• 한국미생물·생명공학회지
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• 제9권1호
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• pp.35-44
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• 1981

대장균이 생산하는 페니실린 아미다제를 젤라틴에 포괄시켜 사출한 후 글루트알데히드로 가교하여 고정화하였다. 이렇게 하여 만들어진 고정화효소는 약 70%의 높은 효소역가를 나타내었고 보관 및 반응조에서 좋은 안정성을 보여주었다. 반응조 내에서의 효소역가 반감기는 약 50일이었으며 최적 PH 및 온도는 각각 8.5와 5$0^{\circ}C$로 나타났다. 효소역가에 미치는 pH 및 온도의 영향은 고정화하기 전과 큰 차이가 없었으나 고온에서의 안정성이 증가되었다. 기질용액으로 완충액을 사용하여 column을 사용하는 관형식 반응조에서의 반응생성률에 기인하는 pH 감소효과를 최소한으로 줄이므로써 효소반응조를 최적화하였다. 반응조 조작상의 중요한 인자 즉 기질농도, 체류시간, 반응 생성물로의 전환율 및 이에 따르는 생산성을 pH 감소효과와 연관시켜 최적반응조건을 논의하였다.

• 상하수도학회지
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• 제20권3호
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• pp.411-429
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• 2006

To improve Service quality for water and wastewater works, most water and wastewater utility effort to develop not only facility construction but also operation optimization. The operation is optimized by accurate estimation for ongoing situation. And from the accurate estimation, utility operator gain a information about their service quality and problems, So we developed a evaluation tool (Performance Indicators: PI) for service activity of water and wastewater works. The PI was developed in many countries and some international organizations (World Bank, IWA etc.) for service benchmarking. And ISO (international organization for standardization) just has been making a service standard for water and wastewater system (So called ISO/C224). This proceeding for making a service standard is ongoing now and will be launched in 2007. In our study, PI was composed of 6 parts (A human resource, facility management, operation, service quality, finance and environment). To evaluate water utilities, performance indicators for water was consisted of 100 items. Each 2 water utilities were estimated by this performance indicator. From the study, we just know that the performance indicator was a very useful tool to estimate utility service quality. And from the result, it is possible to know the strong and weak point of estimated utilities.

• 한국병원경영학회지
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• 제10권3호
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• pp.45-66
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• 2005

The purpose of this study was to analyze related factors affecting profitability on general hospitals(300-499 beds). The data were derived from survey by the Korean Hospital Association on 33 hospitals during 10 years (from 1993 to 2002). Profitability was measured by 3 ratios - net profit to total assets, normal profit to total assets and operating margin to gross revenue - as dependent variables. Independent variables were classified by general factors (ownership, number of bed, period of establishment, region), financial factors (total asset turnover, current ratio, liabilities to total assets, personnel costs per operation profit, material costs per operation profits), productivity index(number of daily patient per nurse), the score of quality assurance activity and the time lag score. Multiple regression model was used in this study. First, Number of bed, region was not statistically significant for profitability. But ownership was affect positively to normal profit to total assets and operating margin to gross revenue. Private hospitals had higher profitability than that of public hospitals Second, the score of quality assurance activity was not statistically significant to profitability. Third, Those hospitals having more daily patient per nurse had significantly higher profitability than the others. Fourth, Those hospitals having higher proportion in total asset turnover had significantly higher profitability than other hospitals. But liabilities to total assets and liquidity ratio had no difference to the profitability. Those hospitals having higher proportion in personnel costs and material costs per operation profits had significantly lower hospital profitability than others.

• 상하수도학회지
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• 제22권4호
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• pp.467-473
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• 2008

Natural organic matter (NOM) removal by physico-chemical adsorption and biological oxidation was investigated in five slow sand filters with different media depths. Non-purgeable dissolved organic carbon(NPDOC) and $UV_{254}$ absorbance were measured to evaluate the characteristics of NOM removal at different filter depths. Removal efficiency of NOM was in the range of 10-40% throughout the operation time. At start-up of the filters packed with clean sand media, NOM was probably removed by physico-chemical adsorption on the surface of sand through the overall layer of filter bed. However, when Schumutzdecke layer was built up after 30 days operation, the major portion of NPDOC was removed by biological oxidation and/or bio-sorption in lower depth above 50 mm. NOM removal rate in the upper 50 mm filter bed was $0.82hr^{-1}$. It was about 20 times of the rate($0.04hr^{-1}$) in the deeper filter bed. Small portion of NPDOC could be removed in the deeper filter bed by both bio-sorption and biodegradation. SEM analysis and VSS measurement clearly showed the growth of biofilm in the deeper filter bed below 500 mm, which possibly played an important role in the NOM removal by biological activity besides the physco-chemical adsorption mechanism

