• Asian Pacific Journal of Cancer Prevention
• /
• 제17권10호
• /
• pp.4755-4759
• /
• 2016

Introduction: Lung cancer is one of the most common cancers worldwide. In certain countries such as United States of America, it is the leading cause of related cancer mortality among both men and women. Natural products play an important role in overcoming the limitations of chemotherapy and radiotherapy. Objectives: In this study, we investigated the antiproliferative and apoptotic activities of Kanahia laniflora methanolic extract against human non-small cell lung cancer cells (A549). Methods: Sulforhodamine B colorimetric assays were used to determine the inhibitory effects of a leaf methanolic extract against A549 cells. Results: The extract showed strong cytotoxic activity against A549 cells with an $IC_{50}$ value of $0.13{\mu}g/ml$ compared to $0.21{\mu}g/ml$ for doxorubicin. The extract also significantly increased the percentage of apoptotic cells to 49.7% as compared to 1.4% and 47.4% for control and doxorubicin respectively. Conclusion: These results showed, for the first time, that a methanolic extract of Kanahia laniflora leaves can inhibit the proliferation of human non-small cell lung cancer cells (A549). Further attention to its potential as a new effective anticancer agent is warranted.

• 의료법학
• /
• 제8권1호
• /
• pp.235-277
• /
• 2007

In Product Liability law, the 'defection' of the manufactured products is its key concept, defined in detail. The concept had been already developed through the precedents and theories for the past years even before the PL law was enacted and the concept was listed. Especially, the medicine products need the different approach, because they might directly harm to the human life and body due to their being injected or taken, unlikely other manufactured articles. Since the medical products have the double contradictory functions such as effects and side effects, the defection decisions become so difficult. However, because there are high concerns that wrong medical products will directly harm the human life and body, the decision standards should be more strengthened. The decision standards should include the risk-effect standard as the considered components and make the customer-expecting standard as the final standard. The decision time for defection should be made considering the science technology level when the medical products were provided, not when the accident occurred. It is the most important for the manufacturers to prevent the damages by making and selling the non-defective medicine products for themselves, rather than by taking the legal remedy means afterwards. Therefore, the non-defective guidelines for the medicine manufacturers will help increase the effects and minimize the side-effects.

• 대한의생명과학회지
• /
• 제27권4호
• /
• pp.255-263
• /
• 2021

Human Astrovirus (HuAstV) is an important gastrointestinal pathogen that is frequently reported worldwide. Monitoring of contaminated groundwater has been suggested since HuAstV is transmitted through the fecal-oral route. This study developed a test method based on conventional reverse transcription (RT)-nested polymerase chain reaction (PCR) that involves SL^® non-specific reaction inhibitor for unknown non-specific amplification taking place in the groundwater environment. An optimal method for detecting HuAstV in groundwater sample through analysis and comparison against conventionally reported method was also suggested. The developed method enabled the production of nested PCR amplicon of 630 nt, which is a sufficient length for similarity analysis based on sequencing and genotyping. Amplicons suspected to be HuAstV were amplified in two out of the twenty groundwater samples collected in Korea, presenting 99.77% and 99.73% similarity against HuAstV 1 strain lhar/2011/kor (JN887820.1) in sequencing, respectively. These amplicons were identified as HuAstV 1.

• 한국전문물리치료학회지
• /
• 제29권2호
• /
• pp.87-93
• /
• 2022

To solve the pathological problems of the musculoskeletal system based on evidence, a sophisticated analysis of human motion is required. Traditional optical motion capture systems with high validity and reliability have been utilized in clinical practice for a long time. However, expensive equipment and professional technicians are required to construct optical motion capture systems, hence they are used at a limited capacity in clinical settings despite their advantages. The development of information technology has overcome the existing limit and paved the way for constructing a motion capture system that can be operated at a low cost. Recently, with the development of computer vision-based technology and optical markerless tracking technology, webcam-based 3D human motion analysis has become possible, in which the intuitive interface increases the user-friendliness to non-specialists. In addition, unlike conventional optical motion capture, with this approach, it is possible to analyze motions of multiple people at simultaneously. In a non-optical motion capture system, an inertial measurement unit is typically used, which is not significantly different from a conventional optical motion capture system in terms of its validity and reliability. With the development of markerless technology and advent of non-optical motion capture systems, it is a great advantage that human motion analysis is no longer limited to laboratories.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권11호
• /
• pp.5363-5369
• /
• 2012

