• 생물정신의학
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• 제24권4호
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• pp.219-224
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• 2017

Objectives This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence. Methods The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT). Results Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients. Conclusions These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.

• The Korean Journal of Physiology and Pharmacology
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• 제9권3호
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• pp.159-164
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• 2005

Effects of antioxidants on the established nephropathy were investigated. The experimental nephropathy was induced in rats by intravenous injection of adriamycin (2 mg/kg). Six weeks later, when proteinuria was apparent, the rats were supplemented with N-acetylcysteine (NAC, 1 g/kg/day) in drinking water for additional 6 weeks. Glomerulosclerosis score and tubulointerstitial injury index were determined by light microscopy. Expression of transforming growth factor (TGF) ${\beta}1$ and laminin ${\beta}1$ was determined in the renal cortex by reverse transcription-polymerase chain reaction, Western blotting, immunohistochemistry, and immunogold electron microscopy. The adriamycin-induced proteinuria as well as the glomerulosclerosis and tubulointerstitial injury was ameliorated by the treatment with NAC. Adriamycin increased the expression of TGF ${\beta}1$ mRNA and protein, which was ameliorated by NAC. Although the expression of laminin ${\beta}1$ mRNA was increased, adriamycin did not significantly alter that of its protein. These results indicate that antioxidants ameliorate the established nephropathy in association with normalization of overexpressed TGF ${\beta}1$.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1997년도 봄 학술발표회 논문집
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• pp.161-168
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• 1997

The purpose of this study is to evaluate the possibility of normalization of the distibutions of soil parameters taken from soft ground and the reliability of the safety factors of specific objects on it, including sanitary landfill. Through this study it is found that distributions of soil parameters could be adjusted to appropriate normal distributions as possibility density functions(PDF), and that especially the group of initial cohesions and the coresponding safety factors has a perfect linear correlation. According to those results the PDF to initial cohesion as possibility parameter can not only be tmsformed to the PDF to safety factor but also, conseqently, the reliability of the safety factor(SF) simply based on the mean value of soil parameter(Co) can be calculated or easily picked up from the standrad normal distribution table. It is therefore concluded that even though calculated values of safety factors are over any standard requirements some possibility of risk both to the objects and natural soft ground could be still existing, and also a new standard value for this slope stability control system should be derived just by adjusting old one according to the magnitude of risk possibility.

• 한국습지학회지
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• 제25권1호
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• pp.64-73
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• 2023

2022년 이전에는 하천 관리 주체가 이원화되어 생태하천 복원사업을 계획 및 시행하는 과정에서 많은 혼선이 발생하였다. 이로 인해 하천 수생태계 건강성이 확보되지 못하였다. 그러나 2022년 환경부가 생태하천 복원사업을 주관하게 되며, 하천 수생태계 건강성 확보는 복원사업에서 필수적인 요소가 되었다. 따라서 본 연구에서는 기수역과 람사르 습지가 위치하여 하천 수생태계 건강성 확보가 필수적인 한강하구 지역을 대상으로 복원사업이 필요한 하천 구역을 선정하였다. 우선, 생태하천 복원사업의 세부 조사항목을 기반으로 하천의 물리적, 화학적, 공간/인문학적, 수생태계 건강성 평가지수를 산정하였다. 산정된 평가지수에 순위정렬(ranking), 스케일 재조정(re-scaling), z 점수(z-score), t 점수(t-score) 표준화(normalization) 방법을 적용하였으며, 도출된 값을 비교·분석하였다. 이후 각 평가지수에 엔트로피 가중치 방법(entropy weight method)을 적용하였다. 해당 과정을 통해 한강하구 지역 내에서 수생태계 건강성 확보를 목적으로 복원사업이 요구되는 하천(목감천, 안양천 등)을 선정하였다. 본 연구의 결과는 생태하천 복원사업의 우선순위를 선정하는 과정에서 기초연구 자료로 활용될 수 있을 것이다.

• 전기전자학회논문지
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• 제22권1호
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• pp.14-20
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• 2018

The purpose of training a convolutional neural network (CNN) is to obtain weight factors that give high classification accuracies. The initial values of hyper-parameters affect the training results, and it is important to train a CNN with a suitable hyper-parameter set of a learning rate, a batch size, the initialization of weight factors, and an optimizer. We investigate the effects of a single hyper-parameter while others are fixed in order to obtain a hyper-parameter set that gives higher classification accuracies and requires shorter training time using a proposed VGG-like CNN for training since the VGG is widely used. The CNN is trained for four datasets of CIFAR10, CIFAR100, GTSRB and DSDL-DB. The effects of the normalization and the data transformation for datasets are also investigated, and a training scheme using merged datasets is proposed.

