• 정보처리학회논문지C
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• 제11C권6호
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• pp.835-842
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• 2004

본 논문에서는 다중 경고 페이딩 환경 하에서 최적의 다이버시티 기법 중 하나로 알려진 하이브리드 SC/MRC(Selective Combining/Maximal Ratio Combining) (2/3) 기법을 적용하고, 각 경로를 통해 들어오는 수신 신호와 수신기 내의 PLL(Phase Locked Loop)에서 발생된 참조 신호와의 위상차를 위상 에러로 가정한 후, PLL 루프 내의 이득 값을 조정하여 완전 동기 된 수신 신호가 되는 MC-DS/CDMA(Multi-Carrier Direct Sequence/Code Division Multiple Access) 시스템을 분석하였다. 또한, 이동 통신 환경에 대한 채널 모델로 나카가미-m 페이딩 채널 환경을 채택하였으며, 하이브리드 SC/MRC-(2/3) 다이버시티 방식이 적용된 MC/DS-CDMA 시스템에서 고려 사항인 나카가미 페이딩 지수(m), 경로의 수$(L_p),$ 하이브리드 SC/MRC-(2/3) 다이버시티 브랜치 수$(L,\;L_c),$ 사용자 수(K), 부반송파의 수(U), PLL 루프 내의 이득 값 등을 고려하여 수식을 전개하고 시뮬레이션을 수행하였다. 시뮬레이션 결과, 하이브리드 SC/MRC-(2/3) 방식이 적용된 MC/DS-CDMA 시스템에서 완전 동기 된 수신 신호를 수신할 수 있도록 하기 위해 적절한 PLL 루프 이득 값을 조절하여 성능의 개선을 이룰 수 있음을 확인할 수 있었으며 완전 동기 된 수신 신호가 되기 위해 페이딩 지수와 부반송파 확산이득에 따라 조금의 차이는 있지만 PLL 루프 이득 값이 7dB 이상 되어야 각 경로의 수신 신호가 완전 동기 된 수신 신호임을 확인하였다.

• Clinical and Experimental Pediatrics
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• 제55권3호
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• pp.88-92
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• 2012

Purpose: Mucopolysaccharidosis type II (MPS II or Hunter syndrome) is a rare lysosomal storage disorder caused by iduronate-2-sulfatase (IDS) deficiency. MPS II causes a wide phenotypic spectrum of symptoms ranging from mild to severe. IDS activity, which is measured in leukocyte pellets or fibroblasts, was reported to be related to clinical phenotype by Sukegawa-Hayasaka et al. Measurement of residual plasma IDS activity using a fluorometric assay is simpler than conventional measurements using skin fibroblasts or peripheral blood mononuclear cells. This is the first study to describe the relationship between plasma IDS activity and clinical phenotype of MPS II. Methods: We hypothesized that residual plasma IDS activity is related to clinical phenotype. We classified 43 Hunter syndrome patients as having attenuated or severe disease types based on clinical characteristics, especially intellectual and cognitive status. There were 27 patients with the severe type and 16 with the attenuated type. Plasma IDS activity was measured by a fluorometric enzyme assay using 4-methylumbelliferyl- ${\alpha}$-iduronate 2-sulphate. Results: Plasma IDS activity in patients with the severe type was significantly lower than that in patients with the attenuated type ($p$=0.006). The optimal cut-off value of plasma IDS activity for distinguishing the severe type from the attenuated type was 0.63 $nmol{\cdot}4hr^{-1}{\cdot}mL^{-1}$. This value had 88.2% sensitivity, 65.4% specificity, and an area under receiver-operator characteristics (ROC) curve of 0.768 (ROC curve analysis; $p$=0.003). Conclusion: These results show that the mild phenotype may be related to residual lysosomal enzyme activity.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6155-6160
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• 2014

