• Journal of Sasang Constitutional Medicine
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• v.16 no.3
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• pp.18-24
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• 2004

1. Objectives This study is for discovering the characteristics of the sleep in ordinary symptoms based on the Sasang Constitution. The result of this study could be helpful to understand and to identify the patients as Taeumin by contrast with non-Taeumin. 2. Methods There were 1,229 patients(529 men), who answered the questionnaire about their ordinary sleep patterns. They had been diagnosed, including their Sasang Constitution, by the Sasang Constitution specialist at Bundang Oriental Hospital of Dongguk university. Applying the binary logistic regression analysis to each item about ordinary sleep patterns and the diagnosed Sasang Constitution, we can measure the characteristics and influence of ordinary sleep patterns to the dependent variable(Sasang Constitution). 3. Results As a result of the binary logistic analysis on the observed questionnaire, we found the similar features of the ordinary sleep patterns on Taeumin by contrast with non-Taeumin. In order of influence that identify Taeumin or non-Taeumin, first, Taeumin has a tendency that he will snore well or frequently. Second, Taeumin has a tendency that he will not dream, when he sleeps by contrast with non-Taeumin. 4. Conclusions This study will be used to identify patients as Taeumin or non-Taeumin by means of a reference tool.

• Korean Journal of Acupuncture
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• v.19 no.1
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• pp.47-56
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• 2002

The frequency of the hypertension is increasing as the life level is improved and an average span of the life is extended since we approached modern stage. The hypertension is also dangerous disease which raises fatal complication for example with the bleeding aproplexy and the ischemic attack. The medicinal treatment about the hypertension is required patients to take continually. The acupuncture have been introduced because a medicine-chemical treatment hasn't good influence on the human body. It recently has been processed that studies acupuncture effect for blood pressure and have been found out that blood pressure go down. The object of this study observe the effect of LR3 acupuncture on hypertension in Renal Hypertension RAT induced by 2K1C. The 2K1C model was based on renin-angiotensin system. We put the silver clip in renal artery to induce renal hypertension. We try to observe that LR3 acupuncture influence on the blood pressure and c-fos expression in CVLM, NTS, RVLM. In results, the blood pressure was decreased during acupuncture than before acupuncture, after acupuncture. The heart rate was also decreased during acupuncture than before acupuncture, after acupuncture. The LR3 acupuncture significantly effects on blood pressure and heart rate (P<0.05). The increased expression of c-fos was shown in CVLM, NTS, but not in RVLM. In conclusion, LR3 was relived the action of control upon the hypertension and related with medulla, particularly CVLM, NTS. It needs to be closely examined pharmacological mechanism and studied combination with other acupoints.

• Journal of Pharmacopuncture
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• v.3 no.2
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• pp.79-97
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• 2000

Objectives : To investigate the effects of herb-acupunctures of Qi tonification herbs or formula on the rat immune depression induced by an anticancer drug, methotrexate (MTX) Methods: Animals were divided into 5 groups; Normal control group was not given any treatment. Immune depression was induced by oral administration of 1mg/kg MTX b.i.d for 4 days in Control, Sample I, II, and III groups. We treated on CV 4 (Guanyuan) with saline, Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix herb-acupunctures in Control, Sample I, II, and Ill groups, respectively. In both blood and spleen, the assessment of CD4+ T-cell count, CD8+ T-cell count, CD4/CD8 T-cell ratio was performed. Results: Here we show that 3 herb- acupuncture groups have an influence, to some extent, on CD4+ and CD8+ T-cell counts and CD4/CD8 T-cell ratio in both blood and spleen. Astragali Radix herb-acupuncture, in particular, was found to have significantly increased CD4+ T-cell count in blood and CD4/CD8 T-cell ratio in blood and spleen. Conclusions: The results of this study suggest that herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix may have an influence over rat immune depression induced by MTX.

