• 대한화장품학회:학술대회논문집
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• 대한화장품학회 1999년도 IFSCC . ASCS 학술대회 발표 논문
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• pp.145-154
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• 1999

A novel retinol derivative, polyethoxylated retinamide (Medimin A) was synthesized, as an anti-aging agent. Collagen synthesis, skin permeation, stability, and toxicity of Medimin A were evaluated and compared with those of retinol and retinyl palmitate. In vitro collagen synthesis was evaluated by quantitative assay of [$^3H$]-proline incorporation into collagenase sensitive protein in fibroblast cultures. For in vitro skin permeation experiments, Franz diffusion cells (effective diffusion area: $1, 766{\;}\textrm{cm}^2$) and the excised skin of female hairless mouse aged 8 weeks were used The stabilities of retlnoids were evaluated at two different temperature ($25{\;}^{\circ}C$ and $40{\;}^{\circ}C$) and under UV in solubilized state and in OW emulsion. To estimate the safety, acute oral toxicity, acute dermal toxicity, primary skin irritation, acute eye irritation and human patch test were performed The effect of Medimin A on collagen synthesis was similar to that of retinol. The skin permeability of Medimin A was higher than those of retinol and retinyl palmitate. The Medimin A was more stable than retinol and retinyl palmitate. Medimin A was nontoxic in various toxicological tests. These results suggest that Medimin A would be a good anti-aging agent for enhancing bioavailability and stability.

• 대한장애인치과학회지
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• 제8권1호
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• pp.22-25
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• 2012

1. 저산소성 허혈성 뇌병변 환아에서 뇌손상으로 인한 혀내밀기 습관에 의해 외상성 혀궤양이 발생할 수 있으며 Riga-Fede disease로 진단할 수 있다. 2. Riga-Fede disease의 종래의 치료 방법은 하악 유전치의 날카로운 부분을 갈아주는 것, 절단면의 복합레진 수복, 발치 등이 있으며 이번 보고에서는 보존적이며 가역적인 방법인 tongue protector를 제안하였고 혀궤양의 치료 및 혀내밀기습관 개선에 효과적인 것으로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1415-1419
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• 2016

The tongue has been globally considered as an indicator of general health for millennia. This study aimed to determine the prevalence and distribution of tongue lesions in an Iranian population. In this retrospective study, data from 6,435 oral biopsy reports over a 22-year period (1992-2014) were retrieved from archives of Oral and Maxillofacial Pathology Department, Shahid Beheshti Dental School, Tehran, Iran. These reports were analyzed according to age, sex, type of lesion and location. Prevalence of tongue lesions were reported as percentages. Out of total oral lesions, 238 (3.7%) were found in the tongue, with the incidence peak (42%) being between 41-60 years. Men constituted 53% and women 47%of patients. The youngest patient was a 3-year-old girl with pyogenic granuloma and the oldest one was a 93-year-old man with squamous cell carcinoma (SCC). SCC was the most common (25%) lesion generally found in the lateral border of the tongue with a male predilection. The second and third most prevalent lesions of the tongue were benign keratosis (frictional keratosis) (13.4%) and leukoplakia (13%).White-red lesions (38.6%) were the most frequent subgroup followed by neoplastic lesions (28%). Moreover, irritation fibroma, non-specific ulcers, squamous papilloma, and hemangioma were found as the most frequent lesions in their related subgroups.Given the high rate of SCC of the tongue in Iranian patients, this area should be examined more carefully by dental practitioners and physicians.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권1호
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• pp.54-61
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• 2011

Introduction: Bisphosphonates is used widely for the treatment of the Paget's disease, multiple myeloma, bone metastases of malignant tumors with the prevention of pain and their pathological fracture. However, it was recently suggested that bisphosphonates related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate use. Materials and Methods: Twenty-four individuals, who were referred to the Department of Oral and Maxillofacial surgery, Dankook University Dental Hospital, were selected from those who had exposed bone associated with bisphosphonates from January, 2005 to December, 2009 according to the criteria of American Association of Oral and Maxillofacial Surgeons (AAOMS) for BRONJ. The patients group consisted of 7 males and 17 females between the age of 46 to 78 years (average 61.8 years). Each patient had panoramic imaging, computed tomography (CT), whole body bone scanning performed for a diagnosis and biopsy sampling from the necrotizing tissue. C-terminal cross-linking telopeptide of type I collagen (CTX) level of patients who had undergone surgical intervention was measured 7 days before surgery. Results: The main cause of bone exposure was post-extraction (15), chronic periodontitis (4), persistent irritation of the denture (3). Twenty people had undergone BRONJ treatment for two to eight months except for 4 people who had to maintain the bisphosphonates treatment to prevent a metastasis and bone trabecular pain with medical treatment. When the bisphosphonate treatment was suspended at least for 3 months and followed up according to the AAOMS protocols, the exposed necrotizing bones were found to be covered by soft tissue. Conclusion: Prevention therapy, interruption of bisphophonates for at least 3 months and cooperation with the physician for conservative treatment are the essential for treating BRONJ patient with high risk factors. The CTX level of BRONJ patients should be checked before undergoing surgical intervention. Surgical treatments should be delayed in the case of a CTX level <150 pg/mL.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제12권1호
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• pp.193-201
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• 1990