• 한국음향학회지
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• 제20권1호
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• pp.56-61
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• 2001

본 논문은 비동기 방식의 IMT-2000 단말기용 ASIC (주문형 집적회로)에 포함되는 음성부호화기 알고리즘인 AMR(Adaptive Multi Rate) 보코더의 실시간 구현에 관한 것이다. 구현된 AMR 보코더는 12.2kbps에서 4.75kbps까지 8가지의 다중 비트율을 가지고 있으며, 인코더와 디코더 기능 외에 VAD (Voice Activity Detection) 블록과 SCR (Source Controlled Rate operation) 블록 등의 부가기능 및 시스템과의 접속 처리를 위한 프레임 구성 기능도 구현되어 있다. AMR 보코더를 구현하기 위하여 설계된 DSP (디지털 신호처리기)는 TeakLite 코어를 기반으로 하여 메모리 블록, 직렬접속 블록, CPU와의 접속을 위한 레지스터 파일 블록, 인터럽트 제어회로 등으로 구성된 16비트 고정 소수점형 DSP이다. 실시간 구현 방법에서는 메모리의 효율적인 관리를 통하여 계산량을 최적화하여 최대 동작 계산량을 약 24MIPS로 줄였으며, 구현된 AMR 보코더는 3GPP의 표준 시험 벡터를 모두 통과하여 검증을 완료하고, 실시간 보드 시험에서도 안정적으로 동작하는 것이 확인되었다.

• 의학교육논단
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• 제25권2호
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• pp.102-108
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• 2023

This study shares details on the operating process and results of the cohort of students and graduates that was designed and implemented at Konyang University College of Medicine in Daejeon and discusses future directions for cohort establishment and improvement. First, Konyang University College of Medicine established the necessity and defined the purpose of cohort design and implementation. A task force was formed to establish guidelines for analysis targets, procedures, reports, and data management, and cohort operation was classified as a quality control activity. Data were collected through surveys of current students and graduates, and data generated during the curriculum were collected, analyzed, and reported every 2 years. The cohort data collection and analysis methods are designed by the Department of Medical Education, and data collection is carried out by the administrative team and each committee. Data management and analysis are handled by the Center for Medical Education Support, and analysis and reporting are conducted by the Department of Medical Education. Various members of the medical school are working to collect and analyze data, report findings, provide feedback, and improve. In the future, we plan to advance database computerization and work toward more effective data analysis. Cohort operation should not be another burden for medical schools; instead, it is hoped that operating cohorts will be a meaningful activity to increase the effectiveness of medical education and help in the operation and policy decisions of medical schools.

• 융합정보논문지
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• 제11권3호
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• pp.87-94
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• 2021

본 연구는 2016년~2018년도에 수집된 국민건강영양조사 7기 자료의 2차 분석을 통해 심혈관질환자의 활동 제한 여부에 의한 정신 건강과 삶의 질을 확인하였다. 연구대상자는 자료대상자 총 24,269명 중 협심증이나 심근경색 진단 병력이 있는 530명의 성인에서 변수의 누락이 없는 521명이다. SAS 9.4 version으로 활동 제한 유무에 따른 정신 건강과 삶의 질 차이를 Chi-square방법, 활동 제한에 의한 정신 건강과 삶의 질 영향을 Logistic regression 통계 방법으로 분석하였다. 분석 결과 활동 제한이 있을 때 스트레스 정도, 최근 2주간 우울감과 자살 생각 정도가 높아 정신 건강에 유의한 영향이 있었다. 활동 제한이 있을 때 운동능력, 자기관리, 일상활동에 더욱 지장이 있다고 느꼈고, 통증/불편감과 불안/우울감이 증가하여 삶의 질 역시 유의한 영향이 있었다. 따라서 심혈관질환자의 정신 건강 및 삶의 질 증진을 위해 활동 제한을 최소화할 수 있는 효과적인 신체 활동 증진프로그램의 개발 및 운영이 필요함을 제언한다.

