• Journal of Preventive Medicine and Public Health
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• v.26 no.2 s.42
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• pp.251-267
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• 1993

The relationship between lead related subject symptoms and lead exposure indices was studied in 435 male lead workers in thirteen lead using industries. 212 male office workers who were not exposed to lead occupationally were also studied as a control group. Fourteen lead related symptoms were selected. They were further subdivied into 4 sub-symptom groups such as 1) gastrointestinal, 2) neuromuscular and joint 3) constitutional, and 4) psychological symptoms. Symptom questionnaires were provided to the workers and filled up by themselves and reconfirmed by interviewer(doctor). The test used fer the evaluation of lead exposure were blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), hemoglobin(Hb), hematocrit (Hct), delta-aminolevulinic acid in urine(DALA). The results obtained were as follows; 1. The higher prevalence rate in the sub-group of neuromuscular and joint symptoms was observed in occupationally lead exposed subjects than non-exposed subjects. Among the sub-groups, the most frequent symptom was 'numbness of finger, hands or feet', and the prevalence of the symptom of 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia' were higher in order. 2. While the symptom which showed the biggest difference of prevalence rate among the 14 symptoms between exposed and non-exposed subjects was 'numbness of fingers, hands or feet', the symptom which showed the highest prevalence rate was 'feeling tired generally' in exposed and non-exposed subjects, but no statistical difference of symptom prevalence were observed. 3. In total study population, PbB and ZPP had dose-response relationship with 4 symtoms of neuromuscular and joint symptoms ('numbness of finger, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and one symptom of gastrointestinal group('intermittent pains in lower abdomen'). 4. In lead exposed workers, only neuromuscular and joint symptoms group showed dose-response relationship with PbB and ZPP, 5. In lead exposed workers, the prevalance rate of overall symptoms of lead workers with age below 39 years was higher than that of lead workers with age above 40. While neuromuscular and joint symptoms group had a dose-response relationship with PbB in former group, it had a dose-response relationship with ZPP in latter group. 6. Age adjusted odds ratios of symptoms of non-exposed with exposed and odds ratios of low exposed with high exposed workers showed the dose-response relationship of lead exposure with neuromuscular and joint symptoms group('numbness of fingers, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and gastrointestinal symptoms group('intermittent pains in lower abdoman').

• Journal of KIISE
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• v.44 no.2
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• pp.115-123
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• 2017

A message processor is server software that receives non-realtime messages as well as realtime messages from clients that need to be processed within a deadline. With the recent advances of micro-processor technologies and Linux, the message processor is often implemented in Linux-based multi-core servers and it is important to use cores efficiently to maximize the performance of system in multi-core environments. Numerous research efforts on a real-time scheduler for the efficient utilization of the multi-core environments have been conducted. Typically, though, they have been conducted theoretically or via simulation, making a subsequent real-system application difficult. Moreover, many Linux-based real-time schedulers can only be used in a specific Linux version, or the Linux source code needs to be modified. This paper presents the design of a Linux-based message processor for multi-core environments that maps the threads to the cores at user level. The message processor is implemented through a modification of the traditional RM algorithm that consolidates the real-time messages into certain cores using a first-fit-based bin-packing algorithm; this minimizes the response-time delay of the non-real-time messages, while guaranteeing the violation rate of the real-time messages. To compare the performances, the message processor was implemented using the two multi-core-scheduling algorithms GSN-EDF and P-FP, which are provided by the LITMUS framework. The benchmarking results show that the response-time delay of non-real-time messages in the proposed system was improved up to a maximum of 17% to 18%.

• Structural Engineering and Mechanics
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• v.14 no.6
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• pp.679-698
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• 2002

In this paper some techniques for the dynamic analysis of non-classically damped linear systems are reviewed and compared. All these methods are based on a transformation of the governing equations using a basis of complex or real vectors. Complex and real vector bases are presented and compared. The complex vector basis is represented by the eigenvectors of the complex eigenproblem obtained considering the non-classical damping matrix of the system. The real vector basis is a set of Ritz vectors derived either as the undamped normal modes of vibration of the system, or by the load dependent vector algorithm (Lanczos vectors). In this latter case the vector basis includes the static correction concept. The rate of convergence of these bases, with reference to a parametric structural system subjected to a fixed spatial distribution of forces, is evaluated. To this aim two error norms are considered, the first based on the spatial distribution of the load and the second on the shear force at the base due to impulsive loading. It is shown that both error norms point out that the rate of convergence is strongly influenced by the spatial distribution of the applied forces.

