• 대한의생명과학회지
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• 제24권3호
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• pp.230-238
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• 2018

Human enteric Adenovirus-41 (HuEAdV-41) causes gastroenteritis, which detected by the polymerase chain reaction (PCR) base diagnostic system for clinical, food, environmental, fish and shellfish samples. We developed improved PCR and nested PCR primer set which had high specificity, sensitivity and reduced times. In this study, we compared seventeen conditions reported in the previous study that was using the PCR based HuEAdV-41 detection system, and non-enteric Adenovirus were detected in nine conditions. The most sensitive detection condition was up to 25 copies however it took 184 minutes of PCR reaction time. In this study, the PCR primer set developed had same level of sensitivity, it reduced the time of detection for clinical, food and seafood samples to 112 minutes. Developed nested PCR primer set needed 112 minutes but detected up to approximately 1 copy. In addition, developed PCR and nested PCR primer set was validated with twenty samples of underground water at random, of which ten samples showed specific band without non-specific reaction. We expect this study will be used to diagnose HuEAdV-41 from various samples.

• 약학회지
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• 제56권1호
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• pp.14-19
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• 2012

Nonalcoholic steatohepatitis(NASH) is serious metabolic disease related to fatty acid. According to "two hit theory", fatty acid-induced oxidative stress is important factor to progress nonalcoholic steatohepatitis from steatosis. In this study, we evaluated stearic acid induced oxidative stress in human hepatocarcinoma SK-Hep-1 cell. Cell viability, reactive oxygen species (ROS) production, glutathione (GSH), malondialdehyde and expression of antioxidant enzymes were determined at various time-points and concentrations of stearic acid. At 0.2 mM, non-toxic concentration, of stearic acid, production of ROS was significantly increased at 24 hours and the level of GSH was significantly decreased. Expression of superoxide dismutase-1 and 2 was slightly increased in 0.2 mM stearic acid at 24 hours. These results represent that the non-toxic concentration of stearic acid resulted in oxidative stress, suggesting that stearic acid may play a critical role in development of steatohepatitis.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.544-544
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• 2003

We investigated the inhibitory effect of whitening materials with growth factor or alone on melanomas derived from Human (B-16) and mouse (SK-MEL-31) using melanin content. Melanin content was determined by the absorbance value at 470nm per cells. we used the growth factors known as activators of Adenylate cyclase, Protein kinase C and tyrosine kinase pathway separately. In addition, we compared the action of UV-induced with non-biological growth factor with whitening materials in melanomas derived from Human and mouse. The results showed that the aspect of inhibitory effect of whitening materials on B16 and SK-MEL-31 was not different. And, the action of each growth factor involved in the differentiation and proliferation of melanoma on the inhibition of melanogenesis in B-16 and SK-MEL-31 using whitening agents showed no difference. Also, The action of UV -induced and non-biological growth factors didn't exhibit different pattern on the effect of whitening agent in B-16 and SK-MEL-31.

• Journal of the Optical Society of Korea
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• 제19권2호
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• pp.123-129
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• 2015

A pulse is generated when the heart pumps blood into the arterial system. The heart pumps blood only when it contracts, not when it relaxes; therefore, blood enters the arterial system in a cyclical form. Artery beating is visible in some parts of the body surface, such as the radial artery of the wrist. This paper mainly uses the feature in which near-infrared spectroscopy penetrates skin to construct a non-invasive measurement system that can measure small vibration in the subcutaneous tissue of the human body, and then uses it for the pulse measurement. This measurement system uses the optical moir$\acute{e}$ principle, together with the fringe displacement made by small vibration in the subcutaneous tissue, and an image analysis program to calculate the height variation from small vibrations in the subcutaneous tissue. It completes a measurement system that records height variation with time, and that together with a fast Fourier transform (FFT) program, they can convert the pulse waveform generated by vibration (time-amplitude) to heartbeat frequency (frequency-amplitude). This is a new and non-invasive medical assistance system for measuring the pulse of the human body, with the advantages of being simple, fast, safe and objective.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1998년도 제13차 학술회의논문집
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• pp.391-394
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• 1998

The man-machine interface Is an important factor in the computer system, and it is thought that line-of-sight (LOS) detection technology will allow significant advances in this field. Techniques for detecting LOS for use in human interfaces have been studied［1]［2］. In earlier studies, however, LOS was detected with a head piece, goggles, or through fixing the position of the head. The limitations imposed by these fixed conditions render them unsuitable far use in interfaces, as they have adverse mental or physical effects on humans. Therefore. they have not been sufficiently developed for practical application. Research on non-contact LOS detection is expected to result in a usable LOS man-machine interface［3］［4］, and the current study is intended to be a step in that direction. The authors used color contact lenses for LOS detection, and applied this new method to a computer interface. The use of color contact lenses simplifies image processing. The algorithm used in this study is sufficiently accurate for practical applications. This technique can be used in input devices, in virtual reality applications, and in human engineering research.