본 증례는 약 3~4년 전부터 우측 하악 골체부에 골성종창 및 간헐적 둔통이 있어 타병원에서 부분절제술을 시행받았으나 재발의 증세를 보여 내원한 60세 여자환자에 대해 병소부위를 포함하여 partial mandibulectomy와 동시에 metal plate와 iliac bone을 이용한 즉시 재건술을 시행하였으며 조직 병리학적 검사결과 florid osseous dysplasia로 진단 하였고, 술후 6개월이 경과한 현재까지 재발이나 별다른 합병증없이 양호한 치유경과를 보여주고 있다.

• 구강회복응용과학지
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• 제32권2호
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• pp.123-129
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• 2016

의원성의 외상 혹은 감염은 신경 손상의 중요한 원인 중 하나이며, 이는 의사-환자 관계에 매우 큰 영향을 주는 일로 여겨진다. 관련 치과 술식의 예로는 임플란트 시술시 직접적인 혹은 열에 의한 손상, 근관치료시의 약제 유출, 발치시의 외력, 전달국소마취시 바늘에 의한 외상, 악골 수술로 인한 외상 등이 있다. 이러한 신경손상이 발생하지 않도록 위험군 예측 및 시술 시 주의가 필요하며, 신경 손상 시 조기 발견을 통해 제대로 대처하지 않으면 만성적 신경병증으로 발전할 수 있는 가능성이 높아질 수 있으므로 그 징후를 신속히 파악하고 적절히 관리하는 것이 매우 중요하다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제25권4호
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• pp.361-366
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• 1999

Intermaxillary fixation is routine procedure to oral and maxillofacial area in jaw bone fracture, surgical correction of jaw deformity, osseus reconstruction of jaw. After transoral surgery, accompanied by intermaxillary fixation, dysphagia or airway obstruction may be followed due to blood clot, vomitus, or laryngeal spasm resulting from irritation by blood or secretions. Lingual or pharyngeal edema is other contributing factors of airway obstruction. In addition, intermaxillary fixation itself may cause obstruction of airway. In this study, pulmonary function test and arterial blood gas analysis were evaluated before and after intermaxillary fixation in 30 patients suffered from mandibular fractures. Comparative analysis was performed by estimated values. The results were as followed. 1. The spirometric values of FEV1, FEV1/FVC and FEF25-75% without intermaxillary fixation were reduced from 97.57%, 85.1%, 98.3,% to 71.7%, 66.5%, 61.2% with intermaxillary fixation, indicating the presence of obstructive pulmonary impairment. 2. Spirometric value of MVV, as the most influencing value of sensitive to extrapulmonary factors, was changed from 84.5% to 46.48%. 3. After intermaxillary fixation, the spirometric value of FVC, as indicator of restrictive pattern of pulmonary function, was not reduced significantly as measured from 94.47% to 89.97%. 4. $O_2$ saturation of arterial blood gas analysis without intermaxillary fixation was 97.86%. While intermaxillary fixation, $O_2$ saturation was 97.47%. The results indicate that careful airway management is mandatory undergoing intermaxillary fixation of various oral and maxillofacial surgery.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권3호
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• pp.152-159
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• 2012