Background: This study was conducted to investigate whether apparent diffusion coefficient (ADC) measurements by dividing the liver into left and right hepatic lobes may be utilized to improve the accuracy of differential diagnosis of benign and malignant focal liver lesions. Materials and Methods: A total of 269 consecutive patients with 429 focal liver lesions were examined by 3-T magnetic resonance imaging that included diffusion-weighted imaging. For 58 patients with focal liver lesions of the same etiology in left and right hepatic lobes, ADCs of normal liver parenchyma and focal liver lesions were calculated and compared using the paired t-test. For all 269 patients, ADC cutoffs for focal liver lesions and diagnostic accuracy in the left hepatic lobe, right hepatic lobe and whole liver were evaluated by receiver operating characteristic curve analysis. Results: For the group of 58 patients, mean ADCs of normal liver parenchyma and focal liver lesions in the left hepatic lobe were significantly higher than those in the right hepatic lobe. For differentiating malignant lesions from benign lesions in all patients, the sensitivity and specificity were 92.6% and 92.0% in the left hepatic lobe, 94.4% and 94.4% in the right hepatic lobe, and 90.4% and 94.7% in the whole liver, respectively. The area under the curve of the right hepatic lobe, but not the left hepatic lobe, was higher than that of the whole liver. Conclusions: ADCs of normal liver parenchyma and focal liver lesions in the left hepatic lobe were significantly higher than those in the right hepatic lobe. Optimal ADC cutoff for focal liver lesions in the right hepatic lobe, but not in the left hepatic lobe, had higher diagnostic accuracy compared with that in the whole liver.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5383-5387
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• 2014

Purpose: To investigate whether pretreatment serum carbohydrate antigen 19-9 (CA 19-9) levels are associated with pathological responses to preoperative chemoradiotherapy (CRT) in patients with rectal cancer. Materials and Methods: In total, 260 patients with locally advanced rectal cancer (cT3-4NanyM0) who underwent preoperative CRT and radical surgery were analyzed retrospectively. CRT consisted of 50.4 Gy pelvic radiotherapy and concurrent chemotherapy. Radical surgery was performed at a median of 7 weeks after CRT completion. Pathological CRT response criteria included downstaging (ypStage 0-I) and ypT0-1. A discrimination threshold of CA 19-9 level was determined using a receiver operating characteristics analysis. Results: The median CA 19-9 level was 8.0 (1.0-648.0) U/mL. Downstaging occurred in 94 (36.2%) patients and ypT0-1 in 50 (19.2%). The calculated optimal threshold CA 19-9 level was 10.2 U/mL for downstaging and 9.0 U/mL for ypT0-1. On multivariate analysis, CA 19-9 (${\leq}9.0U/mL$) was significantly associated with downstaging (odds ratio, 2.089; 95% confidence interval, 1.189-3.669; P=0.010) or ypT0-1 (OR, 2.207; 95%CI, 1.079-4.512; P=0.030), independent of clinical stage or carcinoembryonic antigen. Conclusions: This study firstly showed a significant association of pretreatment serum CA 19-9 levels with pathological CRT responses of rectal cancer. The CA 19-9 level is suggested to be valuable in predicting CRT responses of rectal cancer cases before treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3451-3455
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• 2015

Objective: To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC). Materials and Methods: The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC. Results: The levels of serum CA19-9, CA125 and CEA in CC patients were higher than that in HCC patients,whereas that of serum AFP was significantly lower s. The area under ROC curve of single detection of serum AFP, CA19-9, CA125 and CEA were 0.05, 0.86, 0.84 and 0.83, with the optimal cutoff values of 15.4 ng/ml, 125.1 U/ml, 95.7 U/ml and 25.9 ng/ml, correspondingly, and the percentage correct single diagnosis was <79%. With joint detection, the diagnostic effect of combined AFP, CA19-9, CA125 and CEA was the highest, with an area under the ROC curve of 0.94 (95%CI 0.88~0.99). Conclusions: Single detection of serum CA19-9, CA125 and EA is not meaningful. The sensitivity, specificity, the rate of correct diagnosis and the area under ROC curve of joint detection of AFP, CA19-9, CA125 and CEA are highest, indicating that the joint detection of these 4 tumor markers is of great importance in the diagnosis of CC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3407-3412
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• 2015

