• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.551-555
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• 2014

Purpose: This study is to investigate if the improvement of visual sensory (VS) by amblyopia treatment affects the ocular functions in refractive errors, accommodative errors and phoria at distance and near. Methods: 10 subjects (17 eyes, mean age of $10.7{\pm}2.9$ years) who treated amblyopia completely, were participated for this study. Refractive errors, accommodative errors, and distance and near phoria were compared between before and after treatments of amblyopia. Refractive errors and accommodative errors at 40 cm were measured using openfield auto-refractor (NVision-5001, Shin Nippon, Japan) and using monocular estimated method (MEM) respectively. Phoria was determined at 3 m for distance and at 40 cm for near using Howell phoria card, cover test or Maddox rod. Results: Mean corrected visual acuity (CVA) significantly increased from $0.46{\pm}0.11$ (decimal notation) for before amblyopia treatment to a level of $1.03{\pm}0.13$ for after amblyopia treatment (p < 0.001). For spherical refractive error, hyperopia significantly decreased from $+2.29{\pm}0.86D$ to a level of $+1.1{\pm}2.38D$ (p < 0.05) but astigmatism did not significantly change; $-1.80{\pm}1.41D$ for before treatment and $-1.65{\pm}1.30D$D for after treatment (p > 0.05). Accommodative error significantly decreased from accommodative lag of $+1.1{\pm}0.75D$ to a level of $+0.5{\pm}0.59D$ (accommodative lag) (p < 0.05). Distance phoria significantly changed from eso $2.9{\pm}6.17PD$ (prism diopters) to a level of eso $0.2{\pm}3.49PD$ (p < 0.05), and near phoria also significantly changed from eso $0.4{\pm}2.32PD$ to level of exo $2{\pm}4.9PD$ (p < 0.05). There was a high correlation (r = 0.88, p < 0.001) between improvement of visual acuity and decrease of accommodative lag. Conclusions: Hyperopic refractive error decreased with improvement of CVA or VS by amblyopia treatment. And the improvement of VS by amblyopia treatment also improved accommodative error, and changed phoria coupled with accommodation.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.533-538
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• 2014

Purpose: This study is to investigate correlation between eye fatigue and letter contrast according to letter contrast changes on monitor display. Methods: Reading speed test were carried out for 53 subjects (mean age: $22.68{\pm}1.85$ years) who have over Best-corrected visual acuity (BCVA) 1.0, and 45 subjects, who could read over 123 out of 163 letters among 53 subjects were selected. They were asked to read the letters which were composed of Black (contrast 100%), Dark gray (contrast 80%), Gray (contrast 80%), Light gray (contrast 30%) randomly. The change of their eye fatigue by letter contrast on monitor display was measured by monitoring their eyes with an eye-tracker while they were reading letters. Results: Event Duration (sec) was 33.635 for Black, 32.266 Dark gray, 33.936 for Gray, and 34.848 for Light gray. Average of Fixation Duration (sec) was 0.224 for Black, 0.218 for Dark gray, 0.239 for Gray and 0.243 for Light gray. Average of Pupil diameter (mm) was 41.133 mm for Black, 41.160 mm for Dark gray, 40.880 mm for Gray and 40.459 mm for Light gray. Frequency (blinks/sec) was 0.211 for Black, 0.206 for Dark gray, 0.221 for Gray, and 0.238 for Light gray. Conclusions: Event Duration and average of Fixation Duration were the shortest for Dark gray and the longest for Light gray. In average Pupil diameter was the biggest Dark gray and the smallest for Light gray. Blink Frequency (blinks/sec) was the lowest for Dark gray and the highest for Light gray. Visual fatigue by brightness of letters on monitor display was the least for Dark gray followed by Black, Gray and Light gray.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.527-532
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• 2014

