• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.78-84
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• 2010

Adult-onset Still's disease (AOSD) is an inflammatory disorder that's characterized by daily, spiking high fever, arthritis and an evanescent, salmon-pink rash. AOSD is diagnosed purely on the basis of the typical clinical features of the illness. The symptoms commonly include swelling of the lymph nodes, enlargement of the spleen and liver, and a sore throat. AOSD is difficult to differentiate from systemic lupus erythematosus (SLE) due to the similar clinical manifestations. We report here on a case of a 16-year-old female patient with autism and epilepsy and who complained of daily spiking fever for 20 days. The patient had maculopapular skin rashes on the face and whole body and lymphadenopathy. The liver function tests were elevated mildly. The initial rheumatoid factor (RF) and antinuclear antibody (ANA) tests were negative. We diagnosed her as having adult-onset Still's disease according to the criteria of Yamaguchi. We successfully treated her with oral prednisolone. But her antinuclear antibody test was changed to positive after discharge. So we finally diagnosed her as having SLE.

• Nutrition Research and Practice
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• 제8권1호
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• pp.46-53
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• 2014

Inorganic arsenic (iAs) is a toxic metalloid found ubiquitously in the environment. In humans, exposure to iAs can result in toxicity and cause toxicological manifestations. Arsenic trioxide ($As_2O_3$) has been used in the treatment for acute promyelocytic leukemia. The kidney is the critical target organ of trivalent inorganic As ($iAs^{III}$) toxicity. We examine if oral administration of astaxanthin (AST) has protective effects on nephrotoxicity and oxidative stress induced by $As_2O_3$ exposure (via intraperitoneal injection) in rats. Markers of renal function, histopathological changes, $Na^+-K^+$ ATPase, sulfydryl, oxidative stress, and As accumulation in kidneys were evaluated as indicators of $As_2O_3$ exposure. AST showed a significant protective effect against $As_2O_3$-induced nephrotoxicity. These results suggest that the mechanisms of action, by which AST reduces nephrotoxicity, may include antioxidant protection against oxidative injury and reduction of As accumulation. These findings might be of therapeutic benefit in humans or animals suffering from exposure to $iAs^{III}$ from natural sources or cancer therapy.

• 대한수의학회지
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• 제46권2호
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• pp.165-169
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• 2006

A 6-year-old female Jindo dog weighing 20 kg was presented to the Veterinary Medical Teaching Hospital of Seoul National University for the formation of crust and erosion of the nasal bridge and planum, and for alopecia of ear margin. Erythema, crusts, alopecia and erosions were present in the nasal planum and the bridge of the nose on physical examination. There were no abnormalities on CBC, serum chemistry, and basic dermatologic examination which included skin scraping, bacterial cultures, and fungal cultures. On cytology, the acantholytic cells were surrounded by non-degenerate neutrophils. Biopsy samples obtained from skin lesionswere diagnosedpemphigus erythematosus by histopathology and immunochemical staining. Therefore the dog was initially treated with oral prednisolone as an immunosuppressive dose for tour weeks, but clinical manifestations did not improve so far.

• 대한소아치과학회지
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• 제30권4호
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• pp.673-677
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• 2003

선천적 무설증은 매우 드물게 보고되는 증상이다. 무설증을 가진 환자는 구개 이상, 하순 결손, 하악 측절치 결손 등을 포함한 하악골의 발육부전을 나타낸다. 무설증의 원인은 밝혀지지 않았으나 유전적 요인이나 발생 4주시기에 기형유발물질의 영향으로 추정되고 있다. 무설증의 치료는 혀를 재건해주는 외과적 술식과 하악골의 성장을 돕는 교정적 술식, 하악골의 길이를 늘리는 distraction osteogenesis 등이 있으며 무설증의 정도에 따라 달라진다. 본 증례는 선천적 무설증과 situs inversus(장기의 좌우가 바뀐 상태)를 가진 6세 여아에서 무설증으로 인한 하악골의 횡적 수축을 악정형 장치를 이용하여 치료하였으며 향후 2차 교정과 외과적 수술을 계획하기에 양호한 결과를 얻을 수 있었다.

