• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.207-216
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• 2021

Supplement of high-protein food plays an important role in improving the symptoms of malnutrition and the immune capacity of the body, but the association of high-protein diet and gut microbiota remained unaddressed. Here, we systematically analyzed the internal organs and gut microbiota in C57(WT) or PD-1H-depleted (KO) mice (T cells were activated) fed with pupae or feed for six weeks. We observed that the body weight gain in the mice fed with pupae increased less significantly than that of the feed group, while the villi and small intestine lengths in the pupa group were reduced compared with that of mice given feed. However, the average body weight of the KO mice increased compared with that of the WT mice fed with pupae or feed. Pupae increased the concentration of blood glucose in WT, but not in KO mice. Moreover, in the feed group, there was no difference in the weight of the internal organs between the WT and KO mice, but in the pupae-fed group, liver weight was decreased and spleen weight was increased compared with that of KO mice. The amounts/plural/amounts of Melainabacteria, Chloroflexi, and Armatimonadetes were specifically upregulated by pupae, and this upregulation was weakened or eliminated by PD-1H depletion. Some bacteria with high abundance in the feed-fed KO mice, such as Deferribacteres, Melainabacteria, Acidobacteria, Bacteroidetes, Spirochaetes and Verrucomicrobia, were decreased in pupae-fed KO mice, and Proteobacteria and Deinococcus were specifically enriched in pupae-fed KO mice. Bacteroidetes, Firmicutes and Akkermansia were associated with weight loss in the pupae-fed group while Lachnospiraceae and Anaerobiospirillum were related glucose metabolism and energy consumption. Based on high-throughput sequencing, we discovered that some gut bacteria specifically regulated the metabolism of a high-protein diet, and PD-1H deficiency improved life quality and sustained blood glucose. Moreover, PD-1H responses to high-protein diet through modulating the type and quantity of gut bacteria. These findings provide evidence about the association among gut microbiota, T cell activation (for PD-1H depletion) and high-protein diet metabolism, have important theoretical significance for nutrition and health research.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.826-835
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• 2020

The purpose of this study was to examine the mediating effect of stress on the relationship between oral health behaviors and health-related quality of life (HRQOL) in the elderly. We analyzed 8148 subjects aged 65 or older who participated in the Korea National Health and Nutrition Examination Survey (2010-2015). All individuals were asked about their socioeconomic history, general health, and oral health behaviors (the frequency of tooth brushing, regular dental check-ups, and use of interdental cleaners). In the results, HRQOL was low in the elderly from a low socioeconomic class, or with diabetes mellitus, hypertension, or poor oral health behaviors. A partial mediating effect from stress was confirmed on the relationship between oral health behaviors and HRQOL. In conclusion, HRQOL was associated with oral health behaviors, with a mediating effect from stress. Therefore, it is necessary that a convergence health promotion program should be planned with an oral health education program and a stress management program for the elderly.

• Journal of the Korea Society of Computer and Information
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• v.26 no.8
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• pp.197-207
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• 2021

Relationship between bone mineral density (BMD) and type 2 diabetes is still inconsistent. Recently, many epidemiologic data show that fracture risk is increased in type 2 diabetic patients regardless of BMD status. In this study, we used nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) to analyze the BMD status in patients with type 2 diabetes compared to non-diabetics. We included subjects aged 50 years or older in men (N=2,959, 2,430 without diabetes, 529 with type 2 diabetes) and postmenopausal women (N=2,902, 2,479 without diabetes, 423 with type 2 diabetes). Subjects with history of medication for osteoporosis or with illness or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Serum was separated from peripheral venous blood samples obtained after 8 hours of fasting. BMD was measured at lumbar spine and femur using dual-energy X-ray absorptiometry (DXA). There was a significant positive association between lumbar spine BMD and type 2 diabetes after adjusting age, gender, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration by multiple regression analysis in all subjects. In the subgroup analysis by gender, this association was maintained both in male and female after adjusting those confounding factors. However, femur BMD was not different between type 2 diabetic and non-diabetic subjects. In conclusion, lumbar spine BMD was significantly higher in type 2 diabetic patients aged 50 years or more in men and postmenopausal women compared to non-diabetic subjects.

