• The Journal of Korean Medicine
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• v.28 no.4
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• pp.1-7
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• 2007

Objectives : This study investigated stroke types, ischemic stroke subtypes, risk factors for stroke, stroke complications and Sasang constitutions in both sexes. Methods : 307 patients with acute stroke within 14 days onset were included, who were admitted to Kyunghee Oriental Medical Center from October 2005 to May 2007. Stroke types, ischemic stroke subtypes, risk factors for stroke, stroke complications and Sasang constitutions in both sexes were examined. Results : Mean age was higher among women than men (64.82${\pm}$10.21 years versus 62.18${\pm}$11.52 years for the 137 female and 170 male patients, respectively, p=0.037). There were no significant differences in stroke type, ischemic stroke subtypes, or stroke risk factors except smoking and Sasang constitutions. Current smoking was more frequent in male patients (p<0.001). Stroke complications, especially urinary tract infection (UTI), were significantly more common in women (p=0.002). Conclusion : Sex does not seem to influence stroke types, ischemic stroke subtypes, or stroke risk factors except current smoking and Sasang constitutions. UTI should be taken into consideration to manage female stroke patients. Smoking cessation is indicated to prevent stroke in men.

• The Journal of Internal Korean Medicine
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• v.27 no.4
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• pp.791-797
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• 2006

Objectives : The objective of the study was to observe the effects of different treatment lengths of Rhizoma Alismatis on diabetes mellitus. Methods : Rats were divided into three groups: normal(non-treated group), control (group administered saline for 4, 11, and 18 days), and RA (group administered 2.45mg/200g Rhizoma Alismatis for 4, 11, and 18 days). The experimental results were derived from the measurement of the levels of glucose, ALP, AST, ALT, creatinine and BUN in the serum from the rats on days 4, 11, and 18. Results : The glucose level in the serum significantly decreased on the 18th day. The ALP level in the serum did not show statistical significance. The GOT and GPT levels in the serum slightly decreased on the 4th, 11th, and 18th days, but did not show statistical significance. The creatinine level in the serum was unchanged for all of them. The BUN level in the serum did not show statistical significance. Conclusions : According to the above results, it is concluded that Rhizoma Alismatis has a therapeutic effect on diabetes mellitus with a longer period ofintake. As to influence upon the liver and kidney, there was no damage orside effects.

• Korean Journal of Medicinal Crop Science
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• v.18 no.1
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• pp.28-33
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• 2010

Glycyrrhiza uralensis (Leguminosae) is a well-known herbal medicine that has long been valued as a demulcent to relieve inflammatory disorders. To compare the influence of different solvents on the anti-inflammatory efficacy of G. uralensis, we measured the inhibition of pro-inflammatory mediators such as NO, TNF-$\alpha$, and $PGE_2$ in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells by extracts produced using different solvents (water, methanol, ethanol, or n-hexane). The results showed that methanol was the most effective solvent for the inhibition of both NO and $PGE_2$ production in RAW 264.7 cells. However, there was no difference among the extracts for inhibition of TNF-$\alpha$. Further study must be performed for the analysis of correlation between the anti-inflammatory activity of extracts produced using different solvents and the content of major bioactive compounds in G. uralensis, such as glycyrrhizin and liquiritin. The present study suggests that methanol may be a more appropriate solvent of G. uralensis than other solvents (water, ethanol, and n-hexane) to yield the greatest anti-inflammatory activity for food additives and medicine.

• Advances in Traditional Medicine
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• v.4 no.2
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• pp.112-119
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• 2004

Glutathione S-transferase polymorphisms (GST) were examined in 98 cases with cerebrovascular disease (CVD) to test the hypothesis that GST polymorphisms confer a risk to an individual to develop CVD. Tobacco smoke is a major cause of both cancer and vascular disease. We therefore were stratified the subjects with CVD for smoking status, and then examined whether polymorphisms in this detoxification enzyme gene, GST, influence risk of CVD. Neither GSTM1 nor GSTT1 genotypes in the CVD group was significantly different from the control group (n=230), even in smokers. We attempted the combined analyses for GSTM1 and GSTT1 genotypes in CVD for smoking status. No significant association observed between the combined genotypes and CVD. We also classified the subjects and control group into four types according to Sasang Constitutional Medicine, Korean Traditional Oriental Medicine, and investigated the association among GST genotypes, CVD, and Sasang constitutional classification. Our observations do not confirm the effect of the GSTM1 and GSTT1 genotypes as a risk factor for CVD, even in smokers. Furthermore, we first attempted to evaluate the efficacy of Sasang Constitutional Medicine, and to find an association with CVD.

