• Title/Summary/Keyword: offspring

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Failure of Toxoplasma - Vaccination in Mice Born to Immune Mothers (Toxoplasma 면역모체로 부터 출산된 신생마우스에 있어서 Vaccination 효능 저하)

  • Lee, Jeong-Ho;Ha, Tai-You
    • The Journal of the Korean Society for Microbiology
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    • v.20 no.1
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    • pp.103-107
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    • 1985
  • Female ICR mice were vaccinated against Toxoplasma gondii(RH strain), infected 2 weeks later and after recovery mated to normal ICR males. Control matings were with normal ICR females. The progeny of the above matings were weaned at 1 week, vaccinated at 1, 2, 3, 4 or 5 weeks of age and infected 2 weeks later with lethal Toxoplasma tachyzoites. As assessed by survival, the effectiveness of vaccination among offspring of vaccinated-recovered mothers was greatly impaired than that of control mice, with respective of age : where mice did survive, recovery was greatly delayed relative to the controls. The protective effect of vaccination among infants born to control mothers was also blocked by maternal specific antibodies, by administration of high-titered specific antibodies or by transfer of nylon wool adherent immune-spleen cells, but was augmented by transfer of nylon wool passed immune-spleen cells. These results indicate that this impairment of vaccination may be due to the transmission of maternal specific antibodies to the offspring which acts to suppress both priming by the vaccine and the generation of parasite-specific helper T cells.

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Hybrid Genetic Algorithms for Solving Reentrant Flow-Shop Scheduling with Time Windows

  • Chamnanlor, Chettha;Sethanan, Kanchana;Chien, Chen-Fu;Gen, Mitsuo
    • Industrial Engineering and Management Systems
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    • v.12 no.4
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    • pp.306-316
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    • 2013
  • The semiconductor industry has grown rapidly, and subsequently production planning problems have raised many important research issues. The reentrant flow-shop (RFS) scheduling problem with time windows constraint for harddisk devices (HDD) manufacturing is one such problem of the expanded semiconductor industry. The RFS scheduling problem with the objective of minimizing the makespan of jobs is considered. Meeting this objective is directly related to maximizing the system throughput which is the most important of HDD industry requirements. Moreover, most manufacturing systems have to handle the quality of semiconductor material. The time windows constraint in the manufacturing system must then be considered. In this paper, we propose a hybrid genetic algorithm (HGA) for improving chromosomes/offspring by checking and repairing time window constraint and improving offspring by left-shift routines as a local search algorithm to solve effectively the RFS scheduling problem with time windows constraint. Numerical experiments on several problems show that the proposed HGA approach has higher search capability to improve quality of solutions.

The Effect of Exogenous $Telazol^{\circledR}$ on the Reproduction in Pregnant Rat ($Telazol^{\circledR}$ 투여가 임신 Rat의 생식에 미치는 영향)

  • 윤은희;김영홍
    • Journal of Veterinary Clinics
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    • v.16 no.1
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    • pp.42-49
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    • 1999
  • The reproductive effect of $Telazol^{\circledR}$ was studied in pregnant rats. Two different doses (20 or 40 mg/kg/day) were injected on days one of 3, 5 or 8 of pregnancy and 3 consecutive days of 3~5 or 5~7 in pregnant rats. On days 8 or 21, the rats were anesthetized, the cesarean section was performed, the uterus was carefully examined, and the numbers of corpora lutea, implantation sites and viable fetuses, fetal and placental weights and pre-and post-implantation losses in rats were surveyed. Simultaneously the concentrations of sodium and potassium of the plasma, uterine and amniotic fluids were determined. And gestation period in pregnant rats, postnatal offspring survival and body weight gains were evaluated. Administration of $Telazol^{\circledR}$ did not exert a bad influence upon body weight gains in pregnant rats. Reproductive indices were normal. The concentrations of sodium and potassium of the plasma, uterine and amniotic fluids in pregnant rats remained unchanged. Gestation period of rats, postnatal offspring survival and body weight gains were normal. It is concluded that $Telazol^{\circledR}$ is devoided of significant adverse reproductive effects in pregnant rats.

