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Multidrug-Resistant Tuberculosis Presenting as Miliary Tuberculosis without Immune Suppression: A Case Diagnosed Rapidly with the Genotypic Line Probe Assay Method

  • Ko, Yousang;Lee, Ho Young;Lee, Young Seok;Song, Junwhi;Kim, Mi-Yeong;Lee, Hyun-Kyung;Shin, Jeong Hwan;Choi, Seok Jin;Lee, Young-Min
    • Tuberculosis and Respiratory Diseases
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    • v.76 no.5
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    • pp.245-248
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    • 2014
  • Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.

Preferential Killing of Human Lung Cancer Cell Lines with Mitochondrial Dysfunction by Non-Thermal Dbd Plasma

  • Panngom, Kamonporn;Baik, Ku Youn;Nam, Min-Kyung;Rhim, Hyang-Shuk;Choi, Eun Ha
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.199-199
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    • 2013
  • The distinctive cellular and mitochondrial dysfunctions of a human epithelial lung cancer cell line (H460) from a human lung fibroblastic normal cell line (MRC5) have been studied by dielectric barrier discharge (DBD) plasma treatment. The DBD plasma device have generated large amount of H2O2 and NOx in culture media which is dependent on plasma exposure time. It is found that the cell number of lung cancer cell H460 has been reduced more than the lung normal cell MRC5 as being increased exposure and incubation time. Also these both cell lines have showed mitochondria fragmentation under 5 minutes' plasma exposure, which is a clue of apoptosis. It is noted in this study that AnnexinV staining has showed not only early apoptosis, but also late apoptosis in lung cancer cell H460. Mitochondria enzyme activity and ATP generation have been also much reduced in lung cancer cell H460. Their mitochondrial membrane potential (${\Delta}{\psi}m$) has been found to be reduced in magnitude and shifted to the induced-potential level of cccp, while MRC5 mitochondrial membrane potential has been shifted slightly to that. These distinctively selective responses of lung cancer cell H460 from lung normal cell MRC5 gives us possibility of applying plasma to cancer therapy.

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A Study of Galactic Molecular Clouds through Multiwavelength Observations

  • Park, Sung-Joon;Min, Kyoung-Wook;Seon, Kwang-Il;Han, Won-Yong;Lee, Dae-Hee;Edelstein, Jerry;Korpela, Eric;Sankrit, Ravi
    • The Bulletin of The Korean Astronomical Society
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    • v.35 no.1
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    • pp.68.1-68.1
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    • 2010
  • We focus on two Galactic molecular clouds that are located in wholly different environments and both are observed by FIMS instrument onboard STSAT-1. The Draco cloud is known as a translucent molecular cloud at high Galactic latitude. The FUV spectra show important ionic lines of C IV, Si IV+O IV], Si II* and Al II, indicating the existence of hot and warm interstellar gases in the region. The enhanced C IV emission inside the Draco cloud region is attributable to the turbulent mixing of the interacting cold and warm/hot media, which is supported by the detection of the O III] emission line and the $H{\alpha}$ feature in this region. The Si II* emission covers the remainder of the region outside the Draco cloud, in agreement with previous observations of Galactic halos. Additionally, the H2 fluorescent map is consistent with the morphology of the atomic neutral hydrogen and dust emission of the Draco cloud. In the Aquila Rift region near Galactic plane, FIMS observed that the FUV continuum emission from the core of the Aquila Rift suffers heavy dust extinction. The entire field is divided into three sub-regions that are known as the- "halo," "diffuse," and "star-forming" regions. The "diffuse" and "star-forming" regions show various prominent H2 fluorescent emission lines, while the "halo" region indicates the general ubiquitous characteristics of H2. The CLOUD model and the FUV line ratio are included here to investigate the physical conditions of each sub-region. Finally, the development of an infrared imaging system known as the MIRIS instrument onboard STSAT-3 is briefly introduced. It can be used in WIM studies through $Pa{\alpha}$ observations.

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A combined pathway of somatic embryogenesis and organogenesis to regenerate radiata pine plants

  • Montalban, I.A.;De Diego, N.;Igartua, E. Aguirre;Setien, A.;Moncalean, P.
    • Plant Biotechnology Reports
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    • v.5 no.2
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    • pp.177-186
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    • 2011
  • This study describes for the first time in Pinus genus a plant regeneration system via a combined pathway of somatic embryogenesis and organogenesis from immature seeds of radiata pine. Somatic embryos were obtained from embryogenic line 2162 of Pinus radiata D. Don on EDM basal medium containing $60{\mu}M$ ABA and 6% sucrose. The explants used for organogenesis experiments were either freshly collected somatic embryos or somatic embryos germinated for 1 week. Germination medium was half-strength LP medium, supplemented with 0.2% activated charcoal. Different induction periods and BA concentrations were assayed for shoot induction. After induction treatments, explants were elongated on the same medium used for germination stage. Rooting medium was quarter-strength LP medium supplemented with three different auxin treatments: $1.5mg\;L^{-1}$ 1-naphthalene acetic acid (NAA), $1.5mg\;L^{-1}$ indole-3-butyric acid (IBA) and $1mg\;L^{-1}$ IBA with $0.5mg\;L^{-1}$ NAA (MIX). The effect of the photon flux ($120mmol\;m^{-2}\;s^{-1}$ and darkness) in the first week of the explants in the rooting media was also tested. This methodology could offer an alternative to overcome some problems associated with somatic embryogenesis such as the seasonality of embryogenic tissue (ET) initiation or a low embryo production from the ET, a particularly important issue in the case of genetically transformed ETs.