• Computers and Concrete
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• v.7 no.4
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• pp.317-329
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• 2010

The paper describes localization of deformation in a bar under tensile loading. The material of the bar is considered as non-linear viscous elastic and the bar consists of two symmetric halves. It is assumed that the model represents behavior of the quasi-brittle viscous material under uniaxial tension with different loading rates. Besides that, the bar could represent uniaxial stress-strain law on a single plane of a microplane material model. Non-linear material property is taken from the microplane material model and it is coupled with the viscous damper producing non-linear Maxwell material model. Mathematically, the problem is described with a system of two partial differential equations with a non-linear algebraic constraint. In order to obtain solution, the system of differential algebraic equations is transformed into a system of three partial differential equations. System is subjected to loadings of different rate and it is shown that localization occurs only for high loading rates. Mathematically, in such a case two solutions are possible: one without the localization (unstable) and one with the localization (stable one). Furthermore, mass is added to the bar and in that case the problem is described with a system of four differential equations. It is demonstrated that for high enough loading rates, it is the added mass that dominates the response, in contrast to the viscous and elastic material parameters that dominated in the case without mass. This is demonstrated by several numerical examples.

• Radiation Oncology Journal
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• v.16 no.3
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• pp.283-289
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• 1998

Purpose : This study was performed to analyze the efficacy of induction chemotherapy fellowed by radiation therapy in locally advanced non-small cell lung cancer Materials and Methods : Eighty patients with locally advanced non-small cell lung cancer treated from 1989 to 1995 at Pusan Paik hospital were analyzed retrospectively. Twenty-one patients were treated with induction chemotherapy followed by radiation therapy and Fifty-nine Patients were treated with radiation therapy alone. Chemotherapy regimen consisted of cisplatin-based combination (2 or 3 drugs). All patients were treated by Co-60 or 6 MV linear accelerators. Radiation dose ranged from 50 Gy to 80 Gy (median 64.8 Gy). We evaluated response rate, survival rate, and pattern of failure in both treatment groups. Results : Overall response rate in induction chemotherapy group and radiotherapy alone group were 48% and 45%, respectively. Of the 80 patients, 46 patients were evaluable for pattern of failure. Initial failure pattern in induction chemotherapy group was as follows: 8 (67%) at locoregional, 4 (33) in distant metastasis. Radiation alone group was 21 (71%) and 5 (29%), respectively. Results showed no difference of distant failure between induction chemotherapy group and radiation alone group. The 1 and 2 year survival rate in induction chemotherapy group were 43% and 14%, respectively and in radiotherapy alone group, 31% and 7%, respectively (p=0.135). Conclusion : In stage III non-small cell lung cancer, induction chemotherapy and radiation therapy showed increased tendency in survival with no statistical significance Induction chemotherapy seems to have no effect of decreasing distant failure and no survival advantage compared with radiotherapy alone.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6267-6271
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• 2013

Objective: To determine clinical efficacy, safety and prognostic factors of pemetrexed plus platinum as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: Clinical characteristics, short-term efficacy, survival and adverse reactions of 47 advanced non-squamous NSCLC patients who had received pemetrexed plus platinum as first-line treatment in Shanghai Pulmonary Hospital from January 2009 to June 2011 were retrospectively analyzed. The Chi-squared test was applied to statistically analyze the overall response rate (ORR), disease control rate (DCR) and toxicity reactions in both groups, while survival data wereanalyzed by Kaplan-Meier and logrank methods, and the COX proportional hazards model was adopted for a series of multi-factor analyses. Results: Only two patients were lost to follow-up. The ORR, DCR, medium progression-free survival time (PFS) and medium overall survival (OS) were 31.9%, 74.5%, 5 months and 15.2 months, while 1- and 2-year survival rates were 63.8% (30/47) and 19.2% (9/47), respectively. Single-factor analysis showed that tumor pathological patterns and efficacy were in association with medium PFS (P<0.05), whereas tumor pathological patterns, smoking history and efficacy were closely connected with medium OS (P<0.05). Multi-factor analyses demonstrated that pathological patterns and efficacy were independent factors influencing OS (P<0.05). The rate of toxicity reactions in degree III/IV was low, including hematologic toxicity marked by decline in white blood cell count and decrease in the platelet count (PLT), and non-hematologic toxicity manifested by gastrointestinal reactions, such as nausea and vomiting. Conclusions: Pemetrexed plus platinum as first-line treatment has excellent efficacy and slight adverse reactions with favorable drug-tolerance in patients with advanced non-squamous NSCLC.

