• International Journal of Advanced Culture Technology
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• v.6 no.2
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• pp.58-64
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• 2018

This main purpose of the study is to identify social network of communicators sharing information on Bokjiro for publicizing welfare policy. This study employs NodeXL pro to understand networks and their role in the social network. The data for social network analysis was collected from Twitter for a week. The result of the analysis shows that the social network of communicators on Bokjiro does not have many nodes. It also has an independent network with high possibility of information distortion. Little communicators have controlling power in information flow in one way of communication. According to the result, it is not effective for marketing strategy of welfare policy in providing online information through Bokjiro. The study suggests that the government should use the transactional approach to marketing based on agent-oriented activity focusing on the exchange relationship between information providers and demanders in an age of networked intelligence.

• Journal of Chest Surgery
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• v.45 no.3
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• pp.199-201
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• 2012

Castleman's disease is a rare disorder characterized by benign tumors that may develop in the lymph node tissue throughout the body. Castleman's disease associated with myasthenia gravis is an especially rare disease. Only less than 10 cases have been reported in the world literature. The cause of Castleman's disease is associated with immune mediated reaction, and myasthenia gravis also develops due to an antibody-mediated process. The cause of myasthenia gravis is the immune activity of Castleman's disease, which may be the promoter of the antibody-mediated process. We report here a case of Castleman's disease, which was incidentally found in a patient diagnosed with myasthenia gravis.

• The Journal of Korea Robotics Society
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• v.4 no.3
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• pp.177-184
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• 2009

This paper presents an active assisted-living system in wireless sensor and actor network (WSAN) in which the mobile robot roles an actor. In order to provide assisted-living service to the elderly people, position recognition of the sensor node attached on the user and localization of the mobile robot should be performed at the same time. For the purpose, we use received signal strength indication (RSSI) to find the position of the person and ubiquitous sensor nodes including ultrasonic sensor which performs both transmission of sensor information and localization like global positioning system. Active services are moving to the elderly people by detecting activity sensor and visual tracking and voice chatting with remote monitoring system.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2719-2724
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• 2015

Objective: The aim of this study was to investigate the clinical significance of annexin a1 (ANXA1) and provide molecular evidence to support that decreased ANXA1 expression could enhance cancer migration and invasion in pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: Immunohistochemistry of a tissue microarray with 162 surgically resected PDAC specimens was performed to examine the expression of ANXA1. We also investigated the relationship between ANXA1 expression and clinicopathological factors and prognosis of PDAC patients. We further studied the role of ANXA1 in PDAC cell proliferation, migration and invasion by cell proliferation assay, migration assay and matrigel invasion assay with reduced ANXA1 expression by RNAi. Western blotting was used to detect matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) expression. We also detected MMP-9 enzyme activity by gelatin zymography. Results: Decreased expression of ANXA1 was significantly associated with poor differentiation, lymph node metastasis and advanced TNM stage of PDAC patients (p<0.05). Moreover, decreased expression of ANXA1 was correlated with poor survival (p<0.05). Furthermore, we found that ANXA1 knockdown inhibited cell proliferation, induced G1 phase cell cycle arrest, increased PDAC cell migration and invasion capacity compared with controls. In addition, Western blotting showed that ANXA1 knockdown increased the MMP-9 protein level and decreased TIMP-1 expression. Gelatin zymography showed that MMP-9 enzyme activity was also elevated. Conclusions: Negative ANXA1 expression is a most unfavorable prognostic factor for PDAC patients. ANXA1 knockdown inhibits cell proliferation by inducing G1 phase cell cycle arrest and increases migration and invasion of PDAC cells through up-regulating MMP-9 expression and activity, implying that ANXA1 may serve as a promising prognostic biomarker and therapeutic target for PDAC.

• Journal of IKEEE
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• v.14 no.1
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• pp.17-24
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• 2010

This paper presents calorie expenditure prediction model of daily activity of elderly living alone for LBS(Location Based Service) applications. The proposed method is to describe the daily activity patterns of older adult using PIR (Passive InfraRed) motion sensors and to examine the relationships between physical activity and calorie expenditure. The developed motion detecting system is composed of a sensing system and a server system. The motion detecting system is a set of wireless sensor nodes which has PIR sensor to detect a motion of elder. Each sensing node sends its detection signal to a home gateway via wireless link. The home gateway stores the received signals into a remote database. The server system is composed of a database server and a web server, which provides web-based monitoring system to caregivers for more effective services. The experiment results show the adaptability and feasibility of the calorie expenditure model.

