• Asian-Australasian Journal of Animal Sciences
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• 제13권4호
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• pp.431-434
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• 2000

Maintaining maximum genetic variability is of critical importance with in-situ conservation of animal species in small populations. Marker-assisted mating (MAM) was suggested to achieve maximum heterozygosity in offspring populations. The aims of this research was to investigate and decide the effectiveness and promising types of MAM to achieve this goal. Analysis of variance with simulation data revealed that the heterozygosity in offspring populations was significantly determined by sire heterozygosity from mating of non-inbred parent animals, and significantly by sire heterozygosity and percent parental difference in offspring reproduced by inbred parents. Seven types of marker-assisted mating schemes were examined, in which offspring exhibited heterozygosity that was -0.01 to 7.37% below or above that from random mating of non-inbred parent animals, and 0.00 to 16.39% above that from random mating of inbred parent animals. The great increase in offspring heterozygosity was observed with mating by tandem maximizing sire heterozygosity, percent parental difference, and dam heterozygosity. Random mating resulted in fluctuation of offspring heterozygosity. These results suggested that MAM was a promising method for maintaining maximum offspring variability in in-situ conservation of animal species in small populations.

• Journal of Plant Biotechnology
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• 제37권2호
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• pp.212-219
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• 2010

Selectable marker gene systems are vital for the development of transgenic plants, but the presence of selectable marker genes encoding antibiotic or herbicide resistance in genetically modified plants poses a number of problems. A lot of research results and various techniques have been developed to produce marker-free GM plants. The aim of this review is to describe the principal methods used for eliminating selectable marker genes to generate marker-free GM plants, concentrating on the three significant methods(co-transformation, site-specific recombinase-mediated excision, non-selected transformation) in several marker-free techniques.

• Asian Spine Journal
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• 제12권6호
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• pp.992-997
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• 2018

Study Design: Feasibility study. Purpose: To evaluate the feasibility of using serum pentosidine level as a potential marker for osteoporotic vertebral compression fracture (OVCF). Overview of Literature: A review of previous studies suggests a negative correlation between serum pentosidine concentration and bone strength. However, it is unclear whether serum pentosidine level might be a potential marker of OVCF in Koreans. Methods: Forty patients who underwent bone mineral density examination were included in this study, and their serum pentosidine levels were prospectively analyzed. Serum pentosidine level was evaluated using enzyme-linked immunosorbent assay. Among all the patients, 11 with OVCF were assigned to the vertebral fracture group and 29 who did not have vertebral fracture were included in the non-fracture group. In addition, we used the Fracture Risk Assessment (FRAX) tool Korean version for assessing the 10-year probability of fracture. Results: There was a statistically significant difference in the mean serum pentosidine level (p=0.04) of the vertebral fracture group (110.8 ng/mL) and the non-fracture group (64.3 ng/mL). Logistic regression analyses showed that serum pentosidine was significantly associated with OVCF. The vertebral fracture group had significantly higher 10-year probability of major osteoporotic fracture as per FRAX than the non-fracture group. There was a positive correlation between pentosidine level and FRAX results (r=0.35, p=0.02). Conclusions: These results suggest that increased serum pentosidine level could be a potential marker for OVCF.

• 한국컴퓨터정보학회논문지
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• 제13권1호
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• pp.89-97
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• 2008

본 논문에서는 인공신경망을 이용하여 사각형 형태 마커 검출 및 인식의 성능을 향상시키는 방법을 제안한다. 본 논문의 방법에서는 입력 영상으로부터 객체의 윤곽선을 찾은 다음에 선분으로 근사화한다. 근사화된 선분으로부터 기하학적 특징을 이용하여 사각형을 찾고 워핑 기법과 확대/축소 변환을 이용하여 사각형 영상을 정사각형 형태로 정규화 한다. 정사각형 형태로 정규화 한 다음에는 주성분 분석을 적용하여 특징 벡터의 크기를 줄인 다음에 인공신경망을 이용하여 마커 영상인지 아닌지를 검사한다. 마커 영상으로 판별된 영상에 대하여 인공신경망을 이용하여 마커의 종류를 인식한다. 인식 실험 결과 인공신경망을 사용함으로써 마커 검출의 오류 줄일 수 있었고 인식의 정확도를 개선할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3037-3046
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• 2012

The diffuse large B-cell lymphoma (DLBCL) encompasses two major groups of tumors with uneven survival outcomes - germinal center B-cell (GCB) and non-germinal center B-cell (non-GCB). In the present study, we investigated the expression of GCB markers (BCL-6 and CD10) and non-GCB markers (CD138 and MUM-1) in an effort to evaluate their prognostic value. Paraffin-embedded tumor biopsies of 46 Jordanian DLBCL patients were analyzed, retrospectively, by immunohistochemistry to investigate the expression of BCL-6, CD10, CD138 and MUM-1. In addition, survival curves were calculated with reference to marker expression, age, sex and nodal involvement. Positive expression of BCL-6, CD10, CD138 and MUM-1 was shown in 78%, 61%, 39% and 91% of the cases, respectively, that of BCL-6 being associated with better overall survival (p = 0.02), whereas positive CD138 was linked with poor overall survival (p = 0.01). The expression of CD10 and MUM-1 had no impact on the overall survival. Among the clinical characteristics studied, diagnosis at an early age, nodal involvement and maleness were associated with a higher overall survival for DLBCL patients. Our results underline the importance of BCL-6 as a marker of better prognosis and CD138 as a marker of poor prognosis for DLBCL patients.

