• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2007년도 춘계학술발표회
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• pp.87-88
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• 2007

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2009년도 심포지엄 및 춘계학술발표회
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• pp.147-148
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• 2009

• 대한본초학회지
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• 제25권4호
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• pp.69-75
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• 2010

Objectives : The root and rhizome of "Gangwhal" have been used as a traditional medicine for the treatment of cold, fever, headache, swelling, arthritis, rhinitis, and cardiovascular diseases in Korea and china. In china, Gangwhal is well known as a useful oriental medicinal plant that treats cardiovascular diseases such as stroke, headache and hypertension, but little research exists about the effect of O. koreanum on cardiovascular disease. Therefore we investigated the vasorelaxant effects of O. koreanum and compared the vasorelaxant effects of four species of Gangwhal. Methods : The vasorelaxant effects of the ethanol extracts of Ostericum koreanum (NK and BK), Notopterygium incisium (NI), and N. forbesii (NF) on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. The vasorelaxant effects of the water extract and ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. And the vasorelaxant effects of chloroform, ethylacetate and water fraction of ethanol extract of NK on phenyleprine ($1{\mu}M$) or KCl (60mM) pre-contracted rat thoracic aorta rings were compared. Results : Ethanol extracts of NK, BK, NI and NF relaxed rat thoracic aorta rings with a concentration-dependent manner, and NK showed the greatest vasorelaxant effect. And ethanol extract of NK was much more effective than water extract of NK. Finally, chloroform, ethylacetate and water fraction of ethanol extract of NK also relaxed rat thoracic aorta rings, and chloroform fraction showed the greatest vasorelaxant effect.

• 대한본초학회지
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• 제25권3호
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• pp.35-41
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• 2010

Objectives : Allergy is an immune dysfunction caused by degranulation from mast cells in the early phase of allergic disease including allergic rhinitis (AR). The purpose of this study was to investigate the effects of Osterici Radix, roots of Ostericum koreanum Maximowicz in human mast cells and experimental allergic animal models. Methods : The anti-allergic effect of Osterici Radix water extract (NK-W) was investigated in human mast cell line, HMC-1 cells, and compound 48/80-induced systemic anaphylactic response in rats and ovalbumin (OVA)-induced AR in mice. Animals were orally administrated with NK-W (10 and 50 mg/kg) or anti-histamine drug, dosodium cromoglycate (50 mg/kg), and then intraperitoneally injected with compound 48/80 (8 mg/kg) or sensitized with 0.1% OVA into nasal. Animals were observed plasma histamine and histological changes of nasal mucosa. Also, mast cell degranulation and histamine production were determined in compound 48/80-stimulated HMC-1 cells. Results : NK-W inhibited compound 48/80-induced degranulation of mast cells and histamine releasing in HMC-1 cells. NK-W decreased mortality and serum histamine releasing in compound 48/80-induced anaphylatic rats in a dose-dependently manner. NK-W also inhibited serum histamine levels in OVA-induced AR mice and improved abnormal histological changes such as expansion of grandular cells and hypertrophy of epithelium in the nasal mucosa. These results indicate that Osterici Radix water extract suppress allergic response through downregulation of mast cell activation. Conclusions : This study suggests that a therapeutic potential of Osterici Radix as a source of anti-allergic agents for use in a number of allergic diseases.

• 혜화의학회지
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• 제14권1호
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• pp.15-22
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• 2005

Source : sources used by Qianghuo is Ostericum koreanum Maximowicz, Notopterygium incisum Ting and Notopterygium forbesii Boissier etc. in Korea and China. And we cirulate a Qianghuo dividing Nanqianghuo and Beiqianghuo. Thought source of Korea Qianghuo is different from china's we use a same name. And source of Beiqianghuo has not made clear yet. According to research accomplished 2002, we have to use Nanqianghuo producted at Jinbu in aspect of aspect. but, Beiqianghuo the outside form of Beiqianghuo similar to china so we think that we have to more make clear source of domestic Qianghuo, verify a source Beiqianghuo and re-establish about effects and functions of domestic Qianghuos. Culture : A term of culture is an nearly one year. so to product Qianghuo of good quality, we must plant directly in autumn or raise seedlings and transplant in spring. Processing : To protect turning to brown, Qianghuo are cirulate mostly as the original form without washing in water, To proteet crushing of Qianghuo when we cut off, Qianghuo were cut off after being soaked in water or steamed by heat. So when we wash and cut off, it has to be made processes which have no decreases of medical effects and be suggested a proper index which verify a medical effects. In summury, after harvesting Qianghuo the first washing $\rightarrow$ the first dry $\rightarrow$ selection $\rightarrow$ the second washing $\rightarrow$ the second dry $\rightarrow$ selection $\rightarrow$ cutting off $\rightarrow$ the third dry.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.196.1-196.1
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• 2003

Angelica genuflexa (Umbelliferae) is a perennial herbaceous plant which has also been variously reported as A. koreana and Ostericum koreanum. The MeOH extract was reported to have strong anti-thrombotic potential in the acute thrombosis model. In our preliminary testing, the MeOH extract and one of the solvent fractions (90% MeOH fr.) were observed to have both platelet anti-aggregating and anti-coagulant effects. Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components. (omitted)

• 한국약용작물학회지
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• 제2권2호
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• pp.114-120
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• 1994

