• 한국식품영양학회지
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• 제23권2호
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• pp.258-268
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• 2010

This study was conducted to examine the hypoglycemic effects of complexcity extract(DB 55) from five oriental medicinal plants on the intake of food, body weight, blood glucose level, insulin content, serum GOP, GPT, BUN and hematocrit value in streptozotocin(STZ)-induced diabetic rats. General nutritional composition was also assessed. Thirty- five male Sprague-Dawley rats were assigned to five groups : normal control group(NC), STZ-diabetic control group (STZ-control), STZ-diabetic DB-1 group(DB 55-1), STZ-diabetic DB-2 group(DB 55-2) and STZ-diabetic DB-3 group(DB 55-3). The animals were fed an experimental diet for 12 weeks. Body weight gain of the STZ-diabetic group was significantly lower but diet intake was significantly higher than the NC group. Blood glucose levels of the DB-1, DB-2 and DB-3 rats were significantly lower than the STZ-control animals. Insulin level of STZ-control rats was lower than the NC serum GOT, GPT and BUN levels were significantly higher in the NC group, but hematocrit value was not significant as compare to the STZ-diabetic group. Blood glucose level was lower observed for the DB 55-1, DB 55-2 and DB 55-3 group. The results will be useful in oriental diet therapy and in the developing functional food resources.

• 대한한의학회지
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• 제17권2호
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• pp.5-16
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• 1996

For distinguish between Lophatherum gracile and Phyllostachys nigra var. henonis based on natural shape and external-internal morphology of medicinal shape, general contents of oriental medicine were rearranged through bibliography. As a result, two medicinal stuffs indicated the difference in shape and structure(external-internal and powder)of origin plant bibiliographically. After this, this contents were utilized to give proof of many effective difference between two medicinal stuff.

• 생약학회지
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• 제32권3호통권126호
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• pp.253-256
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• 2001

The present study was designed for the improvement of routine measurement of superoxide and hydroxyl radical scavenging activities utilized by a microplate reader. Superoxide radical scavenging activity by the ascorbic acid, which is a well-known superoxide scavenger, was determined in a dose-dependent manner. Hydroxyl radical scavenging activity by the thiourea, which is a well-known hydroxyl radical scavenger, was also well detected in a dose-dependent manner. Our results suggest that the use of microplate reader to assay the superoxide and hydroxyl radical scavenging activities improves the accuracy of data and enables the use of much smaller amounts of samples and/or reagents, with much simpler experimental procedure. Therefore, These methods appear to be suitable for screening of superoxide and hydroxyl radical scavenging activities in both the plant medicinal extracts and the isolated compounds.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.415-415
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• 2005

• Advances in Traditional Medicine
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• 제9권1호
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• pp.1-13
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• 2009

Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market, medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are used for applied research. For the last few decades, phytochemistry (study of plants) has been making rapid progress and herbal products are becoming popular. According to Ayurveda, the ancient healing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhita were written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plants along with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integral part of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs (poly-herbal formulations). Medicinal herb contains multitude of chemical compounds like alkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential and fixed). Today there is growing interest in chemical composition of plant based medicines. Several bioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia is an important medicinal plant commonly used in the traditional and Ayurvedic system of medicine for treatment of different ailments. This review illustrates its major constituents, pharmacological actions substantiating the claims made about this plant in the traditional system of medicine and its clinical applications.

• Journal of Plant Biotechnology
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• 제45권2호
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• pp.117-124
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• 2018

병풀(Centella asiatica L. Urban)은 피부상처의 치료제 등의 원료로 해마다 해외 수입량은 증가하고 있으나 국내의 자생하는 Centella asiatica종의 조사 및 재배에 관한 연구는 극히 미진하다. 따라서 본 연구는 경상남도 합천의 농가에서 재배중인 국내 자생종인 병풀에 대하여 항균성, 항염증 등을 조사하고, 피부의 상처 및 노화와 관련된 미백효능과 주름개선효과 등에 관한 기초 실험을 수행한 결과 항균 및 항염증 효능은 메탄올 추출물 그리고 미백효능은 물로 추출한 경우에 가장 높은 효능을 확인 할 수 있었으며 보다 상세하게 설명하면 다음과 같다. 7종의 세균과 1종의 곰팡이에 대하여 50% 메탄올로 추출한 병풀 추출물을 처리한 결과 대부분의 세균들은 대조군으로 처리한 오미자 추출물군과 비교하여 유사하거나 낮은 수준의 유의한 항균력을 나타내었으나 S. pyogenes은 유일하게 병풀추출물에서만 항균력을 보였다. 곰팡이인 C. albicans는 병풀과 오미자 모두의 처리에 대하여 항균활성을 확인 할 수가 없었다. Raw 264.7세포를 이용한 항염증효능을 조사한 결과 50%메탄올로 추출한 추출물을 농도별로 처리한 결과 대조구에 비하여 50% 이상의 산화질소 생성량이 감소함을 확인 할 수 있었다. 한편 B16F10세포주를 이용한 미백효능을 조사한 결과에서는 물로 추출한 추출물을 처리한 결과 대조구에 비하여 멜라닌의 농도가 약 20%까지 감소하였음을 확인하였다. NHDF세포를 이용하여 병풀추출물을 처리한 결과 주름개선효능의 지표에 해당하는 MMP-1의 급격한 감소율을 나타내는 처리농도(400 ppm)를 확인하였으나 강한 세포독성도 동시에 확인이 되어 향후 추가연구가 필요한 것으로 조사되었다.

