• The Plant Pathology Journal
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• 제22권1호
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• pp.1-6
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• 2006

The population shifts of Monilinia fructicola isolates which were resistant to the fungicide benzimidazoles were investigated in four regions of Korea from 1998 to 2000. The isolation frequency of benzimidazole-resistant isolates ranged from 18.8% to 29.6% in Chongdo and from $22.0\%$ to $26.8\%$ in Gyeongsan during the same period. However, the frequency of benzimidazoleresistant isolates was less than $4.0\%$ in Chochiwon and Youngduk during the same period. Benzimidazoleresistant isolates showed cross-resistance among benzimidazoles. On the other hand, none of the isolates showed cross-resistance to diethofencarb and carbendazim. Regardless of the year, the benzimidazole-resistant isolates of $EC_{50}$ higher than 500 $\mug%$ a.i./ml were isolated more frequently in mid and late season than in early season. In an orchard of Gyeongsan that had not been exposed to any fungicides for several years, the population of benzimidazole-resistant isolate had persisted without much fluctuation for three years. These results suggest that benzimidazole resistance of M. fructicola is becoming a problem in controlling brown rot and blossom blight of peach in regions like Chongdo and Gyeongsan.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.915-918
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• 2005

Advances in Information Technology and in Biomedicine have created new uses for CAD technology with many novel and important biomedical applications. Such applications can be found, for example, in the design and modeling of orthopedics, medical implants, and tissue modeling in which CAD can be used to describe the morphology, heterogeneity, and organizational structure of tissue and anatomy. CAD has also played an important role in computer-aided tissue engineering for biomimetic design, analysis, simulation and freeform fabrication of tissue scaffolds and substitutes. And all the applications require precision geometry of the organs or bones of each patient. But the geometry information currently used is polygon model with none solid geometry and is so rough that it cannot be utilized for accurate analysis, simulation and fabrication. Therefore a case study is performed to deduce a transformation method to build free form surface from a rough polygon data or medical images currently used in the application. This paper describes the transformation procedure in detail and the considerations for accurate organ modeling are discussed.

• Food Science and Biotechnology
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• 제16권5호
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• pp.778-782
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• 2007

This study assessed the effects of the antimicrobial substances sulforaphane, grapefruit seed extracts (GSE), and reuterin on the expression of Salmonella HilA and InvF virulence gene using a LacZY assay (${\beta}$-galactosidase assay) with hilA:lacZY and invF:lacZY fusion strains of Salmonella typhimurium SL1344. Salmonella was grown for 8 hr at $37^{\circ}C$ in the presence of diluted antimicrobial substances ($2\;{\mu}g/mL$ sulforaphane, $20\{\mu}g/mL$ GSE, and 0.26 mM reuterin) at concentrations that did not inhibit the cellular growth of Salmonella. Sulforaphane inhibited the expression of HilA and InvF by 50-90 and 20-80%, respectively. GSE also inhibited the expression of both genes, but to a lesser degree. Among the 3 antimicrobial substances, reuterin showed the least inhibition, which was abolished after 3-4 hr. None of the antimicrobial substances inhibited the ${\beta}$-galactosidase enzyme activity of S. typhimurium. The assay used in this study represents a very sensitive method for screening bioactive substances that inhibit the expression of virulence genes in Salmonella.

• Journal of Microbiology and Biotechnology
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• 제19권12호
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• pp.1590-1595
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• 2009

Alternative methods for controlling bacterial endospore contamination are desired in a range of industries and applications. Attention has recently turned to natural products, such as essential oils, which have sporicidal activity. In this study, a selection of essential oils was investigated to identify those with activity against Bacillus subtilis spores. Spores were exposed to 13 essential oils, and surviving spores were enumerated. Cardamom, tea tree, and juniper leaf oils were the most effective, reducing the number of viable spores by 3 logs at concentrations above 1%. Sporicidal activity was enhanced at high temperatures ($60^{\circ}C$) or longer exposure times (up to 1 week). Gas chromatography-mass spectrometry analysis identified the components of the active essential oils. However, none of the major oil components exhibited equivalent activity to the whole oils. The fact that oil components, either alone or in combination, did not show the same level of sporicidal activity as the complete oils suggested that minor components may be involved, or that these act synergistically with major components. Scanning electron microscopy was used to examine spores after exposure to essential oils and suggested that leakage of spore contents was the likely mode of sporicidal action. Our data have shown that essential oils exert sporicidal activity and may be useful in applications where bacterial spore reduction is desired.

• 대한인간공학회지
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• 제15권2호
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• pp.157-163
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• 1996

A single line display menu (SDM) is widely used for the user interface of many electronic consumer products, and the designers need useful guidelines applicable to the SDM. In many studies on menus, major focus has been placed on the optimal menu structure, but only a few standard menu structures, such as $64^{1},8^{2},4^{3}$,and $2^{6}$ are usually tested for optimality. In many cases, however, ill defined or asymmetric structures are suggested as design alternatives. To determine the optimal menu structure, user performance should be obtained in terms of quantitative measures. Hence, a model is needed to provide a predicted value of user performance for a given menu structure. Altough several models have been proposed for ordinary menus, none is available for the SDM yet. To solve this problem a performance model was developed in this study using the neural network approach. This model is capable of providing quantitative measures of human performance for any menu structures without conducting additional experiments, which will save much time and reduce the design cost.

