• 생물정신의학
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• 제2권1호
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• pp.3-19
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• 1995

Numerous investigators have conducted extensive investigation in the search for biological markers in psychiatric illness. There are, as a test of q biological approach to the diagnosis of the psychiatric illness, tests for the neurotransmitters, their metabolites, and related enzymes, the neurotransmitter receptors, the neuroendocrine output and response, the membrane transport, peptides and eletrolytes. They are called the biological markers, and they are helpful for the diagnosis or differential diagnosis, choice of treatment or drugs, symptom improvement, predictor of recurrence and anticipation of suicidal attempt. These studies are among the main purposes that are pursued in the neuroscience and based on the potential utility of the biological markers mentioned above. Since 1970's, lots 01 biological markers' studies for the diagnosis, differential diagnosis or subtypes differentiation have been done but varieties of different opinions have been drawn since then through they could explain the charaters of main psychiatric illness(especially schizophrenia and mood disorder). But, the search for biological markers, including displines of neuroendoclinology and neurochemistry(neurotransmitter and thair metabolite), has yielded a number of putative trait merkers and state markers for psychayric illness. This paper aims to anticipate or evaluate the good response to the therapy(Therpeutic response) with lots of markers. Acoording to the diagnosis of lots of diseases or subtypes, we are going to review the papers, mainly concern with 'Is there any Marker' or 'Is any test possible to detect the improvement clinically?' 'Is it possible to predict the recurrence or good prognsis?' or 'Is it possible to select any drug or therapy to bring the good response?' The biological tests to review are mainly the metabolites of catecholamine neurotransmitter, and especially neuroendocrine test based on the knowledge that hormons of the adenohypophysis are influenced by activity of the cerebral or limbic neurons as well as the hypothalamus ones. Among them, author introduced some clinically available tests that are DST, TRH stimulation test(TRHST), GH stimulation test, and the urine MHPG test that can give us the evaluation of the treatment response, the predictor for recurrence or choice of drug that can bring a good response. So author discussed thair potential utility in clarifying, therapeutic, and prognostic issues in psychatric illness. We hope they'll be used and look forward to more active study on the different opinion.

• Earthquakes and Structures
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• 제25권3호
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• pp.199-208
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• 2023

Seismic performance analysis is one of the fundamental steps in the design of new or retrofitting buildings. In the seismic performance analysis, the adapted spectral acceleration curve for a given site mainly governs the seismic behavior of buildings. Since every soil site (class) has a different impact on the spectral accelerations of input motions, different spectral acceleration curves have to be involved for every soil class that the building is located on top of. Modern seismic design codes (e.g., Eurocode 8, EC8, or Turkish Building Earthquake Code, TBEC) provide design response spectra for all the soil classes to be used in the building design or retrofitting. This research aims to evaluate the EC8 and TBEC based design response spectra using the spectra of real earthquake input motions that occurred (and were recorded at only soil classes A, B and C, no recording is available at soil class D) in a specific area in Turkey. It also conducts response spectrum analyses of 5, 10 and 13 floor reinforced concrete building models under EC8, TBEC and actual spectral response curves. The results indicate that the EC8 and especially TBEC given design response spectra cannot be able to represent the mean actual spectral acceleration curves at soil classes A, B and C. This is particularly observed at periods higher than 0.3 s, 0.42 s and 0.55 s for the TBEC design response spectra, 0.54 s, 0.65 s and 0.84 s for the EC8 design response spectra at soil classes A, B and C, respectively. This is also reflected to the shear forces of three building models, as actual spectral acceleration curves lead to the highest shear forces, followed by the shear forces obtained from EC8 and, then, the TBEC design response spectra.

