• Korean Journal of Pharmacognosy
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• v.38 no.2 s.149
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• pp.123-127
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• 2007

Aristolochic acid (AA) included in the plants Aristolochiaceae have been well known to be nephrotoxic and carcinogenic inducer and to cause renal disease such as Chinese Herb Nephropathy (CHN). In this study, we used a high performance liquid chromatopaphy-mass spectrometry (HPLC-MS) under the positive ion detection mode for the quantitative change of aristolochic acid-I and-II (AA-I and AA-II) in Aristolochiaceae (Aristolochia contorta Bunge, Aristolochia debilis Sieb. et Zucc., Aristolochia fangchi Wu), some related plants (Cocculus trilobus De candolle, Inula helenium Linne, Saussurea lappa Clarke), and its prescriptions (防己茯笭湯, 定喘散) with or without processing. Here, the processing methods and prescriptions in oriental medicine were generally used to alleviate toxicity or alter property of herbal medicines. However, the concentrations of AA-I and AA-II were highly determined in processed material extracts rather than unprocessed those, not measured in some related plants. Also, the concentrations of AA-I and AA-II even at the prescriptions mixed the plants of Aristolochiaceae were detected to range from 0.73 to 2.53 ppm. Thus, the present results suggest that the content of AA-I and AA-II contained to plants of Aristolochiaceae was not reduced by the processing methods or prescriptions which can induce the physico-chemical change and pharmacological transformation in traditional herbal medicines.

• Korean Journal of Medicinal Crop Science
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• v.11 no.4
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• pp.264-267
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• 2003

Korean medicinal plants were screened for their inhibitory activity against HIV-1 protease. The inhibitory activity of protease was determined by incubating the extracts in reaction mixtures containing protease and substrate $His-Lys-Ala-Arg-Val-Leu-(p-NO_{2}-Phe)-Glu-Ala-Nle-Ser-NH_{2}$ to perform proteolytic cleavage reactions. In this study the twenty six extracts from medicinal plants were investigated. Of the extracts tested, the extracts from the stem of Morus alba. exhibited the strongest activity with inhibition of 81% at a concentration of $100{\mu}g/ml$. The extracts of the flower of Saxjfraga stolonifera, and stems of Euonymus japonica and Castanea crenata showed appreciable inhibitory activity (>50%) against HIV-1 protease at same concentration.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.205.2-205.2
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• 2003

As part of our program to isolate bioactive compounds from korean natural sources, we have screened traditional medicinal plants to cytotoxity on human tumor cells. Of them, the MeOH extract from rhizome of Coptis japonica Makino was found to be active against five cultured human tumor cell lines. So, the MeOH extract was subjected to successive solvent partitioning to give n-hexane, chloroform and BuOH. The activity was concentrated into the chloroform extract. The extract was chromatographied on a silica gel column and resulted in the isolation 5 alkaloids. (omitted)

• KSBB Journal
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• v.22 no.3
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• pp.139-145
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• 2007

An oriental medicinal database was used from medicinal plants for screening of anticancer agents. The prescription frequency and dosage of medicinal plats in 170 anticancer prescriptions were analyzed. From the total prescription score of each medical plant, it was found that high-scored medicinal plants have been widely studied in the previous research on the cancer treatment. Consequently, dangui, hwangui, banha, bachul, jinpy, insam, bacjakyak, deahwang, chungoong, jimo, chunnamsung, omija, hyunggae, huekchook, banggi, boclyung, osooyou were selected as raw materials for the screening of anticancer agents.

• KSBB Journal
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• v.19 no.2
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• pp.125-131
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• 2004

Various medicinal plants were examined as resources for antidiabetic biomaterials, using an oriental medicinal database. The prescription frequency and dosage of medicinal plants in 131 antidiabetic prescriptions were analyzed. Total prescription score of each medical plant was summed up from prescription table and score table. High-scored medicinal plants have been widely studied in the previous research on the diabetic treatment. Consequently, dangui, hwangryun, maekmoondong, ginseng, chick, saengjihwang, omija, bokryung, Jimo and cheonhwaboon were assumed to have high antidiabetic activities.

