• Journal of the Korean Society of Groundwater Environment
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• v.5 no.4
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• pp.192-202
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• 1998

We investigated the geochemistry and environmental isotopes of granite-bedrock groundwater in the Yeongcheon diversion tunnel which is located about 300 m below the land surface. The hydrochemistry of groundwaters belongs to the Ca-HCO$_3$type, and is controlled by flow systems and water-rock interaction in the flow conduits (fractures). The deuterium and oxygen-18 data are clustered along the meteoric water line, indicating that the groundwater are commonly of meteoric water origin and are not affected by secondary isotope effects such as evaporation and isotope exchange. Tritium data show that the groundwaters were mostly recharged before pre-thermonuclear period and have been mixed with younger surface water flowing down rapidly into the tunnel along fractured zones. Based on the mass balance and reaction simulation approaches, using both the hydrochemistry of groundwater and the secondary mineralogy of fracture-filling materials, we have modeled the low-temperature hydrogeochemical evolution of groundwater in the area. The results of geochemical simulation show that the concentrations of Ca$\^$2＋/, Na$\^$＋/ and HCO$_3$and pH of waters increase progressively owing to the dissolution of reactive minerals in flow paths. The concentrations of Mg$\^$2＋/ and K$\^$＋/ frist increase with the dissolution, but later decrease when montmorillonite and illitic material are precipitated respectively. The continuous adding of reactive minerals, namely the progressively larger degrees of water/rock interaction, causes the formation of secondary minerals with the following sequence: first hematite, then gibbsite, then kaolinite, then montmorillonite, then illtic material, and finally microcline. During the simulation all the gibbsite is consumed, kaolinite precipitates and then the continuous reaction converts the kaolinite to montmorillonite and illitic material. The reaction simulation results agree well with the observed, water chemistry and secondary mineralogy, indicating the successful applicability of this simulation technique to delineate the complex hydrogeochemistry of bedrock groundwaters.

• Journal of Food Hygiene and Safety
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• v.13 no.2
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• pp.171-187
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• 1998

Garlic occupies a special position among the many foods of vegetable origin because it is the sole food for Koreans during the their lives. And vitamin A has been ingested by forms of food or additives. Cadmium has been described as one of the most dangerous trace elements in the food and environment of man and livestocks. Since the de novo synthesis of stress proteins can be detected early after exposure to some agents, analysis of cadmium-induced changes in gene expression , ie. alterations in patterns of protein synthesis, may be useful to develop as biomarkers of exposure and damage for food hygiene. He acute and chronic combine effects of cadmium (Cd, CdCl2 20mg/kg), garlic oil(Dds: diallyl disulfide 50mg/kg, 3 times a week) and vitamin A(Ra: retinol acetate 50,000 IU/kg, 3 times a week) on Wistar male rats were evaluated concerning cadmium contents, tissues enzyme activity, HSP expression histopathological and electron microscopical examinations. The results of the study are as follows ; 1. Less cadmium was absorbed through the digestive tracts, but the ratio of contents in tissue were not changed by the simultaneous adminstration of diallyl disufide or retinol acetate. 2. ALT(alanine aminotransferase) , AST(aspartate aminotransferase), glucose, BUN (blood urea nitrogen), creatinine, the key indices of the clinical changes in hepatic and renal function were significantly hanged by the cadmium treatment after 1 week in liver, after 4 weeks in kidney. 3. Histopathological changes in cadmium treated rats were appeared at 8 weeks age treatment in kidneys. Homogenous eosinophilic material was accumulated in cortical and collecting tubular lumens at 16 weeks. Degenerated or necrotized tubular cells were observed in cortex and medulla. Degenerated seminiferous tubules and homogeneous eosinophilic material was seen in interstitial tissue of rat treated with cadmium for 16 weeks. Calcium deposits were seen in degenerated seminiferous tubules and the tubules showed severe calcification of rat treated with cadmium for 16 weeks. Electron microscope changes in kidney were observed in rats treated with CdCl2 20 mg/kg. Proximal convoluted tubule cells showed selling of cytoplasm and narrow lumen. Capillary endothelial cells showed cytoplasmic vacuoles and swelling. Degenerated epithelial cells were accumulated in tubular lumen of kidney. 4. Enhanced synthesis of 70 KDa relateve molecular mass proteins were detected in 2 hours after cadmium, exposure, with maximum activity occurring at 8~48 hours. Induction of HSP 70 was evident at proximal tubules and glomeruli in kidney. Testicular cells produced enough HSP to be detected normally. From the above results, it could be concluded that HSP70 induction by the cadmium treatment was a rapid reaction to indicated the exposure of xenobiotics, and retinol acetate reduced the cadmium induced nephrotoxicity.

