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Development of Polymeric Coating Material for Effective Drug-eluting Stent  

Park, Tae-Hyun (Department of Biotechnology, The Catholic University of Korea)
Jo, Eun-Ae (Department of Biotechnology, The Catholic University of Korea)
Na, Kun (Department of Biotechnology, The Catholic University of Korea)
Publication Information
Polymer(Korea) / v.35, no.5, 2011 , pp. 483-487 More about this Journal
Abstract
For the preparation of effective non-vascular drug eluting stent (DES), pullulan acetate (PA) was investigated as a coating material for polytetrafluorethylene (PTFE)-covered stent. PA was coated on PTFE-covered stent (PTFE-stent) by dip coating technique, and then its surface morphology, drug release behavior and cellular toxicity were tested. Field emission-scanning electron microscopy (FE-SEM) result indicated that its surface was smoother after PA coating without any cracking. The sustained release behavior of paclitaxel from PA-coated PTFE membrane was observed for 80 days. Also, the biological stability of paclitaxel in the membrane was confirmed by annexin V binding assays. Furthermore, the antitumor activity was demonstrated by an in vivo test against CT-26 murine colorectal tumors. From the results, we concluded that PA was expected as a useful coating material to design an effective non-vascular DES.
Keywords
drug eluting stent; pullulan acetate; paclitaxel; sustained release;
Citations & Related Records
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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