• 한국약용작물학회지
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• 제14권2호
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• pp.87-91
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• 2006

An efficient plant regeneration of C. asiatica was achieved from organogenesis using petiole explants of in vitro plantlet on MS basal medium controled with different plant growth regulators (NAA,2,4-D, IAA kinetin, and BA). Best results that 50%, efficiency of regeneration per explant for regeneration were obtained with IAA $17.13\;{\mu}M$ and BA $8.9\;{\mu}M$. Formation of adventitious shoots via organogenesis from the petiole explant was verified by histological sectioning of plantlets. Regenerated plants were transplanted into soil.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2008년도 추계학술발표회
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• pp.412-412
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• 2008

• Natural Product Sciences
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• 제17권1호
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• pp.33-37
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• 2011

The plant species reported here are used by traditional healers in Gabon for different ailments such as wounds, malaria, fever, gonorrhea or diarrhea. The aim of this study was to evaluate the antimicrobial activities of 7 plants (Strombosiopsis tetrandra, Tetraberlinia bifoliolata, Dichapetalum barbatum, Guibourtia demeusii, Dacryodes normandii, Manniophytum fulvum, Paropsia grewoides) against different strains of both Methicillin-Resistant Staphylococcus aureus (MRSA) and Salmonella. Disc diffusion was first used to determine the antimicrobial effectiveness of the plants' ethanolic extracts. Then the minimum inhibitory concentrations of the crude extracts of either leaves or stem barks of the 7 plants were determined using broth micro-dilution. The ethanolic plant extracts showed very good activity against both MRSA and Salmonella strains where the MICs ranged from $250\;{\mu}g/ml$ to $1000\;{\mu}g/ml$. The study shows that many of the tested plants used by Gabonese traditional healers have antimicrobial activities and give support to their traditional use.

• 생약학회지
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• 제8권1호
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• pp.1-15
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• 1977

In an attempt to deduce which plants might have been used for their anticancer activities in traditional oriental herb medicine, 127 prescriptions were selected from 'Dong-Eui-Bo-Gam', the Classic Handbook of Korean Traditional Medicine, written by $H_{UH}$ Jun and published in 1613. These are the prescriptions indicated for the systemic treatment of various tumors and some conditions resembling tumors, e.g. inflammatory masses and indurations, and they include 150 natural products of plant origin. The frequency of appearance of each medicinal plant in these selected prescriptions was compared with the frequency of its appearance in all prescriptions listed in 'Bang-Yak-Hap-Pyon', another popular Oriental Medicine Formulary in Korea, written by $H_{WANG}\;Pil-Su$ in 1885. From the latter book, $H_{ONG}$ has recently enumerated frequencies of 235 medicinal plants included in a total of 467 prescriptions. Chi-square tests revealed that 11 plant remedies appear with significantly higher frequency in the prescriptions for "tumors", and 10 for "inflammations". The plants with potential antitumor activities, in decreasing order of statistical significance, are Scirpus maritimus, Curcuma zedoaria, Prunus persica, Rheum coreanum, Foeniculum vulgare, Rhus vernifera, Daphne pseudogenkwa, Galarhaeus sieboldiana, Croton tiglium, Raphanus sativus and Galarhaeus pekinensis. The drugs for potential antibacterial or anti-inflammatory activities are Olibanum(Frankincense), Forsythia coreana, Lonicera japonica, Gleditchia officinalis, $M_{YRRH}$, Trichosanhes kirilowii, Astragalus membranaceus, Rheum coreanum, Platycodon grandiflorum and Fritillaria verticillata. Despite the uncertainties involved in the terminology of various diseases used in pre-modern medicine, and the reservations about the efficacy of remedies used for those diseases, it would be worthwhile to investigate these few selected plants for anticancer, antibacterial, anti-inflammatory or antifungal effects, employing modern scientific methodology.