최근 생약의 수요 및 재배면적이 증가됨에 따라 약초의 재배기술 확립이 요청 되고 있는바 추대로 인한 수량감소와 품질저하가 크다고 알려진 강활에 대하여 파종방법별로 육묘기 생육과 묘크기에 따른 추대 및 수량성을 구명하고자 시험한 결과는 다음과 같다. 1. 파종방법별 출아율은 파종량이 적고 산파했을 경우에 높아지는 경향을 보였고 묘크기에 있어서는 파종량간에 대차 없었으나 파종방법간에는 조파구에서 생장량이 많은 경향이었다. 2. 묘 분포비율은 중묘>소묘>대묘의 순으로 많았는데 소묘생산을 위해서는 산파로서 밀파$(8l\;/33m^2)$ 하는 것이 유리 한 것으로 나타났다. 3. 묘크기에 따른 정식후 생육은 묘의 근경이 굵을수록 개화가 빨라지는 경향이었고 지상부 생육은 조파 소묘 정식이 좋은 경향이었다. 4. 묘크기에 따른 추대율은 대묘 89.6%, 중묘 64.4%, 소묘 36.9% 로 묘가 클수록 높았다. 5. 묘크기에 따른 근비대는 미추대근이 추대근에 비하여 많았고 조파묘보다 산파 묘가 좋았다. 6. 생근수량은 산파 소묘 정식구에서 853kg/10a 으로 가장 증수하였다.

• 대한본초학회지
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• 제21권2호
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• pp.181-188
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• 2006

Objectives : Southern, northern, and wild types of Osterici Radix, and Notopterigii Rhizoma et Radix imported from China are circulated in Korea. Morphological identification was attempted by comparing external and internal forms of these materials. Methods : The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olymphus-BHT. Results : 1. Southern type of Osterici Radix has short rhizome and many small and long roots, while northern type of it is mostly composed of rhizomes with little small reds and sometimes looks like bamboo because of the extention of the parts between joints. 2. Parenchymal cell of southern type of Osterici Radix is filled with starch grain, while that of nothern type includes less starch grain with lamination crossed on its cell wall. 3. Surface of root and rhizome of wild Osterici Radix has some marks of fibrous root raised in the form of nodule, but cultivated Osterici Radix does not have this kind of marks. 4. Notopterigii Rhizoma et Radix is mostly composed of rhizomes, and its form is similar to that of a silkworm or joints of bamboo. Parenchymal cell is filled with starch grains, and lamination is crossed on its cell wall but not salient. Conclusion : Southern, northern, and wild types of Osterici Radix, and Notopterigii Rhizoma et Radix circulated in Korea can be easily identified because of their differences in their external and internal forms.

• 대한본초학회지
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• 제21권4호
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• pp.183-187
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• 2006

Objectives : Southern, northern, and wild types of Osterici Radix, and Notopterigii Rhizoma et Radix imported from China are circulated in Korea. Morphological identification was attempted by comparing powder forms of these materials. Methods : To make the specimen, the samples were grinded, and the powder was mounted by a solution of Glycerin, Acetic acid and Water at the rate of 1 : 1 : 1. The specimen was mounted by optic microscope, photographs were taken and the characteristics were sketched in lines. Result : 1. Korean Osterici Radix was yellow-brown, but Chinese Notopterigii Rhizoma et Radix was dark-brown. 2. Oil ducts were mostly broken, and most of secretory cells were narrow and long, including yellow or light yellow secretion and starch grain. 3. Parenchyma cells were rectangular, and southern type of Osterici Radix and Chinese Notopterigii Rhizoma et Radix include lots of starch grain in parenchyma cells, while northern type of Osterici Radix and wild Osterici Radix include a little. 4. Vessels were usually reticulate vessel, and the diameter of the vessels of Korean Osterici Radix was $25{\sim}88{\mu}m$, while that of the vessels of Chinese Notopterigii Rhizoma et Radix was $13{\sim}52{\mu}m$. 5. The surface of accessory cells were light brown with the shape of irregular polygon. Conclusion : Southern type of Osterici Radix, nothern type of Osterici Radix, wild Osterici Radix, and Chinese Notopterigii Rhizoma et Radix were all alike, except the amount of starch grain in parenchyma cells.

• Plant Resources
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• 제3권1호
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• pp.66-70
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• 2000

Umbelliferae medicinal crops have low germination under natural condition. Special objective of this study is to investigate morphological characteristics of seeds and effects of environmental factors such as light and temperature on their germination and seedling growth in Umbelliferae plants, using them as oriental medicine materials. Fruits of Umbelliferae are bi-partite type and form 2 seeds. Their oil canals and funiculus or carpaphore has apparently specific shape. Seed shape of Buplerum falcatum, Ligusticum acutilobum and Foeniculum vulgare are oblong, Ledeboutiella seseloides, Angelica dahurica, Angelica gigas elliptic, and Ostericum koreanum ovate. Color of seed coats varied from yellow to dark brown. Seed size was 3.2 to 6.9 mm in length, 1.7 to 4.9 mm in width. One thousand-seed weight of Buplerum falcatum was lowest(at 1,660 mg) and Ledebouriella seseloides and Angelica gigas were relatively highest(at 3,970 mg) having larger size than any others. Optimum temperatures for seed germination and seedling growth ranged from 20 to $25^{\circ}C$ and especially temperature at $25^{\circ}C$ improved seed germinations of Ledebouriella seseloides, Angelica dahurica and Ligusticum acutilobum regardless of light condition.