Background: The aim of this study was to evaluate and compare the accuracy of diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) value, and time-intensity curve (TIC) type analysis derived from dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant adnexal masses. Materials and Methods: 47 patients with 56 adnexal masses (27 malignant and 29 benign) underwent DWI and DCE-MRI examinations, prior to surgery. DWI signal intensity, mean ADC value, and TIC type were determined for all the masses. Results: High signal intensity on DWI and type 3 TIC were helpful in differentiating benign from malignant adnexal masses (p<0.001). The mean ADC value was significantly lower in malignant adnexal masses (p<0.001). An ADC value< $1.20{\times}10^{-3}mm^2/s$ may be the optimal cutoff for differentiating between benign and malignant tumors. The negative predictive value for low signal intensity on DWI, and type 1 TIC were 100%. The pairwise comparison among the receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) of TIC was significantly larger than the AUCs of DWI and ADC (p<0.001 for comparison of TIC and DWI, p<0.02 for comparison of TIC and ADC value). Conclusions: DWI, ADC value and TIC type derived from DCE-MRI are all sensitive and relatively specific methods for differentiating benign from malignant adnexal masses. By comparing these functional MR techniques, TIC was found to be more accurate than DWI and ADC.

• 대한전자공학회논문지TC
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• 제44권7호통권361호
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• pp.17-22
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• 2007

OFDM (Orthogonal Frequency Division Multiplexing)시스템은 다수 반송파 전송의 특수한 형태로 볼 수 있으며 하나의 데이터열이 보다 낮은 데이터 전송률을 갖는 부반송파를 통해 전송된다. OFDM을 사용하는 중요한 이유 중 하나는 OFDM을 사용하면 주파수 선택적 페이딩이나 협대역 간섭에 대한 강건함이 증가하기 때문이다. 하지만, 시간 영역 OFDM 신호는 독립적으로 변조된 많은 부반송파들로 구성되므로 이들이 동위상으로 더해질 때 신호의 진폭이 증가하여 PAPR (Peak-to-Average Power Ratio)이 증가된다. 본 논문에서는 수신단의 구조에 변화를 주지 않으며 또한 추가적인 정보의 전송이 필요 없이 기존 수신기를 그대로 사용할 수 있는 PAPR 감소기법의 성능을 평가하였다. 이 방법은 에러 벡터 크기 (Error Vector Magnitude; EVM) 내에서 시간 영역과 주파수 영역 신호에 대하여 클리핑을 사용한 것으로 기존의 최적화 방법과 비교하여 계산량의 복잡도가 낮다. 이 기법을 비선형 증폭기를 사용하는 OFDM 시스템에서 평가하였다. 모의실험 결과, 시간 및 주파수 영역 클리핑 기반의 PAPR 감소기법은 TD (Total Degradation)관점에서 전력효율이 향상되며 증폭기의 비선형 왜곡의 영향을 줄이는 효과가 있음을 확인할 수 있었다.

• 대한영양사협회학술지
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• 제11권3호
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• pp.365-374
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• 2005

This study was conducted to compare the validity of obese index among body mass index(BMI), waist to hip ratio(WHR), and waist circumference(WC) and to determine which is the best in relation to cardiovascular risk factors of middle aged Korean(40-64yr).Data from the 1998 Korean Health and Nutrition Survey were used(N=3380). Anthropometric indices and cardiovascular risk factors were measured. Chi-square test, analysis of variance following duncan's multiple range test, partial correlation analysis, and Receiver Operator characteristic(ROC) curves were used in the analysis. There was a significant increasing trend in WHR, systolic blood pressure(SBP), high density lipoprotein cholesterol(HDL), and fasting blood sugar(FBS) with age categories of male and in BMI, WC, WHR, diastolic blood pressure(DBP), SBP, total cholesterol(TC), low density lipoprotein cholesterol(LDL), triglycerol(TG), and FBS with those of female. Specially female had the characteristics of upper body fat and systolic blood pressure risk(p<0.05). Proportions of subjects with lifestyle factors related to cardiovascular risk in overweight or upper body fat group were higher than that of normal group. Higher proportions of subjects were practiced exercise in upper body fat group of male than in other groups. Among 7 cardiovascular risk factors in partial correlation analysis, BMI had the highest correlation coefficient in 6 risk factors in male, whereas WC in 4 risk factors in female. Mean of each obese index according to cardiovascular risk groups except smoker was higher than that of normal(p<0.05). These trends were shown in upper body fat group and female. In ROC analysis of 12 risk factors and health conditions, the largest area under curve among obese indices for risk factors were BMI in male and WHR in female. The optimal cutoff values of each index(BMI: WHR: WC) for one or more cardiovascular risk factors were 23.13: 0.89: 85.35 in male and 23.57: 0.84: 78.35 in female. The results showed that cardiovascular risk factors were prevalent in middle aged Koreans within normal limits of obese indices like another Asians. For the identification of cardiovascular risk factors of middle aged Koreans, BMI for men and WHR for women are appropriate indices. But it is recommended that BMI, WHR, and WC, all three indices should be considered, when using these indices.