• Applied Chemistry for Engineering
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• v.5 no.2
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• pp.327-336
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• 1994

The synergistic effects in mechanical mixture catalysts of Mo-V-O and metal oxide were investigated for the selective oxidation of acrolein. The metal oxides used are $SnO_2$, ${\alpha}-Sb_2O_4$, $WO_3$, ${\alpha}-Al_2O_3$, CuO, $MnO_2$, $Cu_2O$, MgO, CoO, and ZnO. Mechanical mixtures of Mo-V-O plus $SnO_2$ or ${\alpha}-Sb_2O_4$ had resulted in higher conversion of acrolein and higher yield of acrylic acid than Mo-V-O. The origin of the synergy is attributed to the cooperation of Mo-V-O and $SnO_2$ or ${\alpha}-Sb_2O_4$, in which $SnO_2$ or ${\alpha}-Sb_2O_4$ forms dissociated oxygens at their oxygen vacancies and transports them to Mo-V-O. $Cu_2O$, MgO, CuO, and $MnO_2$, increased conversion of acrolein but decreased yield of acrylic acid. CoO and ZnO inhibited the catalytic performance of Mo-V-O. The different role of these metal oxides is explained in terms of their oxidation-reduction properties.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2465-2477
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• 2015

The number of emigrants along with globalization and internationalization is rapidly increasing. The international migration is creating a new form of acculturation and a new structure of society. Racial or cultural diversity resulting from political, economical, and cultural exchange is drastically increasing. This study aimed to provide policy plans or basic data to improve multicultural acceptability in the future. Accordingly, it was also to set and verify causal effect of multicultural acceptability. For those purposes, a questionnaire was made up based on the literature about acculturation, and a survey was taken in korean. The results are as follows. Dependant variables used in analysis were sub-factors of multicultural acceptability founding three types called 'The Actual Acceptance', 'The Active Acceptance', 'The Passive Acceptance'. It was found that positive effect in multicultural acceptability through media experience was an important factor to reduce discriminant of multicultural community members. Therefore, we need to produce diverse media programs that can improve multicultural acceptability and reduce negative perception of multicultural community members. Additionally, multiculture education to help understanding of other races and other cultures should be developed as subject courses in university.

• Journal of Internet Computing and Services
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• v.20 no.6
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• pp.143-156
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• 2019

Discussion on OTT regulation has become fiercer, as OTT services' impacts on the global and domestic media market have been exponentially growing. In South Korea, it is argued that, on the basis of the similarity between television program and OTT's video content, OTT needs to be regulated in order to protect fair competition and to control sociocultural effects. In many of the discussions, developed countries' cases have been used for supporting OTT regulation. In this paper, we first analyzed the global OTT market trends based on our own categorization of OTT services. then we assessed the validity of the application of the foreign cases in the current OTT regulation debates in Korea. We proposed six OTT types (aggregation, mediation, mediation-aggregation, multi-screen, outlet, and outlet-linear) simultaneously considering service operator' origin, business model, content format, and content delivery. These services have been consistently evolving, and the OTT market has been increasingly competitive especially around content differentiation. Regulators must be wary of hastily introducing competition regulation to the dynamically innovating OTT market. The foreign cases, including the US, EU, the UK, and Japan, hardly seem to be appropriate bases for strengthening OTT regulation. Rather, they were focused more on promoting competition in the domestic media market and enriching the content ecosystem. Therefore, we need to consider revision of the outdated media regulation frameworks instead of fitting OTT under them, and to recognize the priority of securing practical jurisdiction on global service providers before capturing local players into the conventional regulation systems.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.2
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• pp.68-74
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• 2009

Polycyclic aromatic hydrocarbons (PAHs), one of ubiquitous organic pollutants in marine environments, are major toxic components of petroleum and are produced during the incomplete combustion of organic materials. As shipyards are located inside of natural or artificial semi-enclosed bay, even a relatively weak environmental disturbance by ship-building activity can cause severe damage to marine ecosystem in the bay. Many studies of pollution in shipyard area have been focused on the antifouling agent, like tributyltin. This study aimed to investigate the effect of ship-building activity on PAH contamination. Total PAHs concentration was higher nearby and inside shipyard area than outside, implying that shipyard could be one of major source area of PAH contamination to pose harmful effects to surrounding environments. Through PAH profile and source recognition index, the source of PAHs inputs in this area was estimated to originate from both petrogenic and pyrogenic origin. PAH levels showed a significant correlation with total butyltins, indicating that ship-building activity influenced PAH concentration and distribution. Vertical distribution of PAHs historically confirmed the correlation between shipbuilding activity and PAHs contamination.

