• The Korean Journal of Nuclear Medicine
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• v.26 no.1
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• pp.72-81
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• 1992

Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life (< 10 seconds). The diagnostic accuracy and safety profile of adenosine $^{99m}Tc-MIBI$ myocardial scintigraphy were evaluated and comparison with exercise $^{99m}Tc-MIBI$ was performed. Twenty-eight subjects underwent $^{99m}Tc-MIBI$ imaging after adenosine infusion and exercise $^{99m}Tc-MIBI$ imaging. Adenosine was infused intravenously at a dose of 0.14mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate ($64{\pm}12$ at baseline versus $74{\pm}16$ beats/min at peak effect, p<0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression (> 1 mm) and second degree AV block in electrocardiography occured in 11% of the patients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, $^{99m}Tc-MIBI$ myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise $^{99m}Tc-MIBI$ scintigraphy.

• The Journal of Korean Society for Radiation Therapy
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• v.11 no.1
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• pp.53-59
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• 1999

The aim of this study is to improve the accuracy of field placement and junction between adjacent fields and block shielding through the use of a computed tomography(CT) simulator and virtual simulation. The information was acquired by assessment of Alderson Rando phantom image using CT simulator (I.Q. Xtra - Picker), determination of each field by virtual fluoroscopy of voxel IQ workstation AcQsim and colored critical structures that were obtained by contouring in virtual simulation. And also using a coronal, sagittal and axial view can determine the field and adjacent field gap correctly without calculation during the procedure. With the treatment planning by using the Helax TMS 4.0, the dose in the junction among the adjacent fields and the spinal cord and cribriform plate of the critical structure was evaluated by the dose volume histogram. The pilot image of coronal and sagittal view took about 2minutes and 26minutes to get 100 images. Image translation to the virtual simulation workstation took about 6minutes. Contouring a critical structure such as cribriform plate, spinal cord using a virtual fluoroscopy were eligible to determine a correct field and shielding. The process took about 20 minutes. As the result of the Helax planning, the dose distribution in adjacent field junction was ideal, and the dose level shows almost 100 percentage in the dose volume histogram of the spinal cord and cribriform plate CT simulation can get a correct therapy area due to enhancement of critical structures such as spinal cord and cribriform plate. In addition, using a Spiral CT scanner can be saved a lot of time to plan a simulation therefore this function can reduce difficulties to keep the patient position without any movements to the patient, physician and radiotherapy technician.

• Quality Improvement in Health Care
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• v.8 no.1
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• pp.10-21
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• 2001

Background : The Clostridium difficile is the most important identifiable cause of nosocomial infectious diarrhea and colitis, which lengthens hospital stay. Recently incidence of C. difficile has been increasing in an university hospital, and an intervention for prevention and control of C. difficile associated diarrhea (CDAD) was in prompt need. Methods : Subjects were the patients in the neurosurgical intensive care unit(NCU) where C. difficile was most frequently isolated. To increase participation of various departments, we used the CQI method, because management of CDAD requires a wholistic approach including control of antibiotics, barrier precaution and environmental cleaning and disinfection. Duration of the CQI activities was 9 months from April to December 1999. Results : The identified problems were misuse and overuse of antibiotics, lack of consciousness of medical personnels and the possibility of transmission from the contaminated environment and tube feeding. Education for proper use of antibiotics and management of C. difficile infection, use of precaution stickers, supplement of handwashing equipments, emphasis on environmental disinfection, and the change of the process of tube feeding were done. The CDAD rate in NCU was significantly decreased after the CQI program (8.6 case per 1,000 patient days from January to April 1999 vs 4.8 from May to December 1999). The distribution of neurosurgical wards including NCU among the total number of isolated C. difficile from the clinical specimens dropped from 49.4% in January to April to 33,7% in May to December. The average hospital stay of the neurosurgical department changed from 19.6 days to 15.2 days. Also, the effect of the CQI activities for C. difficile may have affected the incidence of vancomycin resistant enterococci (VRE). Duration and dosage of certain antibiotics used in the NS department were decreased. The distribution of neurosurgical department in the number of VRE isolated patients declined from 18.4% to 11.1%. Conclusion : Infection control of resistant organisms such as C. difficile is likely to be successful when management of environmental contamination an collaborative efforts of decreasing the patients' risk factors such as antibiotics management and decreasing the length of hospital stay come simultaneously. For this work, related departments need to actively participate in the entire process under a common target through discussions for identifying problems and bringing up solutions. In this respect, making use of a CQI team is an efficient method of infection control for gathering participation and cooperation of related departments.

