• 대한통합의학회지
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• 제8권4호
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• pp.265-275
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• 2020

Purpose : In this study, we would like to apply oral sensory play therapy program to children with cerebral palsy who have sensitive oral senses to find out the effect on oral sensory ability, oral function, performance ability and sociality. Methods : The subjects of this study were 20 children diagnosed with cerebral palsy, and 10 experimental groups and 10 control groups. Oral sensory play therapy programs, including oral sensory programs, were conducted in the experimental group, while only oral sensory programs were conducted in the control group. Oral Sensory Treatment Level was used to identify the sensory profile and the overall oral function of the oral function was used, and the performance and satisfaction of Canadian occupational performance measure (COPM) were examined to find out the performance of the work, and social skills were examined for social skills (SMS). Results : The level of oral sensory treatment, overall oral function, work performance and sociality all increased significantly in the experimental group, but the oral sense and oral function in the control group were significantly increased, but not significantly in the case of work performance and sociality. Conclusion : Through this study, we confirmed that oral sensory play therapy program is an effective arbitration method for oral sensation, oral function, work performance and social enhancement of children with cerebral palsy. Based on the results of this study, the study of arbitration protocols for children with cerebral palsy with oral sensory problems will have to be more active.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권2호
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• pp.147-154
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• 2002

Genistein that is a component of soy has been reported to have a protective effect on the carcinogenesis of various tumors and to inhibit the growth of a wide variety of tumor cell in vitro. Angiogenesis is an essential process for the carcinogenesis, growth, invasion and metastasis of cancer and genistein has been suggested to act as natural anti-angiogenic agent. The purpose of this study was to evaluate the effects of genistein on the vascular endothelial growth factor (VEGF) expression in hamster buccal pouch oral carcinogenesis model induced by 9, 10-dimethyl 1,2-benzanthracene (DMBA). Experimental group that were supplied with 0.1mg/day genistein were sacrificed by time schedules and routinely processed for immunohistochemical examination of VEGF. In genistein treated group, carcinogenesis was retarded with respect to the acanthosis, hyperkeratosis, and epithelial dysplasia. Immunohistochemical study showed that the VEGF protein of genistein group was less expressed than that of the control group. (p<0.05) Thus, it is postulated that genistein has chemopreventive effect on the oral carcinogenesis, and this chemopreventive effect, at least partly, is originated from the anti-angiogenic effect of genistein

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권6호
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• pp.259-268
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• 2018

Objectives: The purpose of this study was to evaluate the synergic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and low-level laser therapy (LLLT) on bisphosphonate-treated osteoblasts. Materials and Methods: Human fetal osteoblast cells (hFOB 1.19) were cultured with $100{\mu}M$ alendronate. Low-level Ga-Al-As laser alone or with 100 ng/mL rhBMP-2 was then applied. Cell viability was measured with MTT assay. The expression levels of receptor activator of nuclear factor kappa-B ligand (RANKL), macrophage colony-stimulating factor (M-CSF), and osteoprotegerin (OPG) were analyzed for osteoblastic activity inducing osteoclastic activity. Collagen type and transforming growth factor beta-1 were also evaluated for bone matrix formation. Results: The results showed that rhBMP-2 and LLLT had a synergic effect on alendronate-treated osteoblasts for enhancing osteoblastic activity and bone matrix formation. Between rhBMP-2 and LLLT, rhBMP-2 exhibited a greater effect, but did not show a significant difference. Conclusion: rhBMP-2 and LLLT have synergic effects on bisphosphonate-treated osteoblasts through enhancement of osteoblastic activity and bone formation activity.

• 대한기관식도과학회지
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• 제5권1호
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• pp.36-41
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• 1999

Postoperative pain, poor oral intake and various complaints of adenotonsillectomized patients are the main problems for the otolaryngologist. Steroids have been advocated to reduce morbidity after adenotonsillectomy, but the results are conflicting. This study is to determine the effect of preoperative and postoperative oral steroid. Material and Methods : A prospective, randomized study was performed on 40 patients from 4 to 13 years of age. 20 patients undergoing adenotonsillectomy received steroid(experimental group), others undergoing adenotonsillectomy did not receive steroid(control group). An oral prednisolone was administered preoperatively for 3 days and postoperatively 7 days. A dosage was determined by patient's weight. Postoperatively each patients was examined for weight loss as well as for subjective signs of pain, oral intake, activity, mouth odor and analgesic usage. Results： experimental group showed decreased morbidity in view of postoperative pain, oral intake with statistical significance (p<0.05). The usage of analgesics was decreased in steroid group. but, activity, mouth odor and body weight showed no statistical difference. Conclusion： The results showed that preoperative and postoperative oral steroid affect the postoperative morbidity in adenotonsillectomy.

