• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.3
• /
• pp.1235-1239
• /
• 2015

Background: Fragile histidine triad (FHIT) gene is a tumor suppressor gene which involved in breast cancer pathogenesis. Epigenetics alterations in FHIT contributes to tumorigenesis of breast cancer. Objective: Our objective was to study FHIT promoter region hypermethylation in Egyptian breast cancer patients and its association with clinicopathological features. Materials and Methods: Methylation-specific polymerase chain reaction was performed to study the hypermethylation of FHIT promoter region in 20 benign breast tissues and 30 breast cancer tissues. Results: The frequency of hypermethylation of FHIT promoter region was significantly increased in breast cancer patients compared to bengin breast disease patients. The Odd's ratio (95%CI) of development of breast cancer in individuals with FHIT promoter hypermethylation (MM) was 11.0 (1.22-250.8). There were also significant associations between FHIT promoter hypermethylation and estrogen, progesterone receptors negativity, tumor stage and nodal involvment in breast cancer pateints. Conclusions: Our results support an association between FHIT promotor hypermethylation and development of breast cancer in Egyptian breast cancer patients. FHIT promoter hypermethylation is associated with some poor prognostic features of breast cancer.

• Radiation Oncology Journal
• /
• v.4 no.1
• /
• pp.29-34
• /
• 1986

Thirty-six patients with carcinoma of the tonsillar region treated with radical radiotherapy at Yonsei Cancer Center between Jan. 1971 and Dec. 1980 were retrospectively reviewed. The purpose of this study is to evaluate the clinical characteristics and the treatment results. Seventy-five per cent of patients were in advanced stage when they were first seen. Incidence of nodal involvement at the time of initial presentation was $64\%$. Bilateral nodal involvement was found in $19\%$ of cases. Three-year local control rates for T1, T2, T3, and T4 were $88\%,\;46\%,\;25\%,\;and\;11\%$, respectively. Advanced neck nodes were poorly controlled $(N1\;70\%,\;N2\;20\%,\;N3\;12\%)$. The prognosis is mainly affected by the status of the primary and neck nodes Overall three-year local control rate was $42\%$.

• Ocean Systems Engineering
• /
• v.1 no.4
• /
• pp.337-353
• /
• 2011

In the present study, an offshore platform having large partial porous cylindrical members, which are composed of permeable and impermeable cylinders, is suggested. In order to calculate the wave force on large partial porous cylindrical members, the fluid domain is divided into three regions: a single exterior region, N inner regions and N beneath regions, and the scattering wave in each fluid region is expressed by an Eigen-function expansion method. Applying Darcy's law to the porous boundary condition, the effect of porosity is simplified. Wave excitation forces and wave run up on the structures are presented for various wave conditions. For the idealized three-dimensional platform having large partial porous cylindrical members, the dynamic response evaluations of the platform due to wave forces are carried out through the modal analysis. In order to examine the effects of soil-structure interaction, the substructure method is also applied. The displacement and bending stress at the selective nodal points of the structure are computed using various input parameters, such as the shear-wave velocity of soil, the wave height and the wave period. Applying the Monte Carlo Simulation (MCS) method, the reliability evaluations at critical structure members, which contained uncertainties caused by dynamic forces and structural properties, are examined by the reliability index with the results obtained from MCS.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
• /
• 2011.04a
• /
• pp.258-261
• /
• 2011

실내에서 화재가 발생한 경우에 매연의 크기분포 및 형상(morphology) 변화 특성은 경보장치의 작동 및 흡입에 의한 인체피해 등과 관련되어 중요한 연구 분야이다. 이와 관련하여 많은 연구가 이루어져 왔으나 실험에 의한 연구는 각 연구마다 결과치가 정량적 또는 정성적 측면에서 많은 편차를 보이고 있고, 이론적인 연구는 몇몇 특정 조건에 대하여 제한적으로 이루어져 있어서, 실재 구획화재에 적용하는 데는 어려움이 있다. 이 연구에서는 구획화재에 대하여 발열속도이력(history of heat release rate) 및 매연발생률(soot yield) 등에 따른 매연입자의 크기분포 및 형상 변화 해석을 위한 방법을 개발하였으며, 이를 유럽표준시험화재(EN54 Part7)에 규정된 폴리우레탄폼화재(TF4)에 대하여 시험 적용하였다. 이 방법에서는 입자의 크기분포방정식(dynamic equation for the discrete-size spectrum)을 푸는데 있어서 계산시간을 줄이기 위하여 결절방법(nodal method)을 도입하였으며, 또한 실재 화재에서의 매연입자의 성장에 따른 입경범위에 맞추기 위하여 분자운동영역(free molecular region)과 연속영역(continuum region)을 포괄하는 입자크기에 적용되는 충돌빈도함수(collision frequency function)를 사용하였다.