• Journal of KIISE:Information Networking
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• v.34 no.6
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• pp.435-445
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• 2007

Snoop protocol is one of the efficient schemes to compensate TCP packet loss and enhance TCP throughput in wired-cum-wireless networks. However, Snoop protocol has a problem: it cannot perform local retransmission efficiently under the bursty-error prone wireless link. To solve this problem, SACK-Aware-Snoop and SNACK mechanism have been proposed. These approaches improve the performance by using SACK option field between base station and mobile host. However in the wireless channel with high packet loss rate, SACK-Aware-Snoop and SNACK mechanism do not work well because of two reason: (a) end-to-end performance is degraded because duplicate ACKs themself can be lost in the presence of bursty error, (b) energy of mobile device and bandwidth utilization in the wireless link are wasted unnecessarily because of SACK option field in the wireless link. In this paper, we propose a new local retransmission scheme based on Cross-layer approach, called Cross-layer Snoop(C-Snoop) protocol, to solve the limitation of previous localized link layer schemes. C-Snoop protocol includes caching lost TCP data and performing local retransmission based on a few policies dealing with MAC-layer's timeout and local retransmission timeout. From the simulation result, we could see more improved TCP throughput and energy efficiency than previous mechanisms.

• Journal of Sasang Constitutional Medicine
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• v.23 no.3
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• pp.351-360
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• 2011

1. Objective: This study was designed to analyze the characteristics of each Sasang constitutional type using the Temperament and Character Inventory (TCI). 2. Methods: A total of 135 healthy subjects (age 19-30) participated in this study, consisting of 35 Soyang-type, 66 Taeeum-type, 30 Soeum-type, and 4 Taeyang-type subjects. A Sasang Constitutional Medicine specialist determined each subject's Sasang constitutional type based on the Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD) and comprehensive constitutional assessment. The subjects were also asked to complete the TCI. 3. Results: Among the four temperament dimensions, the Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Novelty Seeking (NS). The Soeum-type subjects showed significantly higher scores than the Taeum- and Soyang-type subjects in Harm Avoidance (HA) (Soeum type > Taeeum type > Soyang type). The Soyang-type subjects showed significantly higher scores than the Soeum-type subjects in Reward Dependence (RD). The Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Persistence (P). Among the three character dimensions, the Soyang-type subjects showed significantly higher score than the Taeeumand Soeum-type subjects in Self-Directedness (SD) (Soyang type > Taeeum type > Soeum type). The Soyang-type showed significantly higher scores than the Taeeum-type in Cooperativeness (C). 4. Conclusions: Differences in temperament and character were discovered across the Sasang constitutional types. The Sasang constitutional characteristics should be investigated in larger studies in the future. Similar studies could add to the growing knowledge of Sasang constitutional typology and contribute to a more accurate Sasang constitutional diagnosis.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.10 s.352
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• pp.79-89
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• 2006

TCP is the most widely used transport protocol in Internet applications that guarantees a reliable data transfer. But, in the wireless multi-hop networks, TCP performance is degraded because it is designed for wired networks. The main reasons of TCP performance degradation are contention for wireless medium at the MAC layer, hidden terminal problem, exposed terminal problem, packet losses in the link layer, unfairness problem, reordering problem caused by path disconnection, bandwidth waste caused by exponential backoff of retransmission timer due to node's mobility and so on. Specially, in the mobile ad-hoc networks, discrepancy between a station's transmission range and interference range produces hidden terminal problem that decreases TCP performance greatly by limiting simultaneous transmission at a time. In this paper, we propose a new MAC algorithm for mobile ad-hoc networks to solve the problem that a node can not transmit and just increase CW by hidden terminal. In the IEEE 802.11 MAC DCF, a node increases CW exponentially when it fails to transmit, but the proposed algorithm, changes CW adaptively according to the reason of failure so we get a TCP performance enhancement. We show by ns-2 simulation that the proposed algorithm enhances the TCP performance by fairly distributing the transmission opportunity to the failed nodes by hidden terminal problems.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.9
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• pp.11-20
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• 2014

For Web-based applications in IoT environment, IETF CoRE WG has standardizing the CoAP. One of limitations of CoAP is that CoAP standard does not consider the mobility management of the CoAP sensor node. In this paper, we propose the mobility management protocol of CoAP sensor node by considering the characteristics of the constrained network. The proposed mobility management protocol supports for Web client to be transmitted the sensing data from CoAP node reliably while the CoAP sensor moves into different wireless networks. To do this, we designed the architecture with the separate IP address management of CoAP sensor node and presented the mobility management protocol, which includes the holding and binding mode, in order to provide the reliable transmission. Finally, the numerical analysis and simulation with NS2 tool have been done for the performance evaluation in terms of the handover latency and packet loss with comparing the proposed mobility management protocol with other the existing mobility management protocols. The performance result shows that the proposed mobility management can provide the transmission of sensing data without the packet loss comparing with the existing mobility management protocol reliably.

