• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2238-2246
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• 2012

Molecular dynamics simulations have been performed to investigate hydrogen bonding characteristics of hydroxyl groups in glucose aqueous solutions with different concentrations. The hydrogen bonding abilities and strength of different O and H atom types have been calculated and compared. The acceptor/donor efficiencies have been predicted and it has been found that: (1) O2-HO2 and O3-HO3 are more efficient intramolecular hydrogen bonding acceptors than donors; (2) O1-HO1, O4-HO4 and O6-HO6 are more efficient intramolecular hydrogen bonding donors than acceptors; (5) O1-HO1 and O6-HO6 are more efficient intermolecular hydrogen bonding acceptors than donors while hydroxyl groups O2-HO2 and O4-HO4 are more efficient intermolecular hydrogen bonding donors than acceptors. The hydrogen bonding abilities of hydroxyl groups revealed that: (1) the hydrogen bonding ability of OH2-$H_w$ is larger than that of hydroxyl groups in glucose; (2) among the hydroxyl groups in glucose, the hydrogen bonding ability of O6-HO6 is the largest and the hydrogen bonding ability of O4-HO4 is the smallest; (3) the intermolecular hydrogen bonding ability of O6-HO6 is the largest; (4) the order for intramolecular hydrogen bonding abilities (from large to small) is O2-HO2, O1-HO1, O3-HO3, O6-HO6 and O4-HO4.

• Biomolecules & Therapeutics
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• v.29 no.1
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• pp.73-82
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• 2021

Hsp90 is often overexpressed with activated form in cancer cells, and many key cellular proteins are dependent upon the Hsp90 machinery (these proteins are called "client protein"). Nowadays, more client proteins and more inhibitors of Hsp90 are being discovered. Chaetocin has been identified as an inhibitor of histone methyl transferase SUV39H1. Herein, we find that Chaetocin is an inhibitor of Hsp90 which binds to the C-terminal of Hsp90α. Chaetocin inhibited a variety of Hsp90 client proteins including AMl1-ETO and BCL-ABL, the mutant fusion-protein in the K562 and HL-60 cells. SUV39H1 mediates epigenetic events in the pathophysiology of hematopoietic disorders. We found that inhibition of Hsp90 by Chaetocin and 17-AAG had ability to induce degradation of SUV39H1 through proteasome pathway. In addition, SUV39H1 interacted with Hsp90 through co-chaperone HOP. These results suggest that SUV39H1 belongs to a client protein of Hsp90. Moreover, Chaetocin was able to induce cell differentiation in the two cells in the concentration range of Hsp90 inhibition. Altogether, our results demonstrate that SUV39H1 is a new client protein of Hsp90 degradated by Chaetocin as a novel C-terminal inhibitor of Hsp90. The study establishes a new relationship of Chaetocin and SUV39H1, and paves an avenue for exploring a new strategy to target SUV39H1 by inhibition of Hsp90 in leukemia.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.240-249
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• 2021

Phenotypic plasticity is a rapid response mechanism that enables organisms to acclimate and survive in changing environments. The Chinese mitten crab (Eriocheir sinensis) survives and thrives in different and even introduced habitats, thereby indicating its high phenotypic plasticity. However, the underpinnings of the high plasticity of E. sinensis have not been comprehensively investigated. In this study, we conducted an integrated gut microbiome and muscle metabolome analysis on E. sinensis collected from three different environments, namely, an artificial pond, Yangcheng Lake, and Yangtze River, to uncover the mechanism of its high phenotypic plasticity. Our study presents three divergent gut microbiotas and muscle metabolic profiles that corresponded to the three environments. The composition and diversity of the core gut microbiota (Proteobacteria, Bacteroidetes, Tenericutes, and Firmicutes) varied among the different environments while the metabolites associated with amino acids, fatty acids, and terpene compounds displayed significantly different concentration levels. The results revealed that the gut microbiome community and muscle metabolome were significantly affected by the habitat environments. Our findings indicate the high phenotypic plasticity in terms of gut microbiome and muscle metabolome of E. sinensis when it faces environmental changes, which would also facilitate its acclimation and adaptation to diverse and even introduced environments.

