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Preparation and Release Behaviors of Poly(ε-caprolactone) Microcapsules Containing SiO2 and Nifedipine  

Park, Soo-Jin (Advanced Materials Division, Korea Research Institute of Chemical Technology)
Lee, Yun-Mok (Advanced Materials Division, Korea Research Institute of Chemical Technology)
Han, Mijeong (Advanced Materials Division, Korea Research Institute of Chemical Technology)
Publication Information
Applied Chemistry for Engineering / v.16, no.4, 2005 , pp. 588-593 More about this Journal
Abstract
In this study, biodegradable poly(${\varepsilon}$-caprolactone) (PCL) microcapsules containing chemically treated $SiO_2$ and nifedipine were prepared by oil-in-water (O/W) emulsion solvent evaporation method. The microcapsules containing drugs were confirmed using FT-IR spectra. The morphologies of the microcapsules were observed with scanning electron microscope (SEM). The nifedipine's release behaviors from the microcapsules were also examined with UV/vis spectroscopy. As a result, the inclusion of nifedipine into the microcapsules was determined by the presence of nifedipine's specific peak, i.e., C=O stretch vibration at $1682cm^{-1}$. The average particle size of the microcapsules decreased with increasing stirring rate. The nifedipine adsorption capacity and release rate of treated $SiO_2$ that was treated with basic solution decreased because with the increased basicity it lowered the specific surface area of $SiO_2$ and promoted stronger acid-base interactions between $SiO_2$ and nifedipine.
Keywords
microcapsule; poly(${\varepsilon}$-caprolactone); nifedipine; $SiO_2$; chemical treatment;
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