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Protected versus Unprotected Carotid Artery Stenting : Meta-Analysis of the Current Literature

  • Cho, Young Dae;Kim, Sung-Eun;Lim, Jeong Wook;Choi, Hyuk Jai;Cho, Yong Jun;Jeon, Jin Pyeong
    • Journal of Korean Neurosurgical Society
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    • v.61 no.4
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    • pp.458-466
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    • 2018
  • Objective : To compare peri-operative any symptomatic stroke after carotid angioplasty and stenting (CAS), based on the application or absence of a cerebral protection device. Methods : A systematic literature review using PubMed, Embase, and the Cochrane Central was done across an online data base from January 1995 to October 2016. Procedures which were performed due to carotid dissection or aneurysm, procedures using covered stents or conducted in an emergency, were excluded. The primary endpoint was perioperative any symptomatic stroke within 30 days after the procedure. A fixed effect model was used in cases of heterogeneity less than 50%. Results : In the 25 articles included in this study, the number of stroke events was 326 (2.0%) in protected CAS and 142 (3.4%) in unprotected CAS. The use of cerebral protection device significantly decreased stroke after CAS (odds ratio [OR] 0.633, 95% confidence interval [CI] 0.479-0.837, p=0.001). In the publication bias analysis, Egger's regression test disclosed that the intercept was -0.317 (95% CI -1.015-0.382, p=0.358). Regarding symptomatic patients (four studies, 539 CAS procedures), the number of stroke was six (1.7%) in protected CAS and 11 (5.7%) in unprotected CAS. The protective effect against stroke events by cerebral protection device did not have a statistical significance (OR 0.455, 95% CI 0.151-1.366, p=0.160). Conclusion : The use of protection device significantly decreased stroke after CAS. However, its efficacy was not demonstrated in symptomatic patients. Routine use of protection device during CAS should be critically assessed before mandatory use.

Endovascular Treatment with Intravenous Thrombolysis versus Endovascular Treatment Alone for Acute Anterior Circulation Stroke : A Meta-Analysis of Observational Studies

  • Kim, Chul Ho;Jeon, Jin Pyeong;Kim, Sung-Eun;Choi, Hyuk Jai;Cho, Yong Jun
    • Journal of Korean Neurosurgical Society
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    • v.61 no.4
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    • pp.467-473
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    • 2018
  • Objective : The aim of this study was to determine outcome of ischemic stroke patients in the anterior circulation treated with endovascular treatment (EVT) with intravenous thrombolysis (IVT) versus EVT alone group. Methods : A systemic literature review was performed using online database from January 2004 to January 2017. Primary outcomes were successful recanalization seen on finial angiography and good outcome at three months. Secondary outcomes were mortality and the development of symptomatic intracranial hemorrhage (S-ICH) after the procedure. A fixed effect model was used when heterogeneity was less than 50%. Egger's regression test was used to assess publication bias. Results : Five studies were included for final analysis. Between EVT with IVT and EVT alone group, successful recanalization (odds ratio [OR] 1.467, p=0.216), good clinical outcome at three months (OR 1.199, p=0.385), mortality (OR 0.776, p=0.371), and S-ICH (OR 1.820, p=0.280) did not differ significantly. Egger's regression intercept with 95% confidence interval (CI) was 1.99 (95% CI -2.91 to 6.89) in successful recanalization and -0.27 (95% CI -6.35 to 5.80) in good clinical outcome, respectively. Conclusion : The two treatment modalities, EVT with IVT and EVT alone, could be comparable in treating acute anterior circulation stroke. Studies to find specific beneficiary group for EVT alone, without primary IVT, are needed further.

Glutathione S-transferase M1 Null Genotype and Hepatocellular Carcinoma Susceptibility in China and India: Evidence from an Updated Meta-analysis

  • Liu, Hong-Zhou;Peng, Jie;Peng, Chun-Yan;Yan, Ming;Zheng, Fang
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.12
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    • pp.4851-4856
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    • 2014
  • Background: Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. However, the effect of the GSTMl null genotype was divergent in the literature and we therefore performed the present meta-analysis to explore the relationship in detail. Materials and Metbods: Reported studies were searched from 1990 to March 1, 2014 in PubMed and Wanfang Med Online. The total odds oatio (OR) and 95% CI were calculated and analyzed by Review Manager 5.1 and STATE 12. Results: Total OR was calculated from 26 articles with 3,769 cases and 5,517 controls and the association proved significant (OR [95%CI]=1.50 [1.25, 1.80], P<0.05) in the Chinese population. However, there was no significant association between hepatocellular carcinoma risk among subjects carrying the GSTM1 null genotype (OR [95%CI]=1.20 [0.88-1.64], P=0.24) in subgroups of publication in English and in Indian populations (OR [95%CI]=1.80 [0.80-4.20], P=0.15). Conclusions: The GSTM1 deletion polymorphism might not have a significant effect on the susceptibility of hepatocellular carcinoma overall.