• Advances in Traditional Medicine
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• v.10 no.3
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• pp.191-199
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• 2010

Acanthopanax Koreanum stem (AK) has been used in Korea as a tonic and sedative as well as a drug with ginseng like activities. The purpose of our present study was to investigate the effects of AK extract (AKE) and Eleutheroside E, major component of AKE on an exacerbated immune function through utilization of protein-energy malnutrition (PEM) diet by using forced swimming test (FST). The immobility time were significantly decreased in the AKE or Eleutheroside E-administrated group compared with the control group on the FST (P < 0.05). The level of blood parameters were not changed significantly. PEM-induced weight loss of mice was reduced by oral administration of 500 mg/kg AKE. AKE oral administration improved the nutritional status such as the food efficiency ratio and the adrenal gland weight. AKE treatment significantly increased the production of interferon (IFN)-$\gamma$ compared with unstimulated splenocytes but not interleukin (IL)-4. Eleutheroside E also significantly increased the IFN-$\gamma$ production but not IL-2 and IL-4 in T cell line, MOLT-4 cells. These results suggest that AKE and Eleutheroside E may influence to immune-enhancing through increasing the physical endurance capacity and immune cell activation.

• Journal of Society of Preventive Korean Medicine
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• v.15 no.1
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• pp.71-87
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• 2011

Objective : The present study is aimed at providing basic data to help oriental medical hospitals devise efficient operational plans by analyzing the medical expenses of in-patients in an oriental medical hospital and the factors affecting such expenses. Methods : PASW 18.0 was used to analyze the medical insurance program data of 929 patients who were discharged from a university oriental medical hospital(with 105 sick-beds) during the period from January 1 to December 31, 2010 after treatment under the coverage of health insurance and medical aid. Results : 1) Of all the patients hospitalized, 63.3% were females, their mean age was 52.73 years old, and 87.7% was covered by the health insurance program. The biggest number or 31.2% of the patients were treated by the department of acupuncture, 31.5% suffered mainly from the diseases of musculoskeletal system and connective tissues, and the average length of stay at the hospital was 19.49 days. 2) There were statistically significant differences in total medical expenses by age, clinical department in charge, principal diagnosis, and number of days hospitalized while daily average medical expenses differed depending on age, type of medical security, clinical department, principal diagnosis, and number of days staying at the hospital. 3) Total medical expenses were found significantly influenced by age, type of medical security, clinical department, principal diagnosis, and number of days hospitalized(explanatory power : 95.9%), whereas type of medical security, clinical department and principal diagnosis turned out to exercise significant influence on the daily average medical expenses(explanatory power : 26.9%). Conclusion : Oriental medical hospitals are suggested to make efforts to ensure geographical and economical accessibility for their main clients, the elderly and middle-aged, as well as to improve satisfaction of the clients with the medical service provided. They are also encouraged to work out systems to specialize in treatment with a focus on chronic degenerative and adult diseases. In addition, they are expected to try to enhance people's awareness of oriental medicine in an attempt to diversify the brackets of clients and increase frequency of their utilization.

• Journal of Korean Medicine Rehabilitation
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• v.15 no.1
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• pp.109-126
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• 2005

