• 대한본초학회지
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• 제27권3호
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• pp.15-21
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• 2012

Objective : This study aimed to compare the difference between $Angelica$ $decursiva$, Peucedanum $praeruptorum$ and $Anthriscus$ $sylvestris$ which have been used as herbal medicine, Jeonho (Angelicae Decursivae Radix) in Korea and provided the evidence to exclude $A.$ $sylvestris$ not to use as Joenho. Methods : The similarities of original medicinal herb with samples from local market were evaluated including morphological appearance and chromatographic fingerprint. In addition, relation between original medicinal herb and local samples were analyzed using statistical clustering methods. Results : $A.$ $decursiva$, $P.$ $praeruptorum$ and $A.$ $sylvestris$ represented different morphological appearances and chromatographic fingerprint. Several samples from China exhibited similar morphological and chromatographic appearance with $A.$ $decursiva$ or $P.$ $praeruptorum$. Eleven samples from Korea showed identical similarity to $A.$ $sylvestris$. Conclusions : Since $A.$ $sylvestris$ represented obvious differences compared to $A.$ $decursiva$ and $P.$ $praeruptorum$, it is required not to use $A.$ $sylvestris$ as medicinal herb, Jeonho. Additionally, exact identification and quality control must be applied to $A.$ $decursiva$ or $P.$ $praeruptorum$ from China in order to maintain therapeutical efficacy.

• 한국한의학연구원논문집
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• 제17권3호
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• pp.61-68
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Wenbingtiaobian(溫病條辨)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 258 medicinal herbs in 206 prescriptions, and found meaningful combinations of 700. Among these, the most meaningful combinations are the two of 8 herbs. One consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Sojae Semen Praeparatum, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonic, the other consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Arctium lappa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonica. The former is Yeonkyo-san without Arctium lapp, the letter is Yeonkyo-san without Sojae Semen Praeparatum. It means these combinations are kind of modified Yeonkyo-san which is effective in outthrustting through the exterior with pungent-cool and clearing heat and detoxify. In conclusion, prescriptions of "Wenbingtiaobian(溫病條辨)" involve herbs mostly used to outthrust through the exterior with pungent-cool and clear heat and detoxify. Through this study, we know the author' s one of medical view points on outthrustting through the exterior with pungent-cool and clearing heat and detoxify.

• 대한본초학회지
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• 제22권1호
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• pp.25-34
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• 2007

Objectives : The plans can be used for medicinal purposes, among Farinales in korea and examined their effects and distributions. Methods : The examined herbalogical books and research papers which published at home and abroad. Results: 1. There were totaled to 8 genera and 24 species in Farinales Korea and among them medicinal plants arc 8 genera, 11 species, some 46% in total. 2. Eriocaulon is main kind enough that it has 11 species among total 24 species in the Farinales, of which medicinal plants are Commelina and Monochoria that they have each 2 species 3. The herb is the main medicinal parts of medicinal plants in the Farinales which is used in 9 species. 4. According to nature and flavor of medicinal plants in the Farinales, they were classified into cool 9 species; sweet taste 9 in the order. 5. According to meridian propism of medicinal plants in the Farinales, they were classified into liver meridian 6 species. 6. According to the properties and principal curative action. they were classified into drugs for detoxicant 12, drugs for antifebrile 11 species, drugs for drain damp 8 in the order. 7. It was noticed that 1 medicinal plant in the Farinale is toxic. Conclusion: There were totaled to 8 genera and 24 species in Farinales in Korea and among them medicinal plants are 8 genera, 11 species, some 46% in total.

• 대한본초학회지
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• 제21권4호
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• pp.213-218
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• 2006

Objectives : Radix Bupleuri is from the dried root of the herb of the Perennial herbaceous plant, Bulpleurum falcatum L. or Bulpleurum chinense DC. or Bulpleurum. scorzonerifolium Willd., family Umbelliferae. Medicinal Properties are bitter and pungent in flavor, slightly cold in nature and attributed to the liver and gallbladder meridians. Actions in modern Materia Medica are regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking. The ‘uplift yang-qi to raise sinking’ efficacy, out of three efficacies (regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking), has been disputed in the medical profession for a long period. Hereupon, this study ascertained the reason why it has been disputed. Methods : With respect to this medicinal herb, the efficacies of regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking were described as to what was written in ‘Shen Nong's Herbal’ from Chin and Han dynasties until Jin and Yuan dynasties. Results : The beginning of Jin and Yuan dynasties, it began to deal with the ‘uplift yang-qi to raise sinking’ efficacy and so it has been carried on modern textbooks and medical books. The reason why it was added is that it was influenced by the theory of ‘Raise Sinking’ advocated by Zhang jieku who lived in the period of Jin and Yuan dynasties. Since then, the properties of ‘Radix Bupleuri’ have been wrongly known to the public. Additionally, ‘Radix Stellariae Seu Gypsophilae’, which was begun to be introduced from the Four Cities since the Five Dynasties, has been combined with the best stuffs of ‘Radix Bupleuri’ produced from Yin Zhou. Consequently, its original properties were remarkably disordered. Likewise, respective medical schools’ theories were changed by the influence of ‘Bulpleurum. scorzonerifolium Willd’ begun to be used since Tang dynasty. Conclusion : it is considered that the current ‘Raise Sinking’ efficacy of Radix Bupleuri is unreasonable to be applied to the efficacy of the whole Radix Bupleuri because it is limited to certain species.