• Interaction and multiscale mechanics
• /
• v.1 no.2
• /
• pp.211-230
• /
• 2008

Owing to the growing size of the eigenvalue problem and the growing number of eigenvalues desired, solution methods of iterative nature are becoming more popular than ever, which however suffer from low efficiency and lack of proper convergence criteria. In this paper, three efficient iterative eigenvalue algorithms are considered, i.e., subspace iteration method, iterative Ritz vector method and iterative Lanczos method based on the cell sparse fast solver and loop-unrolling. They are examined under the mode error criterion, i.e., the ratio of the out-of-balance nodal forces and the maximum elastic nodal point forces. Averagely speaking, the iterative Ritz vector method is the most efficient one among the three. Based on the mode error convergence criteria, the eigenvalue solvers are shown to be more stable than those based on eigenvalues only. Compared with ANSYS's subspace iteration and block Lanczos approaches, the subspace iteration presented here appears to be more efficient, while the Lanczos approach has roughly equal efficiency. The methods proposed are robust and efficient. Large size tests show that the improvement in terms of CPU time and storage is tremendous. Also reported is an aggressive shifting technique for the subspace iteration method, based on the mode error convergence criteria. A backward technique is introduced when the shift is not located in the right region. The efficiency of such a technique was demonstrated in the numerical tests.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.5
• /
• pp.2439-2443
• /
• 2016

Purpose: To determine the risk factors, clinical symptoms and patterns of spread in laryngeal cancer. Materials and Methods: A cross sectional study was carried out in the Regional Cancer Centre, Imphal, Manipur, India. One hundred and sixteen patients with laryngeal cancer were retrospectively reviewed for epidemiological data and descriptive statistics were reported for various variables. Results: Median age at presentation was 65 years and 32.8% were undernourished at presentation. The male to female ratio was 5.4:1. Heavy smoking and tobacco chewing was associated in 91.4% and 33.6% of patients respectively. Tracheostomy was required in 21.5% leading to diagnosis of laryngeal cancer. Almost all were squamous cell carcinoma with neuroendocrine and verrucous carcinoma accounting for less than 2%. Supraglottic, glottic and trans-glottic tumors were 56.9%, 36.3% and 6.9% respectively. Nodal metastases were seen in 81.8% of supraglottic cancers and 31.6% of glottic cancers with supraglottic involvement. Level II neck nodes were the commonest site followed by level III. Distant metastases (only liver) were apparent in 1.7% at presentation. Including these liver metastases, unresectable cases were limited to 6% of the patients. Conclusions: Tobacco use is implicated in almost all of the cases and the sex ratio has also decreased due to increased female smokers. The supraglottis remains the commonest site and incidence of nodal metastases is higher than in other countries. There is also a higher requirement for tracheostomy at presentation in this region.

• Korean journal of applied entomology
• /
• v.62 no.4
• /
• pp.347-354
• /
• 2023

Mythimna loreyi (Duponchel, 1827) (Lepidoptera: Noctuidae) is a pest that damages agricultural plants, such as rice, wheat, and maize. We sequenced the entire 15,314-bp mitochondrial genome of this species. It has a typical set of genes (13 protein-coding genes, two ribosomal RNA genes, and 22 transfer RNA genes) as well as one major non-coding A+T-rich region. Using concatenated sequences of 13 protein-coding genes and two rRNAs (13,376 bp, including gaps), phylogenetic analysis demonstrated that the sister relationship between M. loreyi and M. separata had the highest nodal support. The monophyly of each family (Noctuidae, Euteliidae, Nolidae, Erebidae, and Notodontidae) of the superfamily Noctuoidea was supported by the highest nodal support.

• Proceedings of the KIEE Conference
• /
• 2002.07c
• /
• pp.1953-1955
• /
• 2002

An efficient automatic mesh generator suitable for the harsh model, which contains abrupt regions and thin layers, is implemented. It adopts two kinds of node placement scheme. In the beginning, the initial nodes on the boundary are generated automatically by an efficient boundary node generation scheme. And then the inner nodes are placed using nodal spacing value technique repeatedly from the initial mesh to final mesh. The effectiveness of the proposed technique is verified by a thin film micro-strip line modeling, where the final mesh contains no sliver elements.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1994.10a
• /
• pp.205-209
• /
• 1994

The main purpose of this study is constructing new velocity fields on the base of shape function used in finite element method and showing the possibility of application it to metal forming processes. Utilizing the 8-node quadratic rectangular element, we expressed the velocity within the deformation region by interpolating the velocity of each nodal points. And the upper-bound formulation from this velocity fields was derived. In order to confirm the validity of this method we applied it to axisymmetic combined extrusion problem. the results of load show that this method is on better agreement with experiment than the conventional UBET, and also the flow pattern and profile of extruded part are reasonable.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1997.10a
• /
• pp.87-94
• /
• 1997

The circular plate resting on Boussinesq's half-space model under axisymmetric loading is studied by a finite element procedure to evaluate the distribution of contact pressure between plate and elastic half-space. The displacement of half-space due to axisymmetric surface loading can be evaluated by double integration of Boussinesq's solution. On that case the analytical integration can be executed for the radial direction but the analytical integration for the circumferential direction is impossible and the numerical integration should be considered. With the radial integration we can get non-dimensional function. Then the numerical integration for the formula is executed for the circumferential direction and the results are approximated 5th order Polynomials by using the least square method. With these 5th order approximate formula, the flexibility matrix of half-space is constructed as the coefficient matrix of nodal contact pressure by the finite element procedures. Iteration procedures are attempted by using this method to determine the separated region.