Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Flow Cytometric DNA Analysis of Thyroid Papillary Carcinoma

갑상선 유두상암의 핵산분석

  • Chu Hyung-Ro (Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine) ;
  • Jung Do-Kwang (Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine) ;
  • Woo Jeong-Su (Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine) ;
  • Choi Jong-Ouck (Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine) ;
  • Kim In-Sun (Department of Pathology, Korea University, College of Medicine)
  • 주형로 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 정도광 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 우정수 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 최종욱 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김인선 (고려대학교 의과대학 해부병리과)
  • Published : 1994.11.01
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Abstract

The indolent course of most thyroid papillary carcinomas, even the presence of regional lymph node metastasis, make them unique among human malignant head and neck cancers. Age, sex, extracapsular invasion and anaplastic change are known to be correlated with prognosis. The purpose of this study is to clarify the significance of DNA content analysis as a prognostic factor. Twenty five thyroid papillary carcinomas were possible to be examined by flow cytometric analysis using fresh surgical specimens and three nodular hyperplasias and seven follicular adenomas were included as control group. The results were as follows: l) All of twenty five thyroid papillary carcinomas showed diploidy. 2) S-phase fraction was $1.94{\pm}2.77%$ in normal control group and $2.60{\pm}2.66%$ in papillary carcinoma group. The proliferation index was $8.44{\pm}3.89%$ in normal control and $7.70{\pm}3.63%$ in papillary carcinoma group with even low value. 3) Age, sex, extracapsular spread and lymph node metastasis showed no significant difference. In conclusion, low proliferative activity of thyroid papillary carcinomas are thought to be related with good prognosis.

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