Purpose: The matching of the optical center and the pupil center was measured by photographs in wearing glasses. In this study, the influences of the induced prism by the mismatching are studied. Methods: 74 subjects (148 eyes) who were spectacles wearer were participated in this study. The mean age was $29.19{\pm}12.22$ years (range 19-55 years). The facial photographs of subjects were taken while wearing spectacles. The matching of the corneal reflected image and optical center of the spectacle lens in the horizontal deviations, and the vertical deviations were measured by the observation of the photo image. The prisms induced in accordance with various frame type were calculated from the mismatching deviations. Results: The binocular horizontal deviations were $1.55{\pm}1.70mm$ for the metal frame, $1.71{\pm}2.21mm$ for the clings type plastic frame, and $1.15{\pm}1.38mm$ for the plastic frame. In the horizontal direction induced prism, the ratio over the tolerance was 23%. The ratio were the 17.6% at the BI prism, and 5.4% at the BO prism. The binocular vertical deviation comparisons were $3.93{\pm}1.91mm$ for the metal frame, $5.79{\pm}1.93mm$ for the clings type plastic frame, and 1$6.01{\pm}2.94mm$ for the plastic frame. In the vertical direction induced prism, the ratio over the tolerance was 44.6%. Based on the refraction power, the ratio were 12.2% at -0.25${\leq}-3.00$, and 32.4% at -3.00${\leq}-12.00D$. Conclusions: The induced prisms in the horizontal direction were much in the BI prism. The binocular vertical deviations of the glasses.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.273-281
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• 2011

Purpose: In order to provide the fundamental information for the design development of RGP lenses and its clinical prescription, the corneal types of Korean twenties were analyzed according to corneal shapes, astigmatic degree, and the certain distance from the corneal apex. Methods: Corneal types of total 252 eyes in 20s were firstly classified, then their corneal radii from the certain distance from the corneal apex were measured by corneal topography and further analyzed based on the astigmatic degree. Results: Korean 20s' corneal types were classified as 14.3%(36 eyes) of round, 31.3%(79 eyes) of oval, 28.6%(72 eyes) of symmetric bow tie, 17.5%(44 eyes) of asymmetric bow tie, 8.3%(21 eyes) of irregular shapes. The round and oval typed corneas had mild astigmatic degree whereas the higher astigmatic degree in symmetric and asymmetric bow tie typed corneas were shown. The relative corneal radii of round and oval typed corneas at each distance from corneal apex were shown to consistently increase regardless of astigmatic degrees when they measured at certain distances from the corneal apex. However, the relative corneal radii of symmetric and asymmetric bow tie typed corneas within 1.0-1.5mm from the corneal apex were decreased, which showed steeper slope than it within 1.0 mm and somewhat different based on astigmatic degrees. Bigger change of corneal radii outer 3.5 mm from the corneal apex in symmetric bow tie typed corneas with astigmatism of 1.50-2.00 D and 2.25-2.75 D appeared. Conclusions: The consideration of radial change from the central cornea to peripheral cornea is necessary for manufacturing RGP lens and its prescription since they showed different change in corneal radii by corneal patterns and astigmatic degrees.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.265-272
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• 2011

Purpose: The clinical usefulness of rotation evaluation using objective refraction in toric soft lenses fitting was investigated. Methods: Toric soft lenses were fitted for 32 subjects (64 eyes; mean age of 24.69 ${\pm}$ 1.65 years) with astigmatism and both eyes of each subject were fitted with toric soft lenses. Objective refraction-based lenses rotation was evaluated from refraction and over-refraction data by indirect calculating technique. These calculated data were compared with the measured data from slit lamp with direct measuring technique. Results: Orientation of toric soft lenses around zero position (within ${\pm}$ 5$^{\circ}$ vertical line) was investigated. The orientations to the direction of nose of measured and calculated values were 69.78% and 63.64%, respectively, which showed similar values between two techniques. Agreement frequency between measured and calculated values in the magnitude of lenses rotation 54.69% and 82.82% for 10$^{\circ}$ and 20$^{\circ}$ of vertical line, respectively. The 95% limits of agreement between calculation and measurement were from -10.08$^{\circ}$ to 12.65$^{\circ}$, and mean difference was 1.29$^{\circ}$ within ${\pm}$ 10$^{\circ}$. The result showed there was no significant difference (p = 0.1984) and high correlation (r = 0.56, p = 0.0004) between two techniques. But the 95% limits of agreement was widen in ${\pm}$ 20$^{\circ}$ of vertical line. The magnitude of lens rotation between two methods was 9.66 ${\pm}$ 6.16$^{\circ}$, 16.17 ${\pm}$ 12.38$^{\circ}$ and 10.58 ${\pm}$ 12.02$^{\circ}$ for normal, loose and tight fitted conditions. Conclusions: From the results with smaller difference between two techniques, it was found that higher availability of subjective over-refraction data can be used as a supplementary tool for subjective refraction. An application using objective refraction with direct measuring could be provide high success in prescription on toric soft lenses.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.3
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• pp.79-87
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• 2008

