• 폴리머
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• 제35권5호
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• pp.483-487
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• 2011

효율적 비혈관용 약물방출 스텐트 제조를 위해 풀루란 아세테이트(pullulan acetate, PA)가 테프론(poly-tetrafluorethylene; PTFE)으로 피막된 스텐트(PTFE-stent)의 코팅재료로 연구되었다. 파크리탁셀 함유 PA가 코팅된 PTFE-stent의 표면, 약물 방출 거동, 세포독성이 측정되었으며, 동물실험을 통해 이의 가능성이 검토되었다. 전자현미경으로 표면을 관찰한 결과 표면이 PTFE 피막에 비해 훨씬 매끄러웠고, 약물은 80일 동안 서방적 방출 거동을 보였다. PA와 함께 코팅된 파크리탁셀의 안정성을 annexin V 결합 염색법을 통하여 측정한 결과 apoptosis의 비율이 천연 파크리탁셀과 유사한 것으로 보아 봉입된 파크리탁셀의 변성이 없음을 알 수 있었다. 소동물 실험에서는 파크리탁셀이 봉입된 PA-PTFE가 고형암의 성장을 억제하였다. 위의 결과로 보아 PA는 효율적 비혈관계 약물방출 스텐트 개발에 매우 유용한 물질이라고 기대된다.

• Nutrition Research and Practice
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• 제10권1호
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• pp.67-73
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• 2016

BACKGROUND/OBJECTIVES: This study was aimed at examining the association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome (MetS) in Korean women with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A cross-sectional analysis was performed among 502 female T2DM patients (non-MetS group; n = 129, MetS group; n = 373) who were recruited from the Huh's Diabetes Clinic in Seoul, Korea between 2005 and 2011. The dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) and the data was analyzed using the Computer Aided Nutritional Analysis program (CAN-Pro) version 4.0 software. The intake of flavanones was estimated on the basis of the flavonoid database. RESULTS: In the multiple linear regression analysis after adjustment for confounding factors, daily flavanones intake was negatively associated with CVD risk factors such as total cholesterol, LDL-cholesterol, and apoB and apoB/apoA1 ratio only in the MetS group but not in the non-MetS group. Multiple logistic regression analysis revealed that the odds ratio for a higher apoB/apoA1 ratio above the median (${\geq}0.74$) was significantly low in the $4^{th}$ quartile compared to that in the $1^{st}$ quartile of dietary flavanones intake [OR: 0.477, 95% CI: 0.255-0.894, P for trend = 0.0377] in the MetS group. CONCLUSIONS: Dietary flavanones intake was inversely associated with the apoB/apoA1 ratio, suggesting a potential protective effect of flavanones against CVD in T2DM women with MetS.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제2권3호
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• pp.153-165
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• 2021

The objective of this study was to provide basic data for the conservation of wetland ecosystems in the Civilian Control Zone and the management of Yongyangbo wetlands in South Korea. Yongyangbo wetlands have been designated as protected areas. A field survey was conducted across five sessions between April 2019 and August of 2019. A total of 248 taxa were identified during the survey, including 72 families, 163 genera, 230 species, 4 subspecies, and 14 varieties. Their life-forms were Th (therophytes) - R₅ (non-clonal form) - D₄ (clitochores) - e (erect form), with a disturbance index of 33.8%. Three taxa of rare plants were detected: Silene capitata Kom. and Polygonatum stenophyllum Maxim. known to be endangered species, and Aristolochia contorta Bunge, a least-concern species. S. capitata is a legally protected species designated as a Class II endangered species in South Korea. A total of 26 taxa of naturalized plants were observed, with a naturalization index of 10.5%. There was one endemic plant taxon (Salix koriyanagi Kimura ex Goerz). In terms of floristic target species, there was one taxon in class V, one taxon in Class IV, three taxa in Class III, five taxa in Class II, and seven taxa in Class I. Three invasive alien species (Ambrosia trifida L., Ambrosia artemisiifolia L., and Humulus japonicus Siebold & Zucc) were observed. For continuous conservation of Yongyangbo Wetlands, it is necessary to remove invasive alien plants and block the inflow of non-point pollutants.

• Journal of Chest Surgery
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• 제54권3호
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• pp.179-185
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• 2021

Background: The use of ProGlide as a percutaneous vascular closure device in cardiac surgery remains inconclusive. This study investigated the clinical outcomes of using ProGlide in the percutaneous cannulation of femoral vessels in adult cardiac surgery. Methods: From September 2017 to July 2018, 131 consecutive patients underwent femoral vessel cannulation during cardiac surgery. The ProGlide (Abbott Vascular Inc., Santa Clara, CA, USA) with percutaneous cannulation was used in 118 patients (mean age, 55.7±15.5 years). The accessibility of femoral cannulation was evaluated through preoperative computed tomography. For cannulation, sonography was routinely used. The postoperative ankle-brachial index (ABI) was used to evaluate femoral artery stenosis. Results: Of the 118 patients, 112 (94.9%) and 6 (5.1%) underwent minimally invasive cardiac surgery and median sternotomy, respectively. Most femoral cannulations were performed on the right side (98.3%) using 15F to 19F arterial cannulas. The technical success rate of cannulation with ProGlide was 99.2%, with no delayed bleeding or cannulation site-related complications during hospitalization. During follow-up, only 1 patient showed femoral artery stenosis with claudication and was treated with interventional balloon angioplasty. The postoperative ABI revealed no significant difference in functional stenosis between the cannulation and non-cannulation sides (n=86; cannulation vs. non-cannulation, 1.2±0.1 vs. 1.1±0). Conclusion: Percutaneous femoral cannulation with ProGlide was safe and feasible in adult cardiac surgery. This technique may be a good alternative option in patients requiring femoral vessel cannulation for cardiac surgery.

