• Clinical and Experimental Pediatrics
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• v.56 no.11
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• pp.482-489
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• 2013

Purpose: The aim of the present study was to investigate the differences in lower airway inflammatory immune responses, including cellular responses and responses in terms of inflammatory mediators in bronchoalveolar lavage fluid (BALF) and the airway, to rhinovirus (RV) infection on asthma exacerbation by comparing a control and a murine asthma model, with or without RV infection. Methods: BALB/c mice were intraperitoneally injected with a crude extract of Dermatophagoides farinae (Df ) or phosphate buffered saline (PBS) and were subsequently intranasally treated with a crude extract of Df or PBS. Airway responsiveness and cell infiltration, differential cell counts in BALF, and cytokine and chemokine concentrations in BALF were measured 24 hours after intranasal RV1B infection. Results: RV infection increased the enhanced pause (Penh) in both the Df sensitized and challenged mice (Df mice) and PBS-treated mice (PBS mice) (P<0.05). Airway eosinophil infiltration increased in Df mice after RV infection (P<0.05). The levels of interleukin (IL) 13, tumor necrosis factor alpha, and regulated on activation, normal T cells expressed and secreted (RANTES) increased in response to RV infection in Df mice, but not in PBS mice (P<0.05). The level of IL-10 significantly decreased following RV infection in Df mice (P<0.05). Conclusion: Our findings suggest that the augmented induction of proinflammatory cytokines, Th2 cytokines, and chemokines that mediate an eosinophil response and the decreased induction of regulatory cytokines after RV infection may be important manifestations leading to airway inflammation with eosinophil infiltration and changes in airway responsiveness in the asthma model.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.1
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• pp.71-76
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• 2001

Purpose: Many diagnostic modalities for neonatal cholestasis have shown features that are helpful, however until recently none of them are not pathognomonic of biliary atresia (BA). We carried out a prospective study of infants with cholestatic jaundice with the aim of establishing an efficient method of diagnosing BA. Methods: Twenty-seven consecutive infants with cholestatic jaundice were enrolled in this study and ranged from 7 to 152 days in age (mean; $51.2{\pm}34.2$ days). Gastroduodenoscopy was carried out using a fiberscope (Olympus N30). All the babies were fasted for at least 4 hours before the procedure and 20 ml of 10% dextrose solution was given at the time of endoscopy. The endoscopic examination focused on the 5 minutes observation of the evidence of biliary secretion. If there was lack of the evidence of the biliary secretion, endoscopy was removed and repeated the examination with some pause. Results: There are lack of the evidence of biliary secretion in all infants with BA. In non-BA group, 8 out of the 10 infants showed biliary secretion on the first trial, however one (Alagille syndrome) of the two infants without evidence of biliary secretion, finally exhibited biliary secretion on the second trial. The above observations resulted in the diagnostic accuracy of 96.3% with 100.0% sensitivity and 90.0% specificity. Conclusion: In light of the results from our relatively small study, endoscopy is a convenient, and relative inexpensive procedure. we strongly support the use of endoscopy for the diagnosis of BA in the screening and evaluation of infantile cholestasis.

• Phonetics and Speech Sciences
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• v.16 no.2
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• pp.99-109
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• 2024

Coarticulation is affected by the continuous movement of the articulator within a limited time and space through the neighboring segments and various overlaps. This study investigated the differences in coarticulation characteristics of children with reading disabilities and nondisabled children in CVC and VCV syllables consisted of stops, affricates, and vowels (a, i, u). The subjects were 13 children with reading disabilities and nondisabled children in the 2nd to 6th grades in elementary school. Two second formants were measured. One was measured at the point where the vowel began, and the other was measured at the mid point of the vowel stable section. Regression analysis was performed with F2 onset and F2 of the following vowel to obtain the locus equation (LE). 3-way ANOVA was conducted to the slope of the LE according to the groups (reading disabilities vs. nondisabled), places of articulation, and phonation types. In CVC syllable, dyslexic children showed a flatter slope than nondisabled children. With respect to the places of articulation, velar or bilabial sounds showed steeper LE slope than alveolar or palatal sounds. There were no main effects regarding group and phonation types variable for VCV syllable, and the significant differences in the places of articulation were also differed from the results for the CVC syllables. This study confirmed that dyslexic children showed a different pattern of coarticulation slope depending on the syllable structure. We also found that the higher pause rate of the dyslexic children had a stronger effect on the coarticulation in VCV structures.

