• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 추계학술대회
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• pp.147-150
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• 1994

To predict light propagation in biological tissues irradiated by laser, the optical properties such as absorption and scattering coefficients are required. There have been various techniques for measuring these coefficients. One method requires tissue samples, often a slab of thin tissue, is invasive. On the other hand, non-invasive method usually measures back-scattered light from a subject with no physical intervent ions. Advantages and disvantages of using different methods are investigated. A careful attention should be made in order to select the best method for a given experimental condition since, even either for invasive or non-invasive method, accuracy is subject to governing models and sample preparations.

• 대한의생명과학회지
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• 제21권3호
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• pp.135-143
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• 2015

Electrocardiogram measures the electric impulses generated by the heart during its cycle. Recently genome-wide association studies on electrocardiogram traits revealed many relevant genetic loci. Therefore, these findings need to be validated and investigated to determine the underlying mechanisms using mouse models. Invasive radiotelemetry has been widely used to record the electrocardiogram in mice because it has several advantages over non-invasive measurements. However, radiotelemetry is expensive and requires complicated surgery. On the other hand, a non-invasive method using 3 electrodes (one for earth) for lead II is easy to establish and allows for rapid measurement. In this study, eleven mice were measured with this non-invasive method and no statistical difference among them was found in any ECG measurements. In addition, repeat measurement in the same mouse was performed in 9 sets of experiment and the results indicated that non-invasive method was reliable for reproducibility. Further it was shown that measurements for 1, 5, 10, and 15 minutes were not different so that a short recording such as 5 minutes was enough to estimate the ECG values including heart rate. Further this method was validated by measuring the ECG of Balb/c and FVB that were previously shown to differ in ECG values by radiotelemetry. Significant differences were found in heart rate, PR interval and corrected QT interval between these mouse strains. This study partially proved that non-invasive method also could provide the accuracy and reproducibility. Based on these results, the non-invasive ECG recordings of lead II is recommended as a useful method for quick test in mouse model.

• 한국정보통신학회논문지
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• 제5권7호
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• pp.1263-1271
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• 2001

There are two methods in blood pressure measurement ; Invasive methode and Non-invasive method. The Invasive methode can get the 띠cod pressure measurement but, patient feel uncomfortable. So Non-invasive methode used generally. The Oscillometric method is typical Non-Invasive method. This method is commonly used to measure BP in electric sphygmomanometer and has various algorithm. In this paper it is described about a algorithm, it controls, determinates the cuff pressure, and fillers the measured BP data. This system can interface with PC(personal computer) by RS-232 and save the measured data in PC. This system deflates the cuff pressure by Solenoid valve. The main algorithm are oscillometric and maximum amplitude algorithm(MAA). MAA has various measured oscillation, it depends on patient's age, height, weight and arm circumference size. In this paper proposed system can measure Systolic BP, Diastolic BP, and Mean BP using Interpolation, Auto Reinflation algorithm.

• 전자통신동향분석
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• 제36권5호
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• pp.9-20
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• 2021

A technology to replace the traditional blood sampling method for glucose monitoring has been sought for a long time. It is now possible to measure the blood glucose change rate continuously for more than 24 hours using a minimally invasive method that does not involve blood collection. Furthermore, various technology development efforts are being made for innovative diabetes management through intermittent or continuous blood glucose monitoring in a non-invasive manner. In this paper, we present an overview of diabetes and the need for continuous blood glucose measurement techniques., and then introduce various non-invasive blood glucose measurement techniques currently being studied. In addition, through research and analysis of the recent commercialization development status of minimally invasive, non-invasive, and wearable continuous blood glucose measurement technologies, we examine global development trends of future technologies.

• 약학회지
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• 제46권5호
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• pp.331-336
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• 2002

The purpose of this study is to develop a non-invasive blood glucose measurement method by a portable near infrared (NIR) system which was newly integrated by our lab. The portable NIR system includes a tungsten halogen lamp, a specialized reflectance fiber optic probe and a photo diode array type InGaAs detector; which was developed by a microchip technology based on the lithography. Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were recorded by using a fiber optic probe. The spectra were collected over the spectral range 1100 ∼ 1740 nm. Partial least squares regression (PLSR) was applied for the calibration and validation for the determination of blood glucose. The calibration model from earlobe spectra presented better results, showing good correlation with a glucose oxidase method which is a mostly used standard method. This model predicted the glucose concentration for validation set with a SEP of 33 mg/dL. This study indicated the feasibility for non-invasive monitoring of blood glucose by a portable near infrared system.

• Journal of Platform Technology
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• 제10권3호
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• pp.3-10
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• 2022

The effectiveness of an innovative skin treatment system that delivers an anti-aging solution deep into the skin without invasiveness and pain using a non-invasive air technology was investigated. In addition, an effective change using a non-invasive technique for delivering a solution for skin improvement was confirmed. The equipment named Cellre Jet is an effective skin care and drug delivery equipment that instantly opens the skin epidermis by using a maximum output pressure of 6 bars and high-pressure purified oxygen of 75-90% purity to deliver various nano-sized vital substances deep into the skin, and it uses the method of precisely controlling the equipment through an 8-inch digital touch display to accurately dispense the prescribed dosage. In this study, changes in skin condition were analyzed using this equipment and nano ampoules on subjects with actual skin problems through a related comparison and effectiveness judgment program. Through this study, skin care and drug delivery are possible, which will contribute to verifying the effectiveness of this non-invasive drug delivery equipment in the future, and is expected to establish the systematic effect in observing and studying changes in the skin.