• Journal of Computational Design and Engineering
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• 제1권4호
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• pp.289-297
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• 2014

Although big-sized markers are good for accurate marker recognition and tracking, they are easily occluded by other objects and deteriorate natural visualization and level of immersion during user interaction in AR environments. In this paper, we propose an approach to exploiting the use of rectangular markers to support tangible AR interaction based on fingertip touch using small-sized markers. It basically adjusts the length, width, and interior area of rectangular markers to make them more suitably fit to longish objects like fingers. It also utilizes convex polygons to resolve the partial occlusion of a marker and properly enlarges the pattern area of a marker while adjusting its size without deteriorating the quality of marker detection. We obtained encouraging results from users that the approach can provide better natural visualization and higher level of immersion, and be accurate and tangible enough to support a pseudo feeling of touching virtual products with human hands or fingertips during design evaluation of digital handheld products.

• 한국멀티미디어학회논문지
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• 제10권7호
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• pp.923-933
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• 2007

본 논문에서는 SVM(Support Vector Machine)과 LDA(Linear Discriminant Analysis)를 이용하여 사각형 형태 마커 검출 및 인식의 성능을 향상시키는 방법을 제안한다. 본 논문의 방법에서는 사각형 형태의 마커 검출을 위하여 입력 영상을 이진 영상으로 변환하고 객체들의 윤곽선을 추출한 다음에 윤곽선을 선분으로 근사화 한다. 근사화된 선분으로부터 기하학적 특징을 이용하여 사각형을 찾는다. 마커의 사각형 영역을 찾은 다음에는 워핑 기법과 확대/축소 변환을 이용하여 사각형 영상을 정사각형 형태로 정규화한다. 정사각형 형태로 정규화한 다음에는 주성분 분석을 적용하여 특징 벡터의 크기를 줄인 다음에 SVM을 이용하여 마커 영상인지 아닌지를 검사한다. 마커 영상으로 판별된 영상에 대하여 LDA를 적용하여 특징 벡터의 크기를 더 줄이고 표준 마커에 대한 특징 벡터와의 최소 거리법에 의해 마커의 종류를 인식한다. 인식 실험 결과 SVM을 사용함으로써 마커 검출의 오류를 줄일 수 있었고 LDA를 사용함으로써 특징 벡터의 크기는 줄어들고 인식률이 높아짐을 알 수 있었다.

• 한국언어정보학회지:언어와정보
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• 제20권1호
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• pp.51-71
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• 2016

The status of the Korean morphological marker '-e ci' has been controversial whether it is a passive marker, an anticausative marker, or a passive/anticausative marker. However, the previous approaches that tried to classify '-e ci' constructions based on the syntactic verb classes (i.e. intransitive or transitive) were short of explaining the properties of the constructions. In this study, the '-e ci' constructions were distinguished based on agentivity, following Levin & Rappaport Hovav (1995) and Alexiadou et al. (2006). Moreover, how the verbal root meaning is associated with the passive/anticausative construction was investigated by means of Distributed Morphology (DM) (Embick 2010; Marantz 1997). I argued that the morphological marker '-e ci' is the instantiation of the absence of external arguments. With respect to the behavior of the Korean '-e ci' constructions with the semantics of each verbal root class, I found out that the '-e ci' constructions can form passives with the verbal roots that require the external arguments; whereas, the anticausatives cannot be formed with the roots that necessarily require the agentive arguments. However, contrary to the previous arguments that '-e ci' passives can be only formed with transitive verbs, it is discovered that non-agentive transitive roots do form anticausatives. Moreover, I argued that there are two types of the anticausatives - zero and '-e ci' anticausatives. Since the valency reduction is marked by the non-active voice morphology, the zero anticausatives appear only with the roots that do not require external arguments. The different '-e ci' constructions (passives, '-e ci', and zero anticausatives) are represented by the distinct syntactic structures. I proposed that the morphological similarity between the passives and the '-e ci' anticausatives is due to the presence of VoiceP, which introduces the external arguments. Moreover, the lack of the voice morphology in the zero anticausatives is explained by the absence of the VoiceP.

• 대한두경부종양학회:학술대회논문집
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• 대한두경부종양학회 2005년도 제22차 추계학술대회
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• pp.244-244
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• 2005

• 생명과학회지
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• 제16권2호
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• pp.219-224
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• 2006

ISSR markers를 이용하여 수박 18품종의 유전적 유연관계를 분석하여 얻어진 결과를 요약하면 다음과 같다. 수박 18품종의 genomic DNA와 ISSR primer 100개를 PCR 반응시킨 결과 다형성을 뚜렷하게 나타내는 primer는 21개 이였으며, 이들 primer에 의해 증폭된 밴드는 105개 이였고 다형성을 보이는 밴드는 58개 였으며 증폭된 DNA 단편의 크기는 $0.2{\sim}5.0kb$ 사이에 위치하였다. 다형성을 나타낸 primer는 18개의 anchored primer와 3개의 non-anchored primer로 구분되었고 모든 anchored primer는 2개의 염기서열이 반복된 형태를 나타내었으며, non-anchored primer보다. 다형성 정도가 높게 나타났다. 수박 18품종은 유전적 유사도 값 0.42를 기준으로 할 때 18개 품종을 2개의 그룹 으로 구분할 수 있었으며, 국내에서 육성된 품종은 유전적 유사도가 아주 높은 것으로 분석 되었고, 이들 품종은 수박의 과형에 따라 유사하게 구분되었다.