• 한국수산과학회지
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• 제29권3호
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• pp.386-392
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• 1996

A numerical method based on genetic algorithms was introduced to characterize the grain-size distribution more effectively. This technique was proved significant particularly for multimodal size distributions, as was verified for samples from Korea Strait continental shelf. Sediment samples collected from the Korea Strait continental shelf revealed that $96\%$ of the grain-size distributions were multimodal. Therefore, the use of grain-size parameters was not the ideal method. As an alternative method, the decomposition of sue curves into elementary normal component curves was used. Means and standard deviations of 593 decomposed normal components were calculated by a numerical method from 268 size curves of Korea Strait sediments. The mean values of decomposed normal components showed peaks at $1\~3\phi\;and\;7\~9\phi$ size classes. The plot of mean and standard deviation values of the coarse fraction normal components on the map showed a characteristic areal distribution. The characteristic distribution was found to derive from underlying Pleistocene sediment on the basis of sea bottom geologic distribution of the area. The method of decomposition into normal components was found to be more effective than the analysis using traditional grain-size parameters in investigation of multimodal size distribution of Korea Strait shelf sediment.

• 척추신경추나의학회지
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• 제5권2호
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• pp.9-16
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• 2010

Objectives : This study is planned to classify different biomechanics of men and women, from the comparison of normal range and hip internal rotation angle in chronic low back pain patients. Methods : We measured the hip internal rotation angle of the 30 men and 30 women patients with low back pain that has been over 3 months in BuCheon Jaseng Hospital of Oriental medicine. We set 35-45 degrees as normal range, and found the patients with exceeding normal range, the patients with normal range, and the patients with under normal range. Results : Men appeared to have less hip internal rotation angle than women. Especially, the men's left hip internal rotation angle was less than normal range. On the other hand, women's right hip internal rotation angle was often larger than normal range which was stastically significant. Conclusions : Contraction of hip external rotation muscle including gluteus maxius muscle and piriformis muscle in men, or relaxation of posterior gluteus medius, gluteus maxius and piriformis muscle with contraction of tensor fasciae latae, a part of hip internal rotation muscle, in women seems to be the basis for biomechanics of chronic low back pain.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2393-2399
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• 2013

본 논문에서는 특이값 분해(SVD: singular value decomposition)에 의한 기저 스펙트럼의 합성을 통해 혈소판 라만 스펙트럼에서 알츠하이머병(AD: Alzheimer's disease)을 검출하는 방법을 제안하였다. AD가 유도된 형질 전환 실험용 쥐의 혈소판에서 측정한 라만 스펙트럼은 가산 잡음과 배경 잡음의 제거와 정규화로 구성된 전처리 과정을 수행한다. 각 데이터 행렬의 열벡터는 AD와 정상(NR: normal)의 라만 스펙트럼으로 구성한다. 이 데이터 행렬을 SVD로 분해한 다음 각 행렬의 열벡터 12개를 AD와 NR의 기저 스펙트럼으로 결정한다. 분류 과정은 각 클래스의 기저 스펙트럼을 선형 합성한 스펙트럼과 분류 스펙트럼의 평균제곱근오차(root mean square error)가 최소인 클래스를 선택하는 것으로 완료된다. 278개의 혈소판 라만 스펙트럼을 사용한 실험에 따르면 제안한 방법의 평균 분류율은 약 97.6%로 주성분 분석(principle components analysis)으로 추출한 특징에 MLP(multi-layer perceptron)를 이용한 경우보다 약 6.1% 정도의 우수한 성능을 보였다. 이 결과에서 SVD에 의한 기저 스펙트럼이 혈소판 라만 스펙트럼에서 AD의 검출에 적합하게 사용될 수 있음을 확인하였다.

• 대한치과보철학회지
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• 제26권1호
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• pp.171-184
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• 1988

The establishment of an optimal and functional condylar position (centric relation) as the therapeutic and diagnostic reference position during occlusal treatment for patients with temporomandibular joint and muscle pain. dysfunction has long been an important subject in dentistry. The objective of this study was to compare the reproducibility md the changes of condylar position in normal group to those in patient group after use of the occlusal biteplane splint. For this study, 11 normal adults who had no symptoms of masticatory dysfunction and 18 patients who had visited at the department of occlusion in dental infirmary of Yonsei University were selected. For each subject three centric relation records were recorded before treatment, after 2 weeks and after symptoms were improved. And the condylar positions in centric relation were measured using articulators and a Vericheck. On the basis of this study, the following results were obtained. 1. In normal group, there was no significant difference of reproducibility in condylar position before and after the use of the occlusal biteplane splint for 2 weeks. 2. In patient group there was significant improvement in the reproducibility of condylar position after treatment (P<0.01). The reproducibility in patient group, however, was less than normal group. (P<0.01) 3. The mean distance of condylar movements was $0.38{\pm}0.22mm$ after 2 weeks in normal group. 4. In patient group, condylar movements were $1.36{\pm}0.70mm$ (P<0.01), significantly different from normal group. (P<0.01) 5. In patient group, the main direction of condylar movements after treatment was toward anterior and superior, preponderance being at superior direction.