• Journal of Oriental Neuropsychiatry
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• v.12 no.2
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• pp.53-68
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• 2001

This study was performed to investigate the anti-depression effect of Guibiondamtang in rat model of depression. The rats in the experiment were stratified into 3 groups, ie, Guibiondamtang, saline, normal (non-stressed) groups. Chronic exposure to mild unpredictable stress such as white noise, flashing lights and restriction of food and water, causes the behavioral symptoms correspondent to depression. Consumption of 1% sucrose solution fell in rats exposed to CMS for 4 weeks. In the open field test , the exploratory activity ie. locomotion and centering decreased after CMS. We then evaluated the sucrose consumption and activity during 4 weeks of treatment with experimental drugs. The results were as follows: 1) There was no relation between sucrose intake and weight. 2) The Guibiondamtang(歸脾溫膽湯) group reinstated sucrose consumption within 5-6 weeks while having no influence on sucrose intake in normal group. 3) The Guibiondamtang(歸脾溫膽湯) group restored some exploratory activity in the open field test. 4) The Guibiondamtang-group had a-reduced potentiated startle response.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.65-72
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• 2005

Objectives : This study is for discovering the clinical Features of the sleep in ordinary symptoms based on the Sasang Constitution. The result of this study could be helpful to understand and to identify the patients as Soyangin in contrast with the other constitutions -Soeumin, Taeumin and Taeyangin. Methods : There were 1,229 patients(700 female), who answered the questionnaire about their ordinary sleeping patterns. They had been diagnosed, including their clinical Sasang Constitution, by the Sasang Constitution specialist at Bundang Oriental Hospital of Dongguk University. By applying the binary logistic regression analysis, we can measure the characteristics and the influence of ordinary sleeping patterns to the dependent variable(Sasang Constitution). Results : As a result of the binary logistic analysis on the observed questionnaire, we found the characteristics of the ordinary sleeping patterns on Soyangin in contrast with the other constitutions. Firstly, Soyangin has a tendency that he wouldn't dreams more, when he sleeps in contrast with the others. Secondly, Soyangin has a tendency that he wouldn't sleep longer than 6-7hours. Thirthly, Soyangin has a tendency that he will sleep well in contrast with the others. Conclusion : This study will be used to identify patients as Soyangin in contrast with the others-Soemin, Taeumin and Taeyangin.

• The Journal of Pediatrics of Korean Medicine
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• v.14 no.1
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• pp.153-168
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• 2000

The cough is one of the most common respiratory symptom in children. Boeumjunggi-tang(BEJG) is herbal medicine mainly treat cough due to yin deficiency(陰虛咳嗽) in Oriental Medicine. During 3 momths from February, 1, 2000 to April, 30, 2000, BEGJ is administered to the pediatric out-patients with the cough due to yin deficiency have visited Pundang Dongguk Oriental medicine Hospital and among these patients, this study is performed for 50 patients of which the result of treatment could be gained. The conclusion is following. 1. In the distribution of patients, male(60%) is more than female(40%) and group of age in between 1 and 6 years(76%) are the first. 2. In the type of cough, group of chronic(more than 3 weeks), and group that the symptom make worse in night are the most. 3. In the distribution of remedial effect, group of symptom-relieved is the first(58%), symptom-disappearing is second(22%), symptom-unchanging is third(14%), symptom-aggravated is fifth(6%). 4. The chracteristic of cough have little influence on the remedial effect of BEGJ.

• Journal of Korean Medical classics
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• v.22 no.4
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• pp.153-166
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• 2009

This article looks into Lee-Gyujun(李圭晙)'s life course, Confucian thoughts, and philosophical ideas on the Medicine of Boosting Yang(陽), by thoroughly translating and analyzing selectively the second half of Lee-Gyujun(李圭晙)'s "Seokgoksango(石谷散稿)". Translating his works is said to be necessary to fully understand the significance of the boosting-yang theory[扶陽論] in the historical landscape of Korean medicine, not to mention comprehension of the medical contents itself. Through this translation and analysis, first, it is found that Lee-Gyujun(李圭晙) had visited Seo-Changyu(徐贊奎) for over 10 years and had great influence on qi(氣) monism. Second, within the Gihohakpa(畿湖學派), Lee-Gyujun was much closer to Horon(湖論) rather than Nanron(洛論). Third, during his days, he became well known across the peninsula through his medical fame. Last, he wrote down the unknown manufacturing technique of dried ginger[乾薑].

