• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.470-475
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• 2010

Calcium-channel blockers such as nifedipine could be associated with gingival overgrowth. The aim of this study was to examine the role of Paeonia lactiflora Pallas(PLP) on nifedipine-induced gingival hyperplasia along with submandibular secretory function in rats. Animals in divided groups received nifedipine (250 mg/kg) alone and in PLP(100, 200 mg/kg) in orally administration for 3 weeks. Pure submandibular saliva was collected intraorally by micropolyethylene cannula and the mandibular gingiva was examined by means of dissecting microscope for signs of redness, tickness, inflammation and exuda. Twenty-one days nifedipine treatment induced gingival hyperplasia accompanied with reduced salivary flow rate and concentrations total protein, epidermal growth factor(EGF) and calcium in comparison with normals. Co-treatment of animals with nifedifine and PLP protected from gingival hyperplasia and retained flow rate, and concentrations of total protein, EGF and calcium in normal levels.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.240.1-240.1
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• 2003

The purpose of this study was to investigate the effect of nifedipine (10 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (50 mg/kg) orally coadministered and pretreated in rats. The plasma concentration of paclitaxel in combination with nifedipine was significantly (p<0.05 at 10 mg/kg coadmin., p<0.01 at pretreat.) increased compared to that of control, from 2 hr to 24 hr. Area under the plasma concentration-time curve (AUC) of paclitaxel with nifedipine was significantly (p＜0.05 at 10 mg/kg coadmin., p＜0.01 at pretreat.) higher than that of control (omitted)

• Applied Chemistry for Engineering
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• v.16 no.4
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• pp.588-593
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• 2005

In this study, biodegradable poly(${\varepsilon}$-caprolactone) (PCL) microcapsules containing chemically treated $SiO_2$ and nifedipine were prepared by oil-in-water (O/W) emulsion solvent evaporation method. The microcapsules containing drugs were confirmed using FT-IR spectra. The morphologies of the microcapsules were observed with scanning electron microscope (SEM). The nifedipine's release behaviors from the microcapsules were also examined with UV/vis spectroscopy. As a result, the inclusion of nifedipine into the microcapsules was determined by the presence of nifedipine's specific peak, i.e., C=O stretch vibration at $1682cm^{-1}$. The average particle size of the microcapsules decreased with increasing stirring rate. The nifedipine adsorption capacity and release rate of treated $SiO_2$ that was treated with basic solution decreased because with the increased basicity it lowered the specific surface area of $SiO_2$ and promoted stronger acid-base interactions between $SiO_2$ and nifedipine.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.978-983
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• 2004

The effects of glycyrrhizic acid (GLZ) on protein binding of diltiazem, verapamil, and nifedipine were investigated. Protein binding studies (human serum, human serum albumin (HSA) and (X1-acid glycoprotein (AAG)) were conducted using the equilibrium dialysis method with and without addition of GLZ. The binding parameters, such as the number of moles of bound drug per mole of protein, the number of binding sites per protein molecule, and the association con-stant, were estimated using the Scatchard plot. The serum binding of nifedipine, verapamil, and diltiazem was displaced with addition of GLZ, and the decreases of Ks for serum were observed. GLZ decreased the association constants of three drugs for HSA and AAG, while the binding capacity remained similar with addition of GLZ. Although the characteristics of interaction were not clear, GLZ seemed to mainly affect HSA binding of nifedipine rather than AAG binding, while GLZ seemed to affect both AAG- and HSA-bindings of verapamil and dilt-iazem resulting in a serum binding displacement.

• Korean Journal of Veterinary Research
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• v.30 no.3
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• pp.283-286
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• 1990

The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2mg/kg, p.o.) and nifedipine (10 and 20mg/kg, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema. These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan.

• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.57-64
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• 1997

$Amino-{\beta}-lactam$ antibiotics are absorbed by the dipeptide transporter in the small intestine. These uptakes are coupled to a proton influx. The inward proton gradient is partly induced by the $Na^+/H^+$ exchanger and calcium ion is involved in control of this antiport. Interaction between ampicillin which is one of the $Amino-{\beta}-lactam$ antibiotics and nifedipine which is one of calcium channel blocking agents was studied in rats in vivo and with rabbit jejunum mounted on the Sweetana/Grass diffusion cells in vitro. Bioavailability of ampicillin was increased significantly when nifedipine was co-administered orally in rats. There were no differences in the distribution phase and the elimination phase when ampicillin was given either alone or with nifedipine intravenously. Conditions for in vitro experiments were determined. The lift rate of $O_2/CO_2$ gas was controlled to 3 bubbles/sec and ampicillin was stable in the Kreb's buffer at pH 6.0. Absorption of ampicillin was the greatest when the completely-stripped serosal membrane was used. Transport of ampicillin from mucosal to serosal side in the rabbit jejunum was enhanced by 32% in the presence of nifedipine (p=0.059). Above results suggest that nifedipine might increase the plasma level of ampicillin via the improved absorption in the intestine rather than the reduction in the elimination or/and alteration in the distribution.

• The Korean Journal of Physiology
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• v.27 no.1
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• pp.51-55
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• 1993

The effects of a calcium channel blocker and an activator on the release of atrial natriuretic peptide (ANP) were investigated in rats. They were volume expanded (VE) up to 5% of the body weight over 30min by being infused with iso-oncotic saline. Following VE, plasma ANP concentration markedly increased in association with increases in the right atrial pressure. Addition of either nifedipine ($0.4{\mu}m/min$) or Bay K 8644 ($0.4{\mu}m/min$) in the infusate potentiated the VE-induced release, although neither of them affected the right atrial pressure. The nifedipine added group showed a lower mean arterial pressure than the Bay K added group throughout the infusion period. VE decreased plasma renin concentration, the magnitude of which was attenuated by nifedipine but not by Bay K. It may be hypothesized that a decrease in cytoplasmic calcium is primary stimulus far the ANP release, and an increase plays o role in secondary liberation of the ANP accumulated in the interstitium into the lumen of the atria through myocardial contraction. further studies will be needed to confirm the hypothesis.

• Advances in Traditional Medicine
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• v.6 no.2
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• pp.126-133
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• 2006

The cardiovascular drug nifedipine exhibited significant in vitro and in vivo antibacterial activity against 331 strains of bacteria belonging to three Gram-positive and twelve Gram-negative genera. The minimum inhibitory concentration of the drug, as determined both by agar and broth dilution methods, was seen to range from $25\;-\;200\;{\mu}g/ml$ against most test bacteria, including several pathogenic ones, in the in vitro studies. Nifedipine was bacteriostatic in action. in vivo studies with this drug showed that it could offer statistically significant protection (P < 0.001) to mice challenged with a virulent bacterium. Therefore, nifedipine has the potential of an antibacterial agent, which may be developed after further pharmacological studies.

• Bulletin of the Korean Chemical Society
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• v.9 no.5
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• pp.271-274
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• 1988

Irradiaton of nifedipine in methylene chloride at 366 nm yielded 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrosophen yl)-pyridine with the quantum yield 0.37, while irradiation at 254 nm initially gave nitroso compound which in turn is photooxidized to 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrophenyl) -pyridine with the quantum efficiency of 0.014 on further irradiation in the presence of oxygen. The intramolecular hydrogen abstraction of nifedipine proceeded from the triplet excited sitate.

• YAKHAK HOEJI
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• v.32 no.6
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• pp.428-434
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• 1988

The effects of calcium and calcium antagonist, nifedipine on the adrenergic receptor-stimulated glycogenolysis were investigated in isolated rat hepatocytes. The hepatic glycogenolysis induced by alpha-adrenergic receptor stimulation depended on calcium ions, and beta-adrenergic activation was unrelated to calcium ions. Nifedipine decreased the alpha-adrenergic agonist-induced glucose release significantly and the decrease was depended on calcium ions. The glucose release induced by beta-adrenergic agonist was not inhibited by nifedipine.