Objectives: This study evaluated bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients diagnosed with malignant bone tumors. Demographic findings, laboratory, and radiographic analyses were performed to characterize disease severity and progression. Materials and Methods: Patients who had been diagnosed with BRONJ (2005-2010) at the authors' hospital according to the American Association of Oral and Maxillofacial Surgeons were investigated. Twenty-one patients (12 with multiple myelomas, 7 with breast cancer, and 2 with prostate cancer) who had been treated with bisphosphonates (BPs) for malignant bone tumors were included. Radiographic evaluations with a panorama, computed tomography, whole body bone scan, and laboratory findings were evaluated for erythrocyte sedimentation rate (ESR), c-reactive proteins (CRPs), and c-terminal cross-linked telopeptides (CTXs). Results: The average age of the patients was 64.3 (range 51-80), and they were treated with BPs for an average of $35{\pm}19$ months before BRONJ was diagnosed. Types of BPs were zolendronic acid (81%, intravenous [IV]), pamidronate (4.8%, IV), zoledronic acid+pamidronate (4.8%, IV), alendronate (4.8%, per os [PO]), and ibadronate (4.75%, PO). Extraction (67%) and persistent irritation of dentures (20%) were the most common triggering factors. BRONJ in the mandible was reported in 62% of the cases, in the maxilla 24%, and both 14%. BRONJ occurred more frequently in patients with multiple myelomas (n=12, 57.1%). Most of the patients revealed an advanced BRONJ stage; Stage I (n=2, 9%), Stage II (n=13, 62%), and Stage III (n=6, 29%). Conclusion: The differences of the ESR, CRP, and CTX values between the BRONJ-recurring and non-recurring patients after the treatment were not evident. Later stage BRONJ patients showed lower CTX levels. A drug holiday after the diagnosis of BRONJ did not remarkably influence the surgical outcomes. However, the limited number of patients in the study should be considered.

• 보존과학회지
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• 제33권4호
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• pp.255-266
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• 2017

국내 문화재 생물피해 방제는 농약에서 유래한 화학적 약제를 사용하여 왔다. 그러나 인체와 환경에 대한 유해성 문제로 인하여 사용이 점차 제한되고 있으며, 새로운 방제약제의 탐색과 안전성 연구에 대한 관심이 지속적으로 증가되고 있다. 개발된 천연 생물방제제의 안전성은 동물실험을 통한 독성평가로 확인하고 있으며, 치사량과 자극성 평가를 위하여 경구독성, 경피독성, 안점막자극 및 피부자극 시험법을 이용하여 안전성을 평가한다. 독성평가를 위해 실험용 쥐와 토끼를 이용하며, 쥐에 대해 단회 경구독성과 경피독성 시험을 실시하고, 토끼에 대해 안점막자극시험 및 피부자극 시험을 시행한다. 본 시험에 이용한 천연 생물방제물질은 목재부후균과 흰개미에 대한 항진균활성 및 살충활성이 조사된 족두리풀 추출물을 적용하였다. 쥐에 대한 단회 경구투여한 결과 $LD_{50}$ 값이 수컷 4,000 mg/kg 이상, 암컷 2,000 mg/kg 이상으로 판정되었으며, 단회 경피 투여한 결과 $LD_{50}$ 값이 암수 모두 10,000 mg/kg 이상으로 판정되었다. 토끼의 눈에 대한 자극시험에서는 무자극성으로 판정되었으며, 피부에 대해서는 약한 자극성이 있는 물질로 판단되었다. 본 연구를 통해 천연 생물방제물질인 족두리풀 추출물의 안전성을 동물실험으로 확인함으로써 화학 물질의 안전성 검증을 위한 기본적인 유해성 평가 방법으로 제시하고자 한다.

• 대한치과기공학회지
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• 제41권4호
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• pp.305-317
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• 2019

Purpose: The purpose of this study is to provide basic data for the improvement of dental care service for patient care. Methods: The survey period was from December 10, 2018 to June 10, 2019. The subjects were 180 patients who were treated with dental implant in 20 dental hospitals and clinics in Daejeon and Gyeonggi province. A total of 145 questionnaires were analyzed except for 35 copies which were unreliable or difficult to analyze. Results: The most important care method for prolonging the life time of dental implant prosthesis was the highest rate of correct brushing (39.4%), and a majority in the subjects used oral hygiene products (91.0%). With regard to discomfort after dental implant prosthesis, food particles between the teeth showed the highest response (49.7%), and discomfort with gum infections and bleeding and reduced mastication increased significantly with age (p<0.05), whereas feeling of irritation decreased significantly with age (p<0.05). Conclusion: This study is meaningful in that it approached the perception and discomfort of prosthesis from the patients' point of view. It needs to establish the basic data to improve dental treatment service for patient care.