공업화학 (Applied Chemistry for Engineering)

  • 제16권4호
  • /
  • Pages.588-593
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  • 2005
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  • 1225-0112(pISSN)
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  • 2288-4505(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
권호 표지

실리카와 니페디핀을 함유한 Poly(ε-caprolactone) 마이크로캡슐의 제조와 방출 거동

Preparation and Release Behaviors of Poly(ε-caprolactone) Microcapsules Containing SiO2 and Nifedipine

  • 박수진 (한국화학연구원 화학소재연구부) ;
  • 이윤목 (한국화학연구원 화학소재연구부) ;
  • 한미정 (한국화학연구원 화학소재연구부)
  • Park, Soo-Jin (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Lee, Yun-Mok (Advanced Materials Division, Korea Research Institute of Chemical Technology) ;
  • Han, Mijeong (Advanced Materials Division, Korea Research Institute of Chemical Technology)
  • 투고 : 2005.05.11
  • 심사 : 2005.06.27
  • 발행 : 2005.08.10
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초록

본 실험에서는 화학적으로 표면처리된 실리카와 니페디핀을 함유하는 PCL 마이크로캡슐을 O/W 액중건조법을 이용하여 제조하였다. 마이크로캡슐에 대한 심물질의 함입은 FT-IR을 사용하여 측정하였고, 마이크로캡슐의 표면 형태는 주사전자현미경을 통하여 관찰하였다. 또한, 마이크로캡슐의 니페디핀 방출 거동은 UV/Vis. 흡광광도법으로 흡광도를 측정하여 살펴보았다. 실험 결과, 니페디핀의 C=O 결합에 의한 $1682cm^{-1}$ 신축진동 피크가 마이크로 캡슐에서 나타나는 것을 확인할 수 있었다. 마이크로캡슐의 평균 입자크기는 교반 속도가 증가함에 따라 감소하였다. 그리고 실리카를 염기성 용액으로 처리한 경우 니페디핀의 흡착량과 방출 속도가 감소하였음을 확인할 수 있었으며, 이는 표면 염기도의 증가로 인해 실리카 표면의 비표면적이 감소되고 산-염기 상호작용이 증가되었기 때문으로 판단된다.

In this study, biodegradable poly(${\varepsilon}$-caprolactone) (PCL) microcapsules containing chemically treated $SiO_2$ and nifedipine were prepared by oil-in-water (O/W) emulsion solvent evaporation method. The microcapsules containing drugs were confirmed using FT-IR spectra. The morphologies of the microcapsules were observed with scanning electron microscope (SEM). The nifedipine's release behaviors from the microcapsules were also examined with UV/vis spectroscopy. As a result, the inclusion of nifedipine into the microcapsules was determined by the presence of nifedipine's specific peak, i.e., C=O stretch vibration at $1682cm^{-1}$. The average particle size of the microcapsules decreased with increasing stirring rate. The nifedipine adsorption capacity and release rate of treated $SiO_2$ that was treated with basic solution decreased because with the increased basicity it lowered the specific surface area of $SiO_2$ and promoted stronger acid-base interactions between $SiO_2$ and nifedipine.

키워드

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