• The Journal of the Acoustical Society of Korea
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• v.20 no.3
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• pp.24-33
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• 2001

this paper describes a baseline for an implementation of a corpus-based Korean TTS system. The conventional TTS systems using small-sized speech still generate machine-like synthetic speech. To overcome this problem we introduce the corpus-based TTS system which enables to generate natural synthetic speech without prosodic modifications. The corpus should be composed of a natural prosody of source speech and multiple instances of synthesis units. To make a phone level synthesis unit, we train a speech recognizer with the target speech, and then perform an automatic phoneme segmentation. We also detect the fine pitch period using Laryngo graph signals, which is used for prosodic feature extraction. For break strength allocation, 4 levels of break indices are decided as pause length and also attached to phones to reflect prosodic variations in phrase boundaries. To predict the break strength on texts, we utilize the statistical information of POS (Part-of-Speech) sequences. The best triphone sequences are selected by Viterbi search considering the minimization of accumulative Euclidean distance of concatenating distortion. To get high quality synthesis speech applicable to commercial purpose, we introduce a domain specific database. By adding domain specific database to general domain database, we can greatly improve the quality of synthetic speech on specific domain. From the subjective evaluation, the new Korean corpus-based TTS system shows better naturalness than the conventional demisyllable-based one.

• Journal of the Korea Society of Computer and Information
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• v.17 no.9
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• pp.75-84
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• 2012

HMM-based Text-to-Speech systems generally utilize context dependent tri-phone units from a large corpus speech DB to enhance the synthetic speech. To downsize a large corpus speech DB, acoustically similar tri-phone units are clustered based on the decision tree using context dependent information. Context dependent information includes phoneme sequence as well as prosodic information because the naturalness of synthetic speech highly depends on the prosody such as pause, intonation pattern, and segmental duration. However, if the prosodic information was complicated, many context dependent phonemes would have no examples in the training data, and clustering would provide a smoothed feature which will generate unnatural synthetic speech. In this paper, instead of complicate prosodic information we propose a simple three prosodic boundary types and decision tree questions that use rising tone, falling tone, and monotonic tone to improve naturalness. Experimental results show that our proposed method can improve naturalness of a HMM-based Korean TTS and get high MOS in the perception test.

• Journal of the Korean Magnetic Resonance Society
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• v.12 no.1
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• pp.1-13
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• 2008

Acetyl-CoA carboxylase (ACC) catalyzes the first step in fatty acid biosynthesis: the synthesis of malonyl-CoA from acetyl-CoA. As essential regulators of fatty acid biosynthesis and metabolism, ACCs are regarded as therapeutic targets for the treatment of metabolic diseases such as obesity, In ACC, the biotinoyl domain performs a critical function by transferring an activated carboxyl group from the biotin carboxylase domain to the carboxyl transferase domain, followed by carboxyl transfer to malonyl-CoA. Despite the intensive research on this enzyme, only the bacterial and yeast ACC structures are currently available, To explore the mechanism of ACC holoenzyme function, we determined the structure of the biotinoyl domain of human ACC2 and analyze its characteristics using NMR spectroscopy. The 3D structure of the hACC2 biotinoyl domain has a similar folding topology to the previously determined domains from E. coli and P. Shermanii, however, the 'thumb' structure is absent in the hACC2 biotinoyl domain. Observations of the NMR signals upon the biotinylation indicate that the biotin group of hACC2 does not affect the structure of the biotinoyl domain, while the biotin group for E. coli ACC interacts directly with the thumb residues that are not present in the hACC2 structure. These results imply that, in the E. coli ACC reaction, the biotin moiety carrying the carboxyl group from BC to CT can pause at the thumb of the BCCP domain. The human biotinoyl domain, however, lacks the thumb structure and does not have additional non-covalent interactions with the biotin moiety; thus, the flexible motion of the biotinylated lysine residue must underlie the "swinging arm" motion. This study provides insight into the mechanism of ACC holoenzyme function and supports the "swinging arm" model in human ACCs.