Purpose: This study measured Y-intercept that means a fixation disparity, X-intercept that means a associated phoria and slope of a fixation disparity curve (FDC), which are variables of dissociated phoria and the FDC. We searched for the result value and examined the direction, distribution pattern and a variable that give an most affect on dissociated phoria and the FDC at distance and near. Also this study examined that there were statistically significant differences between distance and near, comparing the result value. Methods: We measured the dissociated phoria and the fixation disparity for 51 subjects at distance and near in June, 2007. All subjects ranged from 20 to 25 years of age (average 21.72${\pm}$1.88 years old) and had no eye disease. At distance the dissociated phoria measured with the distance MIM card (muscle imbalance measure card, Bernell co., USA), and the fixation disparity measured with the modified Mallett Far Unit (Bernell co., USA). At near the dissociated phoria measured with the near MIM card (muscle imbalance measure card, Bernell co., USA), and the fixation disparity measured with the Wesson fixation disparity card (American Optical co., USA). Results: The percentage distribution of types of fixation disparity curves was that at distance prevalence of Type I (74.6%) was the highest, followed by Type IV (17.6%) and Type II (3.9%), Type III (3.9%) and that at near prevalence of Type I (53.0%) was the highest, followed by Type III (29.4%), Type IV (13.7%) and Type II (3.9%). 2. There were significantly correlation in dissociated phoria, fixation disparity (Y-intercept) and associated phoria (X-intercept). 3. The fixation disparity at distance was most affected by associated phoria (X-intercept) (p=0.000). The distance dissociated phoria was most affected by fixation disparity (Y-intercept) (p=0.342), but the influence was weak. 4. The fixation disparity at near was most affected by associated phoria (X-intercept) (p=0.000). The near also dissociated phoria was most affected by associated phoria (X-intercept) (p=0.009). The result that compared the each variables with the same variables at distance and near had statistically significant on paired t-test for among dissociated phoria (t=7.529, p=0.000), X-intercept (t=5.860, p=0.000), the Y-intercept (t=4.640, p=0.000) but slope of the FDC did not differ significant (t=1.336 p=0.188). Conclusions: Relationship of fixation disparity and Heterophoria had close correlation at distance and near.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.357-362
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• 2011