• 한국환경성돌연변이발암원학회지
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• 제16권2호
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• pp.83-87
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• 1996

This study was performed by the sister chromatid exchanges (SCEs) to investigate the effects of Aphidicolin (APC) or 2, 4-dinitrophenoi (DNP) on cross-adaptive response to ultraviolet radiation (UV) or ethyl methanesulfonate (EMS) in Chinese hamster ovary (CHO) cells. The pretreatment with 1 J/m$^2$ UV decreased the yield of SCEs induced by subsequent treatment with 8 mM EMS in CHO cells. And the treatment with 10 $\mu$g/ml APC or 50 $\mu$M DNP during incubation after pretreatment with 1 J/m$^2$ UV increased the yield of SCEs induced by 8 mM EMS. The pretreatment with 2 mM EMS decreased the yield of SCEs induced by subsequent treatment with 5 J/m$^2$ UV. The treatment with 10 $\mu$g/ml APC during incubation after 2 mM EMS increased the yield of SCEs induced by 5 J/m$^2$ UV. These results suggest that APC and DNP inhibit cross-adaptive response to pretreatment with UV and subsequent treatment with EMS, and also cross-adaptive response to pretreatment with EMS and subsequent treatment with UV is inhibited by APC in CHO cells.

• Transactions on Control, Automation and Systems Engineering
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• 제4권4호
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• pp.283-288
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• 2002

This paper has shown that the impulse and the unit step responses of 2nd-order systems can be computed by an analytic method. Three different 2nd-order systems are investigated: the prototype system, the system with one LHP(left half plane) real zero and the system with one RHP(right half plane) real zero. It has also shown that the effects of the LHP or the RHP zero are very serious when the zero is getting closer to the origin on the complex plane. Based on these analytic results, this paper has presented two sufficient and necessary conditions for 2nd-order linear SISO(single-input/single-output) stable systems to have the nonovershooting and the monotone nondecreasing step response, respectively. The latter condition can be extended to the sufficient conditions for the monotone nondecreasing step response of high-order systems.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2001년도 제34회 추계학술대회 개최
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• pp.316-321
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• 2001

The paper presents the unbalance response of a rotor-bearing system supported by an active control bearing. The proportional, derivative and integral controls are employed for the control algorithm of an active control bearing to suppress the unbalance response of a rotor-bearing system. Results of analytical investigations on the unbalance responses of a rotor supported by an active control bearing are presented for various control gains. It is found that the unbalance response of a rotor can be greatly suppressed by the proportional, derivative or integral control of the bearing. The proportional control is more effective than the derivative control at low rotational speed, and the derivative control is more effective than the proportional control at high rotational speed. In the case of the integral control of the bearing , the unbalance response of a rotor is increased as a general rule. However, the integral control of the bearing is extremely superior to proportional or derivative control at very low rotational speed.

• Tribology and Lubricants
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• 제18권2호
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• pp.99-104
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• 2002

The paper presents the unbalance response of a rotor-bearing system supported by an active control bearing. The proportional, derivative and integral controls are investigated fur the control algorithm of an active control bearing to suppress the unbalance response of a rotor-bearing system. Results of analytical investigations on the unbalance responses of a rotor supported by an active control bearing are presented for various control gains. It is found that the unbalance response of a rotor can be greatly suppressed by the proportional, derivative or integral control of the bearing. The proportional control is more effective than the derivative control at low rotational speed, and the derivative control is more effective than the proportional control at high rotational speed. In the case of the integral control of the bearing, the unbalance response ova rotor is increased as a general rule. However, the integral control of the bearing is extremely superior to proportional or derivative control at very low rotational speed.

• Ocean Systems Engineering
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• 제9권3호
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• pp.219-240
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• 2019

This paper presents the comparison between SFT response with linear and nonlinear cables. The dynamic response analysis of submerged floating tunnel (SFT) is presented computationally with linear and nonlinear tension legs cables. The analysis is performed computationally for two wave directions one at 90 degrees (perpendicular) to tunnel and other at 45 degrees to the tunnel. The tension legs or cables are assumed as linear and non- linear and the analysis is also performed by assuming one tension leg or cable is failed. The Response Amplitude Operators (RAO's) are computed for first order waves, second order waves for both failure and non-failure case of cables. For first order waves- the SFT response is higher for sway and heave degree of freedom with nonlinear cables as compared with linear cables. For second order waves the SFT response in sway degree of freedom is bit higher response with linear cables as compared with nonlinear cables and the SFT in heave degree of freedom has higher response at low time periods with nonlinear cables as compared with linear cables. For irregular waves the power spectral densities (PSD's) has been computed for sway and heave degrees of freedom, at $45^0$ wave direction PSD's are higher with linear cables as compared with nonlinear cables and at $90^0$ wave direction the PSD's are higher with non-linear cables. The mooring force responses are also computed in y and z directions for linear and nonlinear cables.