• Journal of the Korean association of regional geographers
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• v.20 no.4
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• pp.393-408
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• 2014

In this study, the spatio-temporal characteristics of summer extreme precipitation events in the Republic of Korea are examined based on the daily precipitation data observed at approximately 360 sites of both Automatic Weather Station (AWS) and Automated Synoptic Observation System (ASOS) networks by the Korea Meteorological Administration for the recent decade(2002~2011). During the summer Changma period(late June~mid July), both the frequency of extreme precipitation events exceeding 80mm of daily precipitation and their decadal maximum values are greatest at most of weather stations. In contrast, during the Changma pause period (late July~early August), these patterns are observed only in the northern regions of Geyeonggi province and western Kangwon province as such patterns are detected around Mt. Sobaek and Mt. Halla as well as in the southern regions of Geyeonggi province and western Kangwon province during the late Changma period (mid August~early September) due to north-south oscillation of the Changma front. Investigation of their regional patterns confirms that not only migration of the Changma front but also topological components in response to the advection of moistures such as elevation and aspect of major mountain ridges are detrimental to spatio-temporal patterns of extreme precipitation events. These results indicate that each local administration needs differentiated strategies to mitigate the potential damages by extreme precipitation events due to the spatiotemporal heterogeneity of their frequency and intensity during each Changma period.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.8 no.2
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• pp.137-142
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• 2005

Purpose: To evaluate the safety, efficacy and technical problems of the endoscopic balloon dilatation of esophageal anomalies in children. Methods: The medical records of 8 children treated by endoscopic balloon dilatation for esophageal anomalies over a 10-year period at Pusan National University Hospital were reviewed retrospectively. The balloon catheter (Maxforce TTS or CRE, Boston Scientific Co., USA) was positioned across the area of narrowing by direct visualization. The balloon was slowly inflated with normal saline to specified pressures for each balloon and maintained for 60 seconds and then deflated. After 60 seconds pause, the procedure was repeated with a larger sized balloon (increments of 1 mm for each subsequent dilation) till effective dilatation was confirmed by direct visualization without complications. Results: Three male and five female were included and their mean age was 4.2 years. A total of 27 (average of 3.2 per patient) dilatation were performed. Underlying diseases of patients are postoperative stricture of esophageal atresia in 3 cases, esophageal ring in 2 cases, achalasia, corrosive esophagitis and hypertensive LES in one case respectively. The size of initial dilating balloon was chosen on the basis of the diameter of the narrowing determined by endoscopy. The first dilation in patients with severe esophageal stricture was made with a 6 mm sized balloon. Complications observed were esophageal perforation and respiratory holding during the procedure in one case respectively. Successful outcome was seen in 6 patients (75%). Conclusion: Endoscopic balloon dilatation can provide a safe and effective mean of treating esophageal anomalies in children and should be considered the treatment of choice in the initial management of those cases.

• Journal of the Korean Institute of Gas
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• v.2 no.4
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• pp.79-84
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• 1998

This paper describes the minimum ignition limit voltages for LPG-Air 5.25[Vol$\%$] mixture gas by discharge sparks in radio-frequency limits using RF power supply and IEC type ignition spark apparatus. As a result, the minimum ignition limit voltages is increased in proportional to the rate of increasing of frequency in LPG-Air mixture gas. Especially, the minimum ignition limit voltages increase remarkably between 3[KHz] and 10[KHz]. It is considered that ignition is caused by one discharge until 3[KHz] and, beyond 3[KHz] ignitiof is caused by more than two discharges. The reason is analyzed that energy loss is caused by existing pause interval between discharges. It is considered that the result can be used for not only data for researches and development of intrinsically safe explosion-proof RF machines which are applied tole-equipments and detectors used in dangerous areas but also for datum for its equipment tests.