A Review of the Domestic Trends of Korean Traditional Medicine for Idiopathic Scoliosis (특발성 척추측만증의 한의학적 치료에 대한 국내 연구 동향: 국내 학술지를 중심으로)

  • Lee, Sang-Woon;Chu, Hui-Yeong;Kim, Ho;Lee, Sang-Gun;Choi, Jae-Yong;Lee, Yu-Jin;Choi, Kang-Eah
    • Journal of Korean Medicine Rehabilitation
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    • v.30 no.4
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    • pp.55-64
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    • 2020
  • Objectives This study aimed to analyze the trends of Korean traditional medicine treatment for idiopathic scoliosis. Methods We searched clinical studies used Korean traditional medicine for idiopathic scoliosis in 4 Korean online databases 'Koreanstudies Information Service System', 'Earticle', 'Oriental Medicine Advanced Searching Integrated System', 'Research Information Sharing Service'. We selected 18 studies and analyzed their characteristics according to author, publication year, number/sex/age of patient, treatment period, intervention, outcome measure and result. Results Eighteen case report studies were selected by criteria and randomized controlled trials were not found. The most frequently used therapy was Chuna therapy. Cobb's angle was most commonly used outcome measure. Conclusions In this study, we reviewed studies used Korean traditional medicine treatments for idiopathic scoliosis. However, evidence is limited because all selected studies were case reports. This study suggests that further clinical studies are needed to provide higher evidence about Korean traditional medicine treatment for idiopathic scoliosis.

Analysis on Romanization of Korean Geographical Names in Foreign Countries (해외에서의 한국지명 표기 실태 분석)

  • Kim, Sun-Hee;Park, Kyeong;Lee, Hae-Mi
    • Journal of the Korean Geographical Society
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    • v.44 no.6
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    • pp.706-722
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    • 2009
  • This study aims to find the ways to correct and fix the errors in transcription by analyzing Romanization of Korean geographical names in foreign countries. The gazetteers from many countries, place name databases, and map-providing websites are the main source of research. Common error types found in this study are variant name posting, subordinated marking, double posting, spelling errors, and location errors. In fact, transcription of geographical names exhibits more diverse forms and types. The counter measures to fix these errors are as follows, firstly, consistent efforts with regular monitoring to fix errors are essential. Secondly, the one and only standardized Romanization principle is urgent. Thirdly, prompt update and publication in case of place name and/or boundary change is necessary. Fourthly, efforts to register unregistered geographical names are necessary. Lastly, the establishment of central agency solely for the management of geographical names is required.

Design and Implementation of Online Paper Review System (온라인 논문 심사 시스템 설계 및 구현)

  • Yeon, Dong-Hee;Koh, Gwang-San;Kim, Yun-Ki;Kim, Jin-Soo;Jung, Hoe-Kyung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • v.9 no.2
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    • pp.971-974
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    • 2005
  • Science and technology-related societies in the interior of a country sum up to approximately 660, and are increasing yearly, due to the development of new research fields and segmentation of past studies. Such societies are contributed with latest academic research information, and the submitted studies go through an review process before publication. A majority of the societies employ the traditional off-line review method; various problems and issues occur in delay of submission, review, revision, and management of the numerous paper submitted and published. Therefore, this study suggests the design of, and implemented an on-line paper review system which processes on-line submission and review of paper, facilitates swift and review progress, and enables efficient control and management on general tasks and academic information through integrated administration of members and published works.

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A Study on the Classification System for Social Science Field in Internet Bookstore (인터넷 서점의 사회과학분야 분류체계에 관한 연구)

  • Min, Hye-Young;Lee, Sung-Sook
    • Journal of Information Management
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    • v.43 no.1
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    • pp.41-62
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    • 2012
  • Because of the electronic commerce development, share of the internet bookstore is rising every year in the publication circulation market. Also, the book search in the internet bookstore may smarten more forward according to development trend of the electronic book, and importance of the classification system of the internet bookstore is expected that also rise continuously. The purpose of this study is to offer the classification system that can search the social science books of the internet bookstore efficiently. For this study, compared and analyzed the classification system of internal and external 10 internet bookstores. This study may be used to other subject study of the internet bookstore, and it expect to is used to basic data for the classification system of the internet bookstore in the future.