• Journal of the Korean Data Analysis Society
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• v.20 no.6
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• pp.2873-2881
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• 2018

It is very important to obtain objective and credible information through election polls in order to contribute to the correct voting behavior of the voters or to establish appropriate election strategies for candidates or political parties. Therefore, many related organizations such as political parties, media organizations, and research institutions have been making efforts to improve the accuracy of the results of the polls and the election prediction. Kim et al. (2017) analyzed whether the non-response group responded that there is no support candidate in the election survey to increase the accuracy of the estimation of the vote rate. As a result, it has been confirmed that the accuracy of the estimation of the vote rate can be significantly improved by performing an appropriate classification on the non-response layer. In this study, we propose a method to estimate the turnout by each strata (sex, age group) under the condition that the total turnout rate is given for a specific district (region) and propose a procedure to predict the vote rate by reflecting the turnout. In addition, case studies were conducted using data gathered through telephone interviews for the 20th National Assembly elections in 2016.

• Tuberculosis and Respiratory Diseases
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• v.66 no.4
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• pp.280-287
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• 2009

Background: The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), became an attractive therapeutic option for advanced non-small-cell lung cancer (NSCLC). Several studies suggested that there might be some different efficacy or response predictors between gefitinib and erlotinib. We compared the efficacy and toxicity of gefitinib and erlotinib in Korean patients with advanced NSCLC and evaluated specific predictors of response for both gefitinib and erlotinib. Methods: We collected the clinical information on patients with advanced NSCLC, who were treated with gefitinib or erlotinib at the Ewha Womans University Hospital, between July 2003 and February 2009. Median survival times were calculated using the Kaplan-Meier method. Results: Eighty-six patients (52 gefitinib vs. 34 erlotinib) were enrolled. Patient median age was 64 years; 53 (62%) subjects were male. Out of the 86 patients treated, 83 received response evaluation. Of the 83 patients, 35 achieved a response and 12 experienced stable disease while 36 experienced progressive disease, resulting in a response rate of 42% and a disease control rate of 57%. After a median follow-up of 502 days, the median progression-free and overall survival time was 129 and 259 days, respectively. Comparing patients by treatment (gefitinib vs erlotinib), there were no significant differences in the overall response rate (44% vs. 39%, p=0.678), median survival time (301 days vs. 202 days, p=0.151), or time to progression (136 days vs. 92 days, p=0.672). Both EGFR-TKIs showed similar toxicity. In a multivariate analysis using Cox regression model, adenocarcinoma was an independent predictor of survival (p=0.006; hazard ratio [HR], 0.487; 95% confidence interval [CI], 0.292-0.811). Analyses of subgroups did not show any difference in response predictors between gefitinib and erlotinib. Conclusion: Comparing gefitinib to erlotinib, there were no differences in the response rate, overall survival, progression-free survival, or toxicity. No specific predictor of response to each EGFR-TKI was identified.

• Computers and Concrete
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• v.1 no.4
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• pp.371-388
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• 2004

Our objective is to model static multi-cracking processes in concrete. The explicit dynamic relaxation (DR) method, which gives the solutions of non-linear static problems on the basis of the steady-state conditions of a critically damped explicit transient solution, is chosen to deal with the high geometric and material non-linearities stemming from such a complex fracture problem. One of the common difficulties of the DR method is its slow convergence rate when non-monotonic spectral response is involved. A modified concept that is distinct from the standard DR method is introduced to tackle this problem. The methodology is validated against the stable three point bending test on notched concrete beams of different sizes. The simulations accurately predict the experimental load-displacement curves. The size effect is caught naturally as a result of the calculation. Micro-cracking and non-uniform crack propagation across the fracture surface also come out directly from the 3D simulations.

• Phonetics and Speech Sciences
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• v.4 no.3
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• pp.25-30
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• 2012

This study investigated whether native Korean listeners could use visual cues for the identification of the English consonants /b/ and /v/. Both auditory and audiovisual tokens of word minimal pairs in which the target phonemes were located in word-initial or word-medial position were used. Participants were instructed to decide which consonant they heard in $2{\times}2$ conditions: cue (audio-only, audiovisual) and location (word-initial, word-medial). Mean identification scores were significantly higher for audiovisual than audio-only condition and for word-initial than word-medial condition. Also, according to signal detection theory, sensitivity, d', and response bias, c were calculated based on both hit rates and false alarm rates. The measures showed that the higher identification rate in the audiovisual condition was related with an increase in sensitivity. There were no significant differences in response bias measures across conditions. This result suggests that native Korean speakers can use visual cues while identifying confusing non-native phonemic contrasts. Visual cues can enhance non-native speech perception.