• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8815-8822
• /
• 2014

Background: The incidence of stomach cancer in India is highest in the state of Mizoram. In this population based matched case-control study, we evaluated the relationship between CYP450 2E1 RsaI polymorphism and risk of stomach cancer taking into considering various important dietary habits along with tobacco, alcohol consumption and H. pylori infection status. Materials and Methods: A total of 105 histologically confirmed stomach cancer cases and 210 matched healthy population controls were recruited. CYP2E1 RsaI genotypes were determined by PCR-RFLP and H. pylori infection status by ELISA. Information on various dietary, tobacco and alcohol habits was recorded in a standard questionnaire. Results: Our study revealed no significant association between the CYP2E1 RsaI polymorphism and overall risk of stomach cancer in Mizoram. However, we observed a non-significant protective effect of the variant allele (A) of CYP2E1 against stomach cancer. Tobacco smokers carrying C/C genotype have three times more risk of stomach cancer, as compared to non-smokers carrying C/C genotype. Both Meiziol and cigarette current and past smokers who smoked for more than 10 times per day and carrying the (C/C) genotype are more prone to develop stomach cancer. Smoke dried fish and preserved meat (smoked/sun dried) consumers carrying C/C genotype possesses higher risk of stomach cancer. No significant association between H. pylori infection and CYP2E1 RsaI polymorphism in terms of stomach cancer was observed. Conclusions: Although no direct association between the CYP2E1 RsaI polymorphism and stomach cancer was observed, relations with different tobacco and dietary risk habits in terms of developing stomach cancer exist in this high risk population of north-eastern part of India. Further in-depth study recruiting larger population is required to shed more light on this important problem.

• Journal of the Korean Society of Tobacco Science
• /
• v.31 no.1
• /
• pp.18-28
• /
• 2009

This study describes the manufacturing method of antioxidant filter and evaluate the reduction of free radical and biological activity from mainstream smoke. When we used spray-brush for the application of antioxidant solution to the filter, cv(coefficient of variation) levels of antioxidant added to filter ranged within 3 %, which means stable and constant feeding process. 0.3~0.5mg per cigarette of antioxidant were sprayed to acetate and active carbon part in the filter plug, respectively. It was considered that the use of antioxidant added filter resulted in the reduction of the gaseous compounds of free radicals from 17 % to 19 % in the mainstream smoke. Variation for removal efficiency of free radical in antioxidant filter added to acetate part was more pronounced than that of filter added to active carbon part. Smoking deliveries of tar, nicotine for the antioxidant added filters were similar when comparing to the non-antioxidant added filter, but the delivering amounts of isoprene were significantly reduced. The estimation of consumed GSH(glutathion) showed that the gaseous toxicity of the antioxidant added filter was 14 % ~ 23 % lower than that of non-antioxidant added filter. No significant differences were observed for the total taste quality in sensory evaluation.

• Journal of Preventive Medicine and Public Health
• /
• v.46 no.4
• /
• pp.165-172
• /
• 2013

A noncommunicable disease (NCD) is a medical condition or disease that is by definition non-infectious and non-transmissible among people. Currently, NCDs are the leading causes of death and disease burden worldwide. The four main types of NCDs, including cardiovascular disease, cancer, chronic lung disease, and diabetes, result in more than 30 million deaths annually. To reduce the burden of NCDs on global health, current public health actions stress the importance of preventing, detecting, and correcting modifiable risk factors; controlling major modifiable risk factors has been shown to effectively reduce NCD mortality. The World Health Organization's World Health Report 2002 identified tobacco use, alcohol consumption, overweight, physical inactivity, high blood pressure, and high cholesterol as the most important risk factors for NCDs. Accordingly, the present report set out to review the prevalence and trends of these modifiable risk factors in the Korean population. Over the past few decades, we observed significant risk factor modifications of improved blood pressure control and decreased smoking rate. However, hypertension and cigarette smoking remained the most contributable factors of NCDs in the Korean population. Moreover, other major modifiable risk factors show no improvement or even worsened. The current status and trends in major modifiable risk factors reinforce the importance of prevention, detection, and treatment of risk factors in reducing the burden of NCDs on individuals and society.

• The Journal of Korean Society for School & Community Health Education
• /
• v.7
• /
• pp.33-49
• /
• 2006