• Journal of the Korean Society of Marine Environment & Safety
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• v.22 no.7
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• pp.782-790
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• 2016

When a fire occurs on a ship that has mechanical ventilation facilities, the air supply and exhaust systems directly effect smoke diffusion. And there is a high possibility that occupant's visibility will be harmed because of smoke. In this study, the effects and risks of air supply and exhaust systems with regard to smoke diffusion given a shipboard fire analyzed with a Fire Dynamic Simulator(FDS). Suggested measures are also provided for using air supply and exhaust systems more efficiently. The results showed that, when air supply and exhaust systems were both working at the time of a fire, rather than stopping these systems as previously encouraged, continuing to operate both was an effective measure to gain evacuation time. When a fire occurred and the exhaust system was operating, also starting the air supply system near the origin of the fire was another effective approach to gain evacuation time. However, when only the air supply system was operating and a fire occurred, the air supply system accelerated smoke diffusion, so it was necessary to stop the air supply system to detect smoke diffusion as much as possible.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.1
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• pp.38-52
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• 1991

In this paper, a semi-Lagrangian method is used to solve the nonlinear hydrodynamics of a three-dimensional body beneath the free surface in the time domain. The boundary value problem is solved by using the boundary integral method. The geometries of the body and the free surface are represented by the curved panels. The surfaces are discretized into the small surface elements using a bi-cubic B-spline algorithm. The boundary values of $\phi$ and $\frac{\partial{\phi}}{\partial{n}}$ are assumed to be bilinear on the subdivided surface. The singular part proportional to $\frac{1}{R}$ are subtracted off and are integrated analytically in the calculation of the induced potential by singularities. The far field flow away from the body is represented by a dipole at the origin of the coordinate system. The Runge-Kutta 4-th order algorithm is employed in the time stepping scheme. The three-dimensional form of the integral equation and the boundary conditions for the time derivative of the potential Is derived. By using these formulas, the free surface shape and the equations of motion are calculated simultaneously. The free surface shape and fille forces acting on a body oscillating sinusoidally with large amplitude are calculated and compared with published results. Nonlinear effects on a body near the free surface are investigated.

• Bulletin of the Korean Chemical Society
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• v.29 no.7
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• pp.1303-1310
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• 2008

Inhibitors of farnesyltransferase (FT), a key enzyme in the post-translational modifications of Ras proteins, have been extensively studied as novel anticancer agents in the preclinical stages, some of which are currently in clinical development. Previously, it has been reported that a novel FT inhibitor LB42907 inhibits Ras farnesylation in the nanomolar range in vitro. The aim of this study was to assess the antitumor efficacy of LB42907 in vitro and in vivo. Anchorage-independent growth of various human tumor cell lines was potently inhibited by treatment with LB42907, comparable to other FT inhibitors in clinical development. In the nude mouse, oral administration of LB42907 demonstrated potent antitumor activity in several human tumor xenograft models including bladder, lung and pancreas origin. Interestingly, significant tumor regression in EJ (bladder) and A549 (lung) xenografts was induced by LB42907 treatment. The effectiveness of LB42907 was also investigated in simultaneous combination with paclitaxel, vincristine, cisplatin or gemcitabine against NCI-H460, A549, and HCT116 cells in vitro using median-effect analysis. LB42907 markedly synergized with most anticancer drugs tested in this study in NCI-H460 cell. In contrast, LB42907 displayed antagonism or partial synergism with these drugs in A549 and HCT116 cells, depending on the class of combined drugs and/ or the level of cytotoxicity. Our results demonstrate that LB42907 is an effective antitumor agent in vitro and in vivo and combination of LB42907 with other chemotherapeutic drugs results in synergistic or antagonistic effects mainly in a cell line-dependent manner. Further preclinical study is warranted.

• Korean journal of applied entomology
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• v.26 no.3 s.72
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• pp.151-157
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• 1987

The toxicities of binary mixtures of the four insecticides acephate, demeton-S-methyl, cypermethrin and pirimicarb to the two strains of green peach aphid (Myzus persicae Sulz.) resistant to acephate and demeton-S-methyl were investigated and compared to the toxicities of their individual insecticides. The synergistic action of the insecticide mixtures to the insects were greatly varied with the kind of insecticide combinations, their mixture ratios, and the origin of resistance by an insecticide. The maximum synergistic action of acephate for the acephate resistant strain was obtained at 1:1 mixed with demeton-S-methyl. However, there were some antagonistic effects in all acephate mixtures with pirimicarb and cypermethrin. With the strain of demeton-S-methyl resistance, acephate, cypermethrin, and pirimicarb were synergized at the given mixture ratios by demeton-S-methyl. The maximum synergistic effect was observed at 2:3 with acephate, 1:1 with cypermethrin and 3:2 with pirimicarb.