• 한국어병학회지
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• 제23권3호
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• pp.273-280
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• 2010

To determine whether rock bream Oplegnathus fasciatus can be protected from rock bream iridovirus (RBIV) infection by intramuscular injection of long double-stranded RNAs (dsRNAs), we compared protective effect of virus-specific dsRNAs corresponding to major capsid protein (MCP), ORF 084, ORF 086 genes, and virus non-specific green fluorescent protein (GFP) gene. Furthermore, to determine whether the non-specific type I interferon (IFN) response was associated with protective effect, we estimated the activation of type I IFN response in fish using expression level of IFN inducible Mx gene as a marker. As a result, mortality of fish injected with dsRNAs and challenged with RBIV was delayed for a few days when comparing with PBS injected control group. However, virus-specific dsRNA injected groups exhibited no significant differences in survival period when compared to the GFP dsRNA injected group. Semi-quantitative analysis indicated that the degree of antiviral response via type I IFN response is supposedly equal among dsRNA injected fish. These results suggest that type I IFN response rather than sequence-specific RNA interference might involve in the lengthened survival period of fish injected with virus-specific dsRNAs.

• Earthquakes and Structures
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• 제13권2호
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• pp.103-118
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• 2017

In vertical seismic isolation (VSI), a building is partitioned intentionally by vertical layers into two dynamically different substructures for seismic response reduction. Initially, a 1-story frame was partitioned into two substructures, interconnected by viscous and visco-elastic links, and seismic responses of the original and the vertically isolated structures (VIS) were obtained, considering a large number of stiffness and mass ratios of substructures with respect to the original structure. Color contour graphs were defined for presentation and investigation of large amounts of output results. Dynamic characteristics of the isolated structures were studied by considering the non-classical damping of the system, and then the effects of viscous and visco-elastic link parameters on the modal damping ratios were discussed. On this basis, three states of mass isolation, interactional state, and control mass were differentiated. Response history analyses were performed by Runge-Kutta numerical method. In these analyses, interaction of isolation ratios and link parameters, on response control of VIS was studied and the appropriate ranges for link parameters as well as the optimal ranges for isolation ratios were suggested. Results show that by using the VSI technique, seismic response reduction up to 50% in flexible substructure and even more in stiff substructure is achievable.

• Steel and Composite Structures
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• 제45권5호
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• pp.621-640
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• 2022

In the present article, the vibration response of a geometrically imperfect bi-directional functionally graded plate (2D-FGP) with geometric discontinuities and micro-structural defects (porosities) has been investigated. A porosity model has been developed to incorporate the effective material properties of the bi-directional FGP which varies in two directions i.e. along the axial and transverse direction. The geometric discontinuity is also introduced in the plate in the form of a circular cut-out at the center of the plate. The structural kinematic formulation is based on the non-polynomial trigonometric higher-order shear deformation theory (HSDT). Finite element formulation is done using C° continuous Lagrangian quadrilateral four-noded element with seven degrees of freedom per node. The equations of motion have been derived using a variational approach. Convergence and validation studies have been documented to confirm the accuracy and efficiency of the present formulation. A detailed investigation study has been done to evaluate the influence of the circular cut-out, geometric imperfection, porosity inclusions, partial supports, volume fraction indexes (along with the thickness and length), and geometrical configurations on the vibration response of 2D-FGP. It is concluded that after a particular cut-out dimension, the vibration response of the 2D FGP exhibits non-monotonic behavior.

• 한국안전학회지
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• 제38권6호
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• pp.60-71
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• 2023

The purpose of this study is to propose a quantitative toxicity endpoint distance suitable for the initial response of firefighters by comparing and analyzing the commonly applied toxic level of concern (T-LOC), specifically emergency response planning guidelines (ERPG), acute exposure guideline levels (AEGL), and immediately dangerous to life or health (IDLH). This is to protect the fire brigade, which responds to toxic chemical accidents first during the golden time. Using areal locations of hazardous atmospheres, a damage prediction program, the amount of leakage for both acidic and basic substances, along with the endpoint distance, were analyzed for alternative accident and worst-case accident scenarios. The results showed that the toxicity endpoint distance, serving as a compromise between Level-3 and Level-2 of T-LOC, was longer than ERPG-3 and shorter than ERPG-2 with IDLH, while its values were analyzed in the order of ERPG-2, AEGL-2, IDLH, AEGL-3, and ERPG-3. It is suggested that the application of IDLH in an emergency (red card) and ERPG-2 endpoint distance in a non-emergency (non-red card) can be utilized for the initial response of the fire brigade.

• Archives of Pharmacal Research
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• 제15권1호
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• pp.20-29
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• 1992

Effects of squalene on cellular and non-specific immune responses and antitumor activity in mice were investigated. Cellular and non-specific immunological assay parameters adopted in the present study were delayed-type hypersensitivity reaction and resette forming cells (RFC) for cellular immunity, activities of natural killer (NK) cells and phagocyte for non-specific immunity. Squalene resulted in marked increases of cellular and non-specific immune functions and enhancement of host resistance to tumor challenge in dose-dependent manner.