• Journal of the Korea Society of Computer and Information
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• v.26 no.8
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• pp.209-220
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• 2021

The effect of body composition such as lean mass and fat mass on bone mineral density (BMD) is complex and still controversial. In this study, we investigated the relationship between body composition and bone mineral density using nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) in 2,139 men and 2,193 postmenopausal women aged 50 years or older. Subjects with history of medication for osteoporosis or with diseases or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Fasting blood sample was obtained for blood chemistry analysis. BMD of the lumbar spine, total femur, and femoral neck, and body composition such as total lean mass (TLM), total fat mass (TFM), truncal fat mass (TrFM) were measured using dual-energy X-ray absorptiometry (DXA). There were significant positive correlations between body composition indices such as lean mass and fat mass with BMD. In multiple regression analysis, TLM was positively associated with BMD after adjusting age, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration in both men and postmenopausal women. BMD at lumbar spine and femur in lowest quartile of TLM was significantly lower than other quartiles after adjusting those confounding factors in both gender. TrFM was negatively associated with total femur BMD in male and femur neck BMD in postmenopausal women after adjusting confounding factors. In conclusion, TLM is very important factor in maintaining BMD in subjects aged 50 years or older in men and postmenopausal women.

• Journal of Naturopathy
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• v.11 no.2
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• pp.93-99
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• 2022

Background: It is necessary to understand the correlation between stress and depression according to eating habits in the elderly. Purposes: To empirically verify the mediating effect of eating habits in the relationship between stress and depression in the elderly. Methods: we distributed an 'online questionnaire' to men and women aged 60 or more living in large cities, medium, and small-sized cities in Korea using Google questionnaires, and 365 replies were collected and used for analysis. Results: First, we found that stress in the elderly directly affected depression. In summary, an increment in the stress level of the elderly induces an increment in the depression level. Second, the eating habits of the elderly indirectly mediated the relationship between stress and depression. Conclusions: This study is meaningful in that it has verified eating habits have a mediating effect on the relationship between stress and depression in the elderly, and healthy eating habits of individuals can reduce depression. Therefore, counseling institution must check their daily eating habits when counseling the degree of depression of the elderly. In addition, eating habits are affected by stress, and it is necessary to grasp the individual stress index for the elderly who has terrible eating habits. Furthermore, it is needed to provide continuous nutrition education in institutions and communities to have proper eating habits.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.51-59
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• 2021

This study was undertaken to identify factors that influence high-risk drinking among women. Seventh National Health and Nutrition Survey data were used, and 3,453 women aged 19 or older were studied. Subjects were divided into general and high-risk drinking groups according to high-risk drinking rate indicators, and these groups were compared to identify demographic and sociological characteristics, differences in health-related characteristics, and factors associated with high-risk drinking. The data analysis was performed using IBM SPSS 25.0. The analysis showed 8.8% of the cohort were high-risk drinkers, and that rates of high-risk drinking were higher among women in their 20s to 30s, smokers, and those with experience of depression. In particular, smoking, and depression were associated with a 4.5 [(95% confidence interval (CI)=2.804-7.372, p<0.001)] and 7.0-fold [(95% CI=2.918-16.855, p<0.001)] increases in rates of high-risk drinking. In addition, the risk of high-risk drinking was high among 15- to 19-year-olds, which indicates an urgent need to develop and implement drinking education programs for women in adolescence and early adulthood. We expect the results of this study to be used to create health policies and health promotion programs aimed at reducing the high-risk drinking rate among women.

• 한국체육학회지인문사회과학편
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• v.57 no.4
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• pp.375-386
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• 2018

Due to the rapid increase of the elderly population in Korea, there is a growing interest in 'Healthy Aging.' In this trend, it is important to identify the relationship between their lifestyle factors and quality of life. The purpose of this study was to identify the association of physical activity level, sedentary behavior and health-related quality of life (HRQoL) among Korean older adults. A total of 4,589 older adults at the Sixth and Seventh National Health and Nutrition Examination Survey was analyzed. The results showed that better HRQoL was observed among physically active older female, which was more evident among physically active female with central obesity while no such relationship was observed among older male. On the other hand, higher sedentary time was associated with lower HRQoL in both male and female subjects. Our analyses indicated that central obesity was closely related with HRQoL regardless of their physical activity levels in female subjects. Further analyses investigating association between sub-dimension of HRQoL and sub-domain of physical activity showed that higher transport physical activity was associated with better anxiety/depression score and higher sedentary time was associated with poorer score on mobility, usual activities among male and mobility, self-care, usual activity and anxiety/depression among female. Our finding suggests that physical activity level, sedentary behavior and central obesity associated with HRQoL.