• 대한본초학회지
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• 제27권6호
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• pp.1-6
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• 2012

Objectives : ROS are involved in a wide spectrum of diseases including chronic inflammation and cancer. S.chinensis Baill, a perennial herb commonly called Chinese lizard's tail or Sam-baek-cho in Korea, is used for the treatment of edema and inflammatory diseases in the Oriental folk medicine. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the two extracts, water(WE) and ethyl acetate(EAE) from S.chinensis Baill. Methods : Anti-oxidant activity was evaluated using Fe2+ chelating and hydroxyl radical scavenging assay. DNA cleavage assay, and western blot and immunostaining for phospho-p65 were performed to evaluate anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell. Results : In Fe2+ chelating activity and hydroxyl radical scavenging activity, WE showed more strong scavenging activity for hydroxyl radical than EAE. WE scavenged hydroxyl radical by 12% at 3.2 ${\mu}g/ml$, 21% at 16 ${\mu}g/ml$, 32% at 80 ${\mu}g/ml$, 66% at 400 ${\mu}g/ml$ and 82% at 2000 ${\mu}g/ml$, respectively. In addition, WE showed more strong chelating activity than EAE. WE chelated Fe2+ ion by 1.1% at 3.2 ${\mu}g/ml$, 8.2% at 16 ${\mu}g/ml$, 26.3% at 80 ${\mu}g/ml$, 72% at 400 ${\mu}g/ml$ and 89% at 2000 ${\mu}g/ml$, respectively. Also, WE inhibited oxidative damage via its anti-oxidant activity. In anti-inflammatory effect, EAE inhibited NO production and iNOS expression. In addition EAE suppressed the NF-${\kappa}B$ and MAPK signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions : Together, these data indicate that S. chinensis Baill, shows anti-oxidant activity and anti-inflammatory effect.

• 동의생리병리학회지
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• 제25권3호
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• pp.373-381
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• 2011

Liu Hejian maintained that the six types of energy can become fire and focused on the treatment of fire and heat symptoms along with the prescriptions of cryotherapy, believing that a vast majority of disease are due to fire. In this study, we investigated the characteristics of Hejian's formulae by classifying medicinal ingredients in consideration of medicinal properties and efficacy in order to examine how many cold and hot medicinal ingredients are included in the formulae of Hejian. We analysis 848 formulae among 1,055 formulae in total, excluding 207 redundant ones, which includes 366 Sunmyunglon formulae, 223 Bomyeongjip formulae, 8 Samsolon formulae, 61 Sanghanjigkyeok formulae, 68 Sanghanpyobon formulae, 22 Sanghansimyo formulae, 103 Hwalbeopgiyo formulae, 186 Bodongbiyo formulae, and 18 Gagamyoungbisippalbang formulae. In the analysis of the frequency of using each medicinal herb after classifying medicinal ingredients of Hejian's formulae by medicinal properties, we found that cold medicinal ingredients accounted for 40%, the biggest share in the formulae, and hot medicinal ingredients accounted for around 45%, which indicates that Hejian's formulae consist of both elimination and reinforcement and cold and heat, rather than cold medicinal ingredients only. As a comparison of the frequency of using each medicinal ingredients for the formulae by efficacy, we found that clear heat medicinal ingredients, totify qi and replenish blood medicinal herbs, and activate blood medicinal ingredients were most frequently used.

• 대한본초학회지
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• 제25권3호
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• pp.139-147
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• 2010

Objectives：For the purpose of developing Korean herbalogy of the plants belonging to Crassulaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods：The examined herbalogical books and research papers which published at home and abroad. Results： 1. There were totaled to 6 genera and 39 species in Crassulaceae in Korea and among them medicinal plants are 5 genera, 14 species, some 36% in total. 2. Sedum genus is main kind enough that it has 20 species among 39 species in the Crassulaceae, of which medicinal plants are 9 species. 3. The herb is the main medicinal parts of medicinal plants in the Crassulaceae which is used in 14 species. 4. According to nature and flavor of medicinal plants in the Crassulaceae, they were classified into neutral 12 species; sour taste 14 in the order. 5. According to meridian propism of medicinal plants in the Crassulaceae, they were classified into liver meridian 13 species. 6. According to the properties and principal curative action in the Crassulaceae, they were classified into drugs for detoxicant 19 species, drugs for styptic 18, drugs for detumescence 14 in the order. 7. The number of toxic species in the Crassulaceae was examined to be 3 species. Conclusions：There were totaled to 6 genera and 39 species in Crassulaceae in Korea and among them medicinal plants are 5 genera, 14 species, some 36% in total.

