• Communications for Statistical Applications and Methods
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• 제24권3호
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• pp.255-269
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• 2017

This article explores the analysis of longitudinal surveys in which same units are investigated on several occasions. Multivariate exponential ratio type estimator has been proposed for the estimation of the finite population median at the current occasion in two occasion longitudinal surveys. Information on several additional auxiliary variables, which are stable over time and readily available on both the occasions, has been utilized. Properties of the proposed multivariate estimator, including the optimum replacement strategy, are presented. The proposed multivariate estimator is compared with the sample median estimator when there is no matching from a previous occasion and with the exponential ratio type estimator in successive sampling when information is available on only one additional auxiliary variable. The merits of the proposed estimator are justified by empirical interpretations and validated by a simulation study with the help of some natural populations.

• Communications for Statistical Applications and Methods
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• 제22권5호
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• pp.445-462
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• 2015

This article deals with the problem of estimation of the population mean in presence of multi-auxiliary information in two occasion rotation sampling. A multivariate exponential ratio type estimator has been proposed to estimate population mean at current (second) occasion using information on p-additional auxiliary variates which are positively correlated to study variates. The theoretical properties of the proposed estimator are investigated along with the discussion of optimum replacement strategies. The worthiness of proposed estimator has been justified by comparing it to well-known recent estimators that exist in the literature of rotation sampling. Theoretical results are justified through empirical investigations and a detailed study has been done by taking different choices of the correlation coefficients. A simulation study has been conducted to show the practicability of the proposed estimator.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1997년도 추계학술대회발표논문집; 홍익대학교, 서울; 1 Nov. 1997
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• pp.193-196
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• 1997

In this paper we consider a Bayesian theoretic approach to periodic incomplete preventive maintenance with minimal repair at failure. We assume that the system failure rate is increasing as the frequency of PM increases and that the system is replaced at the K-th PM under this maintenance strategy. The optimal policies which minimize the expected cost rates are discussed. We seek the optimal periodic PM interval x and replacement time K under a Weibull failure intensity. Assuming suitable prior distribution for the Weibull parameters, we derive the posterior distribution incorporating failure data and obtain the updated optimal replacement strategies.

• 한국유기농업학회지
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• 제5권2호
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• pp.13-36
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• 1997

This study aims to point out the basic strategy of agrotechnical and -political approaches toward successful settling for the environmental agriculture system in Korea. Although environmental agriculture & forestry strategy toward the 21st century and it's action program were released in 1996, some scientist from environmental agriculture and organic agriculture still argue on the errors of it's strategy and action program in terms of environmental sound functions. Especially it's strategy and action program of government did not focus the reduction of fertilizer and pesticide as the matters of weight and importance to reduction of fertilizer and pesticide as the matters of weight and importance to realize an environmental sound agriculture system. And korean organic agriculture gets a point in dispute, because 1) they do not practice of Basic Standard of IFOAM and FAO/WHO Codex draft, and 2) organic farming is defined quite differently from internationally recognized core aspects of organic agriculture. Organic farming, in Korea, is taken to mean the replacement of chemical fertilizer by organic manure and avoidance of agricultural chemicals. In the paper it is discussed the necessity, purpose, effect and consequence of basic standard for korean organic agriculture. The reformation of the certification system and t he direct payment system in environmental agriculture & forestry strategy toward the 21st century and it's action program by government, and on the need of the teaching program and curriculum in high education institution, the breeding program of resistant cultivars, the soil testing for optimum fertilization strategy, the nutrient management program, the declaration for 2020 environemntal agriculture are also discussed.

• 한국자동차공학회논문집
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• 제6권4호
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• pp.76-85
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• 1998

Recently, Genetic Algorithm(GA) is widely adopted into a search procedure for structural optimization, which is a stochastic direct search strategy that mimics the process of genetic evolution. This methods consist of three genetics operations maned selection, crossover and mutation. Contrast to traditional optimal design techniques which use design sensitivity analysis results, GA, being zero-order method, is very simple. So, they can be easily applicable to wide area of design optimization problems. Also, owing to multi-point search procedure, they have higher probability of converge to global optimum compared to traditional techniques which take one-point search method. In this study, a method of finding the optimum values of suspension parameters is proposed by using the GA. And vehicle is modelled as planar vehicle having 5 degree-of-freedom. The generalized coordinates are vertical motion of passenger seat, sprung mass and front and rear unsprung mass and rotate(pitch) motion of sprung mass. For rapid converge and precluding local optimum, share function which distribute chromosomes over design bound is introduced. Elitist survival model, remainder stochastic sampling without replacement method, multi-point crossover method are adopted. In the sight of the improvement of ride comfort, good result can be obtained in 5-D.O.F. vehicle model by using GA.

• 한국농공학회지
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• 제45권2호
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• pp.35-44
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• 2003

A system reliability method is proposed to decide reliable serviceability of agricultural irrigation system. Even though reliability method is applied to real engineering situations involving actual life environments and maintaining costs, a number of Issues arise as a modeling and analysis level. This article use concepts that can be described the probability of failure with time variant and series-parallel system reliability analysis model. A proposed method use survivor function that can simulate a time-variant performance function for a lifetime before it is required essential maintenance or replacement to define a target probability of failure in agricultural irrigation canal. In the further study, it is required a relationship between a state of probability of failure and current serviceability to make the optimum repair strategy to maintain appropriate serviceability of an irrigation system.

• Journal of Microbiology and Biotechnology
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• 제31권1호
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• pp.163-170
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• 2021

Enzyme replacement therapy for lysosomal storage diseases usually requires recombinant enzymes containing mannose-6-phosphate (M6P) glycans for cellular uptake and lysosomal targeting. For the first time, a strategy is established here for the in vitro mannosyl-phosphorylation of high-mannose type N-glycans that utilizes a recombinant Mnn14 protein derived from Saccharomyces cerevisiae. Among a series of N-terminal- or C-terminal-deleted recombinant Mnn14 proteins expressed in Pichia pastoris, rMnn1477-935 with deletion of N-terminal 76 amino acids spanning the transmembrane domain (46 amino acids) and part of the stem region (30 amino acids), showed the highest level of mannosyl-phosphorylation activity. The optimum reaction conditions for rMnn1477-935 were determined through enzyme assays with a high-mannose type N-glycan (Man8GlcNAc2) as a substrate. In addition, rMnn1477-935 was shown to mannosyl-phosphorylate high-mannose type N-glycans (Man7-9GlcNAc2) on recombinant human lysosomal alpha-glucosidase (rhGAA) with remarkably high efficiency. Moreover, the majority of the resulting mannosyl-phosphorylated glycans were bis-form which can be converted to bis-phosphorylated M6P glycans having a superior lysosomal targeting capability. An in vitro N-glycan mannosyl-phosphorylation reaction using rMnn1477-935 will provide a flexible and straightforward method to increase the M6P glycan content for the generation of "Biobetter" therapeutic enzymes.