• (The) Research of the performance art and culture
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• no.34
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• pp.277-313
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• 2017

This study is to find out the correlation with buddhist music after analyzing the rhythm of six pieces of PanYeombul sung by Kim Janggil out of Ogu exorcism of East coast the findings summarized are as follows. First, PanYeombul by Kim Janggil, performed on Oct, 16, 2016, was composed of , , , , , , , , , , and . Still, even if PanYeombul is performed by the same male shaman, the composition can be added or left out depending on some circumstances, which means the procedures are flexible. Seeing that there is common component of in additoin to compared with Kimyongtaek, it can be said that the component of is an important part in PanYeombul of Ogu exorcism of East coast Second, is usually referred to 'SinmyojangguDaedalani' in buddhist ritual, While Kim yongtaek accepts this practice in title, Kim Janggil uses 'YeomhwajangguDaedalani' as the title which makes his song different from others. Yeomhwa means "picking up flowers with fingers" which has been used in buddhism, not in common Considering this fact, the conclusion can be reached that by using the term 'Daedalani' from a buddhist chant, but making differentiation from buddhism, Kim Janggil is making the effort to be different from buddhist rituals. give some unique meaning to shaman rituals. Third, PanYeombul of Ogu exorcism of East coast may be divided into two main parts - the former part is PanYeombul and the latter part is Jiokga. In performing PanYeombul, male shaman sits singing alone and playing Jing himself, on the other hand, in case of Jiokga, he stands singing a solo with gwaeggwari in his hand accompanied by other musicians with the rhythm of Samgongjaebi. As the song and the accompaniment are in the form of giving and taking like duet. it is in peak in terms of music. Accordingly, PanYeombul can be divided into PanYeombul and Jiokga, But since it is performed by one male shaman and sung a solo, it is usually seen as one procedure. Jing, which is a kind of accompaniment in PanYeombul by Kim Janggil, has the role to distinguish a phrase and settle the musical paragraph. When the buddhist chant with one word-one note is performed. it requires the performer to catch his or her breath or clear throat. Just then, Jing comes out for filling out the intervals. Also, its role to distinguish a phrase and settle the musical paragraph helps make it clear to deliver words. The rhythm of Jing is mostly made up of small triple time except equal small binary time, comes out with overwhelmingly more frequency of Sutsoe(♪♩) than Amsoe(♩♪), and often shows syncopation. By often using Off Beat or short-long rhythm even in accompaniment of equal small binary time, he tris to give some variation to monotonous and equal rhythm for the musical vitality. These are similar to Sutsoe rhythm which can evoke tension and Kim Janggil makes these things his characierisiic of rhythm. Fifth, all the pieces consist of mi, sol, la, do, re and the descending melody like do'${\searrow}$la${\searrow}$sol${\searrow}$mi appears most frequently. The descending melody usually arouses the feeling of sorrow, so the sadness for the deceased is presented properly, which suggests his musical talent. Generally, pieces take on Menari-tori as a whole where the length of sol appears for a short time in descending la${\searrow}$sol${\searrow}$mi of perfect four degrees. Sixth, Even he accepts the lines of buddhist chant, he changes them in some degree. For example, he inserted some words between lines like 'Wonwangsaeng' and 'NamuAmitabul' and added Korean words like hapsosa to the lines of buddhist service written in Chinese character. Also, he inserted some words like 'iiiiiii~' to express the feeling of sadness. These are to maximize the desire of the deceased to go to the heaven and at the same time to diminish the sign of buddhism and strengthen the features of shamanism. Seventh, the effort to decrease the sign of buddhism is made in pasting lines of two songs. For example, Between the last words 'Wonsuaenapsu of Dage and the first words 'Jisimgwimyeongrye' of Chiljeongrye, there is usually a short pause to distinguish paragraphs, But he continues two songs without any pause to get rid of the feelings of buddhist chant. In terms of melody, he makes a distance from buddhist chant in an effort that he gives some traits to shaman rituals which are different from buddhist even if he uses the lines of buddhist rituals. Eighth, the analyzed pieces can be in four categories - no regular melody , , equal small binary time , eotmori melody of ten eighth time with 3+2+3+2 mixed small time . and Samgongjaebi melody 3+2+3 mixed small time . Each piece has its unique melody. Although of buddhist ritual is often performed, by using eotmori melody, he evokes the feeling of shaman and is another example of giving unique characteristic to the shaman of East coast by using Samgongjaebi melody.