Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix, and Astragali Radix on Immune Responses in Rats

보중익기탕(補中益氣湯), 인삼(人蔘) 및 황(黃)기 약침(藥鍼)이 MTX로 약침(誘發)된 백서(白鼠)의 면역기능저하(免疫機能低下)에 미치는 영향(影響)

  • Kim, Jung-Hun (Dept. of Meridianology, College of Oriental Medicine, Kyunghee University) ;
  • Park, Hi-Joon (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Hyang-Sook (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridianology, Dept. of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
  • 김정헌 (경희대학교 한의과대학 경혈학교실) ;
  • 박히준 (경희대학교 동서의학대학원 한의과대학 침구경락학교실) ;
  • 이향숙 (경희대학교 동서의학대학원 한의과대학 침구경락학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 한의과대학 침구경락학교실)
  • Published : 2000.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : To investigate the effects of herb-acupunctures of Qi tonification herbs or formula on the rat immune depression induced by an anticancer drug, methotrexate (MTX) Methods: Animals were divided into 5 groups; Normal control group was not given any treatment. Immune depression was induced by oral administration of 1mg/kg MTX b.i.d for 4 days in Control, Sample I, II, and III groups. We treated on CV 4 (Guanyuan) with saline, Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix herb-acupunctures in Control, Sample I, II, and Ill groups, respectively. In both blood and spleen, the assessment of CD4+ T-cell count, CD8+ T-cell count, CD4/CD8 T-cell ratio was performed. Results: Here we show that 3 herb- acupuncture groups have an influence, to some extent, on CD4+ and CD8+ T-cell counts and CD4/CD8 T-cell ratio in both blood and spleen. Astragali Radix herb-acupuncture, in particular, was found to have significantly increased CD4+ T-cell count in blood and CD4/CD8 T-cell ratio in blood and spleen. Conclusions: The results of this study suggest that herb-acupunctures of Bojoongiggi-tang (Buzhongyiqi-tang), Ginseng Radix and Astragali Radix may have an influence over rat immune depression induced by MTX.