• Proceedings of KOSOMES biannual meeting
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• 2017.04a
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• pp.159-159
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• 2017

• Journal of Engineering Education Research
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• v.20 no.1
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• pp.63-68
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• 2017

This research is as a case study of innovative engineering education system through idea factory of korea maritime and ocean university and deals with development of temperature-humidity control device (THCD) for fiber storage on composites in viewpoint of problem solving method. Fiber reinforced plastic (FRP) includes many variables on the composite manufacturing process. Above all, the interfacial adhesion between the fiber and the matrix acts as an important thing that decided mechanical property of the FRP, and also it is profoundly linked to external temperature and relative humidity. High void fraction leads to a result in interlaminar fracture. Therefore, in this research, to establish correlation between fiber reinforcement and fiber storage conditions of temperature and relative humidity we developed a THCD for fiber reinforcement. To evaluate performance of the THCD, glass fiber reinforced plastic (GFRP) is made under the extreme conditions each temperature $34^{\circ}C$, relative humidity 98 % and it can be said that there are the change of mechanical properties according to fiber storage conditions. As a result, the THCD showed sufficient possible application for understanding and applied research of composites field in material engineering. Also, we could check that the necessity of introduction of innovative system such as idea factory existed.

• Journal of Fisheries and Marine Sciences Education
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• v.14 no.2
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• pp.161-176
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• 2002

GIS (geographic information system) is a relatively new tool in the coastal and ocean area management toolbox, but its uses and functionality are quickly being recognized. GIS can help identity potential threats to coastal and ocean resources and evaluate alternative land-use and management practices. The application of GIS to coastal and ocean issues continues to grow as the general use of GIS matures. GIS software and technicians with the skills to apply GIS are now commonplace at federal, state and local government agencies as well as many NGOs and the private sector. However, these applications were focused on their special purposes. Therefore, we describe the management strategy of marine GIS and its components. The results of this study can be used as the fundamental guideline for the coastal and ocean management and sustainable development.

• The Journal of the Acoustical Society of Korea
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• v.28 no.2E
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• pp.51-59
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• 2009

Mutual radiation impedance becomes more important in the design and analysis of acoustic transducers for higher power, better beam pattern, and wider bandwidth at low frequency sonar systems. This review paper focused on literature survey about the researches of mutual radiation impedance in the acoustic transducer arrays over 60 years. The papers of mutual radiation impedance were summarized in terms of transducer array structures on various baffle geometries such as planar, cylindrical, spherical, conformal, spheroidal, and elliptic cylindrical arrays. Then the computation schemes of solving conventional quadruple integral in the definition of mutual radiation impedance were surveyed including spatial convolution method, which reduces the quadruple integral to a double integral for efficient computation.

• Journal of Fisheries and Marine Sciences Education
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• v.25 no.5
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• pp.1102-1109
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• 2013

An numerical analysis was performed to obtain the design parameters for parallel micro-channels. The parallel micro-channels consist of 10 square channels with a hydraulic diameter of 300 ${\mu}m$ and inlet/outlet manifolds. The channel length is 5mm, 10mm and 40mm respectively. Mass flux was set between 200~600kg/m2s as inlet boundary condition and atmospheric pressure was set as outlet boundary condition. The pressure drop in channels and manifolds were estimated by using the Shah and London correlation and the flow uniformity was represented by the velocity distributions with dimensionless velocity. The results show that the flow uniformity in channels depends on shapes of manifolds, length and mass flux.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.5
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• pp.1273-1279
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• 2016

Flow boiling pressure drop in multi channels was experimently investigated. The multi channel has a width and depth of 0.45 and 0.2mm respectively, and comprises 15 parallel channels. The measured total pressure drop is expressed by the sum of the frictional pressure drop and acceleration pressure drop. In order to predict the total pressure drop, it is required to obtain the correct frictional pressure drop. The existing correlations to predict the frictional pressure were compared with measured frictional pressure drop. The new correlation was developed in the form of the Chisholm correlation. It was related to Chisholm Constant B as a function of Martinelli parameter. The new correlation predicted the experimental data within a mean absolute error of 5.5%.

• Journal of Fisheries and Marine Sciences Education
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• v.16 no.2
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• pp.227-237
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• 2004

Recently development trends in information technology expand the activity boundaries for human living beyond coastal zones. These rapid changes of paradigm are stimulating scientists and strategists to be encouraged in making adequate model for marine geographic information system (MGIS) and their applications. Coastal zones are places which are affected by many factors, such as water quality, tide, wave, atmosphere, population, industry, etc. Therefore information related to the coast has to be integrated and analyzed for managing it efficiently. GIS-based Ocean Informatics is suited for those purposes and used in the study for establishing and managing coastal geographic and environmental information system. This paper reviews the properties of ocean and coastal spaces, then defines some MGIS related terminologies for clarifying the scope of MGIS boundaries. In this study, coastal geographic information is established by digital geographic information and digital terrain information. Digital coast chart having information on digital chart and map can merge and analyze various coastal information and can be a useful tool for the coastal integrated management.