• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.263-272
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• 2011

Tablet dosage forms have been preferred over other formulations for the oral drug administration due to their low manufacturing costs and ease of administrations, especially controlled-release applications. Controlled-release tablets are oral dosage forms from which the active pharmaceutical ingredient (API) is released over an intended or extended period of time upon ingestion. This may allow a decrease in the dosing frequency and a reduction in peak plasma concentrations and hence improves patient compliance while reducing the risk of undesirable side effects. Conventional singlelayered matrix tablets have been extensively utilized to deliver APIs into the body. However, these conventional single-layered matrix tablets present suboptimal delivery properties, such as non-linear drug delivery profiles which may cause higher side effects. Recently, a multi-layered technology has been developed to overcome or eliminate the limitations of the singlelayered tablet with more flexibility. This technology can give a good opportunity in formulating new products and help pharmaceutical companies enhancing their life cycle management. In this review, a brief overview on the multi-layered tablets is given focusing on the various tablet designs, manufacturing issues and drug release profiles.

• Journal of the Korean Regional Science Association
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• v.10 no.2
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• pp.61-71
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• 1994

Despite of being the criteria to choose the efficient and reasonable alternatioves inactual planning process, the measure of accessibility rarely has applied to practices because each model has unexplicity concept of it and limitations in itself. Accessibility implies transportation system which offers opportunity of movement to overcome spatial separation and, simultaneously, land-use system which represents the location of each activity. Therefore, measures of accessibility have to represent the attractiveness of locations and the interactions of activities, that is, land-use and transportation, with an index. Considering that urban activity is based on the economic efficiency, costs and benfits, accessibility means the economic efficiency of the location of activity and the travel in view of land-use and transport repectively. Combined models that measure accessibility with considering land-use and tranportation simultaneously depend on reasonable concepts, but it is too simple for them to explain the accessibility which resulted from complex interaction of urban activities. Combined urban activity model developed by Kim (1983) and Rho (1989) explains the characteristics of activities in each regions and urban strcture in economic general equilibrium states in the long term of urban system. This model measures a regional accessibility with a dual variable which means the location surplus. This is a more systematic and comprehensive model for calculating the regional accessibility because it considers the interaction of each activity in urban system. It needs efforts to apply the accessibility index as a criterion in actual planning process through finding and quantitification of other explanatory variables to measure it in combined urban activity model.

• KIEE International Transactions on Power Engineering
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• v.5A no.4
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• pp.331-338
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• 2005

In this paper, an improved maintenance scheduling approach suitable for the competitive environment is proposed by taking account of profits and costs of generation companies and the formulated combinatorial optimization problem is solved by using Reactive Tabu search (RTS). In competitive power markets, electricity prices are determined by the balance between demand and supply through electric power exchanges or by bilateral contracts. Therefore, in decision makings, it is essential for system operation planners and market participants to take the volatility of electricity price into consideration. In the proposed maintenance scheduling approach, firstly, electricity prices over the targeted period are forecasted based on Artificial Neural Network (ANN) and also a newly proposed aggregated bidding curve. Secondary, the maintenance scheduling is formulated as a combinatorial optimization problem with a novel objective function by which the most profitable maintenance schedule would be attained. As an objective function, Opportunity Loss by Maintenance (OLM) is adopted to maximize the profit of generation companies (GENCOS). Thirdly, the combinatorial optimization maintenance scheduling problem is solved by using Reactive Tabu Search in the light of the objective functions and forecasted electricity prices. Finally, the proposed maintenance scheduling is applied to a practical test power system to verify the advantages and practicability of the proposed method.

• Journal of the Korean Society for Railway
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• v.9 no.2 s.33
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• pp.212-221
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• 2006

This paper examines the outcomes and tasks of U rail privatization especially focusing on the rail safety. Earlier research which focused on the rail safety had little knowledge of the explanations for recent changes of safety scheme. Moreover, they had difficulty making a direct comparison of safety between national rail and the privatized rail. Therefore we are left without a good explanation which has a comprehensive perspective. I attempt to show the outcomes of safety in the rail privatization process and its tasks focusing on the recent fatal accident. This paper argues that the UK's rail safety has a framework which is too complicated with overlapping responsibilities that brought about inefficiency, increasing costs. Especially infrastructure enterprise did not come to play an appropriate role. However, after 2000, the government took charge of setting the strategy for railway safety, and the Office of Rail Regulation covered safety, performance and cost. I explain that these changes present a good opportunity to solve the problem of passing the buck for rail accident. Through the analysis, I find that outcomes of rail privatization in safety are improved comparing the national rail. However, safety performance, for example the collision of structures of cars and looseness of rail should be improved. In future, the problems of fatal accident and a bit of duplicate safe system should be addressed.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.2 no.1
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• pp.17-30
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• 2006

Federal disability law has evolved from several laws geared to protect people with disabilities since the late 1960s and early 1970s. When U.S. Congress passed the Americans with Disabilities Act (ADA) in 1990, no federal statute prohibited the majority of employers, program administrators, owners and managers of places of public accommodation and others from discriminating against people with disabilities. Toward the ends to assure equality of opportunity, full participation, independent living, and economic self-sufficiency for individuals with the disabilities, the ADA pursues three major strategies: Title I addresses inequality in employment, Title II, inequality in public services, and Title III, inequality in services and accommodations offered by private entities. The purposes of the study were to analyze the impact of the ADA on health care for persons with disabilities and to review the ongoing health policy reforms at the federal and state governments. Essential remedies that the ADA contemplates are based on two principles, simple discrimination and reasonable accommodation, which significantly improved access to quality care, especially long-term care, by persons with disabilities. However, the ongoing Medicaid policy reforms to control rising health care costs in the U.S. could threaten the access to care by persons with disabilities in optional groups and to optional care services by persons with disabilities in mandatory groups.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.7
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• pp.97-105
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• 2002