• Journal of Evidence-Based Herbal Medicine
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• v.2 no.1
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• pp.13-18
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• 2009

The aim of this study was to find out the time when the Araliae Continentalis Radix and Osterici Radix were classified into different divisions as the period were not known to oriental medical science in Korea. It could be said that the Araliae Continentalis Radix and Osterici Radix had been recognized the different shapes since Sui-Tang eras and they had been differently used in their shapes and effects as separated medical plants since Song-Yuan eras. This thesis also presented the effects and shapes of Araliae Continentalis Radix and Osterici Radix as well as showed prescriptions and the uses of them in each dynasty of China.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.18 no.1
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• pp.116-137
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• 2012

The topic of this study is to ask and answer about 'What matters most in medicine'. And the purpose of this study is to establish paradigm which guarantee 'the original principles of science in medicine' and 'the safety of human life in medicine'. The organized characteristics of this study is as follows. 1. 'The harmony of nature (heaven, earth and human)' is the base of medicine. Because medicine control life directly and all life is 'the son of nature'. 2. 'The harmony of Eum and Yang' is the essential power of universe and the key of metabolism of all life including human, animals and plants. Because 'the nature of universe' and all 'Life field' is 'electro-magnetic field'. 3. The Convergence of Oriental medicine and Western medicine orients 'the harmony of Eum and Yang'.

• Journal of the Korean Society of Food Culture
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• v.22 no.3
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• pp.336-341
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• 2007

Antioxidant activity of Astragalus membranaceus, Polygonatum stenophyllum, Angelica gigas, Acanthopanax sessiliflorus and Angelica pubescens extracts cultivated in Jecheon prepared with different solvents were determined by 1,1-diphenyl-2-picrylhydrzyl(DPPH) radical scarvenging ability and thiocyanate method . The highest hydroxy radical scarvenging activity was shown in Acanthopanax sessiliflorus, while the lowest was in Polygonatum stenophyllum. Angelica gigas showed strong antioxidant activity by thiocyanate method. Methanol extracts and water extracts showed higher antioxidant activities than ethanol extracts. Angelica pubescens showed the highest polyphenol contents and Acanthopanax sessiliflorus showed the highest flavonoid contents. Direct correlation between the hydroxy radical scavenging activity and polyphenol contents or flavonoid contents was established by simple regression(r>0.8) in each solvent extracts. Among medicinal plants cultivated in Jecheon, Acanthopanax sessiliflorus and Angelica pubescens showed strong antioxidant activities. These results suggest that methanol or water extracts of several medicinal plant cultivated in Jecheon could be used as natural antioxidants.

• The Journal of Korean Medical History
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• v.18 no.2
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• pp.277-297
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• 2005

As a result of analyzing HyangYakJ ipSeongBang, by focusing on folk medicinal plants, the writer has christened the phrase 'Folk Medical Study' because the medical system of HyangYakJ ipSeongBang was quite different from the usual Korean Medicine or Eastern Medicine. Folk Medicine Study is medical study that emphasizes accessibility of drugs and facility of treatment. Folk Medicine Study is medical study that contains only contents that have been time-tested in our country. Folk Medicine Study is medical study that compiled all herbal knowledge and expertise of prescription of the herbal medicine produced on our land.

• The Journal of Korean Medicine
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• v.21 no.2
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• pp.43-51
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• 2000

Objectives : It is well known that vegetables and fruits contain minerals, including potassium, sodium and phosphorus etc. Though most oriental herbal medications are made of natural plants, western scientists suppose that they also contain certain amounts of minerals and so are injurious to kidney disease such as chronic renal disease. However, by the reason of the limitation of western medical treatment on kidney disease, many patients depend on oriental medical treatment, which includes taking oriental herbal medicine. So, in order to find out the mineral contents in oriental herbal medicine, and to establish the oriental herbal medication's safety in kidney disease, studies were performed. Methods : In this study, we analyzed 42 oriental herbs commonly used in kidney disease by the Inductively Coupled Plasma(ICP) method. Results : 1. The potassium and sodium contents of oriental herbs were 3-10 times as much as of food. 2. The mineral contents of a daily dose of oriental herbal medicine satisfied the restriction of dietary mineral in CRF, though the amount of mineral intakes by food was considered. Conclusions : The mineral contents of oriental herbal medicine are less than the limits of mineral restriction in renal failure. The yielded results, we carefully suggest that oriental herbal medicine does not induce accumulation of minerals or damage in kidney disease patients.