Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.196.1-196.1
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- 2003
Platelet Anti-aggregatory Effects of Coumarins from the Roots of Angelica genuflexa and A. gigas
- Lee, Yong-Yook (Natural Products Research Institute, Seoul National University) ;
- Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
- Jin, Jing-Ling (Natural Products Research Institute, Seoul National University) ;
- ChoiYun, Hye-Sook (Natural Products Research Institute, Seoul National University)
- Published : 2003.10.01
Abstract
Angelica genuflexa (Umbelliferae) is a perennial herbaceous plant which has also been variously reported as A. koreana and Ostericum koreanum. The MeOH extract was reported to have strong anti-thrombotic potential in the acute thrombosis model. In our preliminary testing, the MeOH extract and one of the solvent fractions (90% MeOH fr.) were observed to have both platelet anti-aggregating and anti-coagulant effects. Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components. (omitted)
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