• 한국동물생명공학회지
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• 제37권2호
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• pp.80-86
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• 2022

The ability to determine the sex of bovine embryos before the transfer is advantageous in livestock management, especially in dairy production, where female calves are preferred in milk industry. The milk production of female and male cattle benefits both the dairy and beef industries. Pre-implantation sexing of embryos also helps with embryo transfer success. There are two approaches for sexing bovine embryos in farm animals: invasive and non-invasive. A non-invasive method of embryo sexing retains the embryo's autonomy and, as a result, is less likely to impair the embryo's ability to move and implant successfully. There are lists of non-invasive embryo sexing such as; Detection of H-Y antigens, X-linked enzymes, and sexing based on embryo cleavage and development. Since it protects the embryo's autonomy, the non-invasive procedure is considered to be the safest. Invasive methods affect an embryo's integrity and are likely to damage the embryo's chances of successful transformation. There are different types of invasive methods such as polymerase chain reaction, detection of male chromatin Y chromosome-specific DNA probes, Loop-mediated isothermal amplification (LAMP), cytological karyotyping, and immunofluorescence (FISH). The PCR approach is highly sensitive, precise, and effective as compared to invasive methods of farm animal embryonic sexing. Invasive procedures, such as cytological karyotyping, have high accuracy but are impractical in the field due to embryonic effectiveness concerns. This technology can be applicable especially in the dairy and beef industry by producing female and male animals respectively. Enhancing selection accuracy and decreasing the multiple ovulation embryo transfer costs.

• 한국컴퓨터정보학회논문지
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• 제23권12호
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• pp.131-136
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• 2018

This paper proposes a computer-aided diagnostic algorithm in a non-invasive way. Currently, clinical diagnosis of jaundice is performed through blood sampling. Unlike the old methods, the non-invasive method will enable parents to measure newborns' jaundice by only using their mobile phones. The proposed algorithm enables high accuracy and quick diagnosis through machine learning. In here, we used the SVM model of machine learning that learned the feature extracted through image preprocessing and we used the international jaundice research data as the test data set. As a result of applying our developed algorithm, it took about 5 seconds to diagnose jaundice and it showed a 93.4% prediction accuracy. The software is real-time diagnosed and it minimizes the infant's pain by non-invasive method and parents can easily and temporarily diagnose newborns' jaundice. In the future, we aim to use the jaundice photograph of the newborn babies' data as our test data set for more accurate results.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.1-13
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• 2009

Objective: Optical Coherence Tomography (OCT) has emerged as an important optical imaging modality in non-invasive medical diagnostics. Hence, the aim of this study is to measure the similarity of the diagnosis by a traditional method using doctor's hand for feeling of pulse and by the non-contact/non-invasive pulse analyzing system using OCT on Chon(寸), Kwan(關), Chuk(尺). Method: Four korean medical doctors and the non-contact/non-invasive pulse analyzing system using OCT have measured the rapidity, the dimension, and the power of pulse waves of 25 volunteers. First, four korean medical doctors measured pulse waves of volunteers. During measuring, four doctors were separated from each other and so were volunteers. And then, the pulse waves of volunteers were measured by OCT. This was performed on the right Chon(寸), Kwan(關), Chuk(尺). Results: The study showed that the traditional method and the OCT based method had the 88% matches on the values of the slow and rapid pulse condition (遲數), 64% matches on the values of the small and big pulse condition(微細弱緩大[洪]), and 72% matches on the values of the weak and strong pulse condition(虛實). Conclusions: Based on the high similarities of the measurements of two approaches, we suggest that the OCT based pulse diagnosis method is useful for compensating the traditional method for the pulse diagnosis.

• 대한화장품학회지
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• 제28권3호
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• pp.63-90
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• 2002

멜라닌의 정량은 인체에서 화장품의 미백효과를 평가하기 위한 가장 좋은 방법이지만 인체의 멜라닌 측정을 위한 높은 정확성을 가진 non-invasive방법은 아직 확립되지 않은 실정이다. 피부에서 화장품의 미백효과는 피부색의 밝기로 나타낼 수 있으므로 화장품의 미백효력 평가를 위한 재현성있는 방법으로는 피부색측정을 하는 것이 합리적이다 이에 colorimeter, mexameter와 전문가의 육안평가같은 여러 기기나 분석법이 사용되었다. 이 강연에서는 미백효과에 대한 평가를 위한 다양한 평가방법에 대해 자세히 보고하고 각 방법에 대하여 토의하게 될 것이다 그리고 간단히 임상시험에 대한 결과를 보고하고 마지막으로 melanocyte를 정량하는 새로운 non-invasive방법에 대한 model을 제시하려고 한다.