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Current Status and Prospects of Nuclear Transplantation Technology for Production of Cloned Animals (복제동물 생산을 위한 핵이식기술의 개발 현황과 전망)

  • 이효종
    • Journal of Veterinary Clinics
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    • v.16 no.1
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    • pp.163-176
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    • 1999
  • The nuclear transplantation technique is known as the most potential and efficient method for producing large numbers of genetically identical animals from a single embryo and somatic cells. After Dolly was introduced in 1997, many scientists were amazed. A possibility came to a reality that live offspring could be produced with differentiated somatic cells from an adult animal. On the other side, many in the press and the sensationalists focused on the socially, ethically and scientifically unacceptable sides of the technology. In this article, the history, current status and prospects of the technological development of nuclear transplantation in mammals and its application to the production of cloned animals are described. For the efficient and successful production of cloned embryos by nuclear transplantation, the right selection, preactivation and micromanipulation of oocytes as capacious recipient cytoplasm, the adequate and benefitial preparation of multiple totipotent embryonic and somatic cells as donor nuclei, fusion of them and in vitro production of cloned embryos are very critical. Recently the overall efficiency of production of cloned embryos and offspring in livestock has been much improved. Cloning will also be a more efficient, faster and useful way of creating transgenic fetuses for gene therapies, gene pharming, organs for xenotransplantation by preselection and mass production of transgenic embryos and consequently improving the production efficiency in transgenic animals. Further technical development of nuclear transplantation will enable large-scale production of cloned livestock and in near future the commercial cloning of animals will become a reality.

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Characterization of Host Specificity and Reproductive Compatibility Among Different Isolates of Belonolaimus longicaudatus in Southeastern United States (미국 동남부지역에 분포하는 Belonolaimus longicaudatus 개체군들간의 기주특이성과 생식교합능력 비교)

  • Han, Hye-Rim;Donald, W. Dickson
    • The Korean Journal of Soil Zoology
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    • v.9 no.1_2
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    • pp.12-15
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    • 2004
  • Five isolates of Belonolaimus longicaudatus collected from different geographical locations and hosts in southeastern United Stated were tested to determine their host specificity and reproductive compatibility. Both the Georgia and Lake Alfred isolates reproduced well on cotton, bermudagrass, and citrus. On the other hand, the North Carolina and Gainesville isolates reproduced poorly on all crops. The Hastings isolate reproduced well on cotton and potato. The Lake Alfred and Hastings isolates showed greater host specificity to their original host of citrus and potato, respectively. Except for the Hastings isolate, all isolates reproduced poorly on potato, which clearly differentiated the Hastings isolate from others (P>0.05). Hybridization test presented reproductive compatibility among five different isolates of B. longicaudatus by generating F$_1$ offspring. The Gainesville males showed comparatively poor ability to fertilize other females and generated a lower number of offspring. In contrast, the North Carolina males were attracted by all the other isolates of sting nematode, and produced the highest number of juveniles.

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A Study on the Correlation between the Types of Leisure Activity and Depression in the Elderly - in Bukgu District, Daegu City - (노인의 우울증과 여가활동의 상관성에 관한 연구 - 대구시 북구를 중심으로 -)

  • Kwon, Won-An;Kim, Han-Soo
    • The Journal of Korean Physical Therapy
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    • v.20 no.4
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    • pp.51-59
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    • 2008
  • Purpose: The aim of this study was to evaluate the correlation between the types of leisure activity and Korean form of geriatric depression score in the elderly. Methods: We surveyed elderly (>60 years old) people who participated in leisure activities using interviews in Bukgu district, Daegu city. Data collection was performed from 1 - 31 May, 2008. The data was analyzed with SPSS 12.0 program, which was used for descriptive statistics and Pearson correlation analysis. Results: Common leisure activities scored 'often' and 'very often' were family conversations, offspring visiting, eating out, plant cultivation, entertainment, conversation, walking or jogging, and TV or radio. It was investigated at the rate of 19.2% in the moderate depression and 8.3% in the severely depression. Depression positively associated with newspaper or magazine, family conversation, offspring visiting, social service, movie & theater, exercise and tour. Conclusion: Most elderly people surveyed indicated they were depressed, which should recommend significant leisure activities for elderly to reduce depression in Bukgu district, Daegu city.

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