• Journal of Acupuncture Research
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• 제23권1호
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• pp.179-186
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• 2006

Background : Recently the demand was increasing on the data describing treatment rates and the outcome of Androgenetic Alopecia using Oriental Medicine. Thus this study was designed to observe androgenetic Alopecia treatment using Oriental Medicine including acupuncture and herb because there has been no such statistics. Objectives : Our purpose was determine whether oriental medicine treatment leads to clinical improvement in men with androgenetic alopecia. Methods : Eighty two Men, 17 to 53 years of age, with male pattern hair loss according to a modified Norwood/Hamilton classification scale(II to VI) were enrolled in this study. Patients were treated with multidisciplinary Korean oriental medicine treatment (herbal acupuncture, acupuncture, herb, chuna therapy) at twice a week for 6 months to 12 months. Efficacy was evaluated by patient and investigator assessment, and global photographic review. Results : Oriental medicine treatment improved scalp hair by all evaluation. Patient self assessment demonstrated that Oriental medicine treatment slowed hair loss, increased hair growth, and improvement appearance of hair. These improvements were corroborated by investigator assessments and assessments of photographs. Conclusion : Oriental medicine treatment has significant effects on the androgenetic alopecia. Longer follow up studies are needed to examine whether its effects last long enough for the patients with androgenetic alopecia.

• 대한본초학회지
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• 제21권3호
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• pp.35-45
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• 2006

Objectives : The plans can be used for medicinal purposes among Alismatales in korea and examined their effects and distributions. Methods : The examined herbalogical books and research papers which published at home and abroad. Results : 1. There were totaled to 15 genera and 45 species in Alismatales in Korea and among them medicinal plants are 8 genera, 17 species, some 38% in total. 2. Potamogeton genus is main kind enough that it has 14 species among 45 species in the Alismatales , of which medicinal plants are 6 species. 3. The herb is the main medicinal parts of medicinal plants in the Alismatales which is used in 14 species. 4. According to nature and flavor of medicinal plants in the Alismatales , they were classified into cool 8 species; sweet taste 10 in the order. 5. According to meridian propism of medicinal plants in the Alismatales, they were classified into liver meridian 8 species. 6. According to the properties and principal curative action, they were classified into drugs for antifebrile 12 species, drugs for detoxicant 11 , drugs for drain damp 9 in the order. 7. It was noticed that every medicinal plant in the Alismatales is nontoxic. Conclusion : There were totaled to 15 genera and 45 species in Alismatales in Korea and among them medicinal plants are 8 genera, 17 species, some 38% in total.

• 대한한의학회지
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• 제31권4호
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• pp.115-128
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• 2010

Objectives: The aim of this study was to investigate deodorizing effectsof medicinal herbs (Mume Fructus, Eriobotryae Folium, Acanthopanacis Cortex, Angelicae Dahuricae Radix) for development of a gargle solution. Methods: 1. The antimicrobial effects of medicinal herbs were evaluated with the minimal bactericidal concentration (MBC) and the change of the number of viable cells in the herb extracts(1%) for 48 hrs against P. gingivalis 2561 and Pr. intermedia ATCC 25611. 2. Deodorizing activity of each herb and Garglin $Mint^{(R)}$gainst methyl mercaptan were analyzed by gas chromatography (GC). 3. We used the malodor modeling of the salivary sediment system with a Halimeter. 4. In the preliminary clinical study, the baseline concentration of VSC in the oral cavity of each subject was measured by Halimeter. Subjects would gargle for 30 seconds with cysteine. After 4 minutes subjects would gargle for 30 seconds with Garglin and herb extracts (2%). Subsequently, concentration of VSC were measured at 0, 4, 8, 12 and 20 minutes. Results: 1. MBC of Mume Fructusfor P. gingivalis 2561 was determined to be <1% and MBCs of Eriobotryae Folium for P. gingivalis 2561 and Pr. intermedia ATCC 25611 were determined to be <2% and <1%, respectively. Mume Fructus (1%) completely suppressed the P. gingivalis cell viability from 5 hrs and Eriobotryae Folium (1%) completely suppressed the Pr. intermedia cell viability from 48 hrs. 2. In GC analysis, deodorizing activities were 91.54% with Mume Fructus, 87.97% with Eriobotryae Folium, 100% with Acanthopanacis Cortex, 72.36% with Angelicae Dahuricae Radix and 40.54% with Garglin $Mint^{(R)}$. 3. In malodor modeling of the salivary sediment system, each of the medicinal herbs had significantly inhibitory effect on malodor formation (p<0.05). 4. In the preliminary clinical study, the concentration of VSC of the herb groups was significantly lower than of the control group, but not in Garglin $Mint^{(R)}$. Conclusions: Mume Fructus, Eriobotryae Folium, Acanthopanacis Cortex and Angelicae Dahuricae Radixhave deodorizing activities and potential as an effective mouthwash against oral malodor.