• ETRI Journal
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• 제42권3호
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• pp.324-332
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• 2020

In this paper, a blind symbol timing offset (STO) estimation method is proposed for offset quadrature phase-shift keying (OQPSK) modulated signals, which also works for other linearly modulated signals (LMS) such as binary-PSK, QPSK, 𝜋/4-QPSK, and minimum-shift keying. There are various methods available for blind STO estimation of LMS; however, none work in the case of OQPSK modulated signals. The popular cyclic correlation method fails to estimate STO for OQPSK signals, as the offset present between the in-phase (I) and quadrature (Q) components causes the cyclic peak to disappear at the symbol rate frequency. In the proposed method, a set of close and approximate offsets is used to compensate the offset between the I and Q components of the received OQPSK signal. The STO in the time domain is represented as a phase in the cyclic frequency domain. The STO is therefore calculated by obtaining the phase of the cyclic peak at the symbol rate frequency. The method is validated through extensive theoretical study, simulation, and testbed implementation. The proposed estimation method exhibits robust performance in the presence of unknown carrier phase offset and frequency offset.

• Archives of Pharmacal Research
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• 제15권1호
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• pp.87-90
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• 1992

The syntheses of novel heterocyclic base modified pyrimidine nucleosides are described. 5, 6-dimethyl-4-hydroxy-3-methoxy-1-$(\beta$-D-ribofuranosyl)2(1H)-pyridinone 7 was synthesized by condensation of silylated 5, 6-dimethyl4-hydroxy-3-methoxy-2(1H)-pyridione 7 was synthesized by condensation of silylated 5, 6-dimethyl-4-hydroxy-3-methoxy-2(1H)-pyridinone with $\beta$-D-ribofuranose-1-acetate-2, 3, 5-tribenzoate in dichloroethane in the presence of Lewis acid followed by debenzoylation. The 2, 2'-anhydro-5, 6-dimethyl-2-hydroxy-3-methoxy-1-$\beta$-D-arabinofuranosyl-4-pyridinone 8 was obtained from the reaction of the free ribonucleoside 7 and diphenyl carbonate in DMF. None of these compounds showed any significant antiviral ad antitumor activities in vitro tests.

• International Journal of Knowledge Content Development & Technology
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• 제8권3호
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• pp.41-52
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• 2018

Digital Library websites plays an important role in dissemination of information of the institution and library resources. It acts as a trustworthy mirror of the institute. To evaluate the library website performance webometrics tools and indicators are required. The aim of the present research is study the webometrics of Digital Libraries of Iranian Universities of Medical Sciences on the Web to determine the amount of the visibility a website and web pages. The URL and link of 42 digital library website is obtained directly by visiting the university's website. To extract the number of indexed web pages (size), rich files have used the Google search engine Also, to extract the number of scientific resources retrieved have used the Google Scholar search engine. To calculate and obtain the number of links received have used the MOZ search engine. Generally, the results indicated that the website of Iranian digital libraries did not have a good performance in term of webometric indexes, and none of them were not rated at all indexes, only some of the websites mentioned in one or two indicators.

• Asian-Australasian Journal of Animal Sciences
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• 제16권3호
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• pp.425-429
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• 2003

Staphylococcus aureus is a major pathogen for cattle, causing various forms of subclinical and clinical mastitis and could be a causative agent of food poisoning, it produces various superantigenic exotoxins which have a great public health significance. A total of 72 S. aureus clinical isolates from dairy farms located in Kyunggi Province Korea were examined for the species identification by biochemical method, and for the detection of $\beta$-lactamase, enterotoxin and other exotoxins genes by PCR. The results of species identification by biochemical method agreed with those of PCR done with species specific primer STA-AU. $\beta$-lactamase is an enzyme closely associated with the resistance to antibiotic penicillin, which is an important means of treatment of mastitis, all the isolates were positive for the presence of genes encoding $\beta$-lactamase, which were reproduced in penicillin susceptibility disc assay. Six types of toxin genes, Staphylococcal enterotoxin (SE)A, SEB, SEC, SEE, toxic shock syndrome toxin (TSST-1) and exfoliative toxin A (ET A) were detected in 72 isolates by PCR associated genotypic method in this study, none of the isolates carried the genes for enterotoxin D (SED) and exfoliative toxin B (ETB). The occurrence rate of exotoxin genes rated as 12.5%, and the precision of the PCR identification results has been confirmed using the reference strains.

• 한국정보시스템학회지:정보시스템연구
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• 제8권2호
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• pp.5-27
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• 1999

The recent development of information technology in general and consolidation of communications and multimedia technology in particular have brought enormous changes in education and training methods in many business organizations. Numerous studies in the education engineering field report that teaching using multimedia technologies will more enhance the education/training performance than the traditional instructor-teaching method. However, in the management information systems field, few studies are found which directly investigated effects of multimedia technologies on education and training. None of multimedia-related studies can be found in the top-ranked MIS journals published in Korea for the last five years, and only a few stuides are found even worldwide. The major steps of the current research are as follows. First, in order to identify important factors constituting the effectiveness of multimedia systems, previous research related to the effectiveness of multimedia systems was reviewed and analyzed. Second, individual items which can be considered as candidates to represent the effectiveness of multimedia systems were derived from this previous research review, and a survey questionnaire was developed using those derived items. Based on the developed survey questionnaire, a pretest was administered at several domestic business firms with experiences of multimedia systems. Third, survey questionnaires were distributed to and collected from the 517 employees which experienced using multimedia systems.