Purpose: The narrow-band pass color-filters with a 500 nm central wavelength and 12 nm FWHM using $Ti_3O_5/SiO_2$ mutilayer were fabricated, and their characteristics and structures were studied. Methods: the optical constants, n and k, of the $Ti_3O_5$ and $SiO_2$ thin films were obtained from the transmittances of their thin film. The narrow-band pass color-filters were designed with these optical constants and the AR coating of the filter was also designed. $Ti_3O_5/SiO_2$ multilayer filters were made by electron beam evaporation apparatus and the transmittaces of the filters were measured by spectrophotometer. the number of layers and the thicknesses of filters were calculated from the cross section of filters by SEM image and the composition of filters was analysed by XPS analysis. Results: The optimization of AR coating for the narrow-band pass color-filter was [air$|SiO_2(90)|Ti_3O_5(36)|SiO_2(5)|Ti_3O_5(73)|SiO_2(30)|Ti_3O_5(15)|$ glass], and the optimization of filter layer for the color filter was [air$|SiO_2(192)|Ti_3O_5(64)|SiO_2(102)|Ti_3O_5(66)|SiO_2(112)|Ti_3O_5(74)|SiO_2(120)|Ti_3O_5(68)|SiO_2(123)|Ti_3O_5(80)|SiO_2(109)|Ti_3O_5(70)|SiO_2(105)|Ti_3O_5(62)|SiO_2(99)|Ti_3O_5(63)|SiO_2(98)|Ti_3O_5(51)|SiO_2(60)|Ti_3O_5(42)|SiO_2(113)|Ti_3O_5(88)|SiO_2(116)|Ti_3O_5(68)|SiO_2(89)|Ti_3O_5(49)|SiO_2(77)|Ti_3O_5(48)|SiO_2(84)|Ti_3O_5(51)|SiO_2(85)|Ti_3O_5(48)|SiO_2(59)|Ti_3O_5(34)|SiO_2(71)|Ti_3O_5(44)|SiO_2(65)|Ti_3O_5(45)|SiO_2(81)|Ti_3O_5(52)|SiO_2(88)|$ glass]. It was known that the color-filters fabricated by the simulation data were composed of 41 layers by SEM image and the top layer of filters was $SiO_2$ layer and the filters were composed of $SiO_2$/$Ti_3O_5$ multilayer by XPS analysis. It was also known that the mixed thin film of TiO2 and $Ti_3O_5$ was made during the deposition of the $Ti_3O_5$ material. Conclusions: The narrow-band pass color-filters with a 500 nm central wavelength and 12 nm FWHM using $Ti_3O_5/SiO_2$ mutilayer of 41 layer were fabricated, and it was known that the mixed form of TiO2 and $Ti_3O_5$ thin film was made during the deposition of the $Ti_3O_5$ material.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.1
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• pp.75-84
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• 2013

Purpose: Changes of refractive correction value in different age group were investigated. Regarding the inhibitive effects against myopia progression after wearing reverse geometry contact lenses and myopia control lenses (MC lenses), the effects after wearing single vision lenses were compared. Methods: We organized children between the ages of six and fifteen into three groups by age, and distributed fifty-seven reverse geometry contact lenses, fifty-six MC lenses and seventy-eight single vision lenses among them to be worn. Group 1 consisted of children aged ten and under, Group 2 consisted of children between the ages of eleven and fifteen, and Group 3 represents all of the study participants. The aim of this study was to learn the inhibitive effects against myopia progression attained by changes of refractive correction value and to verify their statistical significance at twelve months and under, thirteen to twenty-four months and twenty-five to thirty-six months. Results: Changes of refractive correction value by each length of use in Group 3 were as follows. For the age group of under twelve months, participants using the reverse geometric contact lens showed no change, while those using the MC or single vision lens had significant changes (P<0.05) of $-0.36{\pm}0.10$ D and $-0.67{\pm}0.52$ D, respectively. Users of all three lens types displayed significant change (P<0.05), in the age group of between thirteen and twenty-four months, of $0.18{\pm}0.49$ D, $0.60{\pm}0.42$ D and $1.37{\pm}0.72$ D for users of the reverse geometry contact lens, the MC lens and the single vision lens, respectively. There were significant changes (P<0.05) of $0.29{\pm}0.61$ D, $0.93{\pm}0.57$ D and $1.72{\pm}0.78$ in the same respective order as the above in the age group of twenty-five to thirty-six months. Refractive correction value showed changes with different age group. Group 1 displayed significant changes (P<0.05) of $0.29{\pm}0.73$ D, $1.07{\pm}0.59$ D and $1.75{\pm}0.74$ D for users of the reverse geometry contact lens, MC lens and single vision lens, respectively, up to thirty-six months of lens wearing; Group 2, also up to thirty-six months, displayed significant changes (P<0.05) of $0.28{\pm}0.42$ D, $0.75{\pm}0.49$ D and $1.70{\pm}0.84$ D in the same respective order, and changes in refractive correction for the age group under ten years was significantly greater (P<0.05) for the age group of eleven and older. Conclusions: The results found in this study demonstrate that there were no changes of refractive correction value for the case of wearing reversing geometry contact lens up to twelve month or less. MC lens showed less changes in variations of visual acuity for all users which might be resulted in inhibiting progression of myoptia. When both reverse geometry contact lens and the MC lens are wearing for the period from 13 to 36 month, both lens showed less changes in variation of visual acuity for all users. The results suggested that the less changes in variation of visual acuity of both lens had an effect on inhibiting progression of myopia.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.319-324
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• 2015