Background & Objectives: This study was designed to examine relationships between smoking behavior and smoking attitudes among 6th-grade students in Korea in order to provide knowledge on school-based programs for preventing adolescent smoking behaviors. Methods: Questionnaires were administered to 464 students attending three public elementary schools in O city from June 13 to June 16, 2006. The total sample size is 458 (response rate = 98.7%). Data were statistically analyzed by frequency analysis, cross tabulation, and multiple regression. Results: First, smoking behavior was significantly influenced by the factors of gender, self-concept, family structure, sibling smoking, school achievement, relationship with teachers, satisfaction with school life, and smoking friends. Theprevalence of ever-smoking was 12.7% among 6th grade students in this study. Students were most likely to initiate smoking in the 5thgrade with curiosity and smoke at their own home. Second, students showed negative attitude toward smoking overall. From the detailed section, students respondednegatively about smoking in public places while they thought that adult smoking with moderate level was okay. Student who showed positive attitudes toward smoking in the present study were significantly related to the factors of self-concept, family environment, parental and sibling smoking status, school achievement, satisfaction with school life, and smoking friends. Third, Students who had tried cigarette smoking were likely to report less negative attitudes toward tobacco than non-smoking students. Fourth, this study found that smoking friends were the most significant predictor of positives smoking attitudes. Other factors significantlyassociated with smoking attitudes were gender, relationship with friends, self-concept, relationship with teachers, paternal smoking status. Conclusions: The study results suggest that smoking prevention programs focus on resisting peer influence and need to be community-incorporated and/or comprehensive from elementary to high school.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.8
• /
• pp.273-284
• /
• 2017

This study performed meta-analysis of published articles to examine the relationship between sarcopenia and smoking. We searched the PubMed, EMBASE, Cochrane library, and RISS database sup to January 2017 using search terms such as sarcopenia AND (smoking OR tobacco OR cigarette). A total of 25 articles were included in the analysis (seven cohort studies and 18 cross-sectional studies). Incidence of sarcopenia in smokers and non-smokers was analyzed by the random effects model. Incidence of sarcopenia was OR 1.49 (95% CI 1.21, 1.84, p<.001, I2 = 88.20%), Asian (OR 1.28, 95% CI 0.91, 1.78, p=0.150, I2=85.32%), and Western (OR 1.65, 95% CI 1.25, 2.17, p<.001, I2=91.08%), Western smokers showed a significantly higher incidence of sarcopenia:males and females with OR 1.25(95% CI 1.11, 1.40, p<.001, 12=87.4%) and 1.80(95% CI 0.98, 3.30, p=.057, 12=89.1 %) respectively. Male smokers showed significantly higher incidence of sarcopenia. Based on the results of the study, smoking in Western males is related to sarcopenia. However, since the criteria for the diagnosis of sarcopenia and the criteria for smoking were different, cumulative individual clinical studies applying uniform assessment for the evaluation of sarcopenia and smoking status are needed in the future.

• Analytical Science and Technology
• /
• v.28 no.6
• /
• pp.385-397
• /
• 2015

Harmful and potentially harmful constituents (HPHCs) are chemical compounds in tobacco smoke that cause harm to smokers and non-smokers. This study established and validated methods for the analysis of HPHCs from mainstream cigarette smoke. The analyzed HPHCs were categorized into seven groups: aromatic amines, volatile organic compounds (VOCs), heavy metals, tobacco specific nitrosamines (TSNAs), benzo[a]pyrene (B[a]P), ammonia, and carbonyl compounds. The methods were validated by specificity, linearity, limit of detection (LOD), accuracy, precision, and recovery. These validated methods were then applied to the reference cigarettes (1R5F, 3R4F). The correlation coefficients (r²) for the calibration curves of the seven groups were over 0.995. The LODs showed values of 0.01-0.04 ng/cig cig for aromatic amines, 0.01-0.16 μg/cig for VOCs, 0.01-1.27 ng/cig for heavy metals, 0.06-0.28 ng/cig for TSNAs, 0.04 ng/cig for benzo[a]pyrene, 0.08 μg/cig for ammonia, and 0.78-1.77 μg/cig for carbonyl compounds. The precisions obtained from the intra and inter-day batches were less than 15%. The accuracy and the recovery range were less than 15% and 79.2-117.5%, respectively. The proposed methods can therefore be applied for determining HPHCs in tobacco mainstream smoke.

• Journal of Preventive Medicine and Public Health
• /
• v.49 no.2
• /
• pp.108-117
• /
• 2016

Objectives: Smoking is known to be associated with nephropathy in patients with diabetes. The distinct effects of smoking before and after diabetes has been diagnosed, however, are not well characterized. We evaluated the association of cigarette smoking before and after a diagnosis of diabetes with the presence of diabetic nephropathy. Methods: We analyzed data from the 2011-2013 editions of the Korea National Health and Nutrition Examination Survey. A total of 629 male patients diagnosed with diabetes were classified as non-smokers (90 patients), former smokers (225 patients), or continuing smokers (314 patients). A "former smoker" was a patient who smoked only before receiving his diagnosis of diabetes. A "continuing smoker" was a patient who smoked at any time after his diabetes had been diagnosed. Diabetic nephropathy was defined as the presence of albuminuria (spot urine albumin/creatinine ratio ${\geq}30mg/g$) or low estimated glomerular filtration rate ($<60mL/min/1.73m^2$). Multiple logistic regression models were used to assess the independent association after adjusting for age, duration of diabetes, hemoglobin A1c, body mass index, systolic blood pressure, medication for hypertension, and medication for dyslipidemia. Female patients were excluded from the study due to the small proportion of females in the survey who smoked. Results: Compared to non-smokers, continuing smokers had significantly higher odds ratio ([OR], 2.17; 95% confidence interval [CI], 1.23 to 3.83) of suffering from diabetic nephropathy. The corresponding OR (95% CI) for former smokers was 1.26 (0.70 to 2.29). Conclusions: Smoking after diagnosis of diabetes is significantly associated with the presence of diabetic nephropathy in the Korean male population.