High-risk human papillomavirus (HPV) especially HPV-16 and HPV-18 types are speculated to be important risk factors in non-smoking associated lung cancer in Asia. Increasing evidence has demonstrated that HPV oncoproteins may contribute to lung tumorigenesis and cell transformation. Importantly, HPV 16/18 E6 and E7 oncoproteins can mediate expression of multiple target genes and proteins, such as p53/pRb, VEGF, HIF-$1{\alpha}$, cIAP-2, and hTERT, and contribute to cell proliferation, angiogenesis and cell immortalization through different signaling pathways in lung cancer. This article provides an overview of experiment data on HPV-associated lung cancer, describes the main targets on which HPV E6/E7 oncoproteins act, and further discusses the potential signaling pathways in which HPV E6/E7 oncoproteins are involved. In addition, we also raise questions regarding existing problems with the study of HPV-associated lung cancer.

• Coupled systems mechanics
• /
• 제1권4호
• /
• pp.297-309
• /
• 2012

As a result of the medium coupling, propagation characteristics of ultrasonic waves guided by a multi-phase medium can be different from those in a homogeneous system. This phenomenon becomes prominent for a medium consisting of phases with considerably distinct material and physical properties (e.g., submerged structures or human bones covered with soft tissues). In this study, the coupling effect arising from both fluid and soft tissues on wave propagation in engineering structures and human bone phantoms, respectively, was explored and calibrated quantitatively, with a purpose of enhancing the precision of ultrasonic-wave-based non-destructive evaluation (NDE) and clinical quantitative ultrasound (QUS). Calibration results were used to rectify conventional NDE during evaluation of corrosion in a submerged aluminium plate, and QUS during prediction of simulated healing status of a mimicked bone fracture. The results demonstrated that with the coupling effect being appropriately taken into account, the precision of NDE and QUS could be improved.

• IEIE Transactions on Smart Processing and Computing
• /
• 제6권4호
• /
• pp.246-252
• /
• 2017

Non-invasive and non-restrictive methods for measuring the physiological functions of the human body are useful for health care, security, and surveillance. In this paper, a new method that extracts human heartbeat information by utilizing ultra-wideband (UWB) impulse radar is proposed. The amplitude spectra of received radar pulses reflected from the human body are accumulated at specific time intervals, and chirp z-transform (CZT) is used to extract the heartbeat frequency from the amplitude spectra. The heartbeat frequency can be extracted with high-frequency resolution in the frequency band of the heartbeat of interest using CZT. Experimental results to verify the performance of the proposed method show that a highly accurate extraction of the heartbeat frequency is possible using this method.

• 대한안전경영과학회지
• /
• 제19권2호
• /
• pp.69-80
• /
• 2017

This study is analyse method for Industrial disester prevention of E-9 foreign workers. To do this, We adapted tp TRIZ 's creative problem solving theory and AHP, QFD. TRIZ is determined some parameters for problem solving and selected the inventive principles for each parameters. So, We made new parameters and inventive principles under theory of the TRIZ process for reduced to the foreign worker's disaster rate. After, The derived parameters and the inventive principles are used to evaluate the importance of factors through the AHP, and determine the weight of the relation through QFD expansion. Finally. this paper applies statistical data according to the determined model process, analyzes the result and proposes improvement method for the prevention of disaster of foreign workers.

• 한국항해항만학회지
• /
• 제31권4호
• /
• pp.295-307
• /
• 2007

The statistics of Korean Maritime Safety Tribunal and Japan Marine Accidents Inquiry Agency shows that the major muses of collision at sea are Improper lookout and Non-compliance with marine traffic rules. Those two muses are occupying more than 70% of collision, and it's clear that those muses are undoubtedly closely related to simple human error. In this paper we tried to find out the root muses of this kind of human error of OOWs(officers on watch) through risk identification method and studied how to tackle them via risk control theory. In conclusion, the measures studied in this paper could be applied to help OOWs avoid their own human error as well as be used in shipping company for their fleets' safety management.

• 대한의생명과학회지
• /
• 제25권2호
• /
• pp.113-122
• /
• 2019

Long-non coding RNAs (LncRNAs) constitute a wide and extremely diverse family of RNA transcripts that are greater than 200 base pairs in length and are not translated into proteins. X-inactive specific transcript (XIST) was the first long non-coding RNA to be discovered, back in 1991. Its function in X-chromosome inactivation has been extensively studied for three decades, though other functional roles of XIST that involve a variety of fascinating mechanisms remain to be elucidated. Here, we review the emerging oncogenic role of XIST in various human cancers.