Objectives : This study is to examine the influence of exorcise program to body shape and body composition of women. Exercise program is composed muscular resistance exercise and aerobic exorcise with 70min/time, 5day/week for 4weeks and designed for the reinforcement of muscular strength and the decease the decrease of obesity. Methods : The subjects of this study are 26 females who are from twenty until thirty-nine years old and are divided into two groups according to Obese Rate. normal weight group is 18 females under a BMI of 23 and overweight group is 8 females over a BMI of 23. we measured body compositon and body shape with body composition analyzer(inbody 3.0) measured body compositions are body weight, Lean body mass, base metabolic rate, body fat, %body fat, waist hip ratio, body mass index. measured 6body shade are upper arm circumference, chest circumference, waist circumference, hip circumference, thigh circumference. the measurements had been taken before exercise of each group, after 4 weeks, after 8 weeks, after 12 weeks. Body compositon and body shape of the measured data were analyzed by two-way repeated ANOVA followed by Dunnett's Post hoc test using SPSS. Differences were considered significant at p<0.05. Results and Conclusions : The weight was reduced at a significant level in overweight group after 4 weeks. Body fat percent was reduced at a significant level in normal group alter 4 weeks and overweight group after 8 weeks. Waist-hip ratio was reduced at a significant level in normal and overweight group after 4 weeks. Lean body mass and body metabolic rate were reduced but did not satisfy statistical significance. Circumference of all body parts showed an decrease after 12 weeks exercise program. Upper Arm, Chest, Waist, Hip Circumference were reduced at a significant level in overweight group after 4 weeks, but In normal group only Waist Circumference was reduced at a significant level after 4 weeks. Aerobic and Circuit weight training for 12 weeks reduced body weight and body fat percent, waist circumstance statistically significant without loss of lean body mass and body metabolic rate. Also these change was more effective in overweight group than in normal group.

• Journal of Acupuncture Research
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• v.29 no.6
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• pp.57-71
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• 2012

Objectives : The purpose of this study is to find the effects of Sa-Am stomach tonifying acupuncture on radial pulse through the parameters difference. Methods : Forty healthy subjects participated in this study, acupuncture group and control group were divided. Radial pulse were measured using 3 dimensional pulse imaging system(DMP-3000). 19 parameters that significantly changed were selected after comparing between acupuncture group and control group. Then, 19 parameters were analyzed before, immediately after, 30 minutes after and 60 minutes after acupuncture in acupucture group. Results : 1. Heart rate, pulse period, T/T1, T2/T, T4/T, T5/T, T-T4, (T-T4)/T and T4/(T-T4) significantly changed after acupuncture. 2. H1 Amplitude, H2 Amplitude, H4 Amplitude and H5 Amplitude significantly changed after acupuncture. 3. Area of Pulse Wave, Systolic Pulse Area, Diastolic Pulse Area and Area of W significantly changed after acupuncture. 4. AIx/HR significantly changed after acupuncture. Conclusion : Stomach Tonifying Acupuncture exerts an influence on radial pulse parameters. Further radial pulse change study on various acupuncture treatment is required.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1881-1891
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• 2004

Daejowhan-gamibang(DJG) is used to prevention and treatment of cerebrovascular disease, heart disease, dementia, hyperlipdemia circulatory disturbance. Korean traditional herbal prescriptions and herb medicines in neuronal cells, which have been used for the treatment of stroke and brain diseases in Korean traditional medicine were screened to study the antioxidant effects and its mechanism. Daejowhan-gamibang water extract(DJGWE) was tested on their antioxidant activity using radical scavenging effects against ABTS. It showed significant antioxidant capacities at 50㎍ concentration. The antioxidant activity of DJGWE was determined in the different concentration (10㎍, 50 ㎍, and 100㎍). At the same time, the antiperoxidation effects was determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was significantly inhibited by DJGWE in vitro. DJGWE showed a potent antioxidant and antiperoxidative activity, further investigation, in vitro and in vivo, will be needed for the confirm of possibility as an antioxidant therapeutic agents and their optimal treatment of brain diseases in human. In searching the mechanism of antioxidant effects of DJGWE, it showed the inhibition of activity of JNK, p38, ERK and caspase 3 induced by hypoxia. So, DJGWE should be surveyed for the use of the potential therapeutic prescription for stroke and brain degenerative diseases such as pakinson's disease, dementia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.270-278
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• 2005

Alopecia is an increasing disease recently. Alopecia has social and psychological influence on the alopecia patients. But there is no perfect treatment of alopecia. Authors performed clinical study to evaluate the therapeutic effects of herbal soap Sangmogen in patients with alopecia. Twenty patients with alopecia were included in this study. The patients shampooed with herbal soap Sangmogen everyday. Efficacy was determined by investigating counts of hair, terminal hair, vellus hair, hair follicle, hair pull test, erythema, scale and fissure. After a experiment, self-assessment was checked. As the result of the study, we found that a significant effect was observed. So we concluded that herbal soap Sangmogen has a clinical effect on the alopecia.