• Preventive Nutrition and Food Science
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• v.17 no.1
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• pp.14-21
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• 2012

The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.265-269
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• 2008

Home health care with compact wearable units sounds to be a convenient solution for the elderly people living independently. This paper presents a method to detect fall from the other activities of daily living and also to classify those activities. This kind of ambulatory monitoring enables them to get an emergency help in the case of the fatal fall event and can provide their general health status by observing the activities being performed in daily life. A tri-axial accelerometer sensor is used to get the acceleration anomalies associated with the user's movements. The three axis acceleration data are transferred to the base station sensor node via an IEEE 802.15.4 compliant zigbee module. The base station sensor node sends the data to base station PC for an offline processing. This work shows the feature set preparation using the principal component analysis (PCA) for the designing of neural network. The work includes the most common activities of daily living (ADL) like Rest, Walk and Run along with the detection of fall events from ADL. The angle from the vertical is found to be the most significant feature parameter for classification of fall while mean, standard deviation and FFT coefficients were used as the feature parameter for classifying the other activities under consideration. The accuracy for detection of fall events is 86%. The overall accuracy for ADL and fall is 94%.

• Korean Journal of Head & Neck Oncology
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• v.10 no.2
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• pp.102-105
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• 1994

The indolent course of most thyroid papillary carcinomas, even the presence of regional lymph node metastasis, make them unique among human malignant head and neck cancers. Age, sex, extracapsular invasion and anaplastic change are known to be correlated with prognosis. The purpose of this study is to clarify the significance of DNA content analysis as a prognostic factor. Twenty five thyroid papillary carcinomas were possible to be examined by flow cytometric analysis using fresh surgical specimens and three nodular hyperplasias and seven follicular adenomas were included as control group. The results were as follows: l) All of twenty five thyroid papillary carcinomas showed diploidy. 2) S-phase fraction was $1.94{\pm}2.77%$ in normal control group and $2.60{\pm}2.66%$ in papillary carcinoma group. The proliferation index was $8.44{\pm}3.89%$ in normal control and $7.70{\pm}3.63%$ in papillary carcinoma group with even low value. 3) Age, sex, extracapsular spread and lymph node metastasis showed no significant difference. In conclusion, low proliferative activity of thyroid papillary carcinomas are thought to be related with good prognosis.

• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.326-336
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• 2016

Saccharomyces cerevisiae is one of the most employed cell factories for the production of bioproducts. Although monomeric hexose sugars constitute the preferential carbon source, this yeast can grow on a wide variety of nitrogen sources that are catabolized through central nitrogen metabolism (CNM). To evaluate the effects of internal perturbations on nitrogen utilization, we characterized strains deleted or overexpressed in GLT1, encoding for one of the key enzymes of the CNM node, the glutamate synthase. These strains, together with the parental strain as control, have been cultivated in minimal medium formulated with ammonium sulfate, glutamate, or glutamine as nitrogen source. Growth kinetics, together with the determination of protein content, viability, and reactive oxygen species (ROS) accumulation at the single cell level, revealed that GLT1 modulations do not significantly influence the cellular physiology, whereas the nitrogen source does. As important exceptions, GLT1 deletion negatively affected the scavenging activity of glutamate against ROS accumulation, when cells were treated with H₂O₂, whereas Glt1p overproduction led to lower viability in glutamine medium. Overall, this confirms the robustness of the CNM node against internal perturbations, but, at the same time, highlights its plasticity in respect to the environment. Considering that side-stream protein-rich waste materials are emerging as substrates to be used in an integrated biorefinery, these results underline the importance of preliminarily evaluating the best nitrogen source not only for media formulation, but also for the overall economics of the process.

• The Journal of the Acoustical Society of Korea
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• v.27 no.6
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• pp.279-285
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• 2008

This study includes the efficiency assessment of a multiple access protocol for UUV (Underwater unmanned vehicle) control. Most of UUVs are controled by wire now; however, wireless control is demanded because of the demerit of the wire control that limits the place and activity. This study simulates efficiency of a standardization multiple access protocol (Pure ALOHA, Slotted ALOHA, Nonpersistent CSMA, Slotted Nonpersistent ISMA) formed for the purpose of performing wireless communication controlled by the ship or communication buoy at the sea surface and by the under water communication node at the bottom in order to efficiently control the UUV's. Results show that no significant changes occur related to changing type of the mother ship and the communication node; In addition, the Non-persistent CSMA and the Slotted Non-persistent ISMA show relatively high efficiency for underwater acoustic communication.