• Parasites, Hosts and Diseases
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• 제51권3호
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• pp.327-334
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• 2013

Vaccination is considered a promising alternative for controlling tick infestations. Haemaphysalis longicornis midgut proteins separated by SDS-PAGE and transferred to polyvinylidene difluoride (PVDF) membrane were screened for protective value against bites. The western blot demonstrated the immunogenicity of 92 kDa protein (P92). The analysis of the P92 amino acid sequence by LC-MS/MS indicated that it was a H. longicornis paramyosin (Hl-Pmy). The full lenghth cDNA of Hl-Pmy was obtained by rapid amplification of cDNA ends (RACE) which consisted of 2,783 bp with a 161 bp 3' untranslated region. Sequence alignment of tick paramyosin (Pmy) showed that Hl-Pmy shared a high level of conservation among ticks. Comparison with the protective epitope sequence of other invertebrate Pmy, it was calculated that the protective epitope of Hl-Pmy was a peptide (LEEAEGSSETVVEMNKKRDTE) named LEE, which was close to the N-terminal of Hl-Pmy protein. The secondary structure analysis suggested that LEE had non-helical segments within an ${\alpha}$-helical structure. These results provide the basis for developing a vaccine against biting H. longicornis ticks.

• 한국해양학회지
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• 제28권2호
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• pp.114-120
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• 1993

입도분포의 특징분석에 종래의 조직특성치 대신 수치해석적인 분해법의 적용을 시 도하였다. 그 결과 이 방법이 제주해협의 대륙붕 표층퇴적물과 같은 복모드형 입 도분포의 분석에 매우 유용함이 입증 되었다. 복모드형 입도분포 퇴적물은 제주해협 대륙붕에서는 86%의 높은 비율을 점한다. 종래의 입도특성치(평균, 표준편차, 왜도, 첨도)는 복모드형 입도분포에 대해서는 왜곡된 값을 보인다. 따라서 입도분포의 모드 에 대체로 대응되는 정규성분으로 분해해서 각 정규성분의 특성치를 해석함으로써 입 도특성치에서와 같은 특징의 누락이나 왜곡을 피할 수 있다. 제주해협 대륙붕의 167개 퇴적물 입도분포곡선을 비선형 최소자승법을 사용하여 정규성분으로 분해해서 총 387 개의 정규성분을 얻었다. 정규성분의 평균은 1-3 phi 8-9 phi에 집중되는 것이 많다. 이중 조립질 정규성분의 평균치는 복잡하고 특징적인 지리적 분포를 보인다. 이러한 분포는 퇴적물 총층후 분포와 매우 유사하며 해저면의 지질과 지형을 면밀하게 반영하 고 있다. 해저면을 형성하는 퇴적층은 플라이스토세 후기의 해침성 모래층이며 해저지 형은 플라이스토세말 빙하기 저해수면시기의 침식에 의해 형성된 것으로 보인다.

• Toxicological Research
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• 제19권3호
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• pp.247-257
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• 2003

Medicine is undergoing a revolution in the understanding of the mechanisms through which disease processes develop. The advent of genetics and molecular biology to oncology not only is providing surrogate predictors of therapy response and survival which are forming the basis for selection among established treatment options, but is providing targets for new directions in therapy as well. Molecular modification of somatic cells for the purposes of protecting the normal cells from the toxicity of cancer chemotherapy, for the sensitization of the tumor cells to therapy and use of conditionally replicating viral vector have been new directions of cancer treatment which have reached the clinical arena. Advances in molecular pharmacology and vector design summarized in this paper may provide solutions to some of the existing problems in the technology of gene transfer therapy. Continued basic research into the biological basis of human disease, systemic studies of the application of these discoveries to therapy and the improvement of vector for gene delivery all combined may result in advances in this important field of therapy over the next few years.

• 한국정밀공학회지
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• 제22권3호
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• pp.107-114
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• 2005

A new approach which combines implicit surface scheme and point projection method is presented in order to fill the arbitrarily shaped holes in the polygon model. In the method a trimmed surface which has an outer boundary curve is generated by using the implicit surface scheme and normal projection of point onto the base surface. The base surface is constructed by creating smooth implicit surface from the incomplete polygon model through which the surface should pass. In this paper an implicit surface is defined by a radial basis function, a continuous scalar-valued function over the domain $R^3$. The base surface is the set of all points at which this scalar function takes on the value zero and is created by placing zero-valued constraints at the vertices of the polygon model. In order to show the validity of the present study, various hole fillings are carried out for the complex polygon model of arbitrary topology.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 봄 학술발표회 논문집
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• pp.335-342
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• 1999

It is well known that l-girders are weak in torsion and it might be more economical to use a box girder, which has great torsional rigidity. The use of box beams does, however, present a potential problem in that cross-sectional distortions can induce large warping normal stresses and transverse bending stress. Accordingly a sufficient number of diaphragms are provided to make the distortional effects minimal. In engineering practice, diaphragms are spaced in 5m intervals without reasonable basis. It is considered to be noneconomical design to the almost design engineers, and it may produce the unsafe structural systems in special cases such as curved bridges with large initial curvature. These problems have not been solved for the lack of adequate tools of structural analysis. In this study, on the basis of the parametric studies, the design formulas for the distortional warping stress and the reasonable diaphragm spacing of box girder were presented.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.439-442
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• 1997

In our research, we will extract diagnostic parameters by LPC method and wavelet transform. Then, we will design artificial neural network which is based on RBF that can express input features in terms of fuzzy. Because PVC(Premature Ventricular Contraction) has possibility to cause heart attack, the detection of PVC is a very significant problem. To deal with this problem, LPC method which gives different coefficients or different morphologies and wavelet transform which has superior localization nature of time-frequency, are used to extract effective parameters or classification of normal and PVC. Because RBF network can allocate an input feature to the membership degree of each category, total system will be more flexible.