• Journal of Navigation and Port Research
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• v.44 no.4
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• pp.347-353
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• 2020

Aids to Navigation (AtoN) contribute to preventing marine accidents and protecting marine environment by providing various information such as location information etc. to ships. Recognizing the importance of the AtoN, a 24 won of the AtoN service fee is charged for ships entering and leaving international trade ports. However, while the 24 won of the AtoN service fee has been maintained since its establishment in 1999, the demand for new roles of the AtoN service for autonomous shipping and smart port operations, etc. has gradually increasing with the change of shipping and port 4.0. Thus the purpose of this study was to estimate the appropriate level of the AtoN service fee in accordance with such changes in the shipping and port industries. To accomplish this, a method of recovering the total cost was introduced to the PROOF (Pyeongtaek Regional Office of Ocean and Fisheries). It is estimated that there are four cases in which estimation of the AtoN service fee is estimated in two cases year by year and conversion year, the AtoNs of PROOF are classified into the all and part of a ship using the trade port. As a result of the estimation, the AtoN service fee of PROOF is estimated at 53.78-71.62 won (as of 2019), and 29.78-47.62 won is higher than the today at 24 won. The results of this study can be used as useful basic data for the operation of budgets and policy management considering the role of the AtoN.

• The Korean Journal of Community Living Science
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• v.21 no.4
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• pp.571-579
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• 2010

Jeupjang has long been considered only a local delicacy. So, it has gradually been forgotten because its name and definition have not been established. This study was performed in order to provide some basic data by comparing the general components, color, free amino acids, free sugar, organic acids and antioxidant activities between commercial Jeupjang(GG, GD, JM, NJ, NS). Moisture contents, crude protein, crude fat and crude ash contents of Jeupjang were 48.07~61.77%, 4.08~10.53%, 3.92~4.64%, and 3.63~9.95%. pH, titrable acidity and salt in Jeupjang were 4.32~5.50, 9.37~14.82 mL(1N-NaOHmL), and 3.27~8.90%. Amino-type nitrogen content is 42.05~ 138.83mg%. Lightness(L), redness(a) and yellowness(b) values in color of Jeupjang were10.04~21.89, 18.92~28.80, and 17.16~37.56. The total content of free amino acids in commercial Jeupjang ranged from 35.22mg% to 306.02mg% in which it showed wide variation among samples. The major free amino acids were glutamic acid, aspartic acid, alanine and proline. The major free sugars were fructose(0.31~1.60%), glucose(6.20~ 13.61%) and maltose(7.34~10.01%). The major organic acids were succinic acid(29.08~ 103.62 mg%) and citric acid(3.08~108.69 mg%). Total polyphenol contents were from 1.16 mg/g to 1.78 mg/g, DPPH radical scavenging activity is from 0.57 AEAC to 1.53 AEAC and ABTS radical scavenging activity is from 1.58 AEAC to 2.85 AEAC. This result might cause the differences of soybean composition, processing methods and brewing periods. For the succession of traditional fermented food such as Jeupjang, quality standards are required. To this end, the standardization of manufacturing processes must be followed.

• Toxicological Research
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• v.34 no.3
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• pp.221-229
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• 2018

Tenofovir nanoparticles are novel therapeutic intervention in human immunodeficiency virus (HIV) infection reaching the virus in their sanctuary sites. However, there has been no systemic toxicity testing of this formulation despite global concerns on the safety of nano drugs. Therefore, this study was designed to investigate the toxicity of Tenofovir nanoparticle (NTDF) on the liver and kidney using an animal model. Fifteen adult male Sprague-Dawley (SD) rats maintained at the animal house of the biomedical resources unit of the University of KwaZulu-Natal were weighed and divided into three groups. Control animals (A) were administered with normal saline (NS). The therapeutic doses of Tenofovir (TDF) and nanoparticles of Tenofovir (NTDF) were administered to group B and C and observed for signs of stress for four weeks after which animals were weighed and sacrificed. Liver and kidney were removed and fixed in formal saline, processed and stained using H/E, PAS and MT stains for light microscopy. Serum was obtained for renal function test (RFT) and liver function test (LFT). Cellular measurements and capturing were done using ImageJ and Leica software 2.0. Data were analysed using graph pad 6, p values < 0.05 were significant. We observed no signs of behavioural toxicity and no mortality during this study, however, in the kidneys, we reported mild morphological perturbations widening of Bowman's space, and vacuolations in glomerulus and tubules of TDF and NTDF animals. Also, there was a significant elevation of glycogen deposition in NTDF and TDF animals when compared with control. In the liver, there were mild histological changes with widening of sinusoidal spaces, vacuolations in hepatocytes and elevation of glycogen deposition in TDF and NTDF administered animals. In addition to this, there were no significant differences in stereological measurements and cell count, LFT, RFT, weight changes and organo-somatic index between treatment groups and control. In conclusion, NTDF and TDF in therapeutic doses can lead to mild hepatic and renal histological damage. Further studies are needed to understand the precise genetic mechanism.