• Tuberculosis and Respiratory Diseases
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• 제45권5호
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• pp.1094-1097
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• 1998

만성적인 경부 동통을 호소하던 57세 남자가 호흡곤란을 호소하여 경추부 단순 촬영 및 경부 전산화 단층 촬영을 시행한 결과 경추 전방부의 과골화를 포함한 Forestier병의 소견을 보였으며, 기관지 내시경상 경추부 과골화로 인한 기도 협착 및 성문 하부의 부종이 관찰되어 스테로이드로 치료하여 호전되었기에 문헌 고찰과 함께 보고하는 바이다.

• 대한소아치과학회지
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• 제46권4호
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• pp.416-421
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• 2019

선천성 무통무한증(Congenital insensitivity to pain with anhidrosis, CIPA)은 NTRK1 유전자의 돌연변이에 의해 발생하는 드문 유전질환으로 통증에 대한 무감각 및 땀을 흘리지 못하는 것이 특징이다. 지적장애를 동반하는 경우가 많으며, 구강내 임상검사에서는 자해로 인한 병소를 제외하고 특징적인 병소가 발견되지 않으므로 초기 감별진단이 중요하다. 소아치과의사는 이 질환과 동반되는 조절되지 않는 체온, 지각 과민, 통증 반사의 부재와 같은 다양한 임상증상 등을 인지하고 있어야 하며 이를 치과 치료에서 고려해야만 한다. 이 연구는 본원에 첫 내원 이후 6년여간 경과 관찰 중인 선천성 무통무한증 환아의 치험례를 통하여 이 질환의 감별진단 및 치과치료에서의 주의사항 등을 알아보고자 하였다.

• 한국한의학연구원논문집
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• 제16권1호
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• pp.43-50
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• 2010

Background : The varieties of manifestations referred to headache and vertigo have been long complicated physicians in the efficient diagnosis and treatment of these diseases. Objectives : Establish a distinctive and efficient acupuncture method for the treatment of headache and dizziness based in literature research. Method : We reviewed four Korean medical literature, "治腫指南Guide to Swollen Sore Treatment", "東醫寶鑑Treasured Mirror of Eastern Medicine", "鍼灸經驗方Experiential Prescriptions of Acupuncture and Moxibustion", and "舍岩鍼法Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am", and analyzed the therapeutic characteristics in the treatment of headache and vertigo. Result : 1. "治腫指南Guide to Swollen Sore Treatment" inserted needle in GV20百會 and waited until the skin erupts and heat burns, then applied in those regions affected. 2. "東醫寶鑑Treasured Mirror of Eastern Medicine" mostly applied moxibustion on headache, however, needling acupoints such as GV20百會, GV24神庭, GV23上星, GV22顖會 were also considered important. 3. "鍼灸經驗方Experiential Prescriptions of Acupuncture and Moxibustion" used moxa cones on headache in order to disperse heat and direct Gi downward. 4. "校勘 舍岩道人鍼法Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am" defined the cause of dizziness, wood excavates earth and earth kills water. Conclusions : After previous study on eye, oral, glottal, labial, dental diseases and stroke, we could also find various efficient methods according to headache and vertigo, through literature research of Korean medical classics. This study will concurrently result in establishing distinctive therapeutic method characteristic of Korea.