• 대한족부족관절학회지
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• 제8권1호
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• pp.76-80
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• 2004

Purpose: We assessed the results of open treatment of anterior impingement syndrome of the ankle in elite level soccer players and concomitant injuries were idenfied. Materials and Methods: We retrospectively reviewed twenty one elite level soccer players diagnosed with anterior impingement syndrome who underwent open debridement between January 1997 and January 2002. All were men and the mean age at the operation was 21 years (range 16 to 27). The mean follow-up duration was 31 months (13 to 71). Concomitant abnormalities were idenfied through physical examination, bone scan and MRI. On a preoperative lateral radiograph, patients were classified according to McDermott's stage. Anteromedial or anterolateral approach was used at the operation and osteophyte was removed with osteotome and rongeur. When chronic ankle instability was accompanying, we performed Modified Brostrom-Gould procedure and for osteochondral lesion, multiple drilling was applied. The Ogilvie-Harris scoring system was used as a clinical scale to evaluate pain, swelling, stiffness and limitation of activity. The results were scored as excellent (15 to 16 points), good (13 to 14) and otherwise unsatisfactory. The time to return to full activity including sports activity was determined. Results: Eighteen of twenty one patients had an excellent outcome. Three patients were graded unsatisfactory and two of them abandoned their career due to the persistence of residual pain. Concomitant abnormalities were found including twelve cases of chronic ankle instability, three cases of osteochondral lesion and two cases of flexor hallucis longus tendinitis. Conclusion: Open debridement was successfully applied to the elite level soccer player with anterior impingement syndrome of the ankle. Considerable coexistence of other abnormalities such as chronic ankle instability may encourage us to consider additional operative procedure.

• Archives of Reconstructive Microsurgery
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• 제10권2호
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• pp.75-80
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• 2001

Purpose : We have evaluated the morbidity of donor site after transfer of free fibular osseous and osteocutaneous flap to defect site of bone and soft tissue due to chronic osteomyelitis of long tubular bone, open fracture with bony defect, bone or soft tissue tumor and congenital anomaly. Materials and methods : The 54 cases of 79 cases to be carried out from May, 1982 to May, 2001 which could be followed up were reviewed. There were forty nine in male and five in female. The mean age was 35(4 to 66)years old and mean follow up period is 21.3 month(12 to 72). We have retrospectively analyzed the various postoperative complications such as compartment syndrome, donor site infection, skin defect, hypesthesia, hammer toes, ankle instability and activity of daily living by help of questionnaire, telephone, physical examination, follow up x-ray study and chart. Results : In the total 54 cases the medication period for pain control after operation were classified into three groups under 2 weeks(49 cases), from 2 weeks to 6 weeks(3 cases) and over 6 weeks(2 cases). The postoperative morbidity were occurred in total 12 cases(compartment syndrome: 0, infection : 2, skin defect: 1, hypesthesia: 5, hammer toe: 2 ankle pain: 2 discomfort in activity of daily living: 0), and also the morbidity rates of donor site were 23.5% in osseous flap and 21.6% in osteocutaneous flap were occurred. There was no statistical significonce in morbidity between osseous and osteocutaneous free fibular flap transfer(P>0.05). Discussion : In general the morbidity of free fibular flap transfer was relatively high but it did not have any effect on daily activity of living. We think that the meticulous operation technique, detailed wound care and early range of motion exercise will reduce the morbidity of donor site of flap.

• 치과방사선
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• 제19권1호
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• pp.69-87
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• 1989

It is well known that the glucocorticoid induces osteoporosis by suppression of the osteoblast, but its effect on the osteoclast hRS some controversy whether it activates or suppresses the osteoclast. If the calcitonin, which is known to suppress the osteoclast, prevents the osteoporosis by glucocorticoid, then the suppression of the osteoclast by the glucocorticoid is not so significant. And if the calcitonin increases the osteoblastic activity, Tc-99m MDP uptake will be increased in spite of the glucocorticoid effect on the osteoblast. The immobilization operation was performed to the right leg of male Wistar rats weighing about 200gm. each. For 16 weeks after operation, rats were injected glucocorticoid alone or glucocorticoid anci calcitonin. The bone density was measured by means of photodensitometry under reference aluminum step wedge and Tc-99m MDP uptake was available to the index of the osteoblastic activity. 1. The bone density of femora! head was markedly reduced than that of femoral shaft following ration of cancellous and cortical components in both site. 2. Glucocorticoid caused decrease in bone density of spine and femur, md there is significantly increase of it when medication of glucocorticoid and calcitonin injection simultaneously than that of glucocorticoid. 3. Tc-99m MDP uptake was revealed significant reduction in medication of glucocorticoid but increase in gi;.:cocorticoid and calcitonin injection simultaneously in later experimental period. 4. There wail, a slight reduction in plasma osteocalcin in medication of glucocorticoid through experimental periods and an increase in its value in case of giving glucocorticoid and calcitonin simultaneously in later experimental period. From these results, we suggest that osteoporosis by immobilization is more pronounced by glucocorticoid hormone and osteoporosis induced by immobilization and glucocorticoid use is prevented by calcitonin administration with increasing osteoblastic activity.