• Journal of Mechanical Science and Technology
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• 제19권spc1호
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• pp.343-349
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• 2005

There are many things in common between hemodynamics in arterial systems and multibody dynamics in mechanical systems. Hemodynamics is concerned with the forces generated by the heart and the resulting motion of blood through the multi-branched vascular system. The conventional hemodynamics model has been intended to show the general behavior of the body arterial system with the frequency domain based linear model. The need for detailed models to analyze the local part like coronary arterial tree and cerebral arterial tree has been required recently. Non-linear analysis techniques are well-developed in multibody dynamics. In this paper, the studies of hemodynamics are summarized from the view of multibody dynamics. Computational algorithms of arterial tree analysis is derived, and proved by experiments on animals. The flow and pressure of each branch are calculated from the measured flow data at the ascending aorta. The simulated results of the carotid artery and the iliac artery show in good accordance with the measured results.

• Journal of Ginseng Research
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• 제16권3호
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• pp.175-182
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• 1992

Intravenous administration of saponin from the root of Panax ginseng (red ginseng) lowered the blood pressure in a dose-dependent manner (10~100 mg/kg B.W) in anesthetized rats. Therefore, experiments were designed to study whether this lowering of blood pressure is associated with the release of endothelium-derived relaxing factor. Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber. All experiments were performed in the presence of indomethacin (10-5 M). Ginseng saponin (10-5~3$\times$10-4 g/ml) relaxed contractions induced by phenylephrine (10-5 M) in the aorta with endothelium but not in that without endothelium. Treatment of aortic rings with NG_monomethyl-L-arginine (L-NMMA 10-4 M for 30 min), a competive inhibitor of nitric oxide synthase and methylene blue (M.B., 3$\times$10-7 M for 30 min), an inhibitor of soluble guanylate cyclase, diminished the relaxation induced by ginseng saponin. In thoracic aortic rings from rats treated with ginseng saponin for 2 weeks intraperitoneally, the relaxation to acetylcholine was increased compared with non-ginseng treated rings. These data suggest that red ginseng saponin evokes hypotension and that vascular relaxations induced by red ginseng saponin are inediatpd by release of endothelium-derived relaxing factor.

• Journal of Chest Surgery
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• 제47권3호
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• pp.302-305
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• 2014

Popliteal artery entrapment syndrome (PAES) is a non-artherosclerotic cause of claudication and acute ischemia of the legs in young athletic individuals. It is classified in terms of the abnormal anatomical relationship between the popliteal artery and surrounding structures. All types of PAES have the same pathophysiology. Repetitive arterial compression by surrounding structures causes progressive vascular injury. Bilateral PAES is reported in about 30% of cases. Bilateral PAES is usually of the same type in each artery; exceptions are rare. We report a case of a young athletic patient who suffered bilateral PAES of two different types.

• 한국자기학회지
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• 제21권5호
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• pp.180-184
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• 2011

자기장 자극시스템을 통하여 순간펄스 고자기장을 손바닥과 발바닥 그리고 무릎에 인가한 후 체열진단시스템을 통하여 모세혈관을 포함한 인체의 혈관 자극에 의한 혈류개선 효과를 연구하였다. 연령별, 성별 구분을 통하여 자극 후 체열진단을 통해 공통적으로 자극부위에 온도가 상승하는 결과를 얻었으며, 자기장 자극기 코일에서 발생하는 자체 발열량을 제거하기 위해 플라스틱 재질의 성형물로 신체와의 직접적인 접촉을 차단시켰으며 일정거리를 유지하여 실험하였다. 그 결과 비접촉을 통하여 순수하게 자기장의 펄스파형이 피부에 가까운 혈관을 자극하여 내부 전자기 에너지가 피부에 온도상승을 가져온 것으로 고찰된다.

• Clinical Endoscopy
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• 제51권6호
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.

• 운동영양학회지
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• 제23권2호
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• pp.7-12
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• 2019

[Purpose] Eccentric exercise induces a decrease in vascular endothelial function. Curcumin, a major component of turmeric, has potent antioxidant and anti-inflammatory properties that are associated with vascular protective effects. The present study examined the effect of acute supplementation of curcumin on eccentric exercise-induced endothelial dysfunction in healthy young men. [Methods] Fourteen healthy sedentary young men (range, 21-29 years) were assigned to either the curcumin (n = 6) or placebo (n = 8) group. All subjects consumed either curcumin or placebo before exercise, and eccentric exercise of the elbow flexors was performed with their nondominant arm. Before and 60 min after exercise, brachial artery flow-mediated dilation (FMD), as an indicator of endothelial function, was measured in the non-exercised arm. [Results] Brachial artery FMD significantly decreased following eccentric exercise (p < 0.05) in the placebo group, but acute supplementation with curcumin before exercise nullified this change. The change in FMD before and after eccentric exercise between the placebo and curcumin groups was significantly different (p < 0.05). [Conclusion] The present study found that acute curcumin supplementation could attenuate the decrease in endothelial function, as measured by FMD, following eccentric exercise in healthy young men.