• 한국인터넷방송통신학회논문지
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• 제9권4호
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• pp.47-52
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• 2009

Source로부터 송신된 신호는 무선 채널을 통하여 Destination에 전달된다. 하지만 이동하는 Destination이 Source의 Coverage를 벗어난 경우나 비록 Source의 Coverage 내의 음영 지역에 Destination이 존재하는 경우, Destination은 Source로부터 송신된 신호를 수신할 수 없고 통신을 할 수 없게 된다. 따라서 이러한 문제점을 극복하기 위해 중계기가 사용된다. 이와 같이 중계기를 사용하는 시스템을 다중 홉 중계 (Multi-hop Relay) 시스템이라 한다. 그런데 다중 홉 중계 시스템에서는 서로 다른 시스템용 중계기의 Coverage가 겹치는 경우가 발생할 수 있고, 이 부분에 Destination이 존재하는 경우 Destination에는 간섭이 발생한다. 본 논문에서는 다중 홉 중계 시스템에서 발생 할 수 있는 동일 채널 간섭 (CCI : Co-Channel Interference) 제거 방법에 관해 연구하였다. 간섭 제거 방법은 우선 Zero Forcing (ZF) 또는 Minimum Mean Square Error (MMSE) 개념을 적용한 선형 수신기를 이용하여 간섭을 제거한 후, 정렬된 연속간섭제거 (OSIC : Ordered Successive Interference Cancellation) 알고리즘을 이용하여 추가적인 다이버시티 이득을 얻고 간섭 제거 성능을 향상시킨다. 무선 채널은 레일레이 (Rayleigh) 페이딩 채널을 고려하여 모의 실험을 하였으며, 시스템 성능은 비트 오류 확률 (Bit Error Probability) 측면에서 분석되었다.

• Clinical and Experimental Reproductive Medicine
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• 제38권1호
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• pp.47-52
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• 2011

Objective: To determine whether characteristics of sperm motility obtained by computer-assisted sperm analysis (CASA) could predict pregnancy after intrauterine insemination (IUI) in couples with unexplained infertility. Methods: Three hundred eighty-three cycles of intrauterine insemination with superovulation were retrospectively analyzed. Semen analysis was performed with CASA before and after swim-up and the parameters were compared between pregnant and non-pregnant women. Results: The pregnancy rate per cycle was 14.1%. Pregnant and non-pregnant women were comparable in terms of age, infertility duration, the number of dominant follicles. While sperm concentration, motility, and parameters such as average path velocity (VAP) and percentage rapid (RAPID) before semen preparation were significantly different between the pregnancy and non-pregnancy groups, there were no differences in sperm parameters when comparing the two groups after preparation. Using a receiver operating characteristic curve to measure sensitivity and specificity, the optimal threshold value for the predictors of pregnancy was revealed to be a concentration of ${\geq}111{\times}10^6/mL$, a motility of ${\geq}$ 51.4%, and RAPID ${\geq}$ 30.1% before preparation for IUI. Conclusion: Sperm parameters including concentration, motility, and RAPID before sperm preparation could have predictive value for pregnancy outcome after intrauterine insemination with superovulation in couples with unexplained infertility, and would be helpful when counseling patients before they make the decision to proceed with IVF/ICSI-ET.