Keywords

References

  1. 細胞分子免疫學 金光赫(外2人)
  2. 最新 免疫學 李淵台(譯)
  3. 精校黃帝內經素問 洪元植(編)
  4. 精校黃帝內經靈樞 洪元植(編)
  5. 慶熙韓醫大論文集 v.11 人蔘水鍼이 methotrexate를 投與한 생쥐의 免疫反應에 미치는 影響 高敬錫(外2人)
  6. 慶熙韓醫大論文集 v.9 人蔘 및 熟地黃이 methotrexate로 誘發된 생쥐의 免疫反應 低下에 미치는 影響 金聖洙(外2人)
  7. 慶熙韓醫大論文集 v.10 白朮과 枸杞子가 생쥐의 細胞性 및 體液性 免疫反應에 미치는 影響 羅瑛杰;金光湖
  8. 大韓鍼灸學會誌 v.11 no.1 濃度差에 따른 黃耆藥鍼이 methotrexate를 投與한 생쥐의 免疫反應에 미치는 影響 朴鎭雄(外2人)
  9. 大韓鍼灸學會誌 v.11 no.1 黃耆藥鍼이 methotrexate를 投與한 생쥐의 免疫反應에 미치는 影響 裵元永;高炯均;金昌煥
  10. 慶熙韓醫大論文集 v.10 水蔘, 白蔘 및 紅蔘이 細胞性免疫反應 및 體液性免疫反應에 미치는 影響 吳勇性(外2人)
  11. 大韓韓醫學會誌 v.10 no.2 四君子湯이 생쥐의 免疫反應 및 NK細胞의 細胞毒性에 미치는 影響 李南九(外2人)
  12. 大韓免疫學會誌 v.1 no.1 人蔘에 대한 細胞學 및 免疫學的 硏究 (제Ⅲ보) 하대유
  13. 大韓免疫學會誌 v.12 no.1 當歸抽出物이 免疫界에 미치는 影響 문혜선(外6人)
  14. 慶熙韓醫大論文集 v.10 鹿茸이 methotrexate로 誘發된 생쥐의 免疫反應 低下에 미치는 影響 崔平洛;金光浩
  15. 大韓韓醫學會誌 v.13 no.1 靈芝水鍼이 寒冷刺戟으로 低下된 생쥐의 免疫反應에 미치는 影響 林사비나;李惠貞
  16. 東醫病理學 文濬典
  17. 晴崗醫鑑 金永勳
  18. 東醫臨床方劑學 尹吉榮
  19. 大韓韓醫學會誌 v.15 no.1 補中益氣湯이 cyclosporin A를 投與한 흰쥐의 肝 및 腎損傷에 미치는 影響 朴宰賢
  20. 方劑學會誌 v.2 no.1 補中益氣湯의 投與가 紫外線 照射로 低下된 마우스의 免疫機能의 恢復에 미치는 影響 閔勇泰
  21. 慶熙韓醫大論文集 補中益氣湯, 手拈散 및 補中益氣湯合手拈散의 抗癌과 免疫調節作用에 관한 實驗的 硏究 韓晟圭(外2人)
  22. 補中益氣湯이 lymphocyte와 CD4+ T-cell에 미치는 影響 金美志
  23. 醫學入門 李천
  24. 方藥合編 黃度淵
  25. 本草求眞 黃宮수
  26. 慶熙醫學 v.5 no.1 三種의 製法에 따른 人蔘水鍼이 methotrexate를 投與한 생쥐의 免疫反應에 미치는 影響 金大洙
  27. 大韓韓醫學會誌 v.9 no.2 人蔘水鍼前處置가 發癌豫防에 미치는 影響 金泰潤;姜成吉
  28. 慶熙醫學 v.4 no.2 人蔘 및 鹿茸水鍼의 時間經過에 따른 免疫效果硏究 黃敬愛(外2人)
  29. 大韓韓方腫瘍學會誌 v.2 no.1 十全大補湯, 瓦松 및 十全大補湯加瓦松의 抗癌效果와 免疫反應에 관한 硏究 黃奎東(外3人)
  30. J Mol Med v.73 no.12 Fas(CD95) expression on CD4+ T-cells from HIV-infected patients increases with disease progression Aries, S.P.(et al.)
  31. Gut. v.36 Natural history and prognosis of diarrhea of unknown cause in patients with AIDS Blanshard, C.;Gazzard, B.G. https://doi.org/10.1136/gut.36.2.283
  32. Gut. v.29 Persistant diarrhoea in Zairian AIDS parients: an endoscopic and histological study Colebunders, R.(et al.)
  33. J Immunol v.149 no.8 Maturation and differentiation-dependent responsiveness of human CD4+ T-helper subsets De Jong R.(et al.)
  34. Leuk Lymphoma v.8 no.6 Hormons and immune responsiveness in chronic lymphocytic leukemia Everaus, H. https://doi.org/10.3109/10428199209051031
  35. Annals of Internal Medicine v.111 CD4+ T-cell Counts as predictors of opportunistic pneumonias in human immuno-deficiency virus infection Henry Masur(et al.) https://doi.org/10.7326/0003-4819-111-3-223
  36. Psychoendocrinology v.16 no.5 Pituitary-Adrenal Immune system in normal subjects and in patients with anorexia nervosa : The number of circulating helper T lymphocytes (CD4+) expressing the homing receptor Leu8 is regulated in part by pituitary-adrenal products Chiappelli, F.(et al.) https://doi.org/10.1016/0306-4530(91)90007-G
  37. AIDS v.10 no.12 Buspirone, a seortonin receptor agonist, increases CD4+ T-cell counts and modulates the immune system in HIV-seropositive subjects Hofmann, B.(et al.) https://doi.org/10.1097/00002030-199610000-00005
  38. J Immunol Meth v.110 Superior leucocyte seperation with a discontinuous one-step Ficoll-Hypaque gradient for the isolation of human neutrophils Kalmar, J.R.(et al.) https://doi.org/10.1016/0022-1759(88)90115-9
  39. 免疫의 意味論 타다 토미오

Cited by

  1. A Case of Improvement of Metastatic Ovarian and Endometrial Cancer Treated by Integrative Medicine Therapy Combined with Chemotherapy vol.19, pp.1, 2014, https://doi.org/10.15432/JKTO.2014.19.1.33
  2. Single Intramuscular-dose Toxicity of Samgihwalryeok-Pharmacopuncture in Sprague-Dawley Rats vol.17, pp.2, 2014, https://doi.org/10.3831/KPI.2014.17.016
  3. Case of Remission of Progressive Breast Cancer Treated by Capecitabine with Integrative Medicine Therapy vol.19, pp.1, 2014, https://doi.org/10.15432/JKTO.2014.19.1.43