolase (Tkt), an important enzyme in the pentose phosphate pathway, is highly expressed at 2 hours of spontaneous maturation in oocytes. Therefore, this study was performed to determine the function of Tkt in meiotic cell cycle regulation, especially at the point of germinal vesicle breakdown (GVBD). Methods: We evaluated the loss-of-function of Tkt by microinjecting Tkt double-stranded RNAs (dsRNAs) into germinal vesicle-stage oocytes, and the oocytes were cultured in vitro to evaluate phenotypic changes during oocyte maturation. In addition to maturation rates, meiotic spindle and chromosome rearrangements, and changes in expression of other enzymes in the pentose phosphate pathway were determined after Tkt RNA interference (RNAi). Results: Despite the complete and specific knockdown of Tkt expression, GVBD occurred and meiosis was arrested at the metaphase I (MI) stage. The arrested oocytes exhibited spindle loss, chromosomal aggregation, and declined maturation promoting factor and mitogen-activated protein kinase activities. The modified expression of two enzymes in the pentose phosphate pathway, Prps1 and Rbks, after Tkt RNAi and decreased maturation rates were amended when ribose-5-phosphate was supplemented in the culture medium, suggesting that the Tkt and pentose phosphate pathway are important for the maturation process. Conclusion: We concluded that Tkt and its associated pentose phosphate pathway play an important role in the MI-MII transition of the oocytes' meiotic cell cycle, but not in the process of GVBD.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.289-290
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• 2008

We consider cooperative opportunistic beamforming that can mitigate the other cell interference (OCI) in correlated multi-user multiple-input single-output (MISO) cellular environments. By only exploiting the spatial channel information of adjacent cells, the proposed scheme generates the cooperative random beam that statistically avoids the OCI from adjacent cells. Each cell selects a user in an opportunistic manner. Thus, the proposed scheme can simultaneously achieve the multi-user diversity (MUD) gain and the OCI avoidance gain.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.10B
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• pp.1641-1647
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• 2000

This paper presents an analysis of coverage and capacity for the multi-layer CDMA cellular system. The multi-layer CDMA system that shares a common frequency band consists of macrocells for outdoor users and picocells for indoor users. Though macrocells and picocells interfere with each other the capacity of the whole system can be increased, We have analyzed the effect of muual interference upon cell coverage soft handover areas and capacities. The parameters involved in the engineering of the system are discussed. The study results sow that we can control the service coverage of indoor picocells with the system parameters set properly. It is also show that the capacity of the whole system that the capacity of the whole system can be enhanced smoothly by deploying the indoor picocells within existing macrocells.

• Journal of Communications and Networks
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• v.15 no.3
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• pp.312-320
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• 2013

Home evolved Node-B (HeNB), also called a femtocell or a femto base station, is introduced to provide high data rate to indoor users. However, two main problems arise in femtocell networks: (1) Small coverage area of HeNB, which results in limited cell-splitting gain and ping-pong handover (HO) problems and (2) high inter-femtocell interference because HeNBs may be densely deployed in a small region. In this study, an efficient cooperation mechanism called an HeNB-aided virtual-HO (HaVHO) scheme is proposed to expand the coverage area of femtocells and to reduce inter-femtocell interference. The cooperation among neighbor HeNBs is exploited in HaVHO by enabling an HeNB to relay the data of its neighbor HeNB without an HO. The HaVHO procedure is compatible with the existing long term evolution specification, and the information exchange overhead in HaVHO is relatively low. To estimate the signal to interference plus noise ratio improvement, the area average channel state metric is proposed, and the amount of user throughput enhancement by HaVHO is derived. System-level simulation shows that HaVHO has a better performance than the other four schemes, such as lesser radio link failure, lesser ping-pong handover, lesser short-stay handover, and higher user throughput.