• 한국정보통신학회논문지
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• 제10권11호
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• pp.2045-2048
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• 2006

본 연구에서는 키보드나 마우스와 같은 기존의 입력 방식이 아닌 CdS센서 배열을 이용하여 비접촉 방식의 입력방식을 제안하였다. 여기에 측정 하고자 하는 위치에 빛을 조사하였다. 이 때 CdS 센서에서 측정된 값을 A/D 변환하였고 주변 CdS 센서와의 비를 구해 좌표 값을 획득하였다. 획득된 좌표값은 RS-232통신으로 PC에 전송하여 LabVIEW를 이용해 모니 터 화면에 나타내었다. 구현된 장치를 이용하여 측정한 결과로 CdS 센서간 거리를 100등 분 했을 때 위치 값을 정확히 표시함을 확인할 수 있었다.

• Nuclear Engineering and Technology
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• 제42권1호
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• pp.89-96
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• 2010

This paper describes the methodology of calculating the internal dose conversion coefficient in order to assess the radiological impact on non-human species. This paper also presents the internal dose conversion coefficients of 25 radionuclides ($^3H,\;^7Be,\;^{14}C,\;^{40}K,\;^{51}Cr,\;^{54}Mn,\;^{59}Fe,\;^{58}Co,\;^{60}Co,\;^{65}Zn,\;^{90}Sr,\;^{95}Nb,\;^{99}Tc,\;^{106}Ru,\;^{129}I,\;^{131}I,\;^{136}Cs,\;^{137}Cs,\;^{140}Ba,\;^{140}La,\;^{144}Ce,\;^{238}U,\;^{239}Pu,\;^{240}Pu$) for domestic seven reference animals (roe deer, rat, frog, snake, Chinese minnow, bee, and earthworm) and one reference plant (pine tree). The uniform isotropic model was applied in order to calculate the internal dose conversion coefficients. The calculated internal dose conversion coefficient (${\mu}Gyd^{-1}$ per $Bqkg^{-1}$) ranged from $10^{-6}$ to $10^{-2}$ according to the type of radionuclides and organisms studied. It turns out that the internal does conversion coefficient was higher for alpha radionuclides, such as $^{238}U,\;^{239}Pu$, and $^{240}Pu$, and for large organisms, such as roe deer and pine tree. The internal dose conversion coefficients of $^{239}U,\;^{240}Pu,\;^{238}U,\;^{14}C,\;^3H$, and $^{99}Tc$ were independent of the organism.

• 한국콘텐츠학회논문지
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• 제3권2호
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• pp.24-30
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• 2003

기존의 토큰 기반이나 지식 기반 또는 이 둘을 결합한 하이브리드 방식은 분실, 도청 등의 문제점을 내포하고 있다. 이를 위해 본 논문에서는 보안성과 편리성이 뛰어난 생체 인증 방법을 이용한 인증 시스템에 대해 다룬다. 특히 생체 특징중 강제성이 없고 비접촉식은 얼굴 생체특징을 이용한 인증 시스템에 대해 제안하고자 한다. 우선 Y-히스토그램을 통해 얼굴의 각 영역들을 분리해 내고 좌표 변환에 의해 기울어진 얼굴 영상에 대한 처리와 카메라 위치에 불변한 스캐일링을 행한다. 그후 각 얼굴요소들간의 거리와 이루는 각 등과 같은 특징점을 추출하고 퍼지 관계 행렬을 통해 유사도를 측정한다. 끝으로 실험을 통해 본 논문의 유용성을 입증하고자 한다.

• 미생물학회지
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• 제55권2호
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• pp.149-151
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• 2019

Parvimonas micra는 그람 양성, 절대 혐기성, 비운동성 및 아포를 생성하지 않는 구균이다. 이 세균 종은 구강의 정상 세균 총 하나이며, 구강 감염성질환 및 전신질환고도 연관이 있다. P. micra KCOM 1037 (= ChDC B276) 균주가 수술후상악낭종 병소에서 분리되었다. 여기에서 P. micra KCOM 1037 균주의 유전체 염기서열을 완전 해독하여 보고한다.

• 미생물학회지
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• 제55권2호
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• pp.152-153
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• 2019

Prevotella denticola는 그람 음성, 절대 혐기성, 비운동성이면서 아포를 형성하지 않는 막대 모양의 세균이다. P. denticola는 치주질환과 관련이 있으며, 치주질환의 위험 인자 중 하나이다. P. denticola KCOM 1525 (= ChDC B698) 균주가 사람 치근단 농양에서 분리되었다. P. denticola KCOM 1525 균주의 유전체 염기서열을 완전 해독하여 보고한다.