Efficacy of intralipid administration to improve in vitro fertilization outcomes: A systematic review and meta-analysis

  • Han, E Jung;Lee, Hye Nam;Kim, Min Kyoung;Lyu, Sang Woo;Lee, Woo Sik
    • Clinical and Experimental Reproductive Medicine
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    • v.48 no.3
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    • pp.203-210
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    • 2021
  • We performed a systematic review and meta-analysis to evaluate whether intralipid administration improved the outcomes of in vitro fertilization. Online databases (PubMed, Cochrane Library, Medline, and Embase) were searched until March 2020. Only randomized controlled trials (RCTs) that assessed the role of intralipid administration during in vitro fertilization were considered. We analyzed the rates of clinical pregnancy and live birth as primary outcomes. Secondary outcomes included the rates of chemical pregnancy, ongoing pregnancy, and missed abortion. We reviewed and assessed the eligibility of 180 studies. Five RCTs including 840 patients (3 RCTs: women with repeated implantation failure, 1 RCT: women with recurrent spontaneous abortion, 1 RCT: women who had experienced implantation failure more than once) met the selection criteria. When compared with the control group, intralipid administration significantly improved the clinical pregnancy rate (risk ratio [RR], 1.48; 95% confidence interval [CI], 1.23-1.79), ongoing pregnancy rate (RR, 1.82; 95% CI, 1.31-2.53), and live birth rate (RR, 1.85; 95% CI, 1.44-2.38). However, intralipid administration had no beneficial effect on the miscarriage rate (RR, 0.75; 95% CI, 0.48-1.17). A funnel plot analysis revealed no publication bias. Our findings suggest that intralipid administration may benefit women undergoing in vitro fertilization, especially those who have experienced repeated implantation failure or recurrent spontaneous abortion. However, larger, well-designed studies are needed to confirm these findings.

Effects of Herbal Medicines on Bone Mineral Density Score in Osteoporosis or Osteopenia: Study Protocol for a Systematic Review and Meta-Analysis (한약이 골다공증 혹은 골감소증 환자의 골밀도에 미치는 영향: 체계적 문헌고찰 및 메타분석을 위한 프로토콜)

  • Hong, Su Min;Lee, Eun Jung
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.2
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    • pp.49-55
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    • 2021
  • Objectives The impact of social and economic losses on society due to the occurrence of osteoporosis patients is serious. The purpose of this study is to identify the types and effects of herbal medicine for osteoporosis and osteopenia. Methods We will investigate 8 online databases (MEDLINE/PubMed, Cochrane library, EMbase, China National Knowledge Infrastructure [CNKI], J-stage, National Digital Science Library [NDSL], Research Information Sharing Service [RISS], Koreanstudies Information Service System [KISS]) without language, publication date limitation for the clinical study of herbal medicine for osteoporosis and osteopenia published between the start of the database and 2021. The frequency, duration and pattern of the any type of herbal medicine utilization will be analyzed. Results Randomized controlled trials about herbal medicine or herbal medicine extracts for osteoporosis and osteopenia should be included in the study. Cochrane risk in bias tools will be used to evaluate the methodological quality of the study. A risk ratio or mean difference with a 95% confidence interval will show the effects of herbal medicine or herbal medicine extracts for osteoporosis and osteopenia. Conclusions The results of the systematic review will reflect the current status of herbal medicine treatment for osteoporosis and osteopenia, and it can be expected to verify the validity of the effectiveness, and provide it as a basic data for the use of herbal medicine in clinical utilization.

Business Failure: Overview and Research Trend (사업실패에 관한 국내외 연구동향)

  • Bae, Tae Jun;Choi, Yun Hyeong
    • Korean small business review
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    • v.42 no.3
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    • pp.43-75
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    • 2020
  • The main purpose of this study is to analyze research trend of 'business failure' from academic papers published in Asia Pacific Journal of Small Business. In this review, first, we reviewed research trend of failure, published in academic journals at abroad, explored the major topics, and set forth the framework of classification. Second, we selected and analyzed 16 Korean articles in a refined search from total 1,060 articles published in Asia Pacific Journal of Small Business from 1979 to 2019. Third, in order to understand overall research trend in Korea, additional publication search was done by online database system using keywords, and 24 other articles were selected. As a result, five research themes were identified and analyzed: (1) bankruptcy prediction, (2) emotion before and after failure, (3) costs of failure, (4) causes of failure, and (5) reentry determinants. We believe that this purposed review will offer future research issues regarding business failure.