• Journal of Food Hygiene and Safety
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• v.38 no.1
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• pp.26-30
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• 2023

In this study, we analyzed the microbial contamination level of ultraviolet sterilizer (UVS) chambers and suggested plans to improve hygiene management. In this study, UVS chambers targeted 98 UVS in some childcare centers in Jeollanam-do, Korea. Total aerobic bacteria and coliform bacteria were tested according to the Korean Food Code. Of the 98 UVS chambers, total aerobic bacteria were detected in 67 (68.4%) and coliform bacteria in 5 (5.1%). Six kinds of food-poisoning bacteria, including Salmonella spp., were not detected, but Bacillus cereus was detected in 1 (2.8%) out of 98 UVS chambers. According to the UV lamp replacement period, the detection rate of total aerobic bacteria was 3 (50%) out of 6 UVS within 3 months, 3 (60%) out of 5 UVS in 3 to 6 months, and 61 (70.1%) out of 87 UVS over 6 months. The detection rate of coliform bacteria according to the UV lamp replacement period was not detected within 6 months, however, they were detected in 5 (5.7%) out of 87 chambers after more than 6 months. The level of microbial contamination in the UVS chambers was higher as the lamp replacement period was longer. Considering these results, it was determined that the UVS chambers should be kept dry and clean, and the UV lamp should be replaced periodically. In addition, it is necessary to provide the staff catering for childcare centers with continuous education regarding the cleaning of UVS chambers and the replacement of UV lamps.

• 한국노년학
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• v.30 no.4
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• pp.1311-1327
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• 2010

This study was conducted to identify the relationship between depression and subjective/objective health status, and to examine predicting factors on depression in the elderly in Korea. This study was a secondary analysis using the data of Korea National Health and Nutrition Examination Survey(VI-1) 2007. A total of 939 data from the subjects ≥60 years who completed health-related survey were used for analysis. Data were analyzed using SAS (version 9.1) PC program. Depression was identified in the 20.3% of the older subjects. Multiple logistic regression analysis showed that women (OR=2.04), senior high school graduation (OR=0.27) and lowermiddle household income (OR=2.83) were significant associating factors(p<0.05). After adjustment for socio-demographic factors, hypertension (OR=1.93) and asthma (OR=3.32) as objective health status, and stress (OR=7.27), limited activity in daily living due to fracture or joint injury (OR=6.59) and poor self-rate health (OR=1.64) as subjective health status were found as factors predicting depression in the elderly(p<0.05). According to the type of health status, the subjects who had chronic disease or perceived poor physical health were 5.94 times more likely to have disposition to depression than the subjects who had no chronic disease or perceived good physical health (p=0.001). These findings suggest that preventive education and intervention focus on preventing and managing chronic diseases such as hypertension, asthma, fracture and joint injury should be needed to decrease depression in the elderly.

• The Journal of the Korea Contents Association
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• v.22 no.8
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• pp.347-357
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• 2022

This study was attempted to identify the health-related quality of life of Chronic Obstructive Pulmonary Disease (COPD) patients and factors influencing the quality of life, focusing on Health-related quality of life with 8 items (HINT-8). The subjects of this study were 451 adults aged 40 years or older who performed lung function tests and whose ratio is less than 0.7 by measuring forced respiratory volume in 1 second [FEV₁] to forced vital capacity in the 2019 National Health and Nutrition Examination Survey, It was analyzed using SAS program. As a result, both the HINT-8 index and EuroQol five-dimensions 3-level version (EQ-5D-3L) index were appropriate as tools to measure the health-related quality of life in COPD patients, and the factors affecting the health-related quality of life were age, gender, income, and smoking status, comorbidities, stress, and subjective health status. Therefore, in order to improve the health-related quality of life of COPD patients, an individualized management program suitable for the characteristics of subjects such as the low-income class and the elderly, including smoking cessation education and stress management, should be developed and applied.