• Pediatric Infection and Vaccine
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• 제27권3호
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• pp.184-189
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• 2020

라임병은 진드기를 매개로 하여 보렐리아속균 감염에 의해 발생하는 세균 질환이다. 가장 흔한 증상으로 초기에 유주성 홍반이 대부분의 환자에게서 관찰되며, 신경, 심혈관계 및 관절을 침범하는 증상이 발현할 수 있다. 저자들은 미국 코네티컷주로 여행력이 있는 13세 남자에게서 발현한 라임병을 진단하여 보고하는 바이다. 환자는 2016년 여름에 미국에서 숲 체험에 참여하던 중 발열, 두통, 양쪽 무릎 관절통을 호소하여 귀국하였으며, 내원 시 양 하지에 다수의 유주성 홍반이 관찰되었다. 심전도 검사에서 1도 방실 차단이 확인되었다. 간접면역형광항체법과 웨스턴블럿법 검사에서 라임병 특이 IgM 항체가 양성으로 확인되었다. 경구 doxycycline으로 4주간 치료하였으며, 유주성 홍반이 소실되고 심전도가 정상 소견으로 회복되었다. 라임병의 진단에 있어 호발 지역으로의 여행력을 확인하는 것이 중요하다. 라임병에 의한 심장염은 무증상 방실 전도차단으로 나타날 수 있고 고도 방실 차단으로 진행할 수 있어 주의를 요하며 적절한 항생제 치료를 통해 회복될 수 있다.

• Childhood Kidney Diseases
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• 제26권2호
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• pp.74-79
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• 2022

Purpose: Children with nephrotic syndrome may experience disease relapse or aggravation triggered by various viral infections. Limited studies on the clinical implications of the coronavirus disease 2019 (COVID-19) pandemic in children with nephrotic syndrome have been published worldwide. Therefore, this study aimed to investigate the effects of COVID-19 on the clinical course of nephrotic syndrome in children. Methods: The medical records of 59 patients with idiopathic nephrotic syndrome who visited our hospital between February and June 2022 were retrospectively analyzed. Results: Twenty of the total 59 patients with nephrotic syndrome were diagnosed with COVID-19 during the study period. The mean age at the time of the diagnosis of nephrotic syndrome and COVID-19 in all 20 patients was 4.6±3.5 and 8.9±3.9 years, respectively. Three patients (15%) were diagnosed with nephrotic syndrome relapse during COVID-19 and the relapse rate was similar to them without COVID-19 (20.5%, 8/39 patients). At the time of the COVID-19 diagnosis, fever (85%) and cough (40%) were the most common symptoms. After the diagnosis of COVID-19, all patients showed improvement with symptomatic treatment, including antipyretic analgesics and cold medicine. None of the critical patients required hospitalization or oral antiviral medications. Conclusions: Despite the use of immunosuppressants, the clinical manifestations of COVID-19 in children with nephrotic syndrome were not severe and are expected to be similar to that in the general population. The relapse rate of nephrotic syndrome in children with COVID-19 was also not different from them without COVID-19.

• Journal of Digestive Cancer Research
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• 제4권2호
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• pp.122-126
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• 2016

Leptomeningeal carcinomatosis occurs in approximately 5% of patients with cancer. The most common cancers involving the leptomeninges are breast, lung cancer and melanoma. However, gastric adenocarcinoma has been rarely reported with leptomeningeal carcinomatosis. The presenting manifestations are usually headache, visual disturbances and seizures. We report a case of leptomeningeal metastasis that presented as a gastric cancer. A 75-year old man was transferred to our hospital for further evaluation and treatment after being diagnosed with adenocarcinoma through endoscopic biopsy during a regular health examination. An abdominal computed tomography (CT) showed AGC, stage IA (cT1N0M0), while an endoscopic examination showed AGC, Borrmann type 2. The patient is currently under observation after undergoing radical subtotal gastrectomy with gastroduodenostomy and subsequent administration of oral chemotherapeutic agents. As an abdominal CT response assessment performed after surgery revealed new metastasis to the liver, the patient received palliative chemotherapy as recurrence was suspected. After receiving chemotherapy in the order of DP (Cisplatin + Docetaxel), FOLFIRI (5-FU + Leucovorin + Irinotecan), an abdominal CT response assessment showed complete response. Since decreased mentality maintained throughout the follow up period based on outpatient clinic, brain MRI was performed and revealed multiple leptomeningeal metastasis. The Patient died 2 days after the diagnosis.