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1138-1142
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• 2002

Dansamchunghyul-tang(丹參淸血湯) is a new formula consist of Salviae Miltiorrhizae Radix and some oriental herbs to treatment of hyperlipidemia. In this study, we investigated the effects of the water extract of Dansamchunghyul-tang(DCT) on hyperlipidemia of the rat. We here studied the influence of DCT on hyperlipidemia in Sprague-Dawley rats. The hyperlipidemia was induced by Triton WR-1339 (tyloxapol) intravenous injection at 200mg/kg body weight. After 18 h, blood was collected for the determination of plasma total cholesterol, triglyceride, phospholipid, HDL-cholesterol, and LDL-cholesterol concentrations. In the model of hyperlipidemia induced by triton WR-1339 in rats, DCT showed decreasing effects on total cholesterol, triglyceride, phospholipid level significantly, in a dose-dependent fashion. DCT showed dose-dependent effects on HDL-cholesterol and LDL-cholesterol level insignificantly. In conclusion, DCT showed significant effects on hyperlipidemia, and the present findings indicate that DCT may prove potentially useful for treatment of hyperlipidemia.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.231-244
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• 2008

Purpose: The purpose of this study is to analyze body composition, obesity according to working pattern of working women. The subjects were workers in the automobile manufacturing industry. Methods: The subjects consisted of 514 industrial women workers who had received Korean oriental medicine health examination and submitted questionires about working pattern, during 8 months from April 2005 to November 2005. The body composition was measured by X-scan(Jawon medical, Seoul, Korea). We analyzed the relationship between body composition analysis, obesity and shift pattern with $X^2-test$ using the SPSS Ver. 12.0 Results: Regarding the realationship between body composition and working pattern, shift worker group had a significantly higher level of body weight, ratio of body fat, visceral fat and abdominal fat than normal worker. Conclusion: From this study, we can know that shift work can influence on working women's body composition and obesity.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.4 no.1
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• pp.211-232
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• 1998

Because there were lots of side effects and tolerances to the existing anticancer therapeutics, the experiment extracting the anticancer effect from medicinal herbs is in progress liviely. Therefore the purpose of this study were to research the tendency and the course of anticancer studies. To research the tendency of anticancer studies, medicinal herbs of fifty three experimental papers were analyzed and to examine the course of studies, anticancer papers in the medical world were used. The obtained results were as follows: Methods of herbal medicinal treatments were elimination the pathogenic factor(祛邪) and supporting healthy energy(扶正) method used. In this study, immediately tumor bearing and immune response were the most important point. The subject of immediately tumor bearing was not in the specific cancer but in the influence on the life span of general cencerous cells. In the experimental study of immune response, the effect on NK cell activity of medicinal herbs most studied. The combined usage of medicinal herbs and anticancer agent mostly intended to know whether it inhibits the tumor cell growth. The serum test and blood cell number test show if medicinal herbs inhibit side effect of anticancer agent. More than 80 percents of used medicinal herbs, there were anticancer activities. However anticancer experimental studies using medicinal herbs two weak points. The one, it was difficult to choose a prescription according to differentiation of symptoms and signs(辨證論) of the Oriental Medicine, because we put to the test not a man but a mouse. The other, as we observed the indirect effect of the whole physiological regulation caused by synergic effects of the complex prescription, we don't understand the detailed mechanism of the herb. Therefore, if the anticancer effect of the herb is proved the experiment, we should research the concrete medical action of medicinal herbs and immunological analysis of herbal medicines to the body.