A Study on the Antigen Characteristics of Rhodotorula rubra (Rhodotorula rubra의 항원특성에 관한 연구)

  • Kwon, Hyuk-Ku;Lee, Jang-Hoon;Ryeon, Kon
    • Journal of Environmental Health Sciences
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    • v.28 no.5
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    • pp.28-34
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    • 2002
  • Antigenicity of Rhodotrula rubra isolated from pulmonary tissue of pulmonary tuberculosis patients was studied by means of agglutination reaction with R. rubra whole cell antiserum. And the serological reactivity of crude polyfac charide from R. frubra, Candida albicans, Candida tropicalis, Candida, glabrata, and Saccharomyces cerevisiae ATCC 26603 with antiserum to R. rubra whole cell was studied by means of immunodiffusion test. R. rubra showed stationary phase after 48h when it was cultured in GYEP broth. While agglutinogen titer was 1:64 at lag phase, agglutinogen titer was 1 :256 after 20h. After growth of R. rubra on different 11 media, nutritional environment showed similar agglu-tination reartivity. The agglutinogen titer of C. albicans, C. tropicalis, C. giabrata, which were isolated from patient's expectoration, to R. rubra antiserum by means of agglutination reaction were 1:16, respectively. But, Sacch. cervisiae ATCC26603 was negative. Those results were lower than that of R. rubra agglutinogen titer 1:256. As a result of immu-nodiffusion test with crude polysaccharide extracted from cell wall of R. rubra, C. albicans, C. tropicalis, C. glabrata, Sacch. cervisiae ATCC26603, precipitin line was found only with R. rubra, of which antibody titer was 8.

Backup Software for SAN with NDMP (SAN환경에서 NDMP를 이용한 백업소프트웨어)

  • 복경수;황홍연;송석일;유재수
    • Journal of KIISE:Computing Practices and Letters
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    • v.9 no.4
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    • pp.455-469
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    • 2003
  • Recently, as new technologies such as SAN and NAS come into wide use to deal with a large amount of data, an efficient backup software for SAN and NAS is very required. In this paper, we design and implement a backup software for SAN that fully supports NDMP. The NUMP is an open standard protocol for network-based backup. The proposed backup software has various unique features such as SAN based tan free backup, automatic and manual backup, on-line backup by using snap shot, file-system, raw-device, database backup and so on. The proposed backup software also can be configured as a backup center that uses SAN as a backup media.

A Study on the expression method in the internet of design with experimental magazine(street magazine or experimental magazine of printed media) - Focused the ttl magazine, Paper, web-zine Sponge - (실험적 잡지(스트리트매거진, 또는 인쇄매체의 실험적 잡지) 디자인의 인터넷에서의 표현방법에 관한 연구 - ttl 매거진, Paper, 웹진 Sponge의 디자인 사례 분석을 중심으로 -)

  • 황상미;최인규
    • Archives of design research
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    • v.15 no.4
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    • pp.15-24
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    • 2002
  • Today, as era of Internet competition, experimental magazines-created especially for young adult group-are also trying to convert themselves into a internet magazines. This study intends to find out contents format and visual expression that should be considered for on-line conversion of these magazines. The industry's leading experimental magazines, for example, 'ttl', 'Paper', and 'webzine sponge' which co-exist in both printed and web-based format are to be examined by their contents, typography, colors, pictures& illustrations and others. This study intends to exam and suggest possible contents format and visual expression which they ought to evolve with.

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A Study of Evolution of the Librarian Job (사서직 업무변화에 관한 연구)

  • Ahn, In-Ja
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.16 no.1
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    • pp.233-246
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    • 2005
  • The evolution of librarian job is influenced by the change of paradigm in library. in theses days, a "good job" is the job that is sensing the changes and applying them in the field. The research is the comparison between '70s and 80s' and 21st century's tasks as a librarian; the law of library, the standards, the influence of department on library and job analysis. The results; the number of technical services have been reduced while professional information services increased as well as media resources. This is because they are trying to satisfy all kind of users. The librarians are acquiring of digital resources, preserving the resources, preparing on-line access, cooperating with other information centers to adjust the great increase of work in digital library.

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Research on control 'Jump' of 3D MMORPG (3D MMORPG의 '점프' 조작에 관한 연구)

  • Bae, Sung-Han;Kim, Myoung-Ho;Lee, Myoung-Hwak
    • Journal of Korea Game Society
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    • v.8 no.4
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    • pp.55-63
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    • 2008
  • 'Jump' control is one of several game controls using mainly in 2D game, and 'Jump' control is also very important in 3D game that has been developed steadily due to the advance of programing technology. 3D MMORPG among some kinds of 3D games is the most popular as on-line game in domestic game market these days. This study will give domestic game developers ideas and solutions through analyzing and testing problems caused by applying 'Jump' control technique as control interface of 3D MMORPG game.

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Lane Spline Generation Using Edge Detection Robust to Environmental Changes (외부 환경 변화에 강인한 에지 검출을 통한 차선의 스플라인 생성)

  • Kwon, Bo-Chul;Shin, Dongwon
    • Journal of Broadcast Engineering
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    • v.17 no.6
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    • pp.1069-1079
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    • 2012
  • Lane detection with the use of a camera is an essential task required for the development of advanced driving assistance system. In this paper, edges of the lane are generated by applying Canny's method. The edge detection usually makes different results for several environmental conditions depending on the clearness of lane quality, so that it sometimes causes wrong lane detection. Therefore, we propose robust algorithm to environmental changes that automatically adjusts parameter for edge detection and generates edges more stably. Based on the acquired edges, we finally generate the spline curve of lane by using Catmull Rom spline.