• 한국융합학회논문지
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• 제11권2호
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• pp.29-35
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• 2020

본 연구는 산업체 근로자의 구강보건 정의적 요인이 구강건강 행위와 구강건강 삶의 질에 미치는 영향을 파악하고자 하였다. 충북지역 산업체 5곳 100명을 대상으로 2018년 1월 19일부터 23일까지 단순무작위 표본추출방법으로 선발하여 설문지법으로 조사하였고, 자료분석은 SPSS 18.0을 이용하여 빈도분석, 독립 T검정, 다중회귀분석을 실시하였다. 그 결과, 구강보건 정의적 요인이 구강건강 행위에 영향을 미치는 것으로 나타났고, 구강보건 실천의지가 높을수록 구강건강 삶의 질에 영향을 미치는 것으로 나타났다. 이를 통해 산업장 근로자의 구강건강 행위와 구강건강 삶의 질을 증진시키기 위해서는 구강보건 정의적 요인을 변화 시킬 수 있는 효율적인 구강건강프로그램이 개발되어야 한다.

• 한국환경보건학회지
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• 제33권2호
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• pp.115-122
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• 2007

Methanol extracts of Perilla and Mugwort were stepwise extracted with hexane, chloroform, ethyl acetate, butanol and water. Anti-microbial activities and inhibitory effect on growth of oral tumor cell of each extract were investigated. Each extracts of Perilla and Mugwort were investigated to anti-microbial effects on oral microbes by means of agar diffusion method and MIC. These results suggest that the hexane extracts of Perilla and Mugwort have antimicrobial activities against S. mutans and potent inhibitory Effect to KB cell growth.

• 약학회지
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• 제49권5호
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• pp.365-369
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• 2005

The inhibitory effect of ferulic acid and related phenolic compounds on the growth of normal cell lines and can­cer cell line was evaluated by the MTT and XTT methods. Ferulic acid decreased the cell viability of human skin melanoma cells by the MTT method and the cell adhesion activity of human oral epithelioid carcinoma cells by the XTT method. These results suggest that ferulic acid has a potential anticancer activity.

• International Journal of Oral Biology
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• 제41권2호
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• pp.75-81
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• 2016

Human mouth environment is known to include a variety bacteria, including Streptococcus spp., Staphylococcus spp., Actinomyces spp., Lactobacillus spp., Candida spp., Enterobacteriaceae, et al. Human oral microorganisms can cause dental caries, gingivitis, periodontitis, respiratory tract infection, and cardiovascular disease. Thus, right denture cleaning is essential to oral and general human health. The aim of this study was to evaluate the bactericidal effect of a sodium dichloroisocyanurate-based effervescent tablet (Aos Denti Germ, Aos Company, Chungbuk, Korea) against oral microorganisms. A total of 5 species Streptococcus spp. (Streptococcus anginosus, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, and Streptococcus sobrinus), Actinomyces oris, Candida albicans, and Escherichia coli were used in this study. All strains were exposed to the distilled water prepared with effervescent tablet. After the exposure, the mixture of strains and effervescent tablet was inoculated onto blood agar or MacConkey agar plate and cultured at $36^{\circ}C$. All strains were killed immediately on exposure to effervescent tablet. The results suggested that effervescent tablet could be used as an effective denture cleanser for dental hygiene.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권5호
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• pp.358-363
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• 2002

Purpose : Authors attempted to evaluate the effect on explanation of pathogenesis and stress management as the initial care of temporomandibular disorders. Materials and methods : The materials were 634 patients with temporomandibular disorder, who had been referred to our Department of Dentistry, Wonju Christian Hospital during recent 5 years. We examined about clinical aspects of temporomandibular disorders, such as, major signs of temporomandibular joint disorder, life environment and habits, radiological findings of temporomandibular joint and electromyography of masseter muscle. The patients were treated by explanation of TMJ pathogenesis and stress management. After that, the patient were evaluated about the effect in third week. Results : The result was more favorable (96.5% success rate) without intolerable signs of temporomandibular joint disorder. Conclusion : The explanation of TMJ pathogenesis and stress management were thought as the very effective care in management of patients with temporomandibular disorder.

• 한국치위생학회지
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• 제22권4호
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• pp.249-257
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• 2022

Objectives: This study aimed to investigate the effect of the oral health status on risk factors for obstructive sleep apnea (OSA) using data from the 2019 National Health and Nutrition Examination Survey. Methods: Of a total of 2,422 persons, 1,295 and 1,127 were categorized into the control group (CG) and OSA risk group (OSARG), respectively. The effect of the oral health status on OSA risk factors was presented in Model 1 by performing a complex sample linear regression analysis. Results: Our findings showed that OSA risk factors decreased by 0.075 points when there were no speaking problems with demographic characteristics adjusted. In addition, when systemic diseases were adjusted for, OSA risk factors decreased to 0.074 points (p<0.05). Conclusions: Therefore, in order to reduce oral problems that affect OSA risk factors, dentists and dental hygienists should seek accurate recognition of OSA and effective oral care methods.