• Childhood Kidney Diseases
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• 제21권1호
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• pp.26-30
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• 2017

Newborn infants with huge and highly vascular sacrococcygeal teratoma (SCT) are frequently subjected to renal hypoperfusion secondary to high-output cardiac failure. Any underlying renal dysfunction is a significant risk factor for the development of contrast-induced nephropathy (CIN). However, reports on CIN in infants are rare. I report here a case of a premature infant born at 28 weeks and 3 days of gestation with a huge SCT who survived preoperative embolization and surgical resection but presented with persistent non-oliguric renal failure that was suggestive of CIN. During radiological intervention, a contrast medium had been administered at about 10 times the manufacturer-recommended dose for pediatric patients. Despite hemodynamic stabilization and normalization of urine output immediately following surgery, the patient's serum creatinine and cystatin-C levels did not return to baseline until 4 months after birth. No signs of reflux nephropathy were observed in follow-up imaging studies. Dosing guidelines for the use of a contrast medium in radiological interventions should be provided for infants or young patients.

• 한국농공학회지
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• 제32권E호
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• pp.20-32
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• 1990

Abstract This study was conducted to pursue the normalization of frequency distribution by making an approach to the coefficient of skewness to nearly zero through the Box-Cox transformation, to get probable flood flows can be calculated by means of the transformation equation which has been derivated by Box-Cox transformation in the annual maximum series of the applied watersheds. It has been concluded that Box-Cox transfromation is proved to be more efficient than logarithmic, square root and SMEMAX transformation which is based on the trigonometric solution of a right triangle whose three verteces repesent the smallest, median and largest observed values of a population in making the coefficient of skewness nearer to zero. Consequently it is shown that probable flood flows according to the return period based on Box-Cox transformation are closer to the observed data as compared to other methods including SMEMAX transformation and fitted probability distributions such as the three parameter lognormal and the type I extremal distribution for the applied watersheds.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.504-507
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• 2006

Airborn Lidar technology has been applied to diverse applications with the advantages of accurate 3D information. Further, Lidar intensity, backscattered signal power, can provid us additional information regarding target's characteristics. Lidar intensity varies by the target reflectance, moisture condition, range, and viewing geometry. This study purposes to generate normalized airborne LiDAR intensity image considering those influential factors such as reflectance, range and geometric/topographic factors (scan angle, ground height, aspect, slope, local incidence angle: LIA). Laser points from one flight line were extracted to simplify the geometric conditions. Laser intensities of sample plots, selected by using a set of reference data and ground survey, werethen statistically analyzed with independent variables. Target reflectance, range between sensor and target, and surface slope were main factors to influence the laser intensity. Intensity of laser points was initially normalized by removing range effect only. However, microsite topographic factor, such as slope angle, was not normalized due to difficulty of automatic calculation.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.869-870
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• 2008

Illumination variation is the most significant factor affecting face recognition rate. In this paper, we propose adaptive smoothing based on combined most significant bit (CMSB) - plane and local entropy for robust face recognition in varying illumination. Illumination normalization is achieved based on Retinex method. The proposed method has been evaluated based on the CMU PIE database by using Principle Component Analysis (PCA).

• 한국산업정보학회논문지
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• 제5권4호
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• pp.32-38
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• 2000

다중 문자 환경의 문서인식 시스템에서 문자를 인식하기 전에 문자의 종류를 먼저 구분하는 것은 인식률의 향상에 중요한 요인이 된다. 각 나라의 문자는 그 문자마다 고유의 구성상의 다양한 특징을 가진다. 본 연구에서는, 문자를 구분하기 위한 방법으로 획 밀도 값을 이용하였고, 대상 문자는 한글, 영문과 한자로 하였다. 다양한 형태의 활자가 사용되는 문서에 적용하기 위해 입력 데이터는 정규화 과정을 거친 후 처리되었다. 제안된 방법은 80% 이상의 높은 확률로 구분이 가능함을 실험 결과로써 입증하였다.