• Journal of Communications and Networks
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• v.13 no.1
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• pp.32-42
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• 2011

Frequency reuse among relay stations (RSs) in a down-link access zone is widely adopted for throughput enhancement in IEEE 802.16j relay networks. Since the areas covered by the RSs or the base station (BS) may overlap, some mobile stations (MSs) at the border between two neighboring transmitting stations (RS or BS) using an identical frequency band may suffer severe interference or outage. This co-channel interference within the cell degrades the quality of service (QoS) fairness among the MSs as well as the system throughput. Exclusive use of a frequency band division (orthogonal resource allocation) among RSs can solve this problem but would cause degradation of the system throughput. We observe a trade-off between system throughput and QoS fairness in the previously reported schemes based on frequency reuse. In this paper, we propose a new frequency reuse scheme that achieves high system throughput with a high fairness level in QoS, positioning our scheme far above the trade-off curve formed by previous schemes. We claim that our scheme is beneficial for applications in which a high QoS level is required even for the MSs at the border. Exploiting the features of a directional antenna in the BS, we create a new zone in the frame structure. In the new zone, the RSs can serve the subordinate MSs at the border and prone to interference. In a 3-RS topology, where the RSs are located at points $120^{\circ}$ apart from one another, the throughput and Jain fairness index are 10.64 Mbps and 0.62, respectively. On the other hand, the throughput for the previously reported overlapped and orthogonal allocation schemes is 8.22 Mbps (fairness: 0.48) and 3.99 Mbps (fairness: 0.80), respectively. For a 6-RS topology, our scheme achieves a throughput of 18.38 Mbps with a fairness of 0.68; however, previous schemes with frequency reuse factors of 1, 2, 3, and 6 achieve a throughput of 15.24 Mbps (fairness: 0.53), 12.42 Mbps (fairness: 0.71),8.84 Mbps (fairness: 0.88), and 4.57 Mbps (fairness: 0.88), respectively.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4108-4122
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• 2016

To address challenges of an unprecedented growth in mobile data traffic, the ultra-dense network deployment is a cost efficient solution to off-load the traffic over other small cells. However, the real traffic is often much lower than the peak-hour traffic and certain small cells are superfluous, which will not only introduce extra energy consumption, but also impose extra interference onto the radio environment. In this paper, an elastic energy efficient cell management scheme is proposed based on flow scheduling among multi-layer ultra-dense cells by a SDN controller. A significant power saving was achieved by a cell-level energy manager. The scheme is elastic for energy saving, adaptive to the dynamic traffic distribution in the office or campus environment. In the end, the performance is evaluated and demonstrated. The results show substantial improvements over the conventional method in terms of the number of active BSs, the handover times, and the switches of BSs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.12
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• pp.2443-2449
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• 2015

Downlink (DL) data rate for a MS is influenced by not only the signal to interference and noise ratio (SINR) but also the amount of radio resources allocated to the MS. Therefore, when a MS uses SINR to select a cell to associate with, it cannot receive the fastest DL data rate all the time if it associates with a congested cell. Moreover, the SINR-based cell selection may result in cell loads unbalance, which decreases the efficiency of a network. To address the issue, we propose a novel cell selection method by considering not only SINR but also a cell load which are combined into two cell selection criteria. One is the maximum achievable data rate and the other is the minimum outage probability. The simulation results show that the cell selection based on the maximum achievable data rate is superior to the SINR-based method and the method using the minimum outage probability in terms of the system efficiency and the fairness in cell loads while the cell selection method based on the minimum outage probability is superior to the others in terms of the outage probability of a MS.

• Journal of Biomedical Engineering Research
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• v.33 no.4
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• pp.169-176
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• 2012

Tumor cell morphology is closely related to its migratory behaviors. An active tumor cell has a highly irregular shape, whereas a spherical cell is inactive. Thus, quantitative analysis of cell features is crucial to determine tumor malignancy or to test the efficacy of anticancer treatment. We use 3D time-lapse phase-contrast microscopy to analyze single cell morphology because it enables to observe long-term activity of living cells without photobleaching and phototoxicity, which is common in other fluorescence-labeled microscopy. Despite this advantage, there are image-level drawbacks to phase-contrast microscopy, such as local light effect and contrast interference ring. Therefore, we first corrected for non-uniform illumination artifacts and then we use intensity distribution information to detect cell boundary. In phase contrast microscopy image, cell is normally appeared as dark region surrounded by bright halo ring. Due to halo artifact is minimal around the cell body and has non-symmetric diffusion pattern, we calculate cross sectional plane which intersects center of each cell and orthogonal to first principal axis. Then, we extract dark cell region by analyzing intensity profile curve considering local bright peak as halo area. Finally, we calculated the Fourier descriptor that morphological characteristics of cell to classify tumor cells into active and inactive groups. We validated classification accuracy by comparing our findings with manually obtained results.