The use of rapid prototyping (RP) has reduced time to market, cut total costs and improved product quality by giving design and manufacturing teams the opportunity to verify and fine tune designs before committing them to expensive tooling and fabrication. In order to improve their unique characteristics according to the working principles, Variable Lamination Manufacturing process (VLM-ST) and corresponding CAD/CAM software (VLM-Slicer) is developed. The objective of this study is to improve the accuracy of VLM-ST process, and it can be done by offset fur cutting error correction, cutting path overrun fur sharp edge and reference shape generation for off-line stacking. It has been shown that, through the verification experiments for given practical shapes, the proposed algorithms are effective for diverse categories of three-dimensional shapes.

• International Commerce and Information Review
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• v.10 no.2
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• pp.305-323
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• 2008

Climate change is one of the broadest and the most complex issues of international environmental cooperation. Concern about climate change has been steadily increasing and has become a worldwide issue. According to IPCC(Intergovernmental Panel for Climate Change)'s recently report, global warming has accelerated vest serious problems. GHG(Green House Gas) emissions trading schemes, including the Kyoto mechanism that spread to solving the problems. Based on the evaluation on GHG emissions trading schemes, we also find some policy implications on the future development of emissions trading the conventional air pollutants in Korea which start to 2007. The regulatory authority needs to make clear how to allocate allowances to new entrants and also to keep the balance between the opportunity costs of reduction between potential shutdown facilities and new entrants. Under the current rule that does not allow shutdown credits, an equivalent level of allowances needs to be allocated to new entrants free of charge. We believe our policy recommendations may be useful not only for Korea but also for a the other countries, since they are facing a similar policy environment as Korea, particularly in the case of climate change.

• International Journal of Highway Engineering
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• v.17 no.3
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• pp.59-68
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• 2015

PURPOSES : This study suggests the application of glow line marking technology for reducing traffic accidents at nighttime. METHODS : In this study, using a statistical analysis, we analyzed the characteristics of traffic accidents occurring at nighttime. Next, the strength, weakness, opportunity, and threat (SWOT) factors were derived based on a current-status analysis of glow line marking technology and road environments. An SO strategy, ST strategy, WO strategy, and WT strategy were established in accordance with the four SWOT factors. RESULTS : This study suggests that the following strategies should be promoted to apply glow line marking technology to a road environment: 1) an activation strategy for the technological development of glow line markings for a new paradigm in reducing traffic accidents, 2) a benefit enhancement strategy applying glow line marking technology in places where nighttime traffic accidents frequently occur, 3) a strategy for the expansion of glow line marking by replacing streetlights, and 4) a strategy for enhancing road applications through the development of various line marking methods in consideration of both performance and costs. CONCLUSIONS : The application of glow line markings in a road environment can contribute to a reduction of traffic accidents at nighttime, and aid energy savings from the replacement of streetlights.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.294-298
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• 2008

The major threats that human being is facing nowadays are the Climate change, depletion of the fossil fuels at a rapid rate and energy costs. A significant portion of world energy consumption is consumed by domestic heating and cooling. And heat pumps, due to their higher utilization efficiencies as compared to conventional heating and cooling systems, offer an attractive solution to this problem. Among the types of heat pumps, the Geothermal heat pump or Ground-source heat pump is a highly efficient, renewable energy technology for space heating and cooling. The Ground-source heat pump uses the Earth as a heat sink in the summer and a heat source in the winter. And the Earth, having a relatively constant temperature, warmer than the air in winter and cooler than the air in summer, offers an excellent heat source in winter and heat sink in summer.. This paper will discuss an overview of the types of heat pumps, its operation, benefits of using geothermal heat pumps, soil characteristics, and overview of some experimental works. Finally it will briefly discuss the opportunity of using these energy efficient systems (EES) in the HVAC market of South Korea.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.803-810
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• 2020

This objective of this study is to enrich the literature by the debt ratio and enterprise performance of Joint stock companies of Vietnam National Coal and Mineral Industries Holding Corporation Limited (Vinacomin). The debt ratio is an important index of capital structure, and it influences and decides the enterprise performance. Therefore, the determination of reasonable debt ratio level is beneficial to the stable operation of Vinacomin's enterprises. Based on the research conclusion about the effect on capital structure of debt ratio from domestic and foreign scholar, collecting data from 2014-2018 of Vinacomin's enterprises as a research sample, the article conducts research on the relationship between debt ratio and business performance of Vinacomin, as measured by return on total Assets. In addition, the study uses free cash flow, company size, growth opportunity, investment opportunities, operating costs to sales ratio as control variables.The study shows the debt ratio of Joint stock companies of Vietnam National Coal and Mineral Industries Holding Corporation Limited has a negative effect on the enterprise performance. Furthermore, the research results of the article are references for Vinacomin' enterprises in the course of production and business activities, determining a reasonable debt ratio, and improving the operational performance of enterprises.