• Journal of Korean Ophthalmic Optics Society
• /
• v.13 no.1
• /
• pp.131-135
• /
• 2008

Purpose: To measure and quantify the factors of intraocular pressure (IOP) variation for normal Korean youth. Methods: The IOP of normal youth 805 persons (male: 367, female: 438) were measured as a function of time and quantity for fixation, reclining posture, hard blinking, drinking water, drinking hard liquor, tobacco and coffee by using non-contact tonometer (AT555, Reichert Co.). In the case of fixation, reclining posture and hard blinking, the intraocular pressure of right and left eye were measured for 6 males and 6 females every 10 minutes during 30 minute. In the case of water, liquor, tobacco and coffee, the measurement for 4 or 5 groups (6 persons/ group) having similar IOP were done for the IOP variation of right eye. Results: The mean IOP was 15.2 mmHg for males and 15.8 mmHg for females (slightly higher than male's), respectively and the 99% of those were in the range of the normal IOP. The measured IOP was increased by fixation, reclining posture and hard blinking with males and females. The gradient of increasing slope was 0.15/0.13/0.07/0.08, 0.09/0.08/0.08/0.08 and 0.19/0.08/0.26/0.31, respectively. The IOP variation was elevated by drinking water (especially in the case of 1000 ml) and lowered in proportion to the amount of drinking by hard liquor. Cigarette smoking was associated with rise in intra ocular pressure, but was not shown a definite relation. And coffee had virtually no effect. Conclusions: Fixation, reclining posture, hard blinking and Tobacco caused a transient increase in IOP, but alcohol elicited a slight reduction in IOP overall.

• Journal of Preventive Medicine and Public Health
• /
• v.34 no.3
• /
• pp.183-190
• /
• 2001

Objective : To estimate the annual economic costs attributable to cigarette smoking in Korea. Methods : The costs were classified as being direct medical and non-medical costs, indirect costs and others. We focused on those costs related that are incurred in the treatment of selected diseases (cardiovascular diseases, respiratory diseases, and cancers), which have been proven to be caused by smoking. In addition to the basic costs of treatment, the additional amount of costs occurred due to smoking was obtained by computing the population attributable risk (PAR%) caused by smoking. To compute the PAR%, relative risks of smoking to the number of outpatient visits, hospitalizations, and the death were estimated using the Cox proportional hazard model, respectively. Our major data source was the 'Korea Medical Insurance Corporation (KMIC) cohort study,' which was composed of a total of 115,682 male and 67,932 female beneficiaries who had complete records of their smoking histories in the year of 1992. Results : The annual costs that could be attributable to smoking were estimated to be in the range of 2,847,500 million Won to 3,959,100 million Won. The maximum estimate of 3,959,100 million Won includes 233,100 million Won for medical costs, 5,100 million Won for transportation costs, 27,600 million Won for care giver's economic costs, 69,100 million Won in productivity loss, 3,435,000 million Won lost because of premature death, 172,100 million Won in costs resulting from passive smoke inhalation and 17,100 million Won for costs that resulted from fires that were caused by careless smoking. Conclusion : Our study confirms that the magnitude of the economic burden of smoking to Korean society is substantial. Therefore, this study provides strong evidence that there is a strong need for a national policy of tobacco control in Korea.

• Journal of dental hygiene science
• /
• v.10 no.3
• /
• pp.131-139
• /
• 2010

The purpose of this study was to evaluate smoking patterns, oral health behavior and perception of dental healthcare of military personnel in the South Korea Army. All 367 subjects were surveyed by the structured questionnaires with convenience sampling method. The questionnaires were consisting of 22 items. Depending on the conditions of military training, the distribution and differences of smoking patterns and oral behaviors were evaluated by frequency test, Weighted Kappa, Paired t-test and ANOVA. The differences of oral health perception on smoking were demonstrated by Mantel-Haenszel Chi-square test. In addition, Generalized Estimating Equation (GEE) was used to estimate the effects of oral behavior for the conditions of military training and smoking. The number of cigarette during military training period was similar to that during non-military training (p=0.109). The perception of smokers such as smoking effect on oral health, oral health and systemic health, and need of education for smoking cessation was significantly lower than non-smokers (p=0.0095, p=0.0007, and p<0.0001). The probability that toothbrush frequency per day was only one was associated with higher during military training period than non-military training (OR=9.29, 95% CI 5.05-17.07). Moreover, the probability that hours of toothbrush were less than one minute was associated with higher during military training than non-military training (OR=2.19, 95% CI 1.78-2.71). To improve knowledge, attitude, and behavior of oral health for the members, the army needs to develop oral health education and tobacco cessation programs. In particular, motivation and practice for oral health care are required to improve poor oral health behavior during the military training.