• 대한약침학회지
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• 제23권4호
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• pp.252-261
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• 2020

Objectives: Chronic diseases (CDs) continue to increase due to advances in medicine and increase in lifespan, affecting quality of life and resulting in economic loss through treatment costs. This study addressed the perception characteristics of the effectiveness of Korean medicine (KM) based on the existence of a CD to determine the national preference for KM treatment. Methods: Using data from the 2017 National Survey of KM Usage, we evaluated the perception on treatment effect of 16 diseases by dividing them into the CD group and the non-CD group. Response reliability was verified by applying the chi-square test (χ2-test) analysis method of the Statistical Package for the Social Sciences (SPSS) statistical program. Results: The analysis of the perception on effectiveness of KM for patients with CD (n = 1,050, 21.0%) and for patients with non-CD (n = 3,950, 79.0%) showed an overall similar trend for all the 16 diseases. The response rates of having some treatment effect were high for nine diseases namely, disc-related disease (CD: 70.7%, non-CD: 73.1%), osteoarthritis (CD: 72.3%, non-CD: 72.4%), frozen shoulder and shoulder pain (CD: 79.6%, non-CD: 81.4%), back pain (CD: 84.6%, non-CD: 85.0%), sprain (CD: 84.8%, non-CD: 84.1%), facial nerve paralysis (CD: 73.5%, non-CD: 71.7%), stroke (CD: 66.2%, non-CD: 62.8%), digestive disease (CD: 53.3%, non-CD: 50.0%), and common cold and rhinitis (CD: 44.7%, non-CD: 44.8%). Conclusion: The present results found that there was little difference in the perception on effectiveness of KM for each of the 16 diseases in patients with CD and non-CD, however, 70% or more of the respondents recognized some treatment effect on musculoskeletal disorders, regardless of the existence of CD. Preferential political support for KM treatment of chronic musculoskeletal disorders is recommended.

• Structural Engineering and Mechanics
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• 제32권1호
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• pp.179-191
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• 2009

A stochastic response spectrum method is proposed for simple evaluation of the structural response of an actively controlled aseismic structure. The response spectrum is constructed assuming a linear structure with an active mass damper (AMD) system, and an earthquake wave model given by the product of a non-stationary envelope function and a stationary Gaussian random process with Kanai-Tajimi power spectral density. The control design is executed using a linear quadratic Gaussian control strategy for an enlarged state space system, and the response amplification factor is given by the combination of the obtained statistical response values and extreme value theory. The response spectrum thus produced can be used for simple dynamical analyses. The response factors obtained by this method for a multi-degree-of-freedom structure are shown to be comparable with those determined by numerical simulations, demonstrating the validity and utility of the proposed technique as a simple design tool. This method is expected to be useful for engineers in the initial design stage for structures with active aseismic control.

• 한국임상약학회지
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• 제18권2호
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• pp.75-83
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• 2008

Purpose: Currently lung cancer ranks second in cancer for incidence rate and is a disease that ranks first for a death rate by cancerous growth because it is already advanced at the time of diagnosis. The purpose of this paper was to analyze the factors that affect the effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) in patients with non-small cell lung cancer. Methods: A retrospective chart review of 100 patients, who took EGFR TKI (erlotinib, gefitinib) among patients who were diagnosed with non-small cell lung cancer in a Hospital in Korea between May 2005 and February 2008, was conducted. The drug effectiveness was evaluated by Response Evaluation Criteria In Solid Tumor. Results: EGFR mutation was the only factor associated with drug response (complete response and partial response). When stable disease was added to drug response as the evaluation parameter, ECOG and rash as well as EGFR mutation were found to be important factors. Survival, however, was not affected by EGFR mutation. The factors influenced on survival were older age (${\geq}65$), low ECOG ($1{\sim}2$), adenocarcinoma and rash. In the case of rash, group with EGFR mutation or low ECOG showed significantly higher chance of occurrence. There was no significant difference in rash occurrence between gefitinib and erlotinib groups. Conclusions: Based on the results, EGFR mutation positive and low ECOG ($1{\sim}2$) were significantly important factors for both effectiveness of EGFR TKI and rash occurrence. Also, rash itself was found to be an independently significant factor for the disease control and survival. Therefore, while administering EGFR TKI, patients who have the factors associated with rash occurrence should be closely monitored for effective and safe drug therapy.

• Wind and Structures
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• 제16권1호
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• pp.1-23
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• 2013

The wind-induced transient response of internal pressure following the creation of a sudden dominant opening during the occurrence of high external pressure, in low-rise residential and industrial buildings was numerically investigated. The values of the ill-defined parameters namely the flow contraction coefficient, loss coefficient and the effective slug length were calibrated by matching the analytical response with the computational fluid dynamics predictions. The effect of a sudden i.e., "instantaneously created" windward opening in the Texas Technical University (TTU) test building envelope was studied for two different envelope flexibility-leakage combinations namely: (1) a quasi-statically flexible and non-porous envelope and (2) a quasi-statically flexible and porous envelope. The responses forced by creating the openings at different time leads/lags with respect to the occurrence of the peak external pressure showed that for cases where the openings are created in close temporal proximity to the peak pressure, the transient overshoot values of internal pressure could be higher than the peak values of internal pressure in the pre-sequent or subsequent resonant response. In addition, the influence of time taken for opening creation on the level of overshoot was also investigated for the TTU building for the two different envelope characteristics. Non-dimensional overshoot factors are presented for a variety of cavity volume-opening area combinations for (1) buildings with rigid/quasi-statically flexible non-porous envelope, and (2) buildings with rigid/quasi-statically flexible and porous envelope (representing most low rise residential and industrial buildings). While the factors appear slightly on the high side due to conservative assumptions made in the analysis, a careful consideration regarding the implication of the timing and magnitude of such overshoots during strong gusts, in relation to the steady state internal pressure response in cyclonic regions, is warranted.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5473-5476
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• 2013

Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.