Purpose: This study was designed to evaluate the changes of phoria and calculated AC/A ratio, and their recovery time points by watching 3D television (3D TV). Methods: 50 subjects (male 30, female 20) of 20s to 40s ages who can watch 3D, were measured phoria using a Howell phoria card at 3 m for distance and 40 cm for near. The phoria was evaluated before watching 3D TV and every 10 minutes from starting of watching 3D TV for 30 minutes, and every 5 minutes after finishing of watching 3D TV for 30 minutes again. Results: For the distance phoria during and after watching 3D TV, it was increased to more exophoria $-0.98{\pm}1.37{\Delta}$ (prism diopters) after 10 minutes from starting of 3D TV watching (p=0.063) and increased to more exophoria $-1.00{\pm}1.28{\Delta}$ after 30 minutes (p=0.024), and started to decrease after finishing of watching 3D TV and recovered to the level of before 3D TV watching ($-0.78{\pm}1.11{\Delta}$) after 20 minutes (p=0.32) with comparing to phoria of before watching 3D TV ($-0.80{\pm}1.12{\Delta}$). For the near phoria, it was also increased to more exophoria $-5.71{\pm}4.45{\Delta}$ after 10 minutes from starting of watching 3D TV (p=0.000) and $-6.58{\pm}4.36{\Delta}$ after 30 minutes (p=0.000), and started to decrease after finishing of watching 3D TV and recovered to the level of before watching 3D TV after 20 minutes ($-4.34{\pm}3.67{\Delta}$) (p=0.32) with comparing to the phoria of before watching 3D TV ($-4.36{\pm}3.66{\Delta}$). AC/A ratio was decreased from $4.92{\pm}1.17{\Delta}/D$ for before 3D TV watching to $4.11{\pm}1.50{\Delta}/D$ for after 30 minutes from starting of watching 3D TV (p=0.000), and increased after the end of watching 3D TV and recovered to the level of before 3D TV watching ($4.93{\pm}1.18{\Delta}/D$) after 25 minutes (p=0.598). Conclusions: During watching 3D TV at near, it showed a tendency of convergence insufficiency by decrease of calculated AC/A ratio as result that exophoria at near was higher increased than exophoria at distance. However, the increased exophoria at both near and distance was recovered to the level of base line after 25 minutes from the end of watching 3D TV. Through this study, it seems to need rational proposals of advice for watching 3D TV.

• Journal of Life Science
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• v.20 no.4
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• pp.528-534
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• 2010

Garlic (Allium sativum) has been well-known as a folk remedy for a variety of ailments since ancient times, and it is well documented that enhanced garlic consumption leads to a decrease in incidences of cancer. Tight junctions (TJs) are critical structures for the maintenance of cellular polarity, acting as paracellular permeability barriers and playing an essential role in regulating the diffusion of fluid, electrolytes and macromolecules through the paracellular pathway. Matrix metalloproteinases (MMPs) have been implicated as possible mediators of invasiveness and metastasis in some cancers. In this study, we investigated the potential effects of water extract of aged black garlic (ABG) on the correlation between tightening of TJs and anti-invasive activity in human gastric carcinoma AGS cells. The inhibitory effects of ABG on cell motility and invasiveness were found to be associated with increased tightness of TJs, which was demonstrated by an increase in transepithelial electrical resistance. Additionally, the activities of MMP-2 and -9 in AGS cells were inhibited by treatment with ABG, and this was also correlated with a decrease in the expression of their mRNA and proteins. Furthermore, RT-PCR and immunoblotting results indicated that ABG repressed the levels of the claudin proteins, major components of TJs that play a key role in the control and selectivity of paracellular transport. In conclusion, these results suggest that ABG treatment may inhibit tumor metastasis and invasion, and therefore may act as a dietary source to decrease the risk of developing cancer.