• Korea-Australia Rheology Journal
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• 제15권2호
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• pp.91-96
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• 2003

The sensitivity of the product to the ongoing sinusoidal disturbances of the process has been investigated in the film casting of viscoelastic polymer fluids using frequency response analysis. As demonstrated for fiber spinning process (Jung et al., 2002; Devereux and Denn, 1994), this frequency response analysis is useful for examining the process sensitivity and the stability of extensional deformation processes including film casting. The results of the present study reveal that the amplification ratios or gains of the process/product variables such as the cross-sectional area at the take-up to disturbances exhibit resonant peaks along the frequency regime as expected for the systems having hyperbolic characteristics with spilt boundary conditions (Friedly, 1972). The effects on the sensitivity results of two important parameters of film casting, i.e., the fluid viscoelasticity and the aspect ratio of the casting equipment have been scrutinized. It turns out that depending on the extension thinning or thickening nature of the fluid, increasing viscoelasticity results in enlargement or reduction of the sensitivity, respectively. As regards the aspect ratio, it has been found that an optimum value exists making the system least sensitive. The present study also confirms that the frequency response method produces results that corroborate well those by other methods like linear stability Analysis and transient solutions response. (Iyengar and Co, 1996; Silagy et al., 1996; Lee and Hyun, 2001).

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.37-42
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• 2024

In this study, we explored the possibility of using sympathetic skin response (SSR), a type of electrodermal activity (EDA), as a method of evaluating a subject's responsiveness to physical or psychological stimulation. To provide physical and psychological stimulation, walking on an acupressure plate and a roller coaster virtual reality experience wearing an HMD (head mounted display) were used. Walking on an acupressure plate significantly increased the SSR signal compared to walking on the bare floor. Additionally, it was observed that the SSR response significantly increased while the subject was wearing an HMD and experiencing a roller coaster compared to the resting state of sitting on a chair. The SSR response to physical or psychological stimulation increased in all subjects, but the degree of reactivity differed. These experimental results suggested that sympathetic skin response (SSR) is a useful tool as a biosignal that can be used to evaluate the human body's responsiveness to physical stimulation or psychological stimulation using virtual reality.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1341-1347
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• 2012

Introduction: Diffuse large B-cell lymphomas (DLBCL) can be divided into germinal centre (GC-DLBCL) and post germinal centre (post GC-DLBCL) groups by applying immunohistochemical antibodies. As these subgroups respond differently to chemotherapy, it is possible at diagnosis to select a poor prognostic subgroup for aggressive treatment. Objective: To determine the frequencies of GC-DLBCL and post GC-DLBCL in patients by immunohistochemistry (IHC) and the clinical response after six cycles of chemotherapy. Subjects and Methods: In this descriptive study conducted in AFIP and CMH, Rawalpindi and NORI, Islamabad, from September 2010 to September 2011, a total of 75 pretreatment cases of DLBCL diagnosed during the study period were included. Cases were segregated in to GC-DLBCL and post GC-DLBCL groups according to results of immunohistochemistry markers CD10, BCL6 and MUM1. Immediate clinical response was assessed after 6 cycles of chemotherapy. Response was divided into complete response, partial response, stable disease or relapse or progression. Results: The mean age was $54.2{\pm}15$. Males were 53 (70.7%). Forty (53.3%) cases comprised the GC-DLBCL group; 25(62.5%) of them showed a complete response. Most patients of the post GC-DLBCL 19(54%) showed relapse/progression. Results of immediate clinical response in both prognostic subgroups were significant (p<0.05). Results regarding positivity with immunohistochemical antibodies CD10 (p 0.011), BCL6 (p 0.013) and MUM1 (p 0.000) regarding immediate clinical response were also significant. Conclusion: GC-DLBCL group shows better response to CHOP chemotherapy regimen. Immunohistochemistry should be used to further classify DLBCL as this can enable us to select aggressive group for aggressive treatment. This manuscript is important because the study is the first to becarried out exclusively in Pakistan or our part of the world.