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http://dx.doi.org/10.4046/trd.2014.76.5.245

Multidrug-Resistant Tuberculosis Presenting as Miliary Tuberculosis without Immune Suppression: A Case Diagnosed Rapidly with the Genotypic Line Probe Assay Method  

Ko, Yousang (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Lee, Ho Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Lee, Young Seok (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Song, Junwhi (Department of Pulmonology, Samsung Changwon Medical Center, Sungkyunkwan University School of Medicine)
Kim, Mi-Yeong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Lee, Hyun-Kyung (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Shin, Jeong Hwan (Department Laboratory Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Choi, Seok Jin (Department Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine)
Lee, Young-Min (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.76, no.5, 2014 , pp. 245-248 More about this Journal
Abstract
Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.
Keywords
Tuberculosis; Multidrug